This week's Neurology digest · 2026-W24
This Week in Neurology: Stroke Interventions and Alzheimer's Risk Factors
Elevated Serum Lipoprotein(a) Levels Associated with Increased Odds of Hemorrhagic Stroke
Higher Lipoprotein(a) levels linked to increased risk of hemorrhagic stroke
This meta-analysis of 526,909 adults evaluated the relationship between serum Lipoprotein(a) and stroke risk. Case-control studies showed an…
A large analysis of over 500,000 people suggests that higher levels of a specific protein may be linked to an increased risk of hemorrhagic …
Ponesimod maintains low disease activity and safety in RRMS over 13 years
Trial Shows Ponesimod Maintains Safety for Relapsing-Remitting Multiple Sclerosis
This Phase 2b randomized controlled trial of 393 participants with relapsing-remitting multiple sclerosis found that ponesimod (10, 20, or 4…
A clinical trial shows that patients with relapsing-remitting multiple sclerosis can stay on ponesimod for up to 13 years with consistent re…
Dry needling significantly reduces upper and lower limb spasticity in patients with post-stroke conditions
Dry Needling Shows Promise for Reducing Post-Stroke Muscle Stiffness
This meta-analysis of 276 adults with post-stroke spasticity found that dry needling significantly reduces overall spasticity (MD = -0.65). …
Dry needling may help reduce muscle stiffness in the arms and legs of adults who have experienced a stroke.
Blood p-tau217 outperforms p-tau181 and p-tau231 for diagnostic performance in Alzheimer's disease
Blood Test p-tau217 Shows Stronger Performance for Alzheimer's Diagnosis
This meta-analysis evaluates the diagnostic performance of blood p-tau subtypes for Alzheimer's disease and related pathologies. The analysi…
A specific blood marker, p-tau217, shows better performance than other markers in identifying different stages of Alzheimer's disease.
Sarcopenia is associated with significantly higher risk of poor functional prognosis in stroke patients
Sarcopenia Linked to Poorer Outcomes in Stroke Patients
This meta-analysis of 36 cohort studies indicates that sarcopenia is associated with a notably elevated risk of poor global functional progn…
Muscle loss after a stroke is linked to lower motor and cognitive scores, making it a key factor in recovery and long-term patient outcomes.
Central vein sign on MRI shows potential diagnostic value in pediatric-onset multiple sclerosis
MRI Central Vein Sign May Help Identify Pediatric Multiple Sclerosis
This meta-analysis of 5 studies evaluated the diagnostic accuracy of the central vein sign (CVS) in pediatric-onset multiple sclerosis. The …
A specific MRI finding called the central vein sign may help doctors identify multiple sclerosis in children and infants.
APOE ε4 carrier status does not accelerate cognitive decline in mild-to-moderate Alzheimer's disease
Genetic markers may relate to Alzheimer's severity but not speed
This observational analysis of the EXPEDITION 1 placebo arm involved 343 patients with mild-to-moderate Alzheimer's disease. The study found…
A new look at Alzheimer's data shows that a specific gene might affect how severe the disease is at first.
Maternal gut microbiota may influence fetal neurogenesis and neurobehavioral outcomes in ASD and ADHD
Maternal Gut Health May Influence Fetal Brain Development
This narrative review explores the maternal microbiota-gut-fetal brain axis and its influence on fetal neurogenesis, synaptogenesis, and lon…
Research suggests the mother's gut bacteria may influence fetal brain development and the risk of conditions like autism and ADHD.
HMGB1 acts as a progression-associated inflammatory amplifier in Alzheimer's, Parkinson's, and ALS models
New research explores a protein linked to several brain diseases
This narrative review explores the role of HMGB1 in various neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS. The auth…
A specific protein called HMGB1 may act as a driver of inflammation in conditions like Alzheimer's and Parkinson's disease.
MMP-7 serves as a diagnostic and prognostic marker for various fibrosing interstitial lung diseases
MMP-7 Levels May Help Identify Lung Disease Severity
This narrative review examines the role of MMP-7 in patients with interstitial lung diseases and other chronic respiratory conditions. The a…
MMP-7 levels may help doctors identify the severity and progression of certain chronic lung diseases like Idiopathic Pulmonary Fibrosis.
Stepwise CSF drainage protocols provide a structured clinical framework for managing hydrocephalus patients
New Clinical Protocol Offers Guidance for Hydrocephalus Drainage Methods
This systematic review evaluates various CSF drainage methods, including EVD, lumbar drainage, and different shunt types, to establish an op…
A new clinical protocol provides neurosurgeons with a step-by-step guide to choosing the best drainage methods for patients with hydrocephal…
Specialist monitoring is required for managing alemtuzumab-induced thyroid dysfunction during pregnancy
Managing thyroid issues in pregnant women after alemtuzumab treatment
This case series and literature review examines the management of alemtuzumab-induced Graves' disease and TRAb-positive hypothyroidism in pr…
Pregnant women who develop thyroid issues after alemtuzumab treatment require close monitoring to manage their health and the health of thei…
All Neurology Articles
- Ponesimod maintains low disease activity and safety in RRMS over 13 years
- Central vein sign on MRI shows potential diagnostic value in pediatric-onset multiple sclerosis
- Dry needling significantly reduces upper and lower limb spasticity in patients with post-stroke conditions
- Elevated Serum Lipoprotein(a) Levels Associated with Increased Odds of Hemorrhagic Stroke
- Blood p-tau217 outperforms p-tau181 and p-tau231 for diagnostic performance in Alzheimer's disease
- Sarcopenia is associated with significantly higher risk of poor functional prognosis in stroke patients
- Maternal gut microbiota may influence fetal neurogenesis and neurobehavioral outcomes in ASD and ADHD
- HMGB1 acts as a progression-associated inflammatory amplifier in Alzheimer's, Parkinson's, and ALS models
- APOE ε4 carrier status does not accelerate cognitive decline in mild-to-moderate Alzheimer's disease
- Subconcussive head impacts are associated with altered brain microstructure in collision and contact sport athletes
- Intensive cognitive behavioral therapy significantly reduces OCD symptoms compared to non-active intervention controls
- Specialist monitoring is required for managing alemtuzumab-induced thyroid dysfunction during pregnancy
- MMP-7 serves as a diagnostic and prognostic marker for various fibrosing interstitial lung diseases
- Stepwise CSF drainage protocols provide a structured clinical framework for managing hydrocephalus patients
- Endovascular thrombectomy for medium vessel occlusion stroke shows favorable outcomes in observational studies
- Warm needle moxibustion combined with rehabilitation improves Fugl-Meyer Assessment scores in post-stroke hemiplegia
- Comprehensive pulmonary rehabilitation may improve exercise capacity and quality of life in post-tuberculosis lung disease
- Narrative Review Proposes Three-Layer Biological Framework Linking Gene Function to Autism Phenotypes
- TCM interventions targeting ferroptosis may offer multi-target anti-ferroptotic strategies for vascular cognitive impairment
- Transcutaneous auricular vagus nerve stimulation shows potential for depression, epilepsy, migraine, and post-stroke rehabilitation
- BCI-Robot Tops Ranking for Upper-Limb Recovery After Stroke
- Exercise interventions improve motor function and freezing of gait scores in Parkinson's disease
- Multicomponent Nonpharmacological Interventions Cut Delirium Incidence in Critically Ill ICU Patients
- PRNP D178N-129MM mutation presents with rapid cognitive decline and extensive cortical DWI ribboning
- Multidisciplinary neurorehabilitation and emerging technologies offer potential for personalized stroke recovery in elderly populations
- Resistance training shows largest effect for global cognition in Alzheimer's and Parkinson's disease
- TCM combined with Western medicine ranks highest for insomnia improvement in network meta-analysis
- Botulinum toxin type A improves passive stretch-evoked activity and CMAP in post-stroke spasticity
- Dyadic Capability Scale protocol targets stroke survivor-caregiver assessment
- HRSN assessment tools lack sufficient psychometric testing and reliability data for geriatric populations
- Lysosomal enhancement via vacuolar H+-ATPase remains experimental for protein misfolding neurodegenerative diseases
- Tubulin code modifications and specific pathways influence ischemic stroke neuroprotection and cytoskeletal remodeling
- Circulating blood biomarker families show promising but methodologically fragile signals for acute ischemic stroke diagnosis
- Impact of Psychosocial Stress Domains on the Incidence of First Ever Stroke
- Gut microbiota dysbiosis and increased intestinal permeability markers are associated with Parkinson's disease
- Immersive virtual reality yields highest effect sizes for upper limb motor function in stroke survivors
- Endovascular thrombectomy shows no overall net advantage over medical management in vertebrobasilar artery occlusion
- Fisetin shows potential as a nutritional senotherapeutic but lacks clinical evidence for chronic kidney disease
- Significant gaps in assessment tools and management resources for post-stroke pain in Africa
- Acupuncture improves total effective rate and reduces tinnitus and anxiety scores in patients
- Neuroecosystem Collapse Framework Links Ferroptosis, Neuroinflammation, and Gut-Brain Axis to Post-Stroke Cognitive Impairment
- Acupuncture significantly improves Water Swallowing Test effective rates in patients with post-stroke dysphagia
- Comparative Efficacy of Electrical Stimulation Modalities for Neurogenic Lower Urinary Tract Dysfunction
- Obstructive sleep apnea is associated with higher blood T-tau and lower CSF amyloid-beta levels
- Newer-generation antiseizure medications improve treatment retention and safety in older adults with epilepsy
- Repeated intravenous thrombolysis shows non-significant trend toward better functional outcomes in recurrent acute ischemic stroke
- Exercise and physical activity may reduce fatigue in adults with systemic lupus erythematosus
- Low-frequency rTMS and cathodal tDCS provide consistent seizure reductions in drug-resistant epilepsy
- Ceiling-mounted AI depth cameras detect more falls than routine reporting in Parkinson's facility
- Intracranial atherosclerosis contributes significantly to global ischemic stroke burden across diverse geographic regions
- sc/snRNA-seq identifies disease-relevant cell states and pathophysiological processes in ischemic stroke research
- PMP22 sequence variants cause HNPP through protein loss or impaired folding and trafficking
- Non-pharmacological Parkinson's trials are broad but too heterogeneous to rank interventions
- Pulsed radiofrequency with nerve block improves clinical response and pain in cervical radiculopathy
- Impact of Receptor Stimulating Antihypertensive Medications on Alzheimer Disease Risk in Elderly Patients
- CAR-T cell therapy shows preliminary clinical activity in refractory neuroimmune diseases
- Physiotherapy consistently improves balance, postural stability, and gait speed after STN deep brain stimulation
- Sleep disturbances and obstructive sleep apnea lower seizure thresholds and impact sleep architecture in epilepsy
- Physical activity programs may increase bone mineral density and weight gain in preterm infants
- Elevated plasma CD147 levels are associated with 1.75 odds ratio for poststroke cognitive impairment
- Transcutaneous auricular vagus nerve stimulation improves dyspeptic symptoms and gastric accommodation in functional dyspepsia
- SLE Tied to More Than Double Stroke Risk Across 25 Cohorts
- MMP-3 polymorphism does not show significant association with Alzheimer's disease risk
- Serum BDNF levels show a significant inverse association with age in adults over 60
- Tenecteplase Matches Alteplase for Function, Cuts Door-to-Needle Time in Stroke
- Cognitive plus non-invasive brain stimulation ranks highest for overall cognitive function in Alzheimer's disease
- Cortical atrophy (GCA 1 vs. 0) associated with lower functional independence in women with ischemic stroke
- Blood GFAP levels provide high specificity for identifying intracerebral hemorrhage in acute stroke patients
- taVNS Improves Memory in Rodent Stroke Models With Large Pooled Effect
- Testosterone impacts self-referential and affective domains via default mode network alterations
- LLM-based risk-of-bias assessments show limited agreement with human reviewers in neurology prognosis studies
- Climate-informed surveillance-to-action models address policy gaps in Somali infectious disease management
- Tenecteplase and alteplase improve functional outcomes in extended windows but increase symptomatic intracranial hemorrhage risk
- Adjunctive acupoint application increases clinical response rates in post-stroke sleep disorders
- Transcranial pulse stimulation improves MMSE and MoCA scores in patients with Alzheimer's disease
- Obstetric CVST: 8.28% maternal mortality acutely, 3.17% recurrence in follow-up cohorts
- Detectable Microembolic Signals on TCD Linked to 2.85-Fold Higher Odds of Poor Stroke Outcome
- Trastuzumab emtansine and sintilimab combination shows lesion size reduction in HER2-positive metastatic gallbladder adenocarcinoma
- Opioid flexion phenotype is a descriptive term for sustained forward flexion in fentanyl exposure
- Attentional dysfunction serves as a candidate organizing mechanism for persistent postural-perceptual dizziness
- Neurofeedback shows potential for motor and non-motor outcomes in idiopathic Parkinson's disease
- DEK emerges as neuron-specific ac4C-linked driver of neuroinflammation in Parkinson's disease
- Digitally Enhanced Composite Endpoints Improve Efficiency in Multiple Sclerosis Clinical Trials
- Low Dose Ticagrelor and Aspirin Reduce Early Neurological Deterioration in Ischemic Stroke
- Fresh-frozen plasma shows no protective effect against intraventricular hemorrhage in preterm infants
- Citicoline increases likelihood of achieving minimal clinically important difference in Parkinson's disease by OR 2.06
- Acupuncture-based interventions improve Fugl-Meyer Assessment scores for post-stroke foot drop compared to conventional treatment
- Deep learning and transfer learning techniques improve cross-variability decoding of motor imagery EEG signals
- Transcranial direct current stimulation combined with cognitive training yields largest improvements in post-stroke cognitive function
- Non-invasive brain stimulation shows favorable tolerability and 94.9% completion rate for post-stroke upper limb rehabilitation
- Robot-assisted gait training improves balance, walking endurance, and spatiotemporal gait parameters in Parkinson's disease
- Technology Assisted Interventions Improve Gait and Balance in Children with Cerebral Palsy
- Robotics-based interventions show stronger evidence for improving upper-limb motor function after stroke
- TLE4, HLA-V/HLA-G, and LRRK2 variants show significant association with Parkinson's disease in East Asian cohorts
- Martius flap, graciloplasty, and delayed coloanal anastomosis are established but evidence-limited options for rectovaginal fistula
- ILC3-to-ILC1 transition is strongly supported in Crohn's Disease but evidence for UC plasticity is limited
- Robot-Assisted Stroke Rehab May Improve Balance, Review Finds
- Excitatory rTMS provides small to moderate MMSE improvements in mild to moderate Alzheimer's Disease
- Bright light therapy improves subjective sleep quality in adults with stroke
- IL-34/CSF1R signaling modulates CNS immune cell development and impacts neurodegenerative disease progression
- Structural failures in surveillance infrastructure and zoonotic emergence increase global pandemic risks
- Leisure rehabilitation improves participation in stroke survivors, but evidence is low certainty
- Mechanism-based PRNP-targeting and anti-PrP immunotherapy represent emerging strategies for prion disease management
- Paired vagus nerve stimulation with task-specific rehabilitation improves durable upper-limb outcomes in chronic ischemic stroke
- Wearable digital biomarkers show potential for neurorehabilitation monitoring, but evidence is heterogeneous and early
- Mobile stroke units cut critical time metrics by 26.3 minutes in acute stroke
- BCI-based interventions improve FMA-UE scores in patients with stroke and poststroke hemiplegia
- eSMARTER digital platform meets non-inferiority goals for Alzheimer's genetic and biomarker result disclosure
- Evaluating Thrombectomy Efficacy and Safety in Patients with Medium or Distal Arterial Occlusions
- No-reflow phenomenon affects at least 25% of patients after reperfusion in acute ischemic stroke
- Efficacy of Intravenous Thrombolysis for Acute Ischemic Stroke Patients Late in Window
- Stroke prevalence 14% after LVAD, highest in Asia, projected to decline
- Curcumin and resveratrol show selective signals for modulating neuroinflammation and microglial inflammatory signaling
- Intravenous tirofiban before endovascular treatment increases risk of parenchymal hematoma type 2
- Tenecteplase shows higher mRS 0 to 1 rates in distal M3 and beyond occlusions
- Efficacy of Pressure-Controlled Active CSF Irrigation in Managing Aneurysmal Subarachnoid Hemorrhage
- Smoking is not significantly associated with disability progression in patients with multiple sclerosis
- Slowly expanding lesions occur in 78% of patients with Multiple Sclerosis
- Organochlorine pesticide exposure is associated with a 2.19 odds ratio for Alzheimer's disease risk
- Prehospital magnesium sulfate shows no significant overall clinical benefit in acute ischemic stroke
- Dual antiplatelet therapy reduces major ischemic events in week 1 of minor stroke or TIA
- Early oral anticoagulants show no significant difference in stroke risk compared to late initiation
- Exercise-based cardiac rehabilitation improves aerobic capacity and systolic blood pressure in stroke and TIA patients
- Traditional Chinese Exercises improve sleep quality and reduce anxiety and depression in post-stroke survivors
- Twelve SNPs associated with Parkinson's disease-related gray matter volume reduction were identified in meta-analysis
- ENTF brain stimulation improves freedom from disability in subacute ischemic stroke patients
- Clinically stable patients with Multiple Sclerosis show 13.0% to 19.1% incidence of new spinal cord lesions
- Hyperhomocysteinemia is associated with a higher risk of silent brain infarcts in patients
- Impact of Domain Specific Physical Activity on Risk of All Cause Dementia
- Clopidogrel plus aspirin for 21 days provides favorable net clinical benefit in minor ischemic stroke
- BCI-based training yields statistically robust but clinically modest improvements in post-stroke lower-limb motor function
- High Lp-PLA2 levels triple recurrent stroke risk in ischemic stroke patients
- Probiotic supplementation may improve fatigue and pain symptoms in patients with multiple sclerosis
- Intensive Blood Pressure Management Reduces Recurrent Stroke Risk After Intracerebral Haemorrhage
- Sleep disorders affect 50% of patients with amyotrophic lateral sclerosis in meta-analysis
- FDA Approves Imaavy (rozanolixizumab) for gMG and wAIHA in Patients 12 Years and Older
- Fibrinogenase for injection improves 90-day mRS scores in acute ischaemic stroke patients
- Loberamisal doses of 20mg, 40mg, and 60mg show no significant difference from placebo
- Remote ischaemic conditioning trial design for patients with acute ischaemic stroke and large-vessel occlusion
- Machine learning models show high AUC for predicting stroke-related dysphagia and aspiration risks
- Probiotics provide the largest reduction in migraine frequency among analyzed nutritional supplements
- Intra-arterial alteplase trial protocol for large vessel occlusion stroke aims to improve outcomes
- Phase 3 Trial Protocol Evaluating Intravenous Loberamisal for Acute Ischaemic Stroke Management
- Video game-based interventions improve swallowing function and quality of life in post-stroke dysphagia
- BNT162b2 vaccination shows no significant increase in stroke risk in meta-analysis
- Continuous nursing care improves post-discharge outcomes and reduces complication risks in children with Hirschsprung's disease
- Pregnancy with Cystic Echinococcosis: Symptoms, Imaging, and Outcomes
- Botulinum toxin type A reduces upper-limb tremor severity in patients with essential tremor
- Active tDCS combined with rehabilitation improves pain intensity in patients with chronic spinal pain
- Hydrocephalus and high Fisher grade blood distribution are strongly associated with post-procedural seizures in SAH
- Music-based interventions significantly improve gait speed and motor function in patients with stroke
- Vestibular rehabilitation improves balance, walking speed, and reduces dizziness in patients with multiple sclerosis
- Epigenetic mechanisms like chromatin remodeling contribute to disease heterogeneity and relapse in autoimmune skin diseases
- Intranasal desmopressin reduces bleeding risk in CKD patients during non-surgical procedures
- Stimuli-responsive nanozyme-hydrogel systems offer a design framework for ischemic stroke therapy, but direct evidence remains limited
- Risk prediction models show AUC of 0.85 and 0.82 for post-stroke cognitive impairment
- p-tau217/Aβ42 ratio nearly doubles the diagnostic odds ratio for amyloid pathology in Alzheimer's disease
- High-risk perfusion phenotypes correlate with early neurological deterioration and poor functional outcomes in low-NIHSS LVO stroke
- Edaravone dexborneol reduces NIHSS scores by 2.27 compared to control in acute ischemic stroke
- Invasive spinal cord stimulation provides variable relief across diverse chronic neuropathic pain conditions
- Pricking-and-cupping bloodletting reduces herpes zoster pain more than conventional medicine
- Carotid artery stenting increases stroke and restenosis risk compared to carotid endarterectomy
- Transcranial direct current stimulation results for upper limb spasticity after stroke remain inconclusive
- Melanin-concentrating hormone serves as a key neuromodulatory network for memory and sleep in Alzheimer's disease
- Multimodal MRI reveals widespread white matter disruption and gray matter thinning in pediatric mild TBI
- Electroacupuncture improves neurological function and reduces infarct volume in animal models of ischemic stroke
- Acupuncture improves symptom scores and vertebrobasilar blood flow in patients with posterior circulation ischemic vertigo
- BCI-mediated rehabilitation improves upper limb motor function and MBI scores after stroke
- GABA-modulating pharmacotherapies show inconsistent results for improving symptoms in autism spectrum disorder
- tACS shows no significant motor benefit in Parkinson's disease, meta-analysis finds
- Brain age gap correlates with slower cognitive processing speed in patients with Multiple Sclerosis
- Exercise plus antioxidants may add neuroprotection in Alzheimer's and Parkinson's, but evidence is context-dependent
- Registry data provides stable disease course and ambulation as preferred endpoint in Vanishing White Matter
- Thrombolysis prior to endovascular thrombectomy increases 90-day functional independence (RR 1.12) in large-vessel stroke
- Proposed methodology aims to establish evidence-based consensus for integrated medicine in pediatric tic disorders
- Echocardiography guided by dynamic measures provides superior prediction of fluid responsiveness in shock management
- Scoping review maps federated analytics for NCD surveillance in European Health Data Space
- GLP-1 receptor agonists promote weight loss and reduce systemic inflammation in patients with inflammatory bowel disease
- Elevated head position does not significantly improve 90-day functional outcomes after endovascular thrombectomy
- Tenecteplase Combined With Thrombectomy Improves Functional Outcomes in Low ASPECTS Stroke Patients
- Ginseng components show potential neuroprotective effects in preclinical models of multiple neurodegenerative diseases
- High-dose corticosteroids combined with IVIG or plasma exchange are preferred for triple-M syndrome
- Bevacizumab plus lomustine significantly improves progression-free survival in recurrent or refractory glioblastoma
- Idarucizumab-mediated reversal of dabigatran before thrombolysis shows 66.6% good functional outcome at 90 days
- Rasagiline and selegiline show comparable efficacy and safety in early Parkinson's disease
- FDA Approves Zavzpret (zavegepant) for Acute Treatment of Migraine in Adults
- Microbial phenolic metabolites may cross the blood-brain barrier and reduce neuroinflammation
- Combined transcranial electrical stimulation with physical or behavioral interventions reduces chronic nonspecific low back pain
- Non-invasive brain stimulation fails to show consistent cognitive benefit after traumatic brain injury
- Transcranial Doppler monitoring aims to reduce new DWI lesions by 50% in carotid stenting
- Multidimensional artificial intelligence decision support may improve precision and individualization in endoscopic submucosal dissection for early gastric cancer
- Glymphatic system failure following acute brain injury drives systemic inflammation and pulmonary damage
- Mechanical thrombectomy shows potential for favorable outcomes in pediatric large-vessel occlusion stroke
- NDV isolates from Kazakhstan chicken carcasses show vaccine-like F protein cleavage motif
- Tavapadon improves motor function and ON-time in patients with Parkinson's disease
- Evaluating Hybrid Architecture Accuracy for Automated Clinical Coding in Rare Disease Registries
- Multifaceted Experiences and Management Strategies for Patients Living with Post-Stroke Fatigue
- Diplopia imposes substantial healthcare costs, exceeding national average in South Korea
- Statistical Plan for PES Trial in Post-Stroke Dysphagia
- Infratentorial lesions result in 58% dizziness prevalence in acute ischemic stroke patients