This week's Neurology digest · 2026-W19
This Week in Neurology: Stroke Interventions and Schizophrenia Findings
Tirofiban Adjunct Therapy Improves Outcomes in Patients with Inadequate Tenecteplase Response
Trial shows tirofiban improves outcomes for some stroke patients
Intravenous tirofiban significantly improves 90-day functional outcomes for acute ischemic stroke patients failing initial tenecteplase ther…
A new clinical trial suggests that adding tirofiban can improve recovery rates for certain types of stroke patients who do not respond well …
Aging impacts multiple sclerosis pathobiology by shifting inflammation toward chronic, compartmentalized neuroinflammation and neurodegeneration
New research explores how aging changes multiple sclerosis treatment
This narrative review examines the impact of aging on the immunological and neuroinflammatory microenvironment in older patients with multip…
As people age, multiple sclerosis can change from sudden flare-ups to a slow, steady progression of nerve damage.
Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
New research explores how inflammation drives nerve damage in diabetes
This narrative review explores the pathophysiology of diabetic peripheral neuropathy, focusing on how hyperglycemia, lipotoxicity, and intes…
Chronic high blood sugar causes more than just high glucose; it triggers a cycle of inflammation and immune stress that damages nerves.
Artificial intelligence shows potential for diagnosis, behavior analysis, and educational support in autism spectrum disorder
Artificial Intelligence Shows Potential to Support Autism Diagnosis and Education
This systematic review of 18 empirical studies evaluates artificial intelligence applications including machine learning, computer vision, a…
New research highlights how artificial intelligence can help identify autism early, analyze social behaviors, and provide personalized educa…
Acupuncture shows consistent signals for dysphagia and depressive symptoms after ischemic stroke
Acupuncture May Help Stroke Patients with Swallowing and Mood
This narrative review synthesizes evidence on acupuncture for ischemic stroke. It finds more consistent signals for dysphagia and depressive…
New research suggests acupuncture may specifically help stroke patients manage swallowing difficulties, depression, and cognitive issues.
Brain-computer interface training improves global cognitive function in stroke survivors with SMD=0.62
Brain computer interface training improves cognitive function after stroke
This systematic review and meta-analysis of randomized controlled trials indicates that brain-computer interface (BCI) training significantl…
New data shows that brain-computer interface training can improve focus and daily tasks for people recovering from a stroke.
Exercise, microbiota, and tRNA modifications may influence mitochondrial function and proteostasis in Parkinson's disease
Exercise and gut health may protect brain cells in Parkinson's
This narrative review explores the exercise-microbiota-queuine-tRNA axis as a potential mechanism for dopaminergic neuroprotection in Parkin…
New research explores how exercise, gut bacteria, and RNA modifications might work together to protect the brain from Parkinson's disease.
Repetitive transcranial magnetic stimulation may enhance upper limb motor function following a stroke
Magnetic stimulation may help arm movement after a stroke
This overview of systematic reviews analyzed 17 meta-analyses and systematic reviews regarding repetitive transcranial magnetic stimulation …
A review of several studies suggests that magnetic brain stimulation could improve arm movement for people recovering from a stroke.
Transcarotid Artery Revascularization shows lower 30-day stroke and death risk compared to TF-CAS
New data shows TCAR may lower risks for carotid artery disease
This meta-analysis of patients with carotid stenosis found that Transcarotid Artery Revascularization (TCAR) showed no significant differenc…
A new analysis finds that the TCAR procedure may offer better safety outcomes than stenting for patients with asymptomatic carotid artery bl…
Menopause does not appear to be a distinct clinical inflection point for multiple sclerosis progression
Menopause does not appear to be a turning point for MS
This narrative review examines the impact of menopause and biological aging on women with multiple sclerosis. The authors conclude that whil…
While menopause can make symptoms harder to manage, it is not a clear biological turning point for the progression of multiple sclerosis.
Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression
New Research Tools Help Map Complex Oral Diseases
This mini-review examines the integration of advanced experimental models, such as organ-on-chip systems and patient-derived organoids, with…
Advanced modeling and AI tools are helping researchers better understand the molecular causes behind conditions like gum disease and oral ca…
Traumatic BPPV triples recurrence risk versus idiopathic BPPV in meta-analysis of 4,074 patients
Traumatic vertigo cases show higher rates of recurring symptoms
A meta-analysis of 4,074 patients found that traumatic BPPV (t-BPPV) has significantly poorer outcomes than idiopathic BPPV (i-BPPV), with a…
People with vertigo caused by an injury may face a much higher risk of their symptoms returning compared to those with the condition on its …
All Neurology Articles
- Aging impacts multiple sclerosis pathobiology by shifting inflammation toward chronic, compartmentalized neuroinflammation and neurodegeneration
- Tirofiban Adjunct Therapy Improves Outcomes in Patients with Inadequate Tenecteplase Response
- Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
- Artificial intelligence shows potential for diagnosis, behavior analysis, and educational support in autism spectrum disorder
- Acupuncture shows consistent signals for dysphagia and depressive symptoms after ischemic stroke
- Brain-computer interface training improves global cognitive function in stroke survivors with SMD=0.62
- Exercise, microbiota, and tRNA modifications may influence mitochondrial function and proteostasis in Parkinson's disease
- Repetitive transcranial magnetic stimulation may enhance upper limb motor function following a stroke
- Transcarotid Artery Revascularization shows lower 30-day stroke and death risk compared to TF-CAS
- FDA Approves Vyepti (eptinezumab-jjmr) for Preventive Treatment of Migraine in Adults
- FDA Approves Epidiolex (cannabidiol) for Seizures Associated with LGS, DS, or TSC
- FDA Approves Ajovy (fremanezumab) for Preventive Migraine Treatment in Adults and Pediatric Patients
- FDA Approves Emgality (galcanezumab) for Preventive Treatment of Migraine and Episodic Cluster Headache
- Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression
- Menopause does not appear to be a distinct clinical inflection point for multiple sclerosis progression
- Traumatic BPPV triples recurrence risk versus idiopathic BPPV in meta-analysis of 4,074 patients
- Periodontal disease is associated with a 2.67 odds ratio for Alzheimer's disease
- Cardio-cerebral ion channel dysfunction links SUDEP and long QT syndrome in epilepsy patients
- MIND diet shows greater cognitive improvement in community-dwelling adults with high biomarker levels over three years
- Oral vitamin B12 reduces deficiency risk in children but shows little impact on growth or cognition
- Isolated hypoglossal nerve palsy from carotid dissection shows 65.6% favorable outcomes with medical management in 87 adult patients
- Meta-analysis shows tirofiban improves functional independence but raises intracranial hemorrhage risk in acute ischemic stroke patients
- Remote transitional care improves depressive symptoms in stroke patients, meta-analysis finds
- Ceramides emerge as key players in Alzheimer's pathology but therapeutic targeting faces hurdles
- Bipolar disorder is associated with a 3.65-fold higher risk of Parkinson's disease in six cohort studies
- Obesity in older adults lowers Alzheimer's risk while underweight status and weight loss increase it
- GLP-1 receptor agonists may reduce cognitive decline in type 2 diabetes patients with dementia
- Delirium-directed interventions show mixed long-term cognitive outcomes in ICU survivors with acute respiratory failure
- Six novel loci and nine recessive loci identified for young onset Parkinson's disease in European ancestry
- Meta-analysis identifies 311 serum metabolite associations in Alzheimer's disease trajectory
- Triple Pill Therapy Lowers Recurrent Stroke Incidence in Patients With Prior Intracerebral Hemorrhage
- HMC3 microglial model illuminates neurodegenerative mechanisms and early therapeutic discovery
- IBD-related neuroimaging shows brain alterations in emotional networks with distinguishable phenotypes for Crohn's and ulcerative colitis
- TREM2 activation lowers amyloid plaques and tau in Alzheimer's disease animal models across twelve studies
- Adding quantitative FDG-PET interpretation improves specificity in Alzheimer's diagnosis
- Acupuncture Boosts Cognition in Alzheimer's and Mild Cognitive Impairment
- FDA Approves Morphine Sulfate Injection for Severe Pain Requiring Opioid Analgesic
- FDA Approves Soliris (eculizumab) for Generalized Myasthenia Gravis and NMOSD
- Ethanol exposure and high-fat diet may impair amyloid-beta clearance and promote oxidative stress in Alzheimer's disease
- Non-invasive brain stimulation with motor imagery improves upper limb function after stroke with WMD 5.75
- Thrombectomy plus intra-arterial alteplase increases excellent functional outcome to 57.5% at 90 days
- Aging is associated with poorer locomotor recovery after traumatic spinal cord injury in preclinical models
- Higher admission WBC predicts favorable methylprednisolone effect after thrombectomy
- Apixaban Reduces Intracranial Bleeding Risk Compared To Aspirin In Patients With Cryptogenic Stroke And Atrial Cardiopathy Evidence
- Post hoc analysis shows unsuccessful thrombectomy does not worsen outcomes for large ischemic infarcts compared to medical treatment alone
- QSM MRI reveals distinct iron deposition patterns differentiating Parkinsonian syndromes
- Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
- Intracranial hemorrhage rates were higher in tenecteplase than standard care at 14.4% versus 9.2% in minor ischemic stroke
- Continuous subcutaneous foslevodopa/foscarbidopa improves off time in Parkinson's disease; severe adverse events higher in prior DBS group
- Endovascular therapy showed no benefit over medical care alone for mild-to-moderate medium or distal vessel occlusion stroke patients in this randomized trial
- Interactive cognitive-motor training improves mobility, gait, and balance in chronic stroke
- Noninvasive brain stimulation reduces pain intensity in central poststroke pain with a pooled effect size of -0.64
- Extended-window alteplase increases functional outcomes but raises hemorrhage risk in acute ischemic stroke patients
- Endovascular thrombectomy boosts functional independence significantly for acute ischemic stroke patients compared to medical management alone
- GBA1 L444P carriers have ninefold higher odds of Parkinson's disease than non-carriers
- Nurse-driven service model reduces door-to-needle time by 16.72 minutes in acute ischemic stroke
- Integrative brain care bundles and transdisciplinary training dismantle structural barriers in maternal-child health globally
- Robot-assisted gait training improves walking ability and functional independence in spinal cord injury
- T cell-microglial interactions drive aging and myelin changes in neurodegeneration models
- High-dose ocrelizumab 1200/1800 mg shows no significant difference in disability progression versus 600 mg in MS
- Ocrelizumab reduces disability progression risk in primary progressive multiple sclerosis versus placebo
- Prasinezumab showed non-significant delay in motor progression versus placebo in early-stage Parkinson's disease
- Oral Semaglutide Failed to Slow Clinical Progression in Early Alzheimer's Disease Across Global Phase 3 Trials
- Non-invasive neural stimulation improves upper limb function in subacute stroke: meta-analysis
- Genetic variants and environmental factors like PM2.5 exposure may increase asthma risk in susceptible individuals
- Network meta-analysis compares alteplase, tenecteplase, and JX10 for acute ischemic stroke treatment outcomes
- Sleep and circadian rhythm alterations associate with prolonged ventilation and worse outcomes in adult ICU patients
- Protocol outlines planned network meta-analysis of electromagnetic stimulation for post-stroke lower limb dysfunction
- Network meta-analysis of Tuina-based combination therapies versus oral medication for insomnia
- Asia-Pacific experts reach consensus on migraine management and anti-CGRP mAb use in adolescents
- Systematic Review: Flavonoids from Traditional Chinese Medicine Show Promise for NAFLD
- Review of glaucoma management without reported intervention details or outcomes
- Narrative review suggests music therapy may improve cognition and neuropsychiatric symptoms in cognitive impairment
- Systematic review and meta-analysis shows dual-task training improves motor function in cerebral palsy children
- Narrative review discusses MS continuum concepts for high-risk individuals
- Review of dopamine receptor targeting for chronic pain and mood disorders notes limited causal evidence
- Systematic review and meta-analysis of retinal biomarkers in frontotemporal dementia and Alzheimer disease
- Meta-analysis suggests specific rTMS protocols improve cognitive and functional outcomes in stroke survivors
- Meta-analysis of exercise for post-stroke cognitive impairment shows cognitive and motor benefits
- Observational study of autonomic responses in 51 dyads shows lower accuracy than self-report
- IV tenecteplase beyond 4.5 hours shows modest benefit but higher bleeding risk in acute ischemic stroke patients
- Ibudilast metabolomics in progressive multiple sclerosis brain atrophy trial
- FDA Approves Fintepla (fenfluramine) for Seizures in Dravet and Lennox-Gastaut Syndromes
- Network meta-analysis finds acupoint stimulation may improve function and fatigue in multiple sclerosis
- This narrative review examines immune-mediated thrombocytopenia and thrombotic thrombocytopenic purpura conditions without specific intervention data or reported outcomes
- Scoping review of factors affecting P100 latency and amplitude in healthy individuals
- Systematic review on EEG monitoring versus ICP in traumatic brain injury patients
- Combined motor and cognitive therapy shows mixed benefits in Parkinson's disease
- Network meta-analysis reviews acupuncture for post-stroke spasticity
- Meta-analysis finds higher peripheral Galectin-3 levels in cognitive impairment
- Systematic review of neural progenitor cell transplantation for spinal cord injury
- Bayesian network meta-analysis compares CGRP therapies for episodic migraine
- Systematic review and meta-analysis of engineered exosomes in preclinical Alzheimer's models
- MAD shows modest BP benefit over CPAP in OSA patients
- Meta-analysis finds probiotics modestly improve sleep quality with low certainty
- Systematic review and meta-analysis of ACT-based interventions for depression in stroke patients
- Review of ferroptosis role in postoperative cognitive dysfunction in older surgical patients
- Sensory cueing improves gait in Parkinson's disease patients
- Endovascular thrombectomy improves outcomes in large-core stroke within 24 hours
- Systematic review and meta-analysis of AI for post-stroke epilepsy prediction and diagnosis
- FDA Approves Onapgo (apomorphine) for Motor Fluctuations in Advanced Parkinson's
- Systematic review examines early erythropoiesis-stimulating agents for preterm infants across multiple clinical outcomes and safety endpoints
- Higher m-cSVD scores linked to increased stroke risk in hemorrhage-prone patients
- Telenursing review shows reduced COPD and asthma exacerbations and hospitalizations
- tDCS improves global cognition in Alzheimer's and MCI
- Restrictive platelet thresholds reduce transfusions without increasing death or bleeding risk in thrombocytopenic neonates
- Narrative review outlines multimodal decision-making for EGFR-mutant NSCLC with leptomeningeal metastasis
- Narrative review synthesizes neural activation patterns in the caudate nucleus and dorsal striatum during gustatory stimulation
- Narrative review links personality traits to Alzheimer's disease risk and cognitive outcomes
- Systematic review finds facial expression recognition shows promise for stroke diagnosis and rehabilitation monitoring
- Narrative review links exercise and sleep architecture to executive function in older adults
- Deep brain stimulation improves motor function and reduces levodopa needs in Parkinson's disease patients regardless of GBA mutation status
- Umbrella review synthesizes evidence on sexsomnia, a disorder of arousal from N2/N3 sleep
- Meta-analysis finds pharmacologic therapies improve RLS in hemodialysis patients
- Systematic review compares CEA, CAS, and TCAR for carotid artery stenosis stroke risk
- FDA Approves Mavenclad (cladribine) for Relapsing Forms of Multiple Sclerosis
- Meta-analysis finds remote ischemic conditioning modestly improves functional independence in acute ischemic stroke
- Narrative review offers qualitative synthesis without reported quantitative outcomes or safety data
- Protocol for a review on neurosurgical intervention versus conservative management in older adults with traumatic brain injury
- Stroke scale expansions improve posterior circulation deficit detection
- Repetitive transcranial magnetic stimulation shows promise for improving cognition and executive function in patients with mild cognitive impairment
- Narrative review proposes integrative monitoring framework for intracerebral hemorrhage
- Meta-analysis of Mendelian randomization suggests GLP-1 receptor agonism lowers vascular dementia risk
- Meta-analysis links mitochondrial polygenic score to alpha-synuclein seeding in LRRK2-related Parkinson's disease
- Individual patient data meta-analysis links blood neurofilament light chain levels to ischemic stroke outcomes
- Review of 2-AG and benzodiazepines for anxiety disorders highlights mechanistic gaps
- Comprehensive review examines nano-adjuvant technologies for poultry vaccines globally
- Review of ivermectin MDA for onchocerciasis and hookworm co-infections in endemic regions
- Narrative review discusses neurodegenerative diseases without reporting specific interventions or outcomes
- Exosome therapy reduces seizures and inflammation in preclinical epilepsy models: a meta-analysis
- AI-assisted PET radiomics improves Alzheimer's diagnosis over conventional methods in meta-analysis
- Tenecteplase linked to higher thrombus migration than alteplase in acute ischemic stroke with EVT
- Early dual antiplatelet therapy improves outcomes after ischaemic stroke thrombolysis
- Narrative review examines RNA editing alterations in Parkinson's disease patients
- Narrative review refutes causal link between endometriosis and migraine
- Glomerular Hyperfiltration Linked to Higher Mortality in Stroke and TIA Patients
- Systematic review and meta-analysis of intra-arterial tenecteplase after endovascular thrombectomy for acute ischemic stroke
- FDA Approves Vyvgart Hytrulo (efgartigimod alfa/hyaluronidase) for CIDP and gMG
- FDA Approves Vyvgart (efgartigimod alfa) for Generalized Myasthenia Gravis
- Narrative review examines exercise effects on anxiety, depression, and metabolic dysfunction without reported outcomes
- Review of PILS-Stroke questionnaire psychometrics in post-stroke individuals discharged for at least one month
- Systematic review and meta-analysis on EVT for anterior circulation LVO with low ASPECTS
- Review highlights microglia-targeted therapies as emerging Alzheimer's strategy beyond amyloid
- Review of nanoparticle systems for Alzheimer's disease brain delivery challenges
- Systematic review and meta-analysis on delirium prevalence in advanced cancer patients
- Exercise timing after stroke influences functional recovery outcomes
- Network meta-analysis of moxibustion-based therapies for lumbar disc herniation pain and function
- Thrombectomy improved functional independence but increased hemorrhage risk in moderate-to-severe acute ischemic stroke patients
- Meta-analysis shows bridging therapy improves outcomes versus endovascular thrombectomy alone in large-vessel occlusion stroke
- Network meta-analysis finds non-pharmacological treatments may improve consciousness in pDOC
- Narrative review of Alzheimer's disease without reported intervention or outcomes
- Narrative review on peptidylarginine deiminase 4 and gasdermin inhibition in autoimmune diseases
- Narrative review links NRXN1 genetic variations to schizophrenia, autism, and other neuropsychiatric disorders
- Meta-analysis links high acute glycemic variability to increased short-term mortality in subarachnoid hemorrhage patients
- FDA Approves Ocrevus (ocrelizumab) for Relapsing and Primary Progressive Multiple Sclerosis
- Guideline-based clinical pathway for trans-sectoral support in severe neuro-disability: a qualitative exploratory study
- Systematic review and meta-analysis on neurodevelopmental outcomes after necrotizing enterocolitis in preterm infants
- Network meta-analysis of drain placement for chronic subdural hematoma recurrence and mortality
- Mini review discusses Minor Neurological Signs in children within child neurology and psychiatry settings
- Narrative review discusses jump assessment for multiple sclerosis disability evaluation
- Meta-analysis of preclinical studies suggests ligustrazine improves outcomes in cerebral ischemia-reperfusion injury
- Meta-analysis links acute kidney injury to increased stroke, delirium, and dementia risk
- Ocrelizumab treatment in multiple sclerosis shows disability improvement in relapsing forms
- Meta-analysis of GLP-1 agonists for Parkinson's disease motor symptoms shows limited benefit
- Review of VLPO subregion definitions and translational challenges in sleep research
- Meta-analysis finds combined exercise and tDCS improves cognition in older adults
- Systematic review and meta-analysis of dual-task walking in adults with dementia shows slower speed and shorter steps versus controls
- Meta-analysis of music interventions for disorders of consciousness shows significant improvement
- Review of animal models links temporal lobe epilepsy to sleep and circadian disruption
- Systematic review and meta-analysis on blood flow restriction training for stroke rehabilitation
- Narrative Review Explores Acupuncture for Post-Stroke Cognitive Impairment via Mitochondrial Mechanisms
- Systematic review of DBS for freezing of gait in Parkinson's disease
- Financial compensation during recruitment did not improve consent rates for Alzheimer's disease study participants in this trial
- Narrative review of Huntington's disease highlights limited clinical validation and safety concerns
- Systematic review and meta-analysis of prediction models for trigeminal neuralgia recurrence
- Systematic review and meta-analysis synthesizes acupuncture effects on sleep in Parkinson's disease
- Scoping review of machine learning models for post-stroke aphasia diagnosis and outcome prediction
- FDA Approves Precedex (dexmedetomidine) for Pediatric Procedural Sedation
- FDA Approves Dexmedetomidine Hydrochloride for ICU and Procedural Sedation in Adults
- Systematic review finds uncertain benefit of olfactory stimulation in preterm infants
- Mini-review discusses amblyopia management without reporting specific clinical trial data or outcomes
- Systematic review and meta-analysis on neuroimaging biomarkers for futile recanalization in stroke thrombectomy
- Meta-analysis shows association between tirofiban and improved functional outcomes in non-LVO acute ischemic stroke
- Meta-analysis of synchronous physiotherapy tele-assessment accuracy in adult stroke patients
- Meta-analysis of taVNS for stroke motor function shows significant improvement
- Review discusses oxidized lipids in carotid artery stenting and in-stent restenosis pathophysiology
- Pragmatic approach addresses post-stroke insomnia through objective sleep phenotyping and coordinated management of dominant drivers
- Plasma p-tau217 demonstrates high diagnostic accuracy for Alzheimer's disease across diverse clinical cohorts and biomarker definitions
- Systematic review synthesizes urgent venous sinus stenting for fulminant idiopathic intracranial hypertension
- Argatroban plus alteplase shows no daytime benefit but nighttime association with better stroke outcomes
- Meta-analysis finds robot-assisted training plus acupuncture improves stroke recovery outcomes
- Network meta-analysis of pediatric atopic dermatitis treatments shows dupilumab and pimecrolimus efficacy
- Review of in vitro methods for foot-and-mouth disease vaccine immunogenicity assessment
- Systematic review and meta-analysis finds 30.2% success rate for MVD in TN-MS patients
- Meta-analysis links loneliness to Alzheimer's disease and suicidal behavior outcomes
- Systematic review of post-stroke delirium prediction models finds moderate discriminative ability
- FDA Approves Nuplazid (pimavanserin) for Parkinson's Disease Psychosis
- FDA Approves Nuplazid (pimavanserin) for Parkinson's Disease Psychosis
- Systematic review identifies ferroptosis as a key mechanism in acquired sensorineural hearing loss
- Review of active therapeutic interventions in 255 people with multiple sclerosis undergoing inpatient rehabilitation