FDA Approves Provocholine (methacholine chloride) for Bronchial Airway Hyperreactivity Diagnosis
FDA approves new test to help diagnose asthma in certain patients
The FDA approved Provocholine (methacholine chloride) for diagnosing bronchial airway hyperreactivity in adults and children aged 5 years an…
The FDA approved Provocholine, a drug used in a breathing test to diagnose airway hyperreactivity in people aged 5 and older who may have as…
Tislelizumab plus chemotherapy improves survival in extensive-stage small cell lung cancer
Immunotherapy combo extends survival in small cell lung cancer
This phase 3 RCT evaluated tislelizumab plus chemotherapy versus placebo plus chemotherapy in previously untreated extensive-stage small cel…
Adding tislelizumab to chemo helped people with extensive-stage small cell lung cancer live 2 months longer, a phase 3 trial shows.
Lower PEEP may increase ventilator-free days in ventilated patients without ARDS
Lower breathing pressure settings showed modest benefits for some critically ill patients without lung injury
This Bayesian re-analysis of an RCT in 980 invasively ventilated critically ill patients without ARDS found that lower PEEP (0-5 cm H2O) com…
A re-analysis of data found that using the lowest safe breathing pressure might help some patients breathe easier. However, the overall bene…
Machine learning models show moderate accuracy predicting neoadjuvant immunotherapy response in NSCLC
Machine learning models predict how well lung cancer patients respond to immunotherapy
This systematic review and meta-analysis of 44 models found that machine learning predicts neoadjuvant immunotherapy response in resectable …
A new analysis of 44 models shows computer programs can guess which lung cancer patients will benefit from immunotherapy, though the study h…
COPD patients show heightened sympathetic nerve activity compared to healthy adults
COPD patients have much higher nerve activity than healthy adults
A meta-analysis finds COPD patients have significantly higher sympathetic nerve activity than controls, with no change from common therapies…
People with COPD show significantly higher sympathetic nerve activity compared to healthy adults, which may explain their heart and exercise…
1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds
1 in 7 COPD patients decline or stop breathing therapy
This systematic review and meta-analysis of patients with COPD newly prescribed long-term noninvasive positive airway pressure (PAP) therapy…
A new analysis finds 14% of COPD patients decline or stop long-term breathing therapy, often within six weeks.
Meta-analysis links baseline and dynamic ctDNA to survival in advanced NSCLC
ctDNA in blood predicts survival in advanced lung cancer
This systematic review and meta-analysis of 43 studies found that detectable or elevated baseline plasma ctDNA was associated with worse ove…
A blood test for tumor DNA can predict survival in advanced lung cancer, helping guide treatment decisions.
Pirfenidone reduces lung cancer incidence by 73% in IPF patients with a pooled risk ratio of 0.39
Antifibrotic drugs may lower lung cancer risk in patients with idiopathic pulmonary fibrosis
This systematic review and meta-analysis evaluated antifibrotic therapies in 15582 patients with idiopathic pulmonary fibrosis. The pooled a…
A large review suggests antifibrotic drugs like pirfenidone might lower lung cancer risk in people with idiopathic pulmonary fibrosis, but m…
Immune checkpoint inhibitors before lung cancer surgery show acceptable safety profile
Immunotherapy before lung cancer surgery is safe, study finds
This meta-analysis of patients with resectable non-small cell lung cancer found that neoadjuvant or perioperative immune checkpoint inhibito…
A new analysis of 2,691 patients shows that immunotherapy before lung cancer surgery is feasible, but comes with specific surgical challenge…
Cutaneous immune-related adverse events associated with improved progression-free survival in non-small cell lung cancer
Skin reactions in lung cancer patients may signal longer life with certain treatments
This meta-analysis evaluated patients with non-small cell lung cancer receiving anti-PD-1, PD-L1, or chemotherapy. The analysis found that c…
A large review found that specific skin reactions linked to cancer drugs are connected to longer survival times for some lung cancer patient…
Irinotecan plus cisplatin shows no RFS benefit over etoposide plus cisplatin in resected lung HGNEC
Five-year follow-up shows irinotecan plus cisplatin matches etoposide plus cisplatin for lung cancer survival
This randomized, open-label, phase III study compared irinotecan plus cisplatin to etoposide plus cisplatin in 221 patients with resected hi…
A five-year look at lung cancer patients found that irinotecan plus cisplatin worked just as well as etoposide plus cisplatin for keeping th…
Metabolomics profiles show elevated phenylalanine and lactate alongside depleted sphingosine 1-phosphate and citrulline in ARDS patients
Metabolomics profiles reveal metabolic signatures in patients with acute respiratory distress syndrome
This systematic review and meta-analysis examines metabolomics profiles in patients with acute respiratory distress syndrome compared to tho…
A new analysis shows specific chemical changes in the blood of patients with acute respiratory distress syndrome compared to those without t…
All Pulmonology & Critical Care Articles
- FDA Approves Provocholine (methacholine chloride) for Bronchial Airway Hyperreactivity Diagnosis
- Tislelizumab plus chemotherapy improves survival in extensive-stage small cell lung cancer
- Lower PEEP may increase ventilator-free days in ventilated patients without ARDS
- Machine learning models show moderate accuracy predicting neoadjuvant immunotherapy response in NSCLC
- Meta-analysis links baseline and dynamic ctDNA to survival in advanced NSCLC
- COPD patients show heightened sympathetic nerve activity compared to healthy adults
- 1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds
- Pirfenidone reduces lung cancer incidence by 73% in IPF patients with a pooled risk ratio of 0.39
- Immune checkpoint inhibitors before lung cancer surgery show acceptable safety profile
- Irinotecan plus cisplatin shows no RFS benefit over etoposide plus cisplatin in resected lung HGNEC
- Metabolomics profiles show elevated phenylalanine and lactate alongside depleted sphingosine 1-phosphate and citrulline in ARDS patients
- Cutaneous immune-related adverse events associated with improved progression-free survival in non-small cell lung cancer
- Respiratory microbiome composition in children offers new ideas for precision treatment of respiratory diseases and asthma
- Systematic review links specific TCM constitutions to worse COPD outcomes in 2,168 patients
- Subcutaneous astegolimab reduced COPD exacerbations in phase 2b and 3 trials versus placebo
- Case report of 3-year-old girl with bilateral Wilms tumor and TP53 mutation treated with VAD chemotherapy and surgery
- Delayed arousal timing links to higher mortality in sleep apnea patients
- Case report suggests second primary glioblastoma in ALK-positive lung adenocarcinoma patient treated with ensartinib and lorlatinib
- Systematic review and meta-analysis shows individualized EIT-guided PEEP reduces postoperative atelectasis in laparoscopic surgery patients
- FDA Approves Adempas (riociguat) for Chronic Thromboembolic and Pulmonary Arterial Hypertension
- Post hoc reanalysis suggests stereotactic radiotherapy may improve local control in medically inoperable Stage I non-small cell lung cancer
- Meta-analysis finds immunotherapy improves survival in mesothelioma
- Systematic review and meta-analysis of repeat corticosteroids in PPROM shows increased maternal infection risk
- Meta-analysis finds balance training improves balance in COPD patients receiving pulmonary rehabilitation
- Real-world meta-analysis supports pembrolizumab for advanced NSCLC with high PD-L1
- Meta-analysis shows biologic therapies reduce annual exacerbations in COPD patients with high eosinophils while maintaining safety profiles
- FDA Approves Breztri Aerosphere (budesonide/glycopyrrolate/formoterol) for COPD Maintenance
- Review of animal models shows unclear causal links between microbial dysbiosis and pulmonary fibrosis
- RNK08954 shows unconfirmed responses in KRASG12D-mutant NSCLC and PDAC in Phase Ia trial
- Subcutaneous tislelizumab shows comparable trough concentrations to intravenous dosing in treatment-naive advanced non-small cell lung cancer patients
- Evidence-based review of transducer selection for lung ultrasound in dogs and cats with pulmonary pathology
- Toripalimab plus anlotinib maintenance shows promise in ES-SCLC after first-line chemo
- Combination therapy shows promising progression-free survival in advanced non-small cell lung cancer patients with high PD-L1 expression
- Dry NaCl Inhalation Fails to Improve Mucociliary Clearance in COPD
- Pembrolizumab improves overall survival versus chemotherapy in Chinese patients with advanced NSCLC and PD-L1 expression
- Meta-analysis shows platinum-etoposide plus PD-1/PD-L1 inhibitor improves survival in extensive-stage small-cell lung cancer
- Systematic review and meta-analysis shows immune checkpoint inhibitors improve survival in first-line ES-SCLC but not as single agents in second-line
- Network meta-analysis of anti-PD-1/PD-L1 regimens in advanced non-squamous NSCLC without EGFR or ALK alterations
- Lung Ultrasound Shows Good Diagnostic Accuracy for ARDS in Meta-Analysis of 5888 Patients
- Review of CFTR modulator impact on cystic fibrosis outcomes from registry data
- Pulmonary barotrauma incidence and risk factors in non-HIV PCP patients
- LSTM analysis of infant tidal breathing detects bronchopulmonary dysplasia with 97% accuracy
- Review synthesizes pilot data on nasal microbiota and respiratory outcomes in infants
- Smartphone app-based music PR program improves walking distance in COPD patients
- Narrative review discusses tumor draining lymph nodes as a target for NSCLC therapy
- Systematic review and meta-analysis of pharmacist-led care in COPD
- Meta-analysis of 15 observational studies links e-cigarette use to higher COPD odds
- Retrospective Study Shows 3D ResNeXt Classifier Distinguishes NTM-LD from PTB in 409 Patients
- Preclinical pig study tests lung ultrasound for regional strain quantification
- FeNO measurement shows limited diagnostic performance for asthma in school-age children
- CPET reference values established for asymptomatic repaired Tetralogy of Fallot patients
- Lung ultrasound and thoracic radiography for acute respiratory distress in dogs and cats
- Host transcriptional biosignatures for TB progression in Indian household contacts
- Network meta-analysis of acupuncture interventions for acute exacerbation of chronic obstructive pulmonary disease
- Retrospective review of methylprednisolone response in children with TBX4-associated pulmonary hypertension and interstitial lung disease
- Feasibility study abstract evaluates home spirometry and FeNO for asthma diagnosis in adults
- Narrative review examines lung microbiome and mucosal IgA in chronic inflammatory lung diseases
- Review of preclinical EVs for sepsis-associated acute lung injury
- Multicomponent breathing and exercise program improves breathlessness mastery in moderate to severe COPD
- Systematic review and meta-analysis of pulmonary telerehabilitation versus center-based care in COPD
- Systematic review finds high relapse rates in pulmonary sarcoidosis across diverse study designs
- LSTM-based model showed improved ventilator triggering metrics compared to Auto-Trak in a small trial
- Umbilical cord-derived mesenchymal stromal cells for severe COVID-19 ARDS show qualitative improvement and tolerability
- Hospitalized COVID-19 patients receiving antiviral, antiretroviral, or immunosuppressive treatments showed variable outcomes
- SABR shows 46% 5-year overall survival in unfit NSCLC patients in phase 2 trial
- Nine patients with PPFE and DGUOK-associated mitochondriopathy show specific genetic and cellular findings
- Spirometry restriction linked to higher interstitial lung disease and mortality risk in a large cohort
- AI nomogram predicts malignancy risk in surgically resected pulmonary nodules ≤3 cm
- FDA Approves Tyvaso (treprostinil) for Pulmonary Arterial Hypertension and Pulmonary Hypertension Associated with Interstitial Lung Disease
- In a phase 2 trial, [Ga]Ga-SSO120 PET/CT detected malignancies in 18 of 19 patients with small cell or large cell neuroendocrine lung cancer
- Prophylactic rhG-CSF with platinum chemotherapy improves immune markers and response rates in advanced lung cancer patients
- Virtual wards and hospital at home show no survival or readmission benefit for ECOPD patients compared to hospital admission
- Mindfulness interventions show mixed effects on breathlessness and pulmonary function in lung cancer patients
- Phase Ib/II trial of nintedanib plus nivolumab in pretreated NSCLC adenocarcinoma shows 25% 6-month PFS rate
- Non-cirrhotic portal fibrosis identified in 32.6% of pre-cirrhotic primary biliary cholangitis patients in a retrospective analysis
- First-line osimertinib shows high response rates in EGFR-mutated NSCLC with active brain metastases
- EMG measurement is feasible in primary care for stable mild to moderate COPD patients
- Age-period-cohort analysis shows declining bacteriologically confirmed pulmonary tuberculosis incidence in Hunan Province, China, 2009–2023
- Retrospective study links IVIG plus azithromycin to higher response rate in pediatric Mycoplasma pneumoniae pneumonia
- Meta-analysis finds inhaled corticosteroids associated with reduced cardiovascular mortality in COPD patients
- In vitro amikacin resistance linked to kanamycin cross-resistance but not streptomycin in M. avium-intracellulare complex
- Daily Vitamin D increased HDAC2 and 25(OH)D levels in stable COPD patients without improving pulmonary function
- Higher Red Cell Distribution Width to Albumin Ratio (RAR) associated with increased mortality in pulmonary sepsis
- Meta-analysis finds limited evidence for CPET variables in COPD mortality prediction
- Monthly phone counseling increased willingness to set lifestyle goals in patients with chronic obstructive pulmonary disease
- Genetic analysis links oral microbiota to COPD risk in East Asian population
- Low-dose theophylline shows modest FEV improvement but no exacerbation reduction in mild to moderate COPD
- Prolonged prone positioning shows oxygenation benefit but inconclusive mortality effect in COVID-19 ARDS
- FDA Approves Nintedanib Capsules (nintedanib esylate) for Idiopathic Pulmonary Fibrosis and Progressive Fibrosing ILDs
- FDA Approves Nintedanib Capsules (nintedanib esylate) for Idiopathic Pulmonary Fibrosis and Progressive Fibrosing ILDs
- SBRT shows early QoL advantage over CHRT in inoperable stage I NSCLC, but long-term scores converge
- Firmonertinib plus anlotinib shows preliminary efficacy in advanced EGFR-mutant NSCLC
- Retrospective cohort study of 74 patients with Chlamydia psittaci pneumonia identifies prognostic indicators and severity associations
- Systematic review of Traditional Chinese Exercise shows improved function and well-being in 2434 COPD patients
- Nonintubated anesthesia lowers postoperative NLR in thoracoscopic lung cancer resection compared to traditional intubation
- Phase II studies evaluate tislelizumab plus sitravatinib or anlotinib maintenance in extensive-stage small-cell lung cancer
- Extended prone positioning associated with lower mortality but more pressure injuries in COVID-19 ARDS
- BACE plus tislelizumab shows activity in advanced NSCLC patients ineligible for standard care
- Durvalumab plus chemotherapy shows 35% response in phase II trial for metastatic pulmonary sarcomatoid carcinoma
- Meta-analysis compares three lung fiducial marker insertion approaches for stereotactic body radiotherapy
- Non-powered stapler linked to fewer postoperative air leaks than powered stapler in severe emphysema LVRS
- Phase I study finds amrubicin-cisplatin with radiotherapy feasible in limited-stage SCLC
- Sputum quality does not affect Xpert MTB/RIF Ultra accuracy for tuberculosis diagnosis in multi-country study
- Observational report describes hospitalized EVALI cases in the United States
- Updated recommendations issued for tuberculosis prevention, control, and elimination
- Updated clinical guidance issued for suspected e-cigarette or vaping product use-associated lung injury
- Three Cases of Multidrug-Resistant Tuberculosis Identified Among Ohio Food Processing Workers
- Nivolumab with chemotherapy and bevacizumab shows improved 4-year survival in advanced nonsquamous NSCLC
- Residential Ammonia Gas Release Leads to Emergency Visits and Hospitalizations
- Progress toward tuberculosis elimination in the United States has slowed
- U.S. COPD prevalence patterns similar across smoking status groups in 2017 observational data
- 215 possible severe pulmonary disease cases associated with e-cigarette use across 25 states
- Interim guidance issued for evaluating patients with suspected vaping-associated lung injury
- Utah EVALI case series describes patient characteristics and vaping practices
- Report describes changes in tuberculosis incidence across the United States population
- Global report assesses progress toward tuberculosis incidence reduction targets
- US survey finds higher COPD prevalence in nonmetropolitan versus metropolitan areas
- U.S. tuberculosis incidence data reported for 2021 in observational analysis
- Field investigation report describes pneumonic plague case(s) in Wyoming in 2021
- Clinical prediction model differentiates NTM pulmonary disease from tuberculosis in hospitalized patients
- Two lung transplant recipients developed Legionnaires' disease from a single donor
- Observational report examines COPD prevalence in US adults aged 18 years and older
- U.S. TB Incidence Increased in 2022, With Ongoing Racial and Ethnic Disparities
- U.S. workers' idiopathic pulmonary fibrosis mortality described by industry and occupation
- Pilot project describes TB contact management in Ugandan households without reported outcomes
- Tuberculosis Cases Increased in the United States During 2023
- Surveillance report updates tuberculosis elimination progress and program performance in the United States from 2016 to 2022
- CureTB program evaluated continuity of care for tuberculosis patients relocating internationally
- ERAS-guided refined nursing associated with earlier mobilization after lung cancer surgery in retrospective cohort
- Phase 2 trial of high-dose thoracic reirradiation shows 30-month median OS for recurrent lung cancer
- Phase 2 trial finds no significant PFS benefit adding SABR to nivolumab in advanced NSCLC
- Vitamin D3 supplementation improved exercise tolerance in deficient male COPD patients in small RCT
- Perioperative tislelizumab plus chemotherapy improves survival in Chinese patients with resectable NSCLC
- Antenatal dexamethasone reduces respiratory support need in late preterm infants in Vietnamese RCT
- Lung cancer trial patients show disparities in optional biospecimen study participation
- HFNC reduces oxygen desaturation and procedure interruptions during bronchoscopy in high-risk patients
- Amivantamab-lazertinib shows OS benefit over osimertinib in Asian EGFR-mutant NSCLC subset
- Acute high-intensity inspiratory muscle training linked to shorter oxygen desaturation time in COPD
- FDA Approves Winrevair for Pulmonary Arterial Hypertension (PAH) in Adults
- Phase III trial tests TTFields plus standard therapy for stage 4 NSCLC after platinum failure
- Phase 2 trial of DS-1062a in pretreated advanced NSCLC with genomic alterations posts no results
- Capmatinib shows efficacy in Chinese NSCLC patients with MET exon 14 skipping mutations
- Meta-analysis: GOLD-PRISm prevalence 10.60%, GOLD-RSP 12.09% in general population
- Phase 2 trial of neoadjuvant/adjuvant pembrolizumab in stage IB-IIIA NSCLC completes enrollment of 35 patients
- Hyper-oncotic Albumin Reduces Mortality in ARDS Compared to Crystalloid
- Phase 2 Trial: Cytisine and ASA for Inflammation in Lifelong Smokers
- Phase 2 Study: L-SABR Plus Standard Therapy in Metastatic NSCLC Patients
- Ivonescimab Phase II Study Targets 55% DCR in Relapsed Pleural Mesothelioma