High tumour mutation burden improves overall survival in solid tumours treated with immune checkpoint inhibitors
High Mutation Counts May Predict Better Cancer Survival Outcomes
May 1, 2026
This systematic review and meta-analysis evaluated 5278 patients with solid tumours treated with immune checkpoint inhibitors or chemotherapy. High tumour mutat…
High mutation counts in tumors may help predict who will survive longer when taking powerful immune-boosting cancer drugs
CPAP Most Effective for Apnea-Hypopnea Index, GLP-1 RAs Improve Weight in OSA
CPAP and weight-loss drugs show different benefits for sleep apnea patients
May 1, 2026
This network meta-analysis of 3964 adults with obstructive sleep apnea found that CPAP produced the largest reduction in apnea-hypopnea index (MD -22.17 events/…
A large analysis found CPAP best for breathing control, while weight-loss drugs improved body weight and blood sugar levels in sleep apnea patients.
Ecnoglutide Reduces HbA1c and Body Weight in Type 2 Diabetes: Meta-Analysis
New diabetes drug cuts sugar and weight in adults with Type 2 Diabetes
May 1, 2026
A meta-analysis of 1643 adults with type 2 diabetes found that ecnoglutide significantly reduced HbA1c (MD -0.44, 95% CI -0.55 to -0.33) and body weight (MD -5.…
A large review shows ecnoglutide lowers blood sugar and body weight in adults with Type 2 Diabetes. It also has an acceptable safety profile.
SMS Text Messaging Lifestyle Programs Show No Significant Benefit for Prediabetes
SMS lifestyle programs show no clear benefit for prediabetes outcomes in this meta-analysis
May 1, 2026
This systematic review and meta-analysis of 4632 adults with prediabetes found that SMS text messaging-delivered lifestyle programs did not significantly improv…
A large review of text message health programs found no significant improvement in weight or diabetes risk for adults with prediabetes.
Lenvatinib plus PD-1 inhibitor improves survival versus bevacizumab plus PD-1 inhibitor in unresectable hepatocellular carcinoma
Meta-analysis shows lenvatinib-based regimens improve survival for unresectable liver cancer in East Asia
May 1, 2026
This systematic review and meta-analysis evaluated first-line treatment for unresectable hepatocellular carcinoma in East Asian populations. Data from 1659 pati…
A meta-analysis of East Asian patients with unresectable liver cancer found lenvatinib-based regimens improved survival compared to bevacizumab-based regimens.
Systematic review suggests modest risk reduction with SGLT2 inhibitors or ARNIs added to standard therapy in severe heart failure.
Moderate evidence supports adding SGLT2 inhibitors to heart failure treatment
May 1, 2026
This systematic review and network meta-analysis evaluated adding SGLT2 inhibitors or angiotensin receptor-neprilysin inhibitors to neurohormonal blockade in pa…
A large analysis suggests adding SGLT2 inhibitors may lower risk of death or hospitalization for heart failure, though caution is advised.
Reversion of Prediabetes to Normoglycemia Linked to 68% Lower Diabetes Risk
Reversing prediabetes cuts diabetes risk by 68 percent in a massive study
May 1, 2026
A meta-analysis of 535,066 participants with prediabetes found that reversion to normoglycemia was associated with a 68% lower risk of incident diabetes (HR: 0.…
Reversing prediabetes to normal blood sugar levels lowers the risk of developing diabetes by 68 percent in people with the condition.
GLP-1RAs reduce weight and HbA1c in severe mental illness with low discontinuation rates
New drugs help people with severe mental illness lose weight safely
May 1, 2026
This systematic review and meta-analysis evaluated glucagon-like peptide-1 receptor agonists in individuals with severe mental illness who have prediabetes or a…
New weight loss drugs work well and stay safe for people with severe mental illness who struggle with obesity and high blood sugar.
Clozapine Use Linked to Higher SARS-CoV-2 Infection Risk in Severe Mental Disorders
Clozapine users faced higher risk of severe COVID-19 in large study
May 1, 2026
A meta-analysis of 155,945 outpatients with severe mental disorders found that clozapine users had a higher rate of SARS-CoV-2 infection compared to non-users (…
A massive analysis of over 155,000 people found that those taking clozapine had higher rates of infection and worse outcomes from COVID-19.
Preoperative psychological factors are associated with postoperative cognitive outcomes in older adults.
Psychological factors linked to cognitive issues after surgery in older adults
May 1, 2026
This systematic review and meta-analysis examined preoperative psychological factors in older adults aged 60 years or older. The analysis included a sample size…
A large review links preoperative anxiety and stress to worse cognitive outcomes after surgery for older patients.
Systematic review shows high prevalence of covert cerebrovascular changes in schizophrenia patients compared to controls
Brain scans show hidden vessel changes in many people with schizophrenia
May 1, 2026
This systematic review and meta-analysis evaluated 11,611 patients with schizophrenia and controls from international and Chinese databases. The analysis found …
A large review found hidden signs of blood vessel issues in many people with schizophrenia, though experts urge caution before drawing firm conclusions.
Meta-Analysis Identifies Risk Factors for Adverse Outcomes in MINOCA Patients
Old heart risk rules fail for this specific chest pain mystery
May 1, 2026
A meta-analysis of 12,081 patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) found that older age, diabetes, elevated creatinin…
New data shows that standard heart risk factors do not predict outcomes for patients with heart attacks and clear arteries.