This week's Infectious Disease digest · 2026-W19
This Week in Infectious Disease: HIV Lipid Management and Sepsis Care
FDA Approves Linezolid Injection for Gram-Positive Infections Including Pneumonia and Skin Infections
FDA approves new antibiotic injection for serious bacterial infections
The FDA approved linezolid injection for nosocomial pneumonia, community-acquired pneumonia, complicated skin infections, and vancomycin-res…
The FDA approved linezolid injection for treating serious infections like pneumonia and skin infections caused by certain bacteria, includin…
Intrawound vancomycin powder reduces postoperative infection risk (OR 0.59) in high-risk fracture fixation cases
Vancomycin Powder May Reduce Infections After High Risk Fractures
This meta-analysis of 3185 patients found that intrawound vancomycin powder significantly reduced postoperative infection rates (OR 0.59; 95…
A review of data suggests that using vancomycin powder in wounds may lower infection rates for patients with serious bone fractures.
Plant essential oils demonstrate significant inhibitory effects against key subgingival plaque microbial complexes in periodontitis
Plant essential oils show promise against gum disease bacteria
This systematic review synthesizes the antibacterial activity of plant essential oils, including carvacrol and thymol, against subgingival p…
Certain plant oils may fight the specific bacteria that cause periodontitis while also helping to block harmful biofilm from forming in the …
Fungal biotransformation platform may generate new anti-infective molecules to combat antimicrobial resistance
Fungal Biotransformation May Help Combat Antimicrobial Resistance
This narrative review discusses fungal biotransformation as a discovery platform for generating structurally refined metabolites with anti-i…
New research explores how fungal systems can transform chemicals into new molecules to help fight stubborn bacterial and fungal infections.
Regenerative endodontic procedures may lead to unusual root morphology in immature teeth
Regenerative procedures can lead to unusual tooth root growth
This case report with literature review describes 2 immature teeth with pulp necrosis secondary to dens evaginatus treated with regenerative…
A new look at dental treatments shows that while some procedures save teeth, they can sometimes cause unexpected changes in how roots grow.
Risk-adapted HLA delisting and imlifidase enable deceased-donor kidney transplantation for highly sensitized candidates
New guide helps transplant kidneys for hardest-to-match patients
This expert consensus provides a practical guideline for managing highly sensitized adult patients on the waitlist for deceased-donor kidney…
A new expert guide shows how to safely transplant kidneys into highly sensitized patients who have few options left.
Gay men show higher rates of PrEP awareness and use than bisexual men
Gay men more likely to use HIV prevention tools
This meta-analysis of 514,543 individuals identified significantly higher rates of PrEP awareness and usage among gay men compared to bisexu…
New data shows significant gaps in PrEP awareness and use among bisexual men compared to gay men, highlighting a need for targeted outreach.
Conjugation governs the spread of resistance genes in bacterial populations across ecological compartments
Gene swapping drives the spread of antibiotic resistance in bacteria
This narrative review examines bacterial populations and the spread of resistance genes. The authors argue that conjugation governs the spre…
A review shows that bacteria sharing genes spreads resistance faster than simple mutation. This process happens across different environment…
Early-life microbiome shapes allergic, metabolic, and respiratory disease risk
Gut and Lung Microbiome in Early Life Linked to Health
This narrative review synthesizes evidence on how the human gut and lung microbiome in early life influences allergic diseases, metabolic di…
A review suggests the gut and lung microbiome in early life may influence allergies, metabolism, and respiratory health.
Water buffalo act as reservoirs for infectious diseases in mixed livestock systems
Water Buffalo May Spread Diseases to Other Livestock
This systematic review analyzes 180 articles regarding infectious diseases in water buffalo. The authors conclude that these animals are inc…
A review of 180 articles suggests water buffalo act as disease reservoirs, meaning they can pass infections to other animals in mixed farmin…
PEG-IFN plus novel agents may boost functional cure in chronic hepatitis B
Combination therapies may improve functional cure rates for chronic hepatitis B
This narrative review examines combining pegylated interferon-α with novel immunotherapies (antigen-reduction strategies, therapeutic vaccin…
A review suggests combining pegylated interferon with new immunotherapies could help achieve functional cure in chronic hepatitis B patients…
Antibiotic prophylaxis reduces UTI risk in children with VUR but increases antibiotic resistance
Taking daily antibiotics lowers UTI risk but raises resistance chances for young patients with reflux
This systematic review and meta-analysis of 2577 children with vesicoureteral reflux found that continuous antibiotic prophylaxis reduced UT…
A large review found that daily antibiotics reduce urinary infections in kids with reflux. However, this treatment also makes bacteria harde…
All Infectious Disease Articles
- FDA Approves Linezolid Injection for Gram-Positive Infections Including Pneumonia and Skin Infections
- Intrawound vancomycin powder reduces postoperative infection risk (OR 0.59) in high-risk fracture fixation cases
- Risk-adapted HLA delisting and imlifidase enable deceased-donor kidney transplantation for highly sensitized candidates
- Regenerative endodontic procedures may lead to unusual root morphology in immature teeth
- Plant essential oils demonstrate significant inhibitory effects against key subgingival plaque microbial complexes in periodontitis
- Fungal biotransformation platform may generate new anti-infective molecules to combat antimicrobial resistance
- Gay men show higher rates of PrEP awareness and use than bisexual men
- Conjugation governs the spread of resistance genes in bacterial populations across ecological compartments
- Early-life microbiome shapes allergic, metabolic, and respiratory disease risk
- Water buffalo act as reservoirs for infectious diseases in mixed livestock systems
- PEG-IFN plus novel agents may boost functional cure in chronic hepatitis B
- Antibiotic prophylaxis reduces UTI risk in children with VUR but increases antibiotic resistance
- Apodemus mice are key reservoirs for Borrelia and Neoehrlichia, but landscape drives tick-borne pathogen risk
- CDK4/6 inhibitors show therapeutic potential in advanced gastrointestinal cancers, review finds
- Standardized environmental AMR detection needed for regulatory interpretation and concern tiering
- HIV linked to lower odds of post-TB lung disease; undernutrition raises risk
- Microbial metabolites may promote or suppress cancer progression through inflammation, DNA damage, or immune modulation
- Inhaled antibiotics improve clinical cure and reduce mortality in ventilator-associated pneumonia
- Bictegravir/emtricitabine/tenofovir alafenamide shows favorable lipid and renal changes versus other regimens in treatment-experienced HIV-1 patients
- Bacteriophages modulate macrophage functions and immune responses in therapeutic applications
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- Correction notice issued for report on alcohol-related deaths and life years lost in US
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- Erratum issued for telehealth trends study during early COVID-19 pandemic
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- Erratum notice published for MMWR Vol. 71, No. 42; no study data available
- Erratum published for MMWR Vol. 69 SS-7, correcting a prior report.
- Erratum notice published for MMWR Vol. 70 SS-9 report
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- Retraction and republication notice issued for study on timing of complementary foods
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- Global bibliometric analysis reveals sustained upward trend in parasite EV research from 2015 to 2025
- Transition from paediatric to adult HIV care is associated with a decline in virological suppression among adolescents and young adults
- Antibiotic stewardship bundle aims to cut antibiotic use in Chinese NICUs
- Digital AMS tools show no significant impact on antibiotic prescribing or patient outcomes
- Newer antibiotics reduce nephrotoxicity and improve eradication of carbapenem-resistant gram-negative bacilli versus generic antibiotics in HABP/VABP
- Bacterial contamination prevalent in ready-to-eat salads across Africa: meta-analysis
- 43% of Pseudomonas aeruginosa isolates in Indonesia are carbapenem-resistant, meta-analysis finds
- Maintaining gut microbiome integrity should be a fundamental component of antimicrobial stewardship strategies aimed at controlling AMR worldwide
- Source control and antibiotic stewardship remain cornerstones of sepsis management
- Mid-turbinate swabs match nasopharyngeal swab sensitivity for any respiratory virus in children
- Bibliometric analysis reveals growing research on Pseudomonas aeruginosa biofilm resistance
- Local antibiotic delivery systems increase healing rates in diabetic foot osteomyelitis compared with control groups in this meta-analysis
- Oral HPV detected in 27.9% of men living with HIV across Brazil, Mexico, and Puerto Rico
- Systemic corticosteroid therapy significantly decreased length of hospital stay and fever duration in children with community-acquired pneumonia
- Women's contraceptive preferences align with method use in Kenya; long-acting preference strongest
- F/TAF PrEP shows similar HIV incidence to F/TDF in cisgender women but noninferiority not proven
- Azithromycin reduces maternal infection in laboring women in low- and middle-income countries
- Preplanned subanalysis shows comparable viral suppression rates for two dolutegravir-based regimens in antiretroviral-naive people with HIV at week 48
- Immediate antituberculosis therapy did not reduce mortality in HIV-related sepsis overall
- Ampicillin-gentamicin cuts chorioamnionitis risk to 1.9% vs 10.6% with ampicillin alone in PROM
- Model-informed precision dosing improves vancomycin target attainment in critically ill children compared to standard therapeutic drug monitoring
- Susceptibility-guided sequential therapy shows no superiority over empirical therapy for H. pylori eradication
- Hospital-based screening yields 18% CRE colonization prevalence, 20% with universal screening
- Educational interventions modestly reduce average drugs per prescription in MENA region hospitals
- Microplastic biofilms enrich antibiotic resistance genes in freshwater environments
- Adjunctive corticosteroids may modestly reduce hospital stay for bacterial facial infections but evidence certainty is low
- Nanomedicine strategies show promise for targeting pancreatic ductal adenocarcinoma
- Triple antibiotic paste shows stronger antimicrobial performance than calcium hydroxide for persistent endodontic infections
- Microbial arsenic transformations influence methane oxidation, denitrification, and carbon fixation in high-arsenic environments
- One in six blood donors in Cameroon carries Plasmodium infection, meta-analysis finds
- Pooled cytomegalovirus retinitis prevalence is 3% among people with HIV in sub-Saharan Africa
- Biofeedback therapy improves constipation response rates and symptom scores in adults compared to control groups
- MESNA-assisted surgery disrupts disease-associated microbiota equilibrium in paediatric cholesteatomatous chronic otitis media
- Review of animal models for allergic fungal airway disease and asthma
- Narrative review examines microorganisms in breast cancer with limited evidence from cross-sectional studies and models
- FDA Approves Hepcludex (bulevirtide) for Chronic Hepatitis Delta Virus Infection
- Review discusses sequential eradication strategies using EGCG, baicalin, and other compounds for potential therapeutic applications
- Meta-analysis finds high fluoroquinolone resistance in E. coli causing UTIs globally
- Review of influenza A and secondary bacterial infections identifies critical knowledge gaps
- Meta-analysis shows carbapenems linked to higher clinical failure in OXA-48-PE infections
- Narrative review on COVID-19 and gut microbiome disruption and immune effects
- Pre-infection vaccination linked to lower cardiovascular and cerebrovascular event risks in SARS-CoV-2 infected individuals
- FDA Approves Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) for HIV-1 Infection
- Meta-analysis of double-expressor lymphoma prognoses and novel therapies
- Case report of YL205 antibody-drug conjugate in platinum-resistant ovarian carcinoma
- Narrative review on unconventional microorganisms for non-alcoholic beer production
- Fecal Microbial Transplantation Shows Promise for Treating Gastrointestinal Acute Graft-Versus-Host Disease in Patients
- Narrative Review Explores Alistipes Genus Role in Inflammatory and Cancers
- Review highlights microbial contamination risks in home-use medicines and devices for vulnerable populations
- Meta-analysis shows lower prosthetic joint infection odds with cephalosporins versus non-cephalosporin prophylaxis in primary arthroplasty
- Systematic review on quinolone-phage synergy mechanisms and clinical strategies
- Two doses of SARS-CoV-2 vaccine show protective effect against MIS-C in children
- FDA approves nuzyra for community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections in adults
- FDA Approves Nuzyra (omadacycline) for Community-Acquired Bacterial Pneumonia and ABSSSI
- Preclinical study compares intranasal BPI3Vc-vector vaccine to commercial vaccine for calves
- Narrative review synthesizes microbial nature-based solutions for contaminant control
- Review of immunoprophylaxis for pyoderma and otitis in dogs notes bacterial antigenic diversity limits efficacy
- Narrative review explores Wnt/β-catenin signaling to improve CAR-T cell persistence in hematologic cancers
- Narrative review compares mNGS enrichment techniques against shotgun sequencing for pathogen detection workflows
- Narrative review discusses mycoremediation for crude oil contamination in the Niger Delta
- Review of Malaria literature lacks reported data on interventions and outcomes
- Cefepime-nacubactam and aztreonam-nacubactam non-inferior for complicated UTI and pyelonephritis
- Meta-analysis reveals high Salmonella prevalence in Chinese eggs compared to international standards
- Meta-analysis shows micro-osteoperforation accelerates orthodontic tooth movement safely across sixteen randomized controlled trials involving patients undergoing treatment
- Network meta-analysis of exercise interventions for cognitive function in sedentary adults
- Review of antifungal options for vulvovaginal candidiasis in women of reproductive age
- Critical narrative review discusses barriers to implementing urinary tract infection diagnostics in clinical practice
- FDA Approves Zerbaxa (ceftolozane/tazobactam) for Complicated Infections and Pneumonia
- Meta-analysis finds Bacillus subtilis and Enterococcus faecium reduce antibiotic-associated diarrhea
- Meta-analysis shows integrated MDA reduces yaws attendances in Papua New Guinea
- Narrative review of vonoprazan for pediatric H. pylori infection
- Network meta-analysis of non-pharmacological interventions for subthreshold depression in youth
- Case report on ivonescimab for EGFR-TKI-resistant lung adenocarcinoma with pericardial effusion
- Review of viral vectors for antimicrobial peptide expression in plants for agriculture
- Systematic review compares viral and bacterial pathogen mechanisms in respiratory infections
- Narrative review discusses CRISPR strategies for MRSA biofilm infections with noted limitations
- Single-tablet regimens improve adherence and persistence compared to multiple-tablet options for adult HIV patients in this meta-analysis
- Intrawound tobramycin plus vancomycin did not reduce deep infection risk compared with vancomycin alone in high-risk tibial fractures
- Narrative review outlines sialidase biology roadmap for genetic syndromes and inflammatory disorders
- Meta-analysis links ceftriaxone to higher 30-day mortality in MSSA bloodstream infections
- Narrative synthesis on CRISPR-Cas systems for multidrug-resistant bacterial infections
- Systematic review and meta-analysis of MDR-TB prevalence in the MENA region
- Post-hoc safety analysis of intramuscular adintrevimab for COVID-19 prophylaxis reports tolerability data