Pulmonology & Critical Care

All Pulmonology & Critical Care Articles

• Rapid on-site evaluation achieves 88.1% sensitivity and 91.7% specificity for lung cancer detection
• Evaluating Bevacizumab Addition to Atezolizumab Carboplatin and Pemetrexed in Nonsquamous NSCLC
• Chemoimmunotherapy improves objective response rate and survival in advanced pulmonary large-cell neuroendocrine carcinoma
• Lily polysaccharide may mitigate radiation-induced pneumonitis by modulating the gut-lung axis and pulmonary signaling
• Early assessment at 4 weeks versus 8 weeks increases abstinence odds in tobacco users
• Treatable traits protocol aims to reduce exacerbations in AECOPD patients
• Polygenic risk scores and air pollutants associated with increased lung cancer risk
• Ensartinib improves 24-month disease-free survival to 86.4% in resected ALK-positive NSCLC
• Low-dose N-acetylcysteine reduces acute exacerbation risk in patients with chronic obstructive pulmonary disease
• Health literacy-sensitive self-management programs improve exercise capacity and symptom burden in patients with COPD
• Biologic therapies targeting T2 inflammatory pathways reduce exacerbation rates in COPD patients
• Organizational resilience and psychological support are key to improving ICU nurse teamwork during pandemics
• Type-2 targeted biologics reduce moderate-to-severe exacerbations in patients with eosinophilic or type 2 COPD
• Individualised PEEP lowers driving pressure but not pulmonary complications in older lung cancer surgery patients
• Aumolertinib Combined with Chemotherapy Improves Progression Free Survival in EGFR Mutated NSCLC
• Nivolumab plus chemotherapy improves pathological complete response in resectable NSCLC with PD-L1 < 1%
• Deep learning AI models for lung nodule malignancy classification show 88% sensitivity and 75% specificity
• Biallelic SLCO2A1 variants may be associated with myelofibrosis in patients with primary hypertrophic osteoarthropathy
• Energy therapies improve exercise capacity and quality of life in patients with chronic obstructive pulmonary disease
• HITHOC with cytoreductive surgery improves survival in pleural mesothelioma without raising early postoperative risk
• WHO reporting system provides balanced diagnostic accuracy for malignancy risk in lung lesions
• Higher Ventilatory Ratio values are associated with increased mortality risk in patients with acute respiratory distress syndrome
• Sublobar resection associated with improved overall survival compared to SBRT in early-stage non-small cell lung cancer
• Osimertinib treatment for EGFR-mutated NSCLC results in hypertension as the most common CVAE
• Inspiratory muscle training improves inspiratory muscle strength and exercise tolerance in stable COPD patients
• Early vvECMO initiation protocol for adult patients with severe ARDS is currently being evaluated
• Metabolic abnormalities are significantly associated with pulmonary infections and asthma exacerbations in children
• Supervised structured exercise improves cardiorespiratory fitness in adults with MASLD by 3.52 mL/kg/min
• COPD caregiver health literacy is low, assessment tools lacking, scoping review finds
• Elevated nocturnal respiratory rate is associated with increased odds of diabetes mellitus in large cohorts
• Vitamin D deficiency increases odds of sepsis and mechanical ventilation in neonates
• FDA Approves Provocholine (methacholine chloride) for Bronchial Airway Hyperreactivity Diagnosis
• Tislelizumab plus chemotherapy improves survival in extensive-stage small cell lung cancer
• Lower PEEP may increase ventilator-free days in ventilated patients without ARDS
• Machine learning models show moderate accuracy predicting neoadjuvant immunotherapy response in NSCLC
• Meta-analysis links baseline and dynamic ctDNA to survival in advanced NSCLC
• COPD patients show heightened sympathetic nerve activity compared to healthy adults
• 1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds
• Pirfenidone reduces lung cancer incidence by 73% in IPF patients with a pooled risk ratio of 0.39
• Immune checkpoint inhibitors before lung cancer surgery show acceptable safety profile
• Irinotecan plus cisplatin shows no RFS benefit over etoposide plus cisplatin in resected lung HGNEC
• Metabolomics profiles show elevated phenylalanine and lactate alongside depleted sphingosine 1-phosphate and citrulline in ARDS patients
• Cutaneous immune-related adverse events associated with improved progression-free survival in non-small cell lung cancer
• Respiratory microbiome composition in children offers new ideas for precision treatment of respiratory diseases and asthma
• Systematic review links specific TCM constitutions to worse COPD outcomes in 2,168 patients
• Subcutaneous astegolimab reduced COPD exacerbations in phase 2b and 3 trials versus placebo
• Case report of 3-year-old girl with bilateral Wilms tumor and TP53 mutation treated with VAD chemotherapy and surgery
• Delayed arousal timing links to higher mortality in sleep apnea patients
• Case report suggests second primary glioblastoma in ALK-positive lung adenocarcinoma patient treated with ensartinib and lorlatinib
• Systematic review and meta-analysis shows individualized EIT-guided PEEP reduces postoperative atelectasis in laparoscopic surgery patients
• FDA Approves Adempas (riociguat) for Chronic Thromboembolic and Pulmonary Arterial Hypertension
• Post hoc reanalysis suggests stereotactic radiotherapy may improve local control in medically inoperable Stage I non-small cell lung cancer
• Meta-analysis finds immunotherapy improves survival in mesothelioma
• Systematic review and meta-analysis of repeat corticosteroids in PPROM shows increased maternal infection risk
• Meta-analysis finds balance training improves balance in COPD patients receiving pulmonary rehabilitation
• Real-world meta-analysis supports pembrolizumab for advanced NSCLC with high PD-L1
• Meta-analysis shows biologic therapies reduce annual exacerbations in COPD patients with high eosinophils while maintaining safety profiles
• FDA Approves Breztri Aerosphere (budesonide/glycopyrrolate/formoterol) for COPD Maintenance
• Review of animal models shows unclear causal links between microbial dysbiosis and pulmonary fibrosis
• RNK08954 shows unconfirmed responses in KRASG12D-mutant NSCLC and PDAC in Phase Ia trial
• Subcutaneous tislelizumab shows comparable trough concentrations to intravenous dosing in treatment-naive advanced non-small cell lung cancer patients
• Evidence-based review of transducer selection for lung ultrasound in dogs and cats with pulmonary pathology
• Toripalimab plus anlotinib maintenance shows promise in ES-SCLC after first-line chemo
• Combination therapy shows promising progression-free survival in advanced non-small cell lung cancer patients with high PD-L1 expression
• Dry NaCl Inhalation Fails to Improve Mucociliary Clearance in COPD
• Pembrolizumab improves overall survival versus chemotherapy in Chinese patients with advanced NSCLC and PD-L1 expression
• Meta-analysis shows platinum-etoposide plus PD-1/PD-L1 inhibitor improves survival in extensive-stage small-cell lung cancer
• Systematic review and meta-analysis shows immune checkpoint inhibitors improve survival in first-line ES-SCLC but not as single agents in second-line
• Network meta-analysis of anti-PD-1/PD-L1 regimens in advanced non-squamous NSCLC without EGFR or ALK alterations
• Lung Ultrasound Shows Good Diagnostic Accuracy for ARDS in Meta-Analysis of 5888 Patients
• Review of CFTR modulator impact on cystic fibrosis outcomes from registry data
• Pulmonary barotrauma incidence and risk factors in non-HIV PCP patients
• LSTM analysis of infant tidal breathing detects bronchopulmonary dysplasia with 97% accuracy
• Review synthesizes pilot data on nasal microbiota and respiratory outcomes in infants
• Smartphone app-based music PR program improves walking distance in COPD patients
• Narrative review discusses tumor draining lymph nodes as a target for NSCLC therapy
• Systematic review and meta-analysis of pharmacist-led care in COPD
• Meta-analysis of 15 observational studies links e-cigarette use to higher COPD odds
• Retrospective Study Shows 3D ResNeXt Classifier Distinguishes NTM-LD from PTB in 409 Patients
• Preclinical pig study tests lung ultrasound for regional strain quantification
• FeNO measurement shows limited diagnostic performance for asthma in school-age children
• CPET reference values established for asymptomatic repaired Tetralogy of Fallot patients
• Lung ultrasound and thoracic radiography for acute respiratory distress in dogs and cats
• Host transcriptional biosignatures for TB progression in Indian household contacts
• Network meta-analysis of acupuncture interventions for acute exacerbation of chronic obstructive pulmonary disease
• Retrospective review of methylprednisolone response in children with TBX4-associated pulmonary hypertension and interstitial lung disease
• Feasibility study abstract evaluates home spirometry and FeNO for asthma diagnosis in adults
• Narrative review examines lung microbiome and mucosal IgA in chronic inflammatory lung diseases
• Review of preclinical EVs for sepsis-associated acute lung injury
• Multicomponent breathing and exercise program improves breathlessness mastery in moderate to severe COPD
• Systematic review and meta-analysis of pulmonary telerehabilitation versus center-based care in COPD
• Systematic review finds high relapse rates in pulmonary sarcoidosis across diverse study designs
• LSTM-based model showed improved ventilator triggering metrics compared to Auto-Trak in a small trial
• Umbilical cord-derived mesenchymal stromal cells for severe COVID-19 ARDS show qualitative improvement and tolerability
• Hospitalized COVID-19 patients receiving antiviral, antiretroviral, or immunosuppressive treatments showed variable outcomes
• SABR shows 46% 5-year overall survival in unfit NSCLC patients in phase 2 trial
• Nine patients with PPFE and DGUOK-associated mitochondriopathy show specific genetic and cellular findings
• Spirometry restriction linked to higher interstitial lung disease and mortality risk in a large cohort
• AI nomogram predicts malignancy risk in surgically resected pulmonary nodules ≤3 cm
• FDA Approves Tyvaso (treprostinil) for Pulmonary Arterial Hypertension and Pulmonary Hypertension Associated with Interstitial Lung Disease
• In a phase 2 trial, [Ga]Ga-SSO120 PET/CT detected malignancies in 18 of 19 patients with small cell or large cell neuroendocrine lung cancer
• Prophylactic rhG-CSF with platinum chemotherapy improves immune markers and response rates in advanced lung cancer patients
• Virtual wards and hospital at home show no survival or readmission benefit for ECOPD patients compared to hospital admission
• Mindfulness interventions show mixed effects on breathlessness and pulmonary function in lung cancer patients
• Phase Ib/II trial of nintedanib plus nivolumab in pretreated NSCLC adenocarcinoma shows 25% 6-month PFS rate
• Non-cirrhotic portal fibrosis identified in 32.6% of pre-cirrhotic primary biliary cholangitis patients in a retrospective analysis
• First-line osimertinib shows high response rates in EGFR-mutated NSCLC with active brain metastases
• EMG measurement is feasible in primary care for stable mild to moderate COPD patients
• Age-period-cohort analysis shows declining bacteriologically confirmed pulmonary tuberculosis incidence in Hunan Province, China, 2009–2023
• Retrospective study links IVIG plus azithromycin to higher response rate in pediatric Mycoplasma pneumoniae pneumonia
• Meta-analysis finds inhaled corticosteroids associated with reduced cardiovascular mortality in COPD patients
• In vitro amikacin resistance linked to kanamycin cross-resistance but not streptomycin in M. avium-intracellulare complex
• Daily Vitamin D increased HDAC2 and 25(OH)D levels in stable COPD patients without improving pulmonary function
• Higher Red Cell Distribution Width to Albumin Ratio (RAR) associated with increased mortality in pulmonary sepsis
• Meta-analysis finds limited evidence for CPET variables in COPD mortality prediction
• Monthly phone counseling increased willingness to set lifestyle goals in patients with chronic obstructive pulmonary disease
• Genetic analysis links oral microbiota to COPD risk in East Asian population
• Low-dose theophylline shows modest FEV improvement but no exacerbation reduction in mild to moderate COPD
• Prolonged prone positioning shows oxygenation benefit but inconclusive mortality effect in COVID-19 ARDS
• FDA Approves Nintedanib Capsules (nintedanib esylate) for Idiopathic Pulmonary Fibrosis and Progressive Fibrosing ILDs
• FDA Approves Nintedanib Capsules (nintedanib esylate) for Idiopathic Pulmonary Fibrosis and Progressive Fibrosing ILDs
• SBRT shows early QoL advantage over CHRT in inoperable stage I NSCLC, but long-term scores converge
• Firmonertinib plus anlotinib shows preliminary efficacy in advanced EGFR-mutant NSCLC
• Retrospective cohort study of 74 patients with Chlamydia psittaci pneumonia identifies prognostic indicators and severity associations
• Systematic review of Traditional Chinese Exercise shows improved function and well-being in 2434 COPD patients
• Nonintubated anesthesia lowers postoperative NLR in thoracoscopic lung cancer resection compared to traditional intubation
• Phase II studies evaluate tislelizumab plus sitravatinib or anlotinib maintenance in extensive-stage small-cell lung cancer
• Extended prone positioning associated with lower mortality but more pressure injuries in COVID-19 ARDS
• BACE plus tislelizumab shows activity in advanced NSCLC patients ineligible for standard care
• Durvalumab plus chemotherapy shows 35% response in phase II trial for metastatic pulmonary sarcomatoid carcinoma
• Meta-analysis compares three lung fiducial marker insertion approaches for stereotactic body radiotherapy
• Non-powered stapler linked to fewer postoperative air leaks than powered stapler in severe emphysema LVRS
• Phase I study finds amrubicin-cisplatin with radiotherapy feasible in limited-stage SCLC
• Sputum quality does not affect Xpert MTB/RIF Ultra accuracy for tuberculosis diagnosis in multi-country study
• Observational report describes hospitalized EVALI cases in the United States
• Updated recommendations issued for tuberculosis prevention, control, and elimination
• Updated clinical guidance issued for suspected e-cigarette or vaping product use-associated lung injury
• Three Cases of Multidrug-Resistant Tuberculosis Identified Among Ohio Food Processing Workers
• Nivolumab with chemotherapy and bevacizumab shows improved 4-year survival in advanced nonsquamous NSCLC
• Residential Ammonia Gas Release Leads to Emergency Visits and Hospitalizations
• Progress toward tuberculosis elimination in the United States has slowed
• U.S. COPD prevalence patterns similar across smoking status groups in 2017 observational data
• 215 possible severe pulmonary disease cases associated with e-cigarette use across 25 states
• Interim guidance issued for evaluating patients with suspected vaping-associated lung injury
• Utah EVALI case series describes patient characteristics and vaping practices
• Report describes changes in tuberculosis incidence across the United States population
• Global report assesses progress toward tuberculosis incidence reduction targets
• US survey finds higher COPD prevalence in nonmetropolitan versus metropolitan areas
• U.S. tuberculosis incidence data reported for 2021 in observational analysis
• Field investigation report describes pneumonic plague case(s) in Wyoming in 2021
• Clinical prediction model differentiates NTM pulmonary disease from tuberculosis in hospitalized patients
• Two lung transplant recipients developed Legionnaires' disease from a single donor
• Observational report examines COPD prevalence in US adults aged 18 years and older
• U.S. TB Incidence Increased in 2022, With Ongoing Racial and Ethnic Disparities
• U.S. workers' idiopathic pulmonary fibrosis mortality described by industry and occupation
• Pilot project describes TB contact management in Ugandan households without reported outcomes
• Tuberculosis Cases Increased in the United States During 2023
• Surveillance report updates tuberculosis elimination progress and program performance in the United States from 2016 to 2022
• CureTB program evaluated continuity of care for tuberculosis patients relocating internationally
• ERAS-guided refined nursing associated with earlier mobilization after lung cancer surgery in retrospective cohort
• Phase 2 trial of high-dose thoracic reirradiation shows 30-month median OS for recurrent lung cancer
• Phase 2 trial finds no significant PFS benefit adding SABR to nivolumab in advanced NSCLC
• Vitamin D3 supplementation improved exercise tolerance in deficient male COPD patients in small RCT
• Perioperative tislelizumab plus chemotherapy improves survival in Chinese patients with resectable NSCLC
• Antenatal dexamethasone reduces respiratory support need in late preterm infants in Vietnamese RCT
• Lung cancer trial patients show disparities in optional biospecimen study participation
• HFNC reduces oxygen desaturation and procedure interruptions during bronchoscopy in high-risk patients
• Amivantamab-lazertinib shows OS benefit over osimertinib in Asian EGFR-mutant NSCLC subset
• Acute high-intensity inspiratory muscle training linked to shorter oxygen desaturation time in COPD
• FDA Approves Winrevair for Pulmonary Arterial Hypertension (PAH) in Adults
• Phase III trial tests TTFields plus standard therapy for stage 4 NSCLC after platinum failure
• Phase 2 trial of DS-1062a in pretreated advanced NSCLC with genomic alterations posts no results
• Capmatinib shows efficacy in Chinese NSCLC patients with MET exon 14 skipping mutations
• Meta-analysis: GOLD-PRISm prevalence 10.60%, GOLD-RSP 12.09% in general population
• Phase 2 trial of neoadjuvant/adjuvant pembrolizumab in stage IB-IIIA NSCLC completes enrollment of 35 patients
• Hyper-oncotic Albumin Reduces Mortality in ARDS Compared to Crystalloid
• Phase 2 Trial: Cytisine and ASA for Inflammation in Lifelong Smokers
• Phase 2 Study: L-SABR Plus Standard Therapy in Metastatic NSCLC Patients
• Ivonescimab Phase II Study Targets 55% DCR in Relapsed Pleural Mesothelioma