This week's Oncology digest · 2026-W18
This Week in Oncology: Colorectal Cancer Surgery and Immunotherapy Advances
High tumour mutation burden improves overall survival in solid tumours treated with immune checkpoint inhibitors
High Mutation Counts May Predict Better Cancer Survival Outcomes
This systematic review and meta-analysis evaluated 5278 patients with solid tumours treated with immune checkpoint inhibitors or chemotherap…
High mutation counts in tumors may help predict who will survive longer when taking powerful immune-boosting cancer drugs
Lenvatinib plus PD-1 inhibitor improves survival versus bevacizumab plus PD-1 inhibitor in unresectable hepatocellular carcinoma
Meta-analysis shows lenvatinib-based regimens improve survival for unresectable liver cancer in East Asia
This systematic review and meta-analysis evaluated first-line treatment for unresectable hepatocellular carcinoma in East Asian populations.…
A meta-analysis of East Asian patients with unresectable liver cancer found lenvatinib-based regimens improved survival compared to bevacizu…
Meta-analysis of bevacizumab therapy in recurrent glioblastoma multiforme shows associations with improved outcomes
Bevacizumab therapy linked to better survival and fewer bleeding risks in recurrent brain cancer
This meta-analysis evaluates bevacizumab (BEV) therapy, temozolomide (TMZ), and lomustine in patients with recurrent glioblastoma multiforme…
A large review of patients with recurrent brain cancer found bevacizumab therapy linked to better survival and fewer bleeding risks compared…
Meta-analysis of pucotenlimab shows improved outcomes across multiple solid tumors
New analysis shows pucotenlimab improves outcomes for several solid tumor types.
This meta-analysis evaluated pucotenlimab (HX008) in patients with gastric, gastroesophageal junction, triple-negative breast cancer, melano…
A new analysis of pucotenlimab shows significantly improved outcomes versus control for patients with gastric cancer, triple-negative breast…
Meta-analysis finds frozen section reliable for tumor-free margins in OSCC
Surgeons rely on frozen sections to ensure clean cuts for oral cancer patients
This systematic review and meta-analysis of 19 studies (9 with complete data) assessed frozen section analysis for detecting tumor-free marg…
A new review confirms that frozen section analysis is a highly reliable way for surgeons to check if oral cancer has been fully removed duri…
Meta-analysis: Temporary uterine artery ligation reduces blood loss in myomectomy
Temporary uterine artery ligation reduces blood loss during fibroid surgery
This systematic review and meta-analysis of 857 women found that adding temporary uterine artery ligation (TUAL) to laparoscopic myomectomy …
A meta-analysis of 857 women found that adding temporary uterine artery ligation to fibroid surgery reduced blood loss and hemoglobin drop.
Systematic review and meta-analysis of unmet supportive care needs in 32,493 adults with cancer
Cancer patients need more help with information and mental health support now
This systematic review and meta-analysis evaluated unmet supportive care needs among 32,493 adults with cancer. The pooled analysis identifi…
A massive review of over 32,000 patients shows that information and emotional support are the biggest gaps in cancer care today
Systematic review and meta-analysis identifies factors influencing quality of life in colorectal cancer survivors
Social support and resilience boost quality of life for colorectal cancer survivors
This systematic review and meta-analysis synthesizes evidence on factors affecting quality of life in colorectal cancer survivors. Fatigue, …
A meta-analysis found that social support, resilience, and self-efficacy are linked to better quality of life in colorectal cancer survivors…
Review of PBMC processing conditions in head and neck squamous cell carcinoma treatment-naive patients
New blood test method avoids risky biopsies for cancer patients
This observational study review examines peripheral blood mononuclear cell (PBMC) processing conditions for treatment-naive patients with he…
A new blood processing method lets doctors track immune health without risky biopsies for head and neck cancer patients.
Network meta-analysis compares exercise modalities for quality of life in breast cancer survivors
Different types of exercise improve life for breast cancer survivors
This systematic review and network meta-analysis evaluated various exercise modalities for improving quality of life in breast cancer surviv…
Many forms of physical activity, from Tai Chi to yoga, help breast cancer survivors feel better and improve their quality of life.
Meta-analysis shows percutaneous irreversible electroporation plus immunotherapy improves outcomes in locally advanced pancreatic cancer
Adding immunotherapy to ablation therapy extends life for pancreatic cancer patients
This systematic review and meta-analysis evaluated percutaneous irreversible electroporation combined with immunotherapy versus irreversible…
Adding immune therapy to ablation therapy helps patients live longer with locally advanced pancreatic cancer without causing more side effec…
PHS601-based stratification increases prostate cancer risk estimates in Norwegian population-based cohorts
Genetic test shows higher prostate cancer risk in specific groups
This cohort study evaluated PHS601-based stratification in Norwegian population-based cohorts. The analysis included 14,688 individuals in c…
A genetic test linked to prostate cancer risk found that men in the top 1.8 percent of scores faced nearly nine times higher risk than avera…