Niraparib plus pembrolizumab maintenance therapy shows no difference in progression-free survival for NSCLC
Trial Shows Niraparib Plus Pembrolizumab Does Not Improve NSCLC Outcomes
This Phase 3 randomized controlled trial of 666 adults with advanced or metastatic NSCLC found that adding niraparib to pembrolizumab mainte…
A Phase 3 trial found that adding niraparib to pembrolizumab for maintenance therapy did not improve progression-free survival for patients …
Biologics Demonstrate Significant Clinical Improvements for Patients with Aspirin-Exacerbated Respiratory Disease
Biologics Linked to Better Nasal and Asthma Symptoms in AERD
A meta-analysis of 15 randomized trials indicates that biologics significantly improve nasal and bronchial outcomes in patients with AERD.
In people with aspirin-exacerbated respiratory disease, biologic drugs were tied to better nasal polyps, congestion, smell, and asthma score…
Mitiperstat 5 mg daily fails to improve time to first exacerbation in COPD
Trial shows mitiperstat does not reduce COPD flare-ups
This Phase 2a randomized controlled trial of 381 adults with moderate-to-severe COPD found no significant difference between mitiperstat and…
A clinical trial of the drug mitiperstat found no improvement in preventing flare-ups for patients with moderate-to-severe COPD.
Prone positioning and HFOV do not improve ventilator-free days in pediatric PARDS patients
Trial shows prone positioning does not improve ventilator-free days
This Phase 3 randomized controlled trial of 424 children with moderate-to-severe PARDS found no significant difference in ventilator-free da…
A large trial of 424 children with severe lung distress found that prone positioning did not increase the number of days spent off a ventila…
Cine MRI shows high sensitivity but modest specificity for chest wall invasion in lung cancer
Cine MRI helps doctors find lung cancer chest wall invasion
This meta-analysis of 190 patients with suspected chest wall invasion found that cine MRI had a sensitivity of 99% and a negative predictive…
A new imaging tool shows high accuracy in ruling out chest wall invasion in lung cancer patients, helping doctors plan safer surgeries.
High-intensity interval training improves specific functional and muscle outcomes in patients with COPD
High intensity training shows specific benefits for COPD patients
This meta-analysis of 401 patients compared high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) for COP…
High intensity interval training can improve muscle strength and walking distance for people living with COPD compared to steady exercise.
Survivors of ARDS with ECMO had significantly shorter noninvasive respiratory support durations before initiation
Shorter Noninvasive Respiratory Support Linked to Better Outcomes in ARDS
This meta-analysis of 718 patients with severe ARDS on ECMO found that survivors spent significantly fewer days on noninvasive respiratory s…
Patients with severe respiratory distress who received shorter periods of noninvasive support before ECMO treatment showed higher survival r…
Neoadjuvant chemoimmunotherapy improves pathologic response and survival in stage II non-small cell lung cancer
Chemoimmunotherapy Shows Promise for Stage II Lung Cancer Patients
This meta-analysis evaluated neoadjuvant chemoimmunotherapy for stage II non-small cell lung cancer compared to chemotherapy and upfront sur…
New data suggests that combining chemotherapy with immunotherapy before surgery may improve survival and treatment response for certain lung…
Heated humidifiers reduce PaCO and increase arterial pH in mechanically ventilated patients with ARDS
Heated humidifiers may improve lung health for patients with ARDS
This meta-analysis of adult patients with ARDS receiving invasive mechanical ventilation found that heated humidifiers were associated with …
Heated humidifiers may help manage carbon dioxide levels and acid balance in patients with severe lung distress.
Motivation and symptom burden link to exercise participation in COPD, but causality is unproven
Motivation Tops the List of What Keeps COPD Patients Exercising
This meta-analysis of 22 studies examined factors associated with regular exercise participation in individuals with COPD. Motivation (effec…
In a review of 22 studies, motivation and milder symptoms were the factors most closely tied to regular exercise in people with COPD.
Complementary therapies improve exercise capacity and psychological outcomes in patients with COPD
Complementary therapies improve breathing and mood for COPD patients
This meta-analysis of 3148 patients found that complementary therapies, including yoga and tai chi, improved exercise capacity and pulmonary…
Yoga, tai chi, and music therapy can improve walking distance and lower anxiety for people living with chronic lung disease.
Airway pressure release ventilation does not improve mortality in patients with acute respiratory distress syndrome
New data shows no mortality benefit for airway pressure ventilation
This meta-analysis of 585 patients evaluated airway pressure release ventilation compared to conventional invasive ventilation in ARDS. The …
A review of 585 patients shows that a specific ventilation method does not improve survival rates for those with severe lung injuries.
All Pulmonology & Critical Care Articles
- Niraparib plus pembrolizumab maintenance therapy shows no difference in progression-free survival for NSCLC
- Mitiperstat 5 mg daily fails to improve time to first exacerbation in COPD
- Biologics Demonstrate Significant Clinical Improvements for Patients with Aspirin-Exacerbated Respiratory Disease
- Cine MRI shows high sensitivity but modest specificity for chest wall invasion in lung cancer
- Prone positioning and HFOV do not improve ventilator-free days in pediatric PARDS patients
- High-intensity interval training improves specific functional and muscle outcomes in patients with COPD
- Neoadjuvant chemoimmunotherapy improves pathologic response and survival in stage II non-small cell lung cancer
- Motivation and symptom burden link to exercise participation in COPD, but causality is unproven
- Survivors of ARDS with ECMO had significantly shorter noninvasive respiratory support durations before initiation
- Heated humidifiers reduce PaCO and increase arterial pH in mechanically ventilated patients with ARDS
- Complementary therapies improve exercise capacity and psychological outcomes in patients with COPD
- Airway pressure release ventilation does not improve mortality in patients with acute respiratory distress syndrome
- FDA Approves Tracleer (bosentan) for Pulmonary Arterial Hypertension in Adults and Pediatric Patients
- FDA Approves Tracleer (bosentan) for Pulmonary Arterial Hypertension
- Intermittent hypoxia may disturb intestinal oxygen homeostasis and impair epithelial barrier function in obstructive sleep apnea
- ECMO treatment for COVID-19 in Central and Eastern Europe is associated with 65% in-hospital mortality
- Multimodal imaging clarifies cardiac mass in sarcomatoid urethral carcinoma despite relentless locoregional progression
- Pilates and Tai Chi improve objective and subjective outcomes in patients with chronic obstructive pulmonary disease
- TCM combined with Western therapy improves BMD and FEV1 in patients with COPD and osteoporosis
- Atezolizumab with SBRT fails to improve survival in early NSCLC
- Internet-Plus home-based pulmonary rehabilitation yields comparable clinical outcomes to center-based rehabilitation in COPD
- Radiation dose to heart and cardiac substructures associated with cardiac events and survival in lung cancer
- Oral Lactobacillus and Bifidobacterium probiotics improve pulmonary function and reduce inflammatory markers in COPD
- Traditional Chinese medicine shows heterogeneous effects on airway and gut microbial abundance in animal models
- FDA Approves Tyvaso DPI (treprostinil) for Pulmonary Arterial Hypertension and PH-ILD
- Pulmonary lymphangitic carcinomatosis may mimic interstitial lung disease in patients with gastric adenocarcinoma
- Tryptophan metabolism pathways and gut microbiota may influence pulmonary vascular remodeling in pulmonary hypertension
- TB prevalence reaches 16% in malnourished Ethiopian children, review finds
- Controlled low central venous pressure with nitroglycerin reduces 7-day postoperative AKI by 14.9% absolute risk
- Acetazolamide reduces AMS risk by 31% but females face 4.8-fold higher risk of side effects
- Short-term exposure to outdoor air pollution is linked to biochemical markers in emergency department patients
- Skeletal muscle dysfunction impacts exercise capacity and exacerbation risk in patients with COPD
- Osimertinib plus chemotherapy improves progression-free survival by 18.4 months in TP53 and EGFR-mutated NSCLC
- Targeted strategies like senolytics and PFKFB3 blockers show preclinical efficacy in chronic kidney disease
- Etoposide plus cisplatin shows higher treatment completion rate of 89.0% vs. 74.1% in HGNEC
- Endobronchial valve treatment triples peri-procedural mortality odds in severe emphysema
- Tailored Physical Activity Programs Improve Functional Capacity and Symptoms in Lung Cancer Patients
- Critically ill lung cancer patients face 73.5% long-term mortality and 51.9% hospital mortality
- Dysphagia affects 38.2% of COPD patients; advanced disease and tooth loss raise risk
- ANCA-associated vasculitis doubles lung cancer risk, meta-analysis finds
- Robotic-assisted thoracoscopic segmentectomy results in lower intraoperative blood loss compared to video-assisted thoracoscopic segmentectomy
- Triple therapy improves SGRQ scores in stable COPD but increases pneumonia risk compared to dual bronchodilation
- iNKT cell activators show promise in preclinical models for stroke-associated pneumonia immunomodulation
- Exercise reduces inflammatory markers in 45.6% of meta-analytic associations, but evidence quality is low
- FDA Approves Jascayd (bexotegrast) for Idiopathic Pulmonary Fibrosis and Progressive Pulmonary Fibrosis
- COPD and OSA overlap syndrome is associated with greater disease burden than either condition alone
- Low-dose corticosteroids reduce 90-day mortality in adults with severe community-acquired pneumonia
- Personalised CT feedback fails to boost quit rates overall in lung cancer screening
- Ultrasound Assessment of Diaphragm Function for Predicting Weaning Success in AECOPD Patients
- EIT-based PEEP titration reduces mortality rate in patients with acute respiratory distress syndrome
- Probiotic regimens may reduce cough duration and illness length in children with respiratory infections
- FDA Approves Orenitram (treprostinil) for Pulmonary Arterial Hypertension
- Occupational exposure to asbestos-free talc does not support increased risk of lung or laryngeal cancers
- Local ablative therapy integrated with first-line EGFR TKI improves progression-free survival and overall survival
- CDQ yields highest sensitivity and AUC for identifying patients with chronic obstructive pulmonary disease
- Reactive nodular fibrous pseudotumor presents with distinct immunohistochemical profiles and no progression in patients
- Respiratory trajectories vary by gestational age in infants born before 26 weeks' gestation
- Non-pharmacologic therapies improve cough in lung cancer; pulmonary rehabilitation may work best
- Immunocompromised Status Associated with Poorer Outcomes in Patients Requiring ECMO for Acute Respiratory Distress Syndrome
- Delirium prevalence of 41% among patients with acute respiratory distress syndrome
- Rapid on-site evaluation achieves 88.1% sensitivity and 91.7% specificity for lung cancer detection
- Evaluating Bevacizumab Addition to Atezolizumab Carboplatin and Pemetrexed in Nonsquamous NSCLC
- Chemoimmunotherapy improves objective response rate and survival in advanced pulmonary large-cell neuroendocrine carcinoma
- Lily polysaccharide may mitigate radiation-induced pneumonitis by modulating the gut-lung axis and pulmonary signaling
- Early assessment at 4 weeks versus 8 weeks increases abstinence odds in tobacco users
- Treatable traits protocol aims to reduce exacerbations in AECOPD patients
- Polygenic risk scores and air pollutants associated with increased lung cancer risk
- Ensartinib improves 24-month disease-free survival to 86.4% in resected ALK-positive NSCLC
- Low-dose N-acetylcysteine reduces acute exacerbation risk in patients with chronic obstructive pulmonary disease
- Health literacy-sensitive self-management programs improve exercise capacity and symptom burden in patients with COPD
- Biologic therapies targeting T2 inflammatory pathways reduce exacerbation rates in COPD patients
- Organizational resilience and psychological support are key to improving ICU nurse teamwork during pandemics
- Type-2 targeted biologics reduce moderate-to-severe exacerbations in patients with eosinophilic or type 2 COPD
- Individualised PEEP lowers driving pressure but not pulmonary complications in older lung cancer surgery patients
- Aumolertinib Combined with Chemotherapy Improves Progression Free Survival in EGFR Mutated NSCLC
- Nivolumab plus chemotherapy improves pathological complete response in resectable NSCLC with PD-L1 < 1%
- Deep learning AI models for lung nodule malignancy classification show 88% sensitivity and 75% specificity
- Biallelic SLCO2A1 variants may be associated with myelofibrosis in patients with primary hypertrophic osteoarthropathy
- Energy therapies improve exercise capacity and quality of life in patients with chronic obstructive pulmonary disease
- HITHOC with cytoreductive surgery improves survival in pleural mesothelioma without raising early postoperative risk
- WHO reporting system provides balanced diagnostic accuracy for malignancy risk in lung lesions
- Higher Ventilatory Ratio values are associated with increased mortality risk in patients with acute respiratory distress syndrome
- Sublobar resection associated with improved overall survival compared to SBRT in early-stage non-small cell lung cancer
- Osimertinib treatment for EGFR-mutated NSCLC results in hypertension as the most common CVAE
- Inspiratory muscle training improves inspiratory muscle strength and exercise tolerance in stable COPD patients
- Early vvECMO initiation protocol for adult patients with severe ARDS is currently being evaluated
- Metabolic abnormalities are significantly associated with pulmonary infections and asthma exacerbations in children
- Supervised structured exercise improves cardiorespiratory fitness in adults with MASLD by 3.52 mL/kg/min
- COPD caregiver health literacy is low, assessment tools lacking, scoping review finds
- Elevated nocturnal respiratory rate is associated with increased odds of diabetes mellitus in large cohorts
- Vitamin D deficiency increases odds of sepsis and mechanical ventilation in neonates
- FDA Approves Provocholine (methacholine chloride) for Bronchial Airway Hyperreactivity Diagnosis
- Tislelizumab plus chemotherapy improves survival in extensive-stage small cell lung cancer
- Lower PEEP may increase ventilator-free days in ventilated patients without ARDS
- Machine learning models show moderate accuracy predicting neoadjuvant immunotherapy response in NSCLC
- Meta-analysis links baseline and dynamic ctDNA to survival in advanced NSCLC
- COPD patients show heightened sympathetic nerve activity compared to healthy adults
- 1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds
- Pirfenidone reduces lung cancer incidence by 73% in IPF patients with a pooled risk ratio of 0.39
- Immune checkpoint inhibitors before lung cancer surgery show acceptable safety profile
- Irinotecan plus cisplatin shows no RFS benefit over etoposide plus cisplatin in resected lung HGNEC
- Metabolomics profiles show elevated phenylalanine and lactate alongside depleted sphingosine 1-phosphate and citrulline in ARDS patients
- Cutaneous immune-related adverse events associated with improved progression-free survival in non-small cell lung cancer
- Respiratory microbiome composition in children offers new ideas for precision treatment of respiratory diseases and asthma
- Systematic review links specific TCM constitutions to worse COPD outcomes in 2,168 patients
- Subcutaneous astegolimab reduced COPD exacerbations in phase 2b and 3 trials versus placebo
- Case report of 3-year-old girl with bilateral Wilms tumor and TP53 mutation treated with VAD chemotherapy and surgery
- Delayed arousal timing links to higher mortality in sleep apnea patients
- Case report suggests second primary glioblastoma in ALK-positive lung adenocarcinoma patient treated with ensartinib and lorlatinib
- Systematic review and meta-analysis shows individualized EIT-guided PEEP reduces postoperative atelectasis in laparoscopic surgery patients
- FDA Approves Adempas (riociguat) for Chronic Thromboembolic and Pulmonary Arterial Hypertension
- Post hoc reanalysis suggests stereotactic radiotherapy may improve local control in medically inoperable Stage I non-small cell lung cancer
- Meta-analysis finds immunotherapy improves survival in mesothelioma
- Systematic review and meta-analysis of repeat corticosteroids in PPROM shows increased maternal infection risk
- Meta-analysis finds balance training improves balance in COPD patients receiving pulmonary rehabilitation
- Real-world meta-analysis supports pembrolizumab for advanced NSCLC with high PD-L1
- Meta-analysis shows biologic therapies reduce annual exacerbations in COPD patients with high eosinophils while maintaining safety profiles
- FDA Approves Breztri Aerosphere (budesonide/glycopyrrolate/formoterol) for COPD Maintenance
- Review of animal models shows unclear causal links between microbial dysbiosis and pulmonary fibrosis
- RNK08954 shows unconfirmed responses in KRASG12D-mutant NSCLC and PDAC in Phase Ia trial
- Subcutaneous tislelizumab shows comparable trough concentrations to intravenous dosing in treatment-naive advanced non-small cell lung cancer patients
- Evidence-based review of transducer selection for lung ultrasound in dogs and cats with pulmonary pathology
- Toripalimab plus anlotinib maintenance shows promise in ES-SCLC after first-line chemo
- Combination therapy shows promising progression-free survival in advanced non-small cell lung cancer patients with high PD-L1 expression
- Dry NaCl Inhalation Fails to Improve Mucociliary Clearance in COPD
- Pembrolizumab improves overall survival versus chemotherapy in Chinese patients with advanced NSCLC and PD-L1 expression
- Meta-analysis shows platinum-etoposide plus PD-1/PD-L1 inhibitor improves survival in extensive-stage small-cell lung cancer
- Systematic review and meta-analysis shows immune checkpoint inhibitors improve survival in first-line ES-SCLC but not as single agents in second-line
- Network meta-analysis of anti-PD-1/PD-L1 regimens in advanced non-squamous NSCLC without EGFR or ALK alterations
- Lung Ultrasound Shows Good Diagnostic Accuracy for ARDS in Meta-Analysis of 5888 Patients
- Review of CFTR modulator impact on cystic fibrosis outcomes from registry data
- Pulmonary barotrauma incidence and risk factors in non-HIV PCP patients
- LSTM analysis of infant tidal breathing detects bronchopulmonary dysplasia with 97% accuracy
- Review synthesizes pilot data on nasal microbiota and respiratory outcomes in infants
- Smartphone app-based music PR program improves walking distance in COPD patients
- Narrative review discusses tumor draining lymph nodes as a target for NSCLC therapy
- Systematic review and meta-analysis of pharmacist-led care in COPD
- Meta-analysis of 15 observational studies links e-cigarette use to higher COPD odds
- Retrospective Study Shows 3D ResNeXt Classifier Distinguishes NTM-LD from PTB in 409 Patients
- Preclinical pig study tests lung ultrasound for regional strain quantification
- FeNO measurement shows limited diagnostic performance for asthma in school-age children
- CPET reference values established for asymptomatic repaired Tetralogy of Fallot patients
- Lung ultrasound and thoracic radiography for acute respiratory distress in dogs and cats
- Host transcriptional biosignatures for TB progression in Indian household contacts
- Network meta-analysis of acupuncture interventions for acute exacerbation of chronic obstructive pulmonary disease
- Retrospective review of methylprednisolone response in children with TBX4-associated pulmonary hypertension and interstitial lung disease
- Feasibility study abstract evaluates home spirometry and FeNO for asthma diagnosis in adults
- Narrative review examines lung microbiome and mucosal IgA in chronic inflammatory lung diseases
- Review of preclinical EVs for sepsis-associated acute lung injury
- Multicomponent breathing and exercise program improves breathlessness mastery in moderate to severe COPD
- Systematic review and meta-analysis of pulmonary telerehabilitation versus center-based care in COPD
- Systematic review finds high relapse rates in pulmonary sarcoidosis across diverse study designs
- LSTM-based model showed improved ventilator triggering metrics compared to Auto-Trak in a small trial
- Umbilical cord-derived mesenchymal stromal cells for severe COVID-19 ARDS show qualitative improvement and tolerability
- Hospitalized COVID-19 patients receiving antiviral, antiretroviral, or immunosuppressive treatments showed variable outcomes
- SABR shows 46% 5-year overall survival in unfit NSCLC patients in phase 2 trial
- Nine patients with PPFE and DGUOK-associated mitochondriopathy show specific genetic and cellular findings
- Spirometry restriction linked to higher interstitial lung disease and mortality risk in a large cohort
- AI nomogram predicts malignancy risk in surgically resected pulmonary nodules ≤3 cm
- FDA Approves Tyvaso (treprostinil) for Pulmonary Arterial Hypertension and Pulmonary Hypertension Associated with Interstitial Lung Disease
- In a phase 2 trial, [Ga]Ga-SSO120 PET/CT detected malignancies in 18 of 19 patients with small cell or large cell neuroendocrine lung cancer
- Prophylactic rhG-CSF with platinum chemotherapy improves immune markers and response rates in advanced lung cancer patients
- Virtual wards and hospital at home show no survival or readmission benefit for ECOPD patients compared to hospital admission
- Mindfulness interventions show mixed effects on breathlessness and pulmonary function in lung cancer patients
- Phase Ib/II trial of nintedanib plus nivolumab in pretreated NSCLC adenocarcinoma shows 25% 6-month PFS rate
- Non-cirrhotic portal fibrosis identified in 32.6% of pre-cirrhotic primary biliary cholangitis patients in a retrospective analysis
- First-line osimertinib shows high response rates in EGFR-mutated NSCLC with active brain metastases
- EMG measurement is feasible in primary care for stable mild to moderate COPD patients
- Age-period-cohort analysis shows declining bacteriologically confirmed pulmonary tuberculosis incidence in Hunan Province, China, 2009–2023
- Retrospective study links IVIG plus azithromycin to higher response rate in pediatric Mycoplasma pneumoniae pneumonia
- Meta-analysis finds inhaled corticosteroids associated with reduced cardiovascular mortality in COPD patients
- In vitro amikacin resistance linked to kanamycin cross-resistance but not streptomycin in M. avium-intracellulare complex
- Daily Vitamin D increased HDAC2 and 25(OH)D levels in stable COPD patients without improving pulmonary function
- Higher Red Cell Distribution Width to Albumin Ratio (RAR) associated with increased mortality in pulmonary sepsis
- Meta-analysis finds limited evidence for CPET variables in COPD mortality prediction
- Monthly phone counseling increased willingness to set lifestyle goals in patients with chronic obstructive pulmonary disease
- Genetic analysis links oral microbiota to COPD risk in East Asian population
- Low-dose theophylline shows modest FEV improvement but no exacerbation reduction in mild to moderate COPD
- Prolonged prone positioning shows oxygenation benefit but inconclusive mortality effect in COVID-19 ARDS
- FDA Approves Nintedanib Capsules (nintedanib esylate) for Idiopathic Pulmonary Fibrosis and Progressive Fibrosing ILDs
- FDA Approves Nintedanib Capsules (nintedanib esylate) for Idiopathic Pulmonary Fibrosis and Progressive Fibrosing ILDs
- SBRT shows early QoL advantage over CHRT in inoperable stage I NSCLC, but long-term scores converge
- Firmonertinib plus anlotinib shows preliminary efficacy in advanced EGFR-mutant NSCLC
- Retrospective cohort study of 74 patients with Chlamydia psittaci pneumonia identifies prognostic indicators and severity associations
- Systematic review of Traditional Chinese Exercise shows improved function and well-being in 2434 COPD patients
- Nonintubated anesthesia lowers postoperative NLR in thoracoscopic lung cancer resection compared to traditional intubation
- Phase II studies evaluate tislelizumab plus sitravatinib or anlotinib maintenance in extensive-stage small-cell lung cancer
- Extended prone positioning associated with lower mortality but more pressure injuries in COVID-19 ARDS
- BACE plus tislelizumab shows activity in advanced NSCLC patients ineligible for standard care
- Durvalumab plus chemotherapy shows 35% response in phase II trial for metastatic pulmonary sarcomatoid carcinoma
- Meta-analysis compares three lung fiducial marker insertion approaches for stereotactic body radiotherapy
- Non-powered stapler linked to fewer postoperative air leaks than powered stapler in severe emphysema LVRS
- Phase I study finds amrubicin-cisplatin with radiotherapy feasible in limited-stage SCLC
- Sputum quality does not affect Xpert MTB/RIF Ultra accuracy for tuberculosis diagnosis in multi-country study
- Observational report describes hospitalized EVALI cases in the United States
- Updated recommendations issued for tuberculosis prevention, control, and elimination
- Updated clinical guidance issued for suspected e-cigarette or vaping product use-associated lung injury
- Three Cases of Multidrug-Resistant Tuberculosis Identified Among Ohio Food Processing Workers
- Nivolumab with chemotherapy and bevacizumab shows improved 4-year survival in advanced nonsquamous NSCLC
- Residential Ammonia Gas Release Leads to Emergency Visits and Hospitalizations