Glofitamab plus selinexor maintenance yields sustained CR in refractory DLBCL case
New treatment strategy shows promise for hard to treat lymphoma
This case report and literature review describes a 70-year-old man with primary refractory DLBCL harboring TP53 and CD58 mutations who achie…
A new treatment plan using glofitamab and selinexor helped a 70-year-old man with a very aggressive form of lymphoma achieve a lasting respo…
Withdrawal from overused medication and prophylactic treatment are key pillars for managing medication-overuse headache
Withdrawal and Prevention Help Manage Medication Overuse Headaches
This narrative review examines the pathophysiology and management of medication-overuse headache (MOH). The authors emphasize that MOH is en…
Medication overuse headaches are preventable, but they require specific withdrawal and prevention strategies to manage the underlying pain s…
Migraine-associated forehead erythema may resolve rapidly with standard acute analgesic treatment
A rare skin condition linked to migraine attacks in one man
This case report and review of literature describes a patient with migraine and red forehead dot syndrome. The report notes that headache an…
A man with migraines experienced a red forehead dot that improved quickly with standard pain medicine, highlighting a rare skin-headache lin…
Peripheral nerve stimulation improves tremor severity and functional disability in patients with essential tremor
Nerve stimulation shows promise for managing essential tremor symptoms
This meta-analysis of 2541 patients found that peripheral nerve stimulation (PNS) significantly improved TETRAS performance scale scores (MD…
New data shows that non-invasive nerve stimulation can reduce tremor severity and improve daily activities for people with essential tremor.
Magnesium sulfate and dexmedetomidine show no significant difference as peribulbar block adjuvants
Trial Shows Magnesium Sulfate and Dexmedetomidine for Eye Surgery Blocks
This meta-analysis evaluated magnesium sulfate versus dexmedetomidine as adjuvants for peribulbar block in ophthalmic surgery. The analysis …
New research compares magnesium sulfate and dexmedetomidine as additives for eye surgery blocks, but shows no clear winner for patient comfo…
Telemedicine improves access and convenience for rural chronic pain patients but lacks consistent pain relief
Telemedicine Can Improve Access for Rural Patients with Chronic Pain
This narrative review examines the use of telemedicine for managing chronic pain in rural populations. The authors synthesize evidence showi…
Telemedicine can improve access and convenience for rural patients with chronic pain, though it does not consistently reduce pain intensity.
East Asian research on online mental health focuses heavily on addiction and negative behaviors
Online Mental Health Research in East Asia Focuses Mostly on Addiction Risks
This systematic review of 54 articles identifies regional patterns in online mental health research in East Asia. The findings indicate a he…
A review of 54 studies finds East Asian online mental health research focuses heavily on addiction and harms, with little attention to posit…
Intrathecal therapy using partially implanted devices reduces pain intensity and opioid use in refractory cancer pain
Intrathecal Therapy Shows Promise for Managing Refractory Cancer Pain
This meta-analysis of 15 studies indicates that intrathecal therapy using partially implanted devices significantly reduces pain intensity a…
A new type of implanted device may help patients with severe cancer pain reduce their reliance on opioid medications.
Neuronal-surface autoantibodies cause synaptic dysfunction and structural injury in various neurological phenotypes
Antibodies Linked to Specific Brain Signaling and Synaptic Dysfunction
This mini review explores the role of neuronal-surface autoantibodies in neurological disorders. The authors synthesize how specific antibod…
New research highlights how specific antibodies can impact brain signaling and cause structural changes in certain neurological conditions.
Chronic pain is associated with poorer executive functioning and processing speed in dementia patients
Chronic pain is linked to poorer thinking in people with dementia
This systematic scoping review explores the relationship between chronic pain and cognitive performance in individuals with dementia. The re…
Living with chronic pain may make it harder for people with dementia to manage tasks and process information quickly.
Motor Guided Imagery significantly reduces pain and improves sleep quality in patients with post-stroke symptoms
Motor Guided Imagery May Relieve Pain for Stroke Patients
This meta-analysis of randomized controlled trials indicates that Motor Guided Imagery (MGI) significantly relieves pain (Hedges' g = -0.524…
A review of clinical trials suggests that Motor Guided Imagery can help reduce pain and improve sleep quality for people living with stroke …
Higher knowledge of neonatal pain is associated with increased use of standardized assessment tools
Few hospital staff use standard tools to measure newborn pain
This multicenter cross-sectional survey of 530 healthcare professionals in the Democratic Republic of the Congo evaluates neonatal pain asse…
While most hospital staff recognize that newborns feel pain, very few use standard tools to measure it or receive specific training on the t…
All Anesthesiology & Pain Medicine Articles
- Glofitamab plus selinexor maintenance yields sustained CR in refractory DLBCL case
- Withdrawal from overused medication and prophylactic treatment are key pillars for managing medication-overuse headache
- Migraine-associated forehead erythema may resolve rapidly with standard acute analgesic treatment
- Peripheral nerve stimulation improves tremor severity and functional disability in patients with essential tremor
- East Asian research on online mental health focuses heavily on addiction and negative behaviors
- Telemedicine improves access and convenience for rural chronic pain patients but lacks consistent pain relief
- Magnesium sulfate and dexmedetomidine show no significant difference as peribulbar block adjuvants
- Intrathecal therapy using partially implanted devices reduces pain intensity and opioid use in refractory cancer pain
- Chronic pain is associated with poorer executive functioning and processing speed in dementia patients
- Neuronal-surface autoantibodies cause synaptic dysfunction and structural injury in various neurological phenotypes
- Motor Guided Imagery significantly reduces pain and improves sleep quality in patients with post-stroke symptoms
- Higher knowledge of neonatal pain is associated with increased use of standardized assessment tools
- El Niño and hydrometeorological disasters cause significant health impacts including infections and food insecurity
- Collaborative care improves depression severity in low-complexity patients with OUD and depression
- Electroacupuncture provides short-term improvements in MoCA and MMSE scores for MCI and early Alzheimer's
- Perioperative gabapentin fails to reduce rest pain at 24 hours after thoracic surgery
- Fast-release paracetamol 650 mg achieves faster onset of analgesia and greater temperature reduction
- Digitally enabled patient education tools for chronic musculoskeletal pain lack tailoring for diverse patient needs
- Ambient cold exposure is associated with increased cardiovascular mortality across diverse geographic and socioeconomic settings
- Perioperative intraoral sucralfate reduces postoperative pain and improves mucosal healing after tonsillectomy
- Physical therapy and respiratory exercises reduce pain scores in patients with arteriovenous fistulas
- NSAIDs provide pain relief comparable to opioids in acute pancreatitis with fewer local complications
- tVNS, especially concha targeting, linked to better sleep quality and lower insomnia severity
- Patient education combined with exercise reduces pain in knee osteoarthritis patients by MD -3.28
- Preemptive photobiomodulation therapy may reduce pain during dental and craniomaxillofacial anesthetic needle punctures
- Complementary health therapies significantly reduce labor pain in women during labor (d = -1.16)
- Reflexology massage significantly reduces neuropathic pain and improves quality of life in patients with diabetes
- Continuous brachial plexus block reduces pain at rest following elective shoulder surgery
- Ibuprofen and acetaminophen show no statistically significant difference in total adverse events for pediatric pain
- Transcranial alternating current stimulation reduces musculoskeletal pain intensity with low certainty of evidence
- Warm-water bathing in labor may reduce instrumental delivery but not analgesia use
- Auriculotherapy Shows Consistent Pain Relief Across Multiple Conditions
- Central Asian Paralympic athlete participation and female representation increased significantly between 1996 and 2024
- Distal targeting SRS provides significantly higher pain relief at 30 days compared to proximal targeting
- Immunonutrition provides the strongest evidence for perioperative immune homeostasis in gastrointestinal cancer surgery
- Gestational diabetes mellitus increases maternal and neonatal morbidity and long-term risk of type 2 diabetes
- Electroacupuncture Regimens May Improve Short-Term Response in Peripheral Facial Palsy
- Erector Spinae Plane Block provides superior pain relief compared to Intercostal Nerve Block
- Comparing Eight Nerve Block Combinations and Local Infiltration Analgesia for Total Knee Arthroplasty
- Greater cumulative unmet social needs associated with higher pain intensity and interference in older adults
- Lidocaine-esketamine infusion reduces movement-evoked pain and opioid consumption in hepatic resection patients
- Stimulant use is associated with increased social needs and severity in patients with opioid use disorder
- Efficacy of Laparoscopic Guided Transversus Abdominis Plane Block for Postoperative Pain Management
- Programmed intermittent boluses of ropivacaine do not reduce opioid consumption compared to continuous infusion
- Sabin-derived inactivated poliovirus vaccine shows comparable safety to conventional IPV in adult booster recipients
- Efficacy of Perioperative Duloxetine for Pain Management in Hip and Knee Arthroplasty
- Hypnosis yields modest reductions in clinical pain compared to non-active controls in meta-analysis
- Ozone injections are more effective than corticosteroids for short and medium term pain in knee osteoarthritis
- Opioid-free perioperative regimens associated with lower pain scores and fewer side effects in hip arthroplasty
- Virtual reality reduces pain and anxiety in children undergoing emergency procedures
- Intrauterine lidocaine significantly reduces pain during IUD insertion in nulliparous and parous women
- Intravenous dexamethasone is most effective for reducing rebound pain after peripheral nerve blocks
- Pain neuroscience education reduces pain intensity in patients with chronic musculoskeletal pain conditions
- Nerve Block Eases Neurogenic Cough in Meta-Analysis
- 4% articaine improves anaesthetic success rates compared to 2% lidocaine in children with MIH
- Multi-scale framework of technologies provides a roadmap for investigating mechanisms of force-based manipulations
- Poorly supported operating room environments compromise nurse wellbeing and professional performance through multiple stressors
- Parathyroidectomy and hypercalcemia management may improve outcomes in patients with primary hyperparathyroidism
- Low back pain affects 53% of Africans at any point, 75% annually
- Perioperative regional nerve blocks reduce postoperative pain scores after robot-assisted transaxillary thyroidectomy
- Opioid receptor agonist-antagonists may improve analgesia and safety when co-administered with full mu-opioid agonists
- Transforaminal epidural steroid injections provide superior pain and disability relief compared to interlaminar techniques
- Exosomes are safe for knee osteoarthritis but show no superiority over placebo in one trial
- Hydrolyzed collagen peptides show a cautious signal for improving pain and function in tendon injuries
- Pain may precede Parkinson's diagnosis, affecting up to 59% before motor symptoms
- Serratus anterior plane block reduces postoperative nausea and opioid consumption after surgery under general anesthesia
- Spinal cord stimulation research skewed by region and industry funding, meta-analysis finds
- Manual acupuncture and sham therapies both reduce pain intensity in tension-type headache patients
- ECAP-controlled closed-loop spinal cord stimulation provides 90% overall pain relief for neuropathic pain
- Spinal cord stimulation with medical management reduces pain intensity in painful diabetic neuropathy
- Live, robotic, and picture parrot therapies reduce venipuncture pain in adults with chronic illness
- Opioid Safety Toolkit increases naloxone requests (OR 2.5) and overdose knowledge compared to standard information
- Comparative Efficacy of Neuromodulation Techniques for Managing Chronic Herpes Zoster Pain
- Perineural dexmedetomidine combined with ropivacaine reduces pain and hospital stay after VATS
- Thermal RFA reduces pain more than steroid injections in facet joint syndrome, but effect may not be clinically meaningful
- Nursing students answer only 45% of pain management knowledge questions correctly
- Virtual reality reduces pain intensity and heart rate in pediatric patients with burns
- Dexmedetomidine added to TAP block reduces tramadol consumption and pain scores during cesarean section
- Opium use and disorder prevalence remains high among Iranian men despite declining trends in students
- External Oblique Intercostal Plane Block reduces postoperative opioid consumption by 19.55 mg compared to standard analgesia
- Immersive virtual reality reduces pain and disability in patients with chronic neck pain
- Opioids provide clinically important pain relief for short durations but lack long-term efficacy in osteoarthritis
- Community engagement and health system strengthening facilitate maternal and child health services for Somali IDPs
- Nerve decompressive surgery of the lower limbs reduces pain scores in patients with diabetic peripheral neuropathy
- Warming-dredging acupuncture significantly improves pain relief rates for patients with cancer-related pain
- ERAS protocols for scoliosis surgery are planned for evaluation in a systematic review meta-analysis
- Pain assessment guidelines for cognitively impaired older adults lack practical detail
- Surgical removal of an ectopic tooth and associated cyst resolves symptoms of unilateral sinusitis
- Natural products modulate non-apoptotic cell death to bypass apoptotic blockades in cancer
- Herbal Medicinal Bath shows stable efficacy for chronic kidney disease-associated pruritus in network meta-analysis
- Spatio-temporal graph neural networks improve prediction accuracy and interpretability for regional disease risk modeling
- VR-assisted physiotherapy improves pain, function, and balance in knee osteoarthritis
- Remifentanil lowers maternal mean arterial pressure at intubation but may decrease 1-minute Apgar scores
- Peripheral nerve stimulation significantly reduces tremor intensity and functional disability in essential tremor
- Classical conditioning enhances engagement of pain modulation regions compared to verbal suggestion alone
- PEID reduces operative time and fluoroscopy frequency compared to PETD for L5/S1 disc herniation
- Epidural analgesia may reduce pain during movement after laparoscopic abdominal surgery compared to PCIA
- Quadratus lumborum block reduces 24-h morphine consumption by 3.19 mg in cesarean section patients
- Perioperative magnesium sulfate reduces pain scores and opioid consumption following spinal or neurological surgery
- Percutaneous Cervical Cordotomy reduces pain and opioid consumption in patients with severe cancer pain
- Empowered Relief trial evaluates if 1-session intervention is non-inferior to 8-session CBT for chronic pain
- Methadone shows significantly higher treatment retention than buprenorphine-naloxone in patients with Opioid Use Disorder
- Esketamine reduces 3-month postpartum depression incidence from 20.89% to 11.59% in primiparae
- Nitrous oxide reduces pain and improves completion rates in office hysteroscopy
- Opioid Wizard tool increases primary care clinician confidence in screening, diagnosing, and referring patients for OUD
- Intraoperative surgeon-performed adductor canal blocks are non-inferior to anesthesiologist-performed blocks for TKA discharge
- Mood disorders and benzodiazepine use increase risk for new persistent opioid use in postsurgical adults
- Tegileridine provides superior analgesic efficacy over placebo for postoperative acute pain with a favorable safety profile
- Tai Chi significantly reduces pain and improves functional disability in chronic non-specific low back pain
- Intermittent hypoxia-hyperoxia therapy significantly improves pain and functional mobility in musculoskeletal dysfunctions
- TENS reduces pain (MD -0.82) and improves muscle strength in patients with knee osteoarthritis
- Percutaneous electrolysis provides superior pain reduction compared to baseline care in lateral epicondylitis
- Trial protocol evaluates three liposomal bupivacaine concentrations for superior trunk block in rotator cuff repair
- Suture-less closure may reduce pain and swelling after mandibular third molar extraction
- Meta Analysis Evaluating Transcutaneous Auricular Vagus Nerve Stimulation for Cognitive Enhancement
- Repetitive transcranial magnetic stimulation may increase network flexibility to address chronic pain through triple-network interactions
- Peripheral nerve blocks reduce 24-hour morphine use by 16.20 mg in kidney transplant recipients
- Blood flow restriction exercise may reduce pain through metabolic and neurological pathways for musculoskeletal injuries
- Fibromyalgia as an oncology comorbidity increases symptom burden and impairs treatment adherence
- Intercostal nerve cryoablation reduces inpatient opioid consumption by 102 morphine milligram equivalents
- Botulinum toxin type A as an add-on improves scar appearance scores in multimodal management
- Liposomal bupivacaine reduces 24-hour resting pain scores by 1.04 points in brachial plexus blocks
- High-dose buprenorphine induction protocol for Opioid Use Disorder in emergency department settings
- Vapocoolant spray reduces pain scores by Cohen's d -0.30 to -0.48 in critically ill adults during arterial puncture
- Descending pain modulation hubs and cortical influences: a narrative review of mechanisms and therapies
- Transversus abdominis plane block reduces morphine use and pain after kidney removal surgery in patients
- Function-oriented, neuroscience-based approaches improve pain and function in older adults with chronic spinal pain
- Systematic review finds aerobic exercise combined with other therapies helps reduce neck pain intensity and improve physical function in adults
- Laparoscopic-endoscopic cooperative surgery achieves R0 resection in gastric synovial sarcoma with no recurrence at nine months
- Whole health team intervention reduced pain interference by 0.58 points versus cognitive behavioral therapy in VA patients
- General anesthesia with reduced rocuronium and sugammadex reversal safely enabled cesarean section in a patient with inclusion body myositis
- Immersive VR reduces pain and anxiety in obstetric procedures
- Systematic review finds ketamine offers no pain advantage over opioids in prehospital trauma care settings
- Intercostal nerve cryoablation reduces length of stay by 2.2 days in pediatric pectus excavatum surgery compared to standard care
- Repetitive transcranial magnetic stimulation cuts neuropathic pain intensity with large effect in meta-analysis
- Hypnotic communication cuts post-ABG pain intensity beta = -0.97 in ED patients
- Dexmedetomidine plus sufentanil cuts postoperative delirium risk to 4.9% vs 15.28% with sufentanil alone
- Laughter therapy shows large anxiety reduction and moderate pain relief in children
- Wound infusion catheter shortens hospital stay and provides comparable analgesia to epidural after laparotomy
- Massage or music listening reduces pain severity in ICU patients within 48 hours after cardiac surgery
- Infrared irradiation reduces postpartum pain after episiotomy, but low-level laser therapy shows no benefit
- Superficial parasternal intercostal plane block reduces 24-hour morphine use by 8.53 mg in cardiac surgery patients
- Mobility strategies during labor significantly shorten stages and reduce cesarean rates in women receiving low-dose epidural analgesia
- Intrauterine lidocaine reduces pain during hysteroscope insertion and improves patient satisfaction
- AI and machine learning improve patient selection and outcomes in spinal cord stimulation
- Electroacupuncture alleviates pain in patients with temporomandibular disorder while maintaining a good safety record
- Electroacupuncture with intradermal needles for Bell's palsy shows no overall benefit but may help severe cases
- Qualitative review of early child care policies in Kenya highlights implementation gaps and resource needs
- Perioperative nefopam failed to lower morphine needs or pain scores in spine surgery patients undergoing randomised trials
- Narrative synthesis on liposomal bupivacaine for autologous breast reconstruction pain
- Acupuncture combined with Chinese medicine reduces cancer pain intensity compared to usual care in a meta-analysis of 884 patients
- Meta-analysis shows PENG+LFCN block reduces pain and weakness versus FICB in hip surgery ERAS pathways
- Narrative review discusses multimodal strategies for rebound pain after extremity fracture surgery
- Systematic review and meta-analysis of olive-derived compounds for osteoarthritis pain
- Acupuncture plus usual care did not improve acute musculoskeletal pain at 1 month
- Laparoscopic assisted TAP block reduces morphine consumption after elective minimally invasive colon surgery
- Meta-analysis shows association between ganglion impar blocks and coccydynia pain reduction
- Meta-analysis shows preoperative COX-2 inhibitors and gabapentin reduce opioid use after arthroscopic surgery
- Systematic review and meta-analysis of gestational diabetes prevalence in African populations
- Network meta-analysis compares analgesic techniques for upper GI surgery pain
- Low-frequency TENS with vocal exercises may improve vocal quality in women with vocal nodules
- Single photobiomodulation session fails to reduce perineal trauma pain in postpartum women
- Adding dexmedetomidine to dexamethasone does not prolong analgesia in upper limb surgery
- Reflexology hand massage reduces pain and anxiety after coronary angiography
- Eye-transcutaneous electrical acupoint stimulation reduced myopia incidence in children aged 6 to 12 years compared with sham stimulation
- Intranasal naloxone reverses opioid-induced respiratory depression in opioid-naive and daily users within 2 to 17 minutes
- High- and low-intensity acupuncture improved pain in chronic recalcitrant plantar fasciitis versus waitlist control
- Nurse-led rehabilitation reduced pain and improved wound healing in noncomplex burn injuries compared to routine care
- Meta-analysis shows methadone exposure linked to higher NAS incidence and treatment needs versus buprenorphine in pregnant women
- Meta-analysis of VR for pain in pediatric ED patients shows mixed results
- Systematic review finds no convincing evidence linking neuraxial labour analgesia to neurodevelopmental disorders in offspring
- Systematic review and meta-analysis shows nonsignificant pain reduction with XR in children
- Kinesio Taping Plus Stretching Improves Pain and Function in Carpal Tunnel Syndrome
- Narrative review discusses link between diamine oxidase deficiency and fibromyalgia pathophysiology
- Narrative review identifies determinants of susceptibility to digital health misinformation
- Acupuncture and Celecoxib for Chronic Knee Pain: Genetic Factors May Influence Response
- Feedback-regulated background infusion reduces postoperative nausea and vomiting in laparoscopic myomectomy patients
- Meta-analysis finds Eat-Sleep-Console care reduces neonatal opioid withdrawal hospital stay
- FAPI PET/CT Shows Higher Sensitivity for Lymph Node Metastases in Breast Cancer
- Propofol and sevoflurane anesthesia show divergent EEG signatures in retrospective surgical patient analysis
- Meta-analysis finds core muscle training reduces pain in chronic nonspecific low back pain patients
- Review indicates non-thermal processing maintains antioxidant capacity and improves bioavailability versus thermal methods
- Bibliometric review of anesthesia-associated postoperative cognitive dysfunction in elderly patients from 2000 to 2024
- Meta-analysis finds TEAS reduces PONV after laparoscopic surgery
- taVNS with ropivacaine block reduces chronic postsurgical pain after off-pump CABG in elderly patients
- In a cohort of 561 individuals with chronic pain, sex and gender identity influenced repeated prescription refill odds
- Narrative review explores strategies to prevent CAR-T cell exhaustion in treatment-resistant non-Hodgkin lymphoma
- Office-based holmium-YAG TULA shows feasibility and safety for recurrent NMIBC in a high-risk cohort
- TEAS at PC6 during hepatectomy does not reduce PONV incidence within 24 hours
- Meta-analysis of Traditional Chinese Exercise for nonspecific low back pain in 3,054 patients
- Rotational effleurage and connective tissue massage reduced labor pain compared to routine care in primiparous women
- High-volume PENG block with dexamethasone showed no analgesic advantage over conventional volume in primary total hip arthroplasty
- Electroacupuncture with Pelvic Floor Training Reduces Stress Urinary Incontinence Leakage
- Meta-analysis shows floating needle therapy improves postpartum pain and incontinence outcomes in China
- Repeated conditioned pain modulation exposure linked to higher heat pain thresholds in healthy adults
- Meta-analysis shows dexmedetomidine lowers mean arterial pressure compared to midazolam-fentanyl in surgical patients
- Review synthesizes rTMS and tDCS efficacy for neuropathic orofacial pain management
- Memantine reduces opioid use but not pain in knee osteoarthritis patients after surgery
- Systematic review of neuropathic pain trials reveals high prevalence of restrictive exclusion criteria
- Review finds TCM stroke trials less likely to define primary outcomes and report safety than Western medicine trials