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Neurology

1145 published articles · Updated continuously

This week's Neurology digest · 2026-W24
This Week in Neurology: Stroke Interventions and Alzheimer's Risk Factors
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HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Elevated Serum Lipoprotein(a) Levels Associated with Increased Odds of Hemorrhagic Stroke
Neurology Meta-analysis
Elevated Serum Lipoprotein(a) Levels Associated with Increased Odds of Hemorrhagic Stroke Higher Lipoprotein(a) levels linked to increased risk of hemorrhagic stroke
This meta-analysis of 526,909 adults evaluated the relationship between serum Lipoprotein(a) and stroke risk. Case-control studies showed an…
A large analysis of over 500,000 people suggests that higher levels of a specific protein may be linked to an increased risk of hemorrhagic …
Ponesimod maintains low disease activity and safety in RRMS over 13 years
Neurology RCT
Ponesimod maintains low disease activity and safety in RRMS over 13 years Trial Shows Ponesimod Maintains Safety for Relapsing-Remitting Multiple Sclerosis
This Phase 2b randomized controlled trial of 393 participants with relapsing-remitting multiple sclerosis found that ponesimod (10, 20, or 4…
A clinical trial shows that patients with relapsing-remitting multiple sclerosis can stay on ponesimod for up to 13 years with consistent re…
Dry needling significantly reduces upper and lower limb spasticity in patients with post-stroke conditions
Neurology Meta-analysis
Dry needling significantly reduces upper and lower limb spasticity in patients with post-stroke conditions Dry Needling Shows Promise for Reducing Post-Stroke Muscle Stiffness
This meta-analysis of 276 adults with post-stroke spasticity found that dry needling significantly reduces overall spasticity (MD = -0.65). …
Dry needling may help reduce muscle stiffness in the arms and legs of adults who have experienced a stroke.
Blood p-tau217 outperforms p-tau181 and p-tau231 for diagnostic performance in Alzheimer's disease
Neurology Meta-analysis
Blood p-tau217 outperforms p-tau181 and p-tau231 for diagnostic performance in Alzheimer's disease Blood Test p-tau217 Shows Stronger Performance for Alzheimer's Diagnosis
This meta-analysis evaluates the diagnostic performance of blood p-tau subtypes for Alzheimer's disease and related pathologies. The analysi…
A specific blood marker, p-tau217, shows better performance than other markers in identifying different stages of Alzheimer's disease.
Sarcopenia is associated with significantly higher risk of poor functional prognosis in stroke patients
Neurology Meta-analysis
Sarcopenia is associated with significantly higher risk of poor functional prognosis in stroke patients Sarcopenia Linked to Poorer Outcomes in Stroke Patients
This meta-analysis of 36 cohort studies indicates that sarcopenia is associated with a notably elevated risk of poor global functional progn…
Muscle loss after a stroke is linked to lower motor and cognitive scores, making it a key factor in recovery and long-term patient outcomes.
Central vein sign on MRI shows potential diagnostic value in pediatric-onset multiple sclerosis
Neurology Meta-analysis
Central vein sign on MRI shows potential diagnostic value in pediatric-onset multiple sclerosis MRI Central Vein Sign May Help Identify Pediatric Multiple Sclerosis
This meta-analysis of 5 studies evaluated the diagnostic accuracy of the central vein sign (CVS) in pediatric-onset multiple sclerosis. The …
A specific MRI finding called the central vein sign may help doctors identify multiple sclerosis in children and infants.
APOE ε4 carrier status does not accelerate cognitive decline in mild-to-moderate Alzheimer's disease
Neurology Phase III
APOE ε4 carrier status does not accelerate cognitive decline in mild-to-moderate Alzheimer's disease Genetic markers may relate to Alzheimer's severity but not speed
This observational analysis of the EXPEDITION 1 placebo arm involved 343 patients with mild-to-moderate Alzheimer's disease. The study found…
A new look at Alzheimer's data shows that a specific gene might affect how severe the disease is at first.
Maternal gut microbiota may influence fetal neurogenesis and neurobehavioral outcomes in ASD and ADHD
Neurology Sys. Review
Maternal gut microbiota may influence fetal neurogenesis and neurobehavioral outcomes in ASD and ADHD Maternal Gut Health May Influence Fetal Brain Development
This narrative review explores the maternal microbiota-gut-fetal brain axis and its influence on fetal neurogenesis, synaptogenesis, and lon…
Research suggests the mother's gut bacteria may influence fetal brain development and the risk of conditions like autism and ADHD.
HMGB1 acts as a progression-associated inflammatory amplifier in Alzheimer's, Parkinson's, and ALS models
Neurology Sys. Review
HMGB1 acts as a progression-associated inflammatory amplifier in Alzheimer's, Parkinson's, and ALS models New research explores a protein linked to several brain diseases
This narrative review explores the role of HMGB1 in various neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS. The auth…
A specific protein called HMGB1 may act as a driver of inflammation in conditions like Alzheimer's and Parkinson's disease.
MMP-7 serves as a diagnostic and prognostic marker for various fibrosing interstitial lung diseases
Neurology Sys. Review
MMP-7 serves as a diagnostic and prognostic marker for various fibrosing interstitial lung diseases MMP-7 Levels May Help Identify Lung Disease Severity
This narrative review examines the role of MMP-7 in patients with interstitial lung diseases and other chronic respiratory conditions. The a…
MMP-7 levels may help doctors identify the severity and progression of certain chronic lung diseases like Idiopathic Pulmonary Fibrosis.
Stepwise CSF drainage protocols provide a structured clinical framework for managing hydrocephalus patients
Neurology Sys. Review
Stepwise CSF drainage protocols provide a structured clinical framework for managing hydrocephalus patients New Clinical Protocol Offers Guidance for Hydrocephalus Drainage Methods
This systematic review evaluates various CSF drainage methods, including EVD, lumbar drainage, and different shunt types, to establish an op…
A new clinical protocol provides neurosurgeons with a step-by-step guide to choosing the best drainage methods for patients with hydrocephal…
Specialist monitoring is required for managing alemtuzumab-induced thyroid dysfunction during pregnancy
Neurology Sys. Review
Specialist monitoring is required for managing alemtuzumab-induced thyroid dysfunction during pregnancy Managing thyroid issues in pregnant women after alemtuzumab treatment
This case series and literature review examines the management of alemtuzumab-induced Graves' disease and TRAb-positive hypothyroidism in pr…
Pregnant women who develop thyroid issues after alemtuzumab treatment require close monitoring to manage their health and the health of thei…

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