This week's Neurology digest · 2026-W24
This Week in Neurology: Stroke Interventions and Alzheimer's Risk Factors
Gabapentinoid use is associated with modestly higher odds of Alzheimer's disease and related dementias
Reviewing the Link Between Gabapentin Use and Risk of Developing Dementia
This meta-analysis of 325,245 individuals found that gabapentinoid use was associated with modestly higher odds of Alzheimer's disease and r…
A large review looked at how gabapentin and pregabalin affect brain health. Some findings suggest a possible link to dementia.
GDF15 acts as a multi-node signaling hub in inflammatory skin diseases and systemic sclerosis
Growth Factor GDF15 Linked to Skin Aging and Inflammation
This narrative review explores GDF15 as a signaling hub affecting melanocyte activity, fibroblast collagen synthesis, and the IL-23/Th17 axi…
A protein called GDF15 may play a key role in skin aging, pigmentation, and inflammatory conditions like psoriasis.
Early Emotional Interventions Boost Stroke Recovery Outcomes
Early Emotional Care After Stroke Boosts Recovery
Meta-analysis of 12,020 patients shows early emotional interventions improve Barthel Index scores, with best results when started within 2 w…
Starting emotional support within 2 weeks of a stroke may improve daily function more than waiting, a new analysis finds.
Combined Mirror Therapy and Transcranial Direct Current Stimulation for Poststroke Upper Limb Recovery
Mirror therapy and brain stimulation improve stroke recovery outcomes
Combining mirror therapy with tDCS may significantly improve upper limb motor function in stroke patients compared to monotherapies.
Combining mirror therapy with electrical brain stimulation may help people regain movement in their arms after a stroke.
Pharmacotherapies targeting inflammatory pathways and neurotransmitters improve cognitive scores in patients with Alzheimer's disease
New analysis shows specific drug targets may help Alzheimer's patients
This network meta-analysis of 68,398 patients with Alzheimer's disease found that interventions targeting inflammatory pathways (SMD -0.24) …
New data suggests that treatments targeting inflammation and the gut-brain axis could offer better cognitive support for people with Alzheim…
Higher admission neutrophil-to-lymphocyte ratio (NLR) associated with unfavorable functional outcomes in acute ischemic stroke
Higher neutrophil-to-lymphocyte ratio linked to poorer outcomes in stroke patients
This meta-analysis of 31,853 patients with acute ischemic stroke identified that a higher admission neutrophil-to-lymphocyte ratio (NLR) is …
A high neutrophil-to-lymphocyte ratio at the time of admission may signal a higher risk of poor recovery and complications for stroke patien…
Cognitive Behavioral Therapy for Managing Fatigue Severity in Adult Stroke Survivors
Cognitive Behavioral Therapy reduces fatigue for stroke survivors
Meta-analysis data indicates Cognitive Behavioral Therapy significantly reduces fatigue and improves sleep quality in post-stroke patients.
Stroke survivors often struggle with heavy exhaustion. New data shows that talk therapy can significantly lower fatigue and improve sleep qu…
Serum neurofilament light chain shows modest diagnostic performance for multiple sclerosis disease activity
Serum neurofilament light chain shows limited accuracy for MS activity
This meta-analysis of 11,213 adults with MS evaluated serum neurofilament light chain (sNfL) as a biomarker for disease activity. The analys…
A large review of data suggests a specific protein in the blood cannot yet be used on its own to track MS disease activity.
Cardiac CT detects thrombi in 6.2% of acute stroke patients, outperforming echocardiography
Cardiac CT finds hidden clots in stroke patients
This meta-analysis of prospective observational cohorts found that cardiac CT during acute stroke imaging detects thrombi in 6.2% of patient…
A quick heart scan during stroke workup finds hidden clots in 6% of patients, more than ultrasound does.
Tenecteplase improves functional outcomes and early neurological recovery in late window acute ischemic stroke
Tenecteplase improves recovery for patients with late stroke treatment
This meta-analysis of randomized controlled trials evaluated intravenous tenecteplase for patients with acute ischemic stroke presenting bey…
A new analysis shows that the drug tenecteplase helps stroke patients regain independence even when treatment starts several hours after sym…
Intravenous thrombolysis combined with endovascular treatment improves 90-day functional independence in tandem lesion stroke
Combined Treatments Show Better Outcomes for Specific Stroke Patients
This meta-analysis of 1756 patients with acute ischemic stroke due to tandem lesions found that intravenous thrombolysis combined with endov…
Combining thrombolytic drugs with endovascular treatment may improve recovery and survival rates for patients with specific types of ischemi…
DOAC therapy reduces odds of symptomatic ischemic stroke compared to aspirin monotherapy
Direct oral anticoagulants show lower risk of stroke than aspirin
This meta-analysis of 3666 patients evaluated DOAC therapy versus aspirin for ischemic cerebrovascular disease. The analysis found a lower o…
New data shows that direct oral anticoagulants may offer better protection against symptomatic strokes compared to taking aspirin alone.
All Neurology Articles
- Early Emotional Interventions Boost Stroke Recovery Outcomes
- GDF15 acts as a multi-node signaling hub in inflammatory skin diseases and systemic sclerosis
- Gabapentinoid use is associated with modestly higher odds of Alzheimer's disease and related dementias
- Virtual reality training improves global cognitive function and short-term memory in Alzheimer's disease patients
- Alzheimer's patients show large emotion recognition impairment versus healthy older adults
- Bilateral training improves motor function in post-stroke patients with distal upper extremity hemiplegia
- Cardiac CT detects thrombi in 6.2% of acute stroke patients, outperforming echocardiography
- Higher admission neutrophil-to-lymphocyte ratio (NLR) associated with unfavorable functional outcomes in acute ischemic stroke
- Tenecteplase improves functional outcomes and early neurological recovery in late window acute ischemic stroke
- Hydrokinesitherapy improves balance function in stroke survivors across multiple assessment measures
- Pharmacotherapies targeting inflammatory pathways and neurotransmitters improve cognitive scores in patients with Alzheimer's disease
- Tirofiban as an adjunct to endovascular thrombectomy is safe and effective for large vessel occlusion
- Cognitive Behavioral Therapy for Managing Fatigue Severity in Adult Stroke Survivors
- Long-term particulate matter exposure increases risk of Parkinson's disease by 10% to 18%
- Intravenous thrombolysis combined with endovascular treatment improves 90-day functional independence in tandem lesion stroke
- Fingolimod reduces annualized relapse rate by 1.17 per patient-year in pediatric MS
- Serum neurofilament light chain shows modest diagnostic performance for multiple sclerosis disease activity
- DOAC therapy reduces odds of symptomatic ischemic stroke compared to aspirin monotherapy
- Anticoagulation associated with lower risk of recurrent stroke in patients with left ventricular systolic dysfunction
- Combined Mirror Therapy and Transcranial Direct Current Stimulation for Poststroke Upper Limb Recovery
- Fecal microbiota transplantation provides modest short-term improvements in daily motor activities for Parkinson's disease
- HIV infection increases odds of severe presentation and delayed diagnosis in skin neglected tropical diseases
- Mindfulness-based exercise improves motor function in Parkinson's disease and shows favorable signals in Alzheimer's
- Tranexamic acid does not improve mortality or neurological outcomes in acute brain injury
- Rotavirus vaccination reduces prevalence but viral diarrhea remains widespread among children in Ghana
- MRI lesion morphology provides more nuanced prognostic information than clinical completeness in spinal cord injuries
- Fire Dragon Cupping may improve clinical efficacy in post-stroke shoulder-hand syndrome
- Elevated neutrophil-to-lymphocyte ratio correlates with greater cerebral small vessel disease burden and white matter hyperintensities
- Exosome and extracellular vesicle therapies show promising signals for spinal cord injury repair
- Stroboscopic visual training improves reaction speed and visuomotor performance in interceptive sports athletes
- GLP-1 receptor agonists are an emerging research focus for metabolic and inflammatory pathways in Parkinson's disease
- Network meta-analysis protocol plans to evaluate brain-computer interface feedback modes for post-stroke upper-limb motor impairment
- Evolocumab plus statin protocol targets early neurological deterioration in acute ischemic stroke
- SAPIEN 3 TAVR shows similar outcomes to SAVR regardless of annular size
- Climate change disproportionately impacts African population health despite minimal global greenhouse gas contributions
- Tigertriever associated with higher reperfusion rates in large vessel occlusion stroke compared to stent-retrievers
- FDA Approves Tyruko (natalizumab) for Relapsing Forms of Multiple Sclerosis and Crohn's Disease
- CRISPR/Cas9 screening identifies host factors and conserved networks for multiple livestock and poultry viruses
- α-Synuclein-lysosome axis central to Parkinson's pathogenesis, systematic review finds
- Gastrodin, intranasal insulin, and cognitive training show greatest preventive effectiveness for postoperative cognitive dysfunction after cardiac surgery
- Music intervention significantly improves GCS scores and awakening rates in patients with disorders of consciousness
- Multidimensional vHIT saccadic parameters provide complementary information for diagnosing central vestibular disorders
- Acupoint stimulation reduces OCD symptoms by 3.14 points on Y-BOCS in meta-analysis
- TMS targeting the ventral attention network may address heterogeneity in alcohol use disorder with depression
- FDA Approves Subvenite (lamotrigine) for Epilepsy and Bipolar Disorder
- Liraglutide reduces stroke recurrence from 18.1% to 5.8% in patients with high insulin resistance
- Mitochondrial ribosomal proteins MRPL44, NAM9, and GEP3 are essential for neuronal homeostasis and survival
- Dexmedetomidine is associated with lower delirium incidence in mechanically ventilated adult ICU patients
- Sedative-hypnotic use associated with OR 1.29 for incident Alzheimer's Disease
- Ischemic stroke patients exhibit distinct gut microbiota profiles and altered functional pathways
- Third-wave therapies significantly reduce post-stroke depression symptoms with sustained mid- to long-term effects
- In-hospital delays before reperfusion correlate with worse outcomes in patients undergoing endovascular thrombectomy
- Low ADAMTS13 activity linked to ischemic stroke in meta-analysis of 8,993 patients
- Maladaptive responses to chronic hypoxia at high altitude increase ischemic stroke risk through thrombogenesis
- Bibliometric analysis identifies growing research trends and key hubs for short-chain fatty acids in cognitive impairment
- New consensus algorithm guides JAK inhibitor choice for alopecia areata
- Heterogeneous management of Radiologically isolated syndrome highlights significant gaps in standardized treatment algorithms
- FDA Approves Rocuronium Bromide Injection for Tracheal Intubation and Muscle Relaxation
- FDA Approves Tegretol (carbamazepine) for Epilepsy and Trigeminal Neuralgia
- FDA Approves Tegretol-XR (carbamazepine) Extended-Release for Epilepsy and Trigeminal Neuralgia
- FDA Approves Tegretol (carbamazepine) for Epilepsy and Trigeminal Neuralgia
- Eye disease prevalence in Sub-Saharan African prisons to be assessed in new meta-analysis protocol
- Shared molecular pathways and hub genes link endocrine disorders with periodontitis progression
- General anesthesia improves functional independence and reperfusion in patients undergoing endovascular thrombectomy for ischemic stroke
- Protocol for systematic review and meta-analysis of Dynamic Scalp Acupuncture for motor function after stroke
- Botulinum toxin type A effectively manages sialorrhea in pediatric and adult neurological disorders
- Readmission rates for COPD patients increase from 15.2% at 1 month to 42.10% at 1 year
- Reduced Vagus Nerve Cross Sectional Area as a Potential Biomarker in Parkinson Disease
- Transcutaneous Vagus Nerve Stimulation utilizes distinct auricular and cervical pathways for non-invasive treatment applications
- Deep learning achieves expert-level accuracy in stroke imaging analysis, review finds
- Vagus nerve stimulation offers promising therapeutic strategy for restoring autonomic balance and gut-brain signaling
- Proteomic, metabolomic, and microRNA signatures offer potential for diagnosing and prognosticating disorders of consciousness
- TCMQE exercises including Baduanjin, Qigong, and Tai Chi improve motor symptoms and balance in Parkinson's disease
- Cryptogenic cerebral palsy cases show 2.21 risk ratio of pathogenic genomic findings compared to non-cryptogenic
- Sports vision training reduces CVS prevalence in males from 76.0% to 44.0% and females from 72.0% to 38.0%
- Multidomain lifestyle interventions provide small but statistically significant benefits for global cognition scores
- TCM combinations with methimazole may improve thyroid function indices in Graves' disease patients
- Ankle pump exercises plus anticoagulants reduce postoperative DVT risk
- Neuromodulation techniques show promise for pain and function in knee osteoarthritis, but evidence is low certainty
- Post-traumatic hydrocephalus management evolves with individualized shunting and advanced diagnostics
- FDA Approves Leqembi Iqlik (lecanemab) for Alzheimer's Disease
- Berberine identified as potential Alzheimer's treatment targeting HMGCR in astrocyte-driven model
- TBI mechanism correlates with long-term functional independence, with recreational injuries showing highest outcomes
- MRgLITT provides comparable QALYs to open resection for children with drug-resistant focal epilepsy
- Early tirofiban improves functional outcomes in non-DM ischemic stroke patients but not in DM
- Trial protocol for intra-arterial alteplase in anterior circulation large-vessel occlusion ischaemic stroke
- TBP expansion in SCA17 can cause dementia-like symptoms and requires etiological reconsideration
- tDCS improves lower limb motor function and walking distance in patients with multiple sclerosis
- Combined tDCS and mirror therapy improves upper limb function and activities of daily living after stroke
- Evaluating the Efficacy of GLP-1 Receptor Agonists in Patients with Parkinson's Disease
- Operator device-selection preference did not correlate with superior first-pass effect rates in stroke thrombectomy
- Mechanical thrombectomy increases parenchymal hematoma risk but maintains better functional outcomes
- Adaptive immune signatures and T cell infiltration characterize pathology in Alzheimer's, Parkinson's, and Lewy Body dementia
- Advanced imaging and targeted treatments may identify and treat occult cerebrospinal fluid leaks in MRI-negative SIH
- Route 92 Reperfusion System increases first-pass effect and near-complete reperfusion in acute ischemic stroke
- Microglia-mediated synaptic pruning and nanodelivery systems offer potential pathways for treating Tourette syndrome
- Cognitive frailty prevalence among older adults with stroke is 33% with higher rates in those aged 80+
- Rituximab is noninferior to ocrelizumab in suppressing T2-weighted MRI lesions from month 6 to 24
- Angiogenic factors in biofluids show no significant difference in Alzheimer's disease
- Exercise training promotes adult hippocampal neurogenesis by influencing the neurochemical environment and cell cycle dynamics
- Traditional Chinese exercises significantly improve motor function and balance in stroke survivors across various stages
- HIIT and MICT improve fitness and walking after chronic stroke, but balance evidence is low
- Early DAPT associated with higher excellent functional outcome in minor stroke patients with history of DM
- Bridging therapy increases parenchymal hemorrhage risk by 2.36 OR in patients with BGI
- Serum cystatin C shows consistent increase in cats with CKD while urinary cystatin B elevates in dogs
- Immediate antihypertensive treatment for acute ischemic stroke may increase risks in specific blood pressure subgroups
- rTMS alleviates post-stroke spasticity and improves motor function in patients with upper limb involvement
- A four-stage progression model identifies potential targets for neurogenic pulmonary edema management
- Transcranial magnetic stimulation improves upper limb function and motion in post-stroke patients
- Complete spinal cord injury and assisted ventilation significantly increase risk of hyponatremia in SCI patients
- GLP-1 receptor agonists improve motor function and mood outcomes in patients with Parkinson's disease
- Stroke etiology does not modify the efficacy of intravenous thrombolysis before endovascular treatment
- Extended-interval natalizumab dosing shows no significant difference in disability progression for relapsing-remitting multiple sclerosis
- Loon Lens outperforms Catchii for title and abstract screening in Parkinson Disease research
- Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH
- rTMS improves motor function in Parkinson's disease, meta-analysis finds moderate effect
- Migraine patients may have an increased risk of neovascular age-related macular degeneration
- Spring and autumn linked to higher Ménière disease occurrence vs summer in large meta-analysis
- FDA Approves Xeomin (incobotulinumtoxinA) for Chronic Sialorrhea in Patients 2 Years and Older
- Thrombolysis plus endovascular therapy for basilar artery occlusion: a trial protocol
- Intensive blood pressure lowering reduces severe cerebral oedema risk in acute ischemic stroke patients
- Verbal fluency is significantly impaired in multiple sclerosis and neuromyelitis optica spectrum disorders
- Multiple factors including advanced age, hemorrhage, and ventilation duration predispose patients to post-traumatic hydrocephalus
- 194 miRNAs exhibit widespread changes in Alzheimer's disease and influence key biological pathways
- Cocaine and amphetamine use significantly increase stroke risk as confirmed by Mendelian randomization
- Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke
- Botulinum toxin reduces spasticity in adult stroke survivors but shows inconsistent benefits for gait and balance
- Efficacy of Levodopa Based Therapy for Motor and Cognitive Recovery After Stroke
- Evaluating High Frequency Repetitive Transcranial Magnetic Stimulation for Post Stroke Cognitive Impairment
- EEG microstate duration and occurrence rates differ significantly between Alzheimer's patients and healthy controls
- Plasma p-tau217 and Aβ42/40 biomarkers show high AUC for discriminating amyloid PET positivity
- Cladribine tablets reduce annualized relapse rate by 58% compared to placebo in active RRMS
- Optical coherence tomography shows significantly reduced retinal measurements in neuromyelitis optica spectrum disorder compared to multiple sclerosis
- Nabiximols reduces pain and spasticity in multiple sclerosis patients
- Resistance training improves quality of life in Parkinson's disease, meta-analysis finds
- Non-immersive virtual reality combined with conventional therapy improves upper limb function and activities of daily living
- Dual antiplatelet therapy reduces stroke recurrence in patients with acute mild ischaemic stroke
- Supratentorial location and intratumoral hemorrhage are common imaging features in DICER1-mutant primary intracranial sarcoma
- Non-pharmacological interventions show potential but uncertain cognitive benefits in TBI
- Inclinometer-based active joint repositioning is the most feasible tool for assessing lumbar proprioception
- Comprehensive intervention measures improve health literacy and self-management ability in patients with epilepsy
- Artificial Intelligence achieves Dice scores of 0.82-0.84 in tumor segmentation and AUC values of 0.80-0.90 for molecular prediction
- Serum neurofilament light chain serves as a robust biomarker of recent neuroaxonal injury in Multiple Sclerosis
- Transcranial Magnetic Stimulation reduces motor overflow in focal dystonia and improves stroke and cerebral palsy outcomes
- Diabetes mellitus acts as a context-dependent modifier of risk and phenotype in neurological disorders
- Sex-specific genetic risk loci and causal proteins in Parkinson's disease
- Amblyopia impacts reading speed, eye movements, and crowding in patients with binocular vision disorders
- Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear
- AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH
- Combined plasma p-tau217 and tau-PET identify high-risk patients with hazard ratios up to 9.98
- Structured exercise training improves motor performance and modulates TMS neurophysiological markers in healthy adults
- FDA Approves Belbuca (buprenorphine) Buccal Film for Severe Persistent Pain
- cGAS-STING signaling pathway activation drives inflammation, fibrosis, and functional decline in various kidney diseases
- DPP-4 inhibitors may reduce drug-resistant epilepsy risk via the gut microbiota and GLP-1 axis
- AhR signaling exhibits dual neurotoxic or neuroprotective effects depending on specific ligand types
- Transcutaneous auricular vagus nerve stimulation mechanisms and parameter optimization reviewed
- Multidimensional biomarker panels suggest a complex pathological basis for post-stroke depression in the DRN-mPFC circuit
- Acupuncture-related therapies significantly reduce overall, physical, and mental fatigue in chronic fatigue syndrome patients
- Intravenous thrombolysis does not improve excellent functional recovery in patients with minor acute ischemic stroke
- Transitional care interventions reduce rehospitalization and improve quality of life in adult stroke survivors
- FDA Approves Morphine Sulfate Oral Solution for Acute and Chronic Pain
- FDA Approves Xtampza ER (oxycodone) for Severe Persistent Pain
- FDA Approves OxyContin (oxycodone) for Severe Pain in Adults and Pediatric Patients
- FDA Approves Morphine Sulfate Tablets for Acute and Chronic Pain
- Transcutaneous auricular vagus nerve stimulation may improve autonomic balance and reduce visceral sensitivity in gastrointestinal disorders
- Neuroprotective anesthesia targets protocol aims to reduce silent brain infarction and perioperative neurocognitive disorders
- NfL serves as a sensitive biomarker for RRMS progression while GFAP lacks independent prognostic value
- Acoustic stimulation provides adjunctive analgesic value for managing acute and chronic pain conditions
- Ferroptosis-driven domino effect links disc degeneration to spinal cord injury
- Neuroinflammation-targeted immunotherapy shows no significant benefit in ischemic stroke meta-analysis
- FDA Approves Rextovy (naloxone) Nasal Spray for Opioid Overdose Emergency Treatment
- One Health approach in Chagas disease remains fragmented, review finds
- Transcatheter aortic valve replacement shows comparable mortality to surgery in severe symptomatic aortic stenosis
- Fecal microbiota transplantation improves motor function and constipation in patients with Parkinson disease
- Tenecteplase shows no significant difference in serious adverse event distribution compared to alteplase
- Vasospasm after thrombectomy may signal microvascular failure needing vasodilators
- MIPS and ES rank highest for functional outcomes in patients with spontaneous intracerebral hemorrhage
- PINGS intervention improves systolic blood pressure control to 67% compared to 43% in usual care
- rTMS interventions significantly reduce modified Ashworth Scale scores for post-stroke limb spasticity
- Safinamide 100 mg outperforms rasagiline 1 mg and zonisamide 25 mg for motor fluctuations
- Anterior location and complex trauma are associated with higher mortality in superior sagittal sinus injuries
- Long-term dual-task training may improve dynamic balance and functional independence in individuals with Down syndrome
- Rapid advancements in imaging and blood-based biomarkers are transforming the diagnosis and management of ADRD
- ACTH and vigabatrin achieved full seizure control in a patient with Ververi-Brady syndrome
- Aging impacts multiple sclerosis pathobiology by shifting inflammation toward chronic, compartmentalized neuroinflammation and neurodegeneration
- Tirofiban Adjunct Therapy Improves Outcomes in Patients with Inadequate Tenecteplase Response
- Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
- Artificial intelligence shows potential for diagnosis, behavior analysis, and educational support in autism spectrum disorder
- Acupuncture shows consistent signals for dysphagia and depressive symptoms after ischemic stroke
- Brain-computer interface training improves global cognitive function in stroke survivors with SMD=0.62
- Exercise, microbiota, and tRNA modifications may influence mitochondrial function and proteostasis in Parkinson's disease
- Repetitive transcranial magnetic stimulation may enhance upper limb motor function following a stroke
- Transcarotid Artery Revascularization shows lower 30-day stroke and death risk compared to TF-CAS
- FDA Approves Vyepti (eptinezumab-jjmr) for Preventive Treatment of Migraine in Adults
- FDA Approves Epidiolex (cannabidiol) for Seizures Associated with LGS, DS, or TSC
- FDA Approves Ajovy (fremanezumab) for Preventive Migraine Treatment in Adults and Pediatric Patients
- FDA Approves Emgality (galcanezumab) for Preventive Treatment of Migraine and Episodic Cluster Headache
- Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression
- Menopause does not appear to be a distinct clinical inflection point for multiple sclerosis progression
- Traumatic BPPV triples recurrence risk versus idiopathic BPPV in meta-analysis of 4,074 patients