Allergy & Immunology

All Allergy & Immunology Articles

• Hypoxia coordinates cancer stem cell phenotypes with immune-related mechanisms and therapeutic resistance in cancer
• Immune-Fibrotic Framework Links Endometriosis and Adenomyosis to Non-Hormonal Targets
• OM-85 did not significantly reduce time to first wheezing lower respiratory tract illness in high-risk children
• Thymosin alpha1 plus chemotherapy improves response rates and immune markers in gastric cancer
• Nasal tissue-resident memory T cells may provide a framework for understanding allergic rhinitis relapse
• Knee osteoarthritis research trends show increasing focus on metabolic syndrome and inflammatory signaling
• Anti-KLHL11 encephalitis requires extensive tumor screening as clinical features do not distinguish from malignancy
• CD4+ T cell subset imbalance drives renal inflammation and fibrosis in diabetic kidney disease
• Integrated nutritional support strategies improve food access and early management of childhood malnutrition
• FDA Approves Joenja (leniolisib) for Activated PI3K Delta Syndrome in Patients 12 and Older
• Anti-rituximab antibodies are associated with lower rituximab levels and increased relapse rates in nephropathies
• Umbilical cord-derived mesenchymal stromal cells balance immune homeostasis and offer potential for inflammatory disease treatment
• Expert consensus provides a framework for harmonizing HLH diagnosis and management in GCC countries
• Thymectomy and immunotherapy improve symptoms in a patient with myasthenia gravis and paraneoplastic syndrome
• Cow's milk consumption supports physical growth, bone health, and cognitive performance in healthy children
• Biologics provide effective and long-lasting disease control for chronic rhinosinusitis with nasal polyps
• MMR status-guided immunotherapy provides favorable cost-effectiveness and quality-adjusted survival in dMMR/MSI-H endometrial cancer
• B-cell targeted therapies show durable immune responses in pemphigus vulgaris and myasthenia gravis
• Add-on therapies fail to beat placebo in cutaneous sarcoidosis, but quality of life may improve
• Mitophagy acts as a core barrier to effective immunotherapy in melanoma and other skin cancers
• Autoantibody positivity and false-negative cytology can mask invasive mucinous adenocarcinoma in patients with IPAF
• Several risk factors including early-life antibiotic use and maternal OCP exposure increase allergic rhinitis risk
• Structured clinical data models show moderate discrimination for predicting relapsing multiple sclerosis outcomes
• Tumor immune microenvironment heterogeneity between thyroid and colorectal cancer drives distinct immune evasion mechanisms
• HLA-B alleles B*39:01, B*13:01, and B*38:02 serve as markers for sulfasalazine-induced SCARs in Asian populations
• Digital assessment modalities show feasibility and reliability in Myasthenia Gravis but lack independent validation
• DNA vaccines against MCPyV LTAg and STAg show potential for Merkel cell carcinoma immunotherapy
• Perioperative and postoperative immunotherapy timing determines clinical outcomes in locally advanced head and neck squamous cell carcinoma
• Comprehensive-component subcutaneous immunotherapy shows the most favorable symptom score reduction in allergic rhinitis
• Erythrocytes function as immunomodulatory participants and potential drivers of pathology in post-traumatic environments
• Allogeneic hematopoietic stem cell transplantation provides salvage for refractory chronic immune thrombocytopenia in a child
• Vunakizumab may induce severe ulcerative colitis and hepatic enzyme elevation in patients with psoriatic arthritis
• Cryopreserved PBMC starting material is a feasible approach for CAR-T cell manufacturing in hematological malignancies
• High Siglec-15 Tumor Expression Tied to Worse Survival
• CAR-engineered immune cells and Treg-cell therapies show biological plausibility but limited human evidence in IBD
• Therapeutic extracellular vesicles may curb inflammation and restore mitochondrial quality in osteoarthritis
• Statin use is associated with improved overall survival and progression-free survival in lung cancer
• mTOR-glycolytic axis activation drives inflammatory loops and mucosal barrier dysfunction in ulcerative colitis
• Ferroptosis and the GPX4 axis contribute to inflammation and barrier dysfunction in autoimmune uveitis
• Depemokimab shows no significant difference from other biologics in reducing severe asthma exacerbations
• Higher school asthma readiness associated with 1.44 odds of asthma exacerbations in children
• 2-octyl cyanoacrylate topical skin adhesives are associated with a 4% incidence of allergic contact dermatitis
• Dupilumab and cendakimab show moderate-to-high certainty benefit for dysphagia in eosinophilic esophagitis
• Postmortem tryptase concentration shows high diagnostic accuracy for identifying fatal anaphylaxis in forensic cases
• Press-needle therapy as an adjunct to medication improves clinical efficacy in pediatric allergic rhinitis
• Nasal saline irrigation significantly reduces nasal symptoms and rescue antihistamine use in pediatric allergic rhinitis
• ALC decline greater than 0.74x10^9/L independently predicts poorer OS and PFS in LA-HNSCC
• Immune checkpoint inhibitors increase risk of myocarditis and other cardiac toxicities in patients
• Small bowel metastasis from esophageal squamous cell carcinoma shows male predominance and 6-month median survival
• E3 ubiquitin ligases regulate DNA repair and promote resistance in gastrointestinal malignancies
• Daratumumab improves progression-free survival in patients with cytogenetically high-risk multiple myeloma
• Plectin knockdown and troglitazone treatment inhibit growth and migration in papillary thyroid carcinoma cell lines
• Organ-specific metastatic niches at vascular-immune interfaces shape the fate of disseminated tumor cells
• mRNA vaccines reshape tumor microenvironment and induce durable anti-tumor immunity in lung cancer
• Platelet-rich plasma, autologous serum, and cyclosporine A show specific benefits in Sjögren's syndrome dry eye
• FDA Approves Takhzyro (lanadelumab-flyo) for Prophylaxis of Hereditary Angioedema Attacks
• Artificial intelligence applications in pediatric nutrition show mixed results for dietary assessment and meal planning
• Perioperative immune checkpoint inhibitors with chemotherapy increase pathological complete response rate by 2.91 RR
• Metabolic parameters MTV and TLG predict poorer survival in NSCLC patients on immune checkpoint inhibitors
• D-VRd ranks highest for progression-free survival among anti-CD38 regimens in transplant-ineligible multiple myeloma
• Photoacoustic imaging enables label-free real-time tumor microenvironment visualization in oncology
• Welding fume exposure induces acute-phase proteins, cytokines, and neutrophilic responses in respiratory immune activation
• Serum complement C3 levels are elevated in polycystic ovary syndrome, meta-analysis finds
• Pyruvylation of STAT1 at Lys201 suppresses type I interferon signaling during high glucose glycolysis
• EGFR inhibitors are associated with a 52.30% pooled incidence of all-grade rash in patients with tumors
• Engineered nanobodies offer programmable platform to overcome limitations of conventional antibodies in angiogenic diseases
• Mitochondrial dysfunction shapes immune cell function across sepsis phases, review finds
• Azithromycin does not reduce severity of wheezing symptoms more than placebo in preschool children
• Finger millet supports sustainable nutrition and climate resilience as an underutilized grain for functional foods
• Inflammatory ovarian remodeling drives premature ovarian insufficiency; cell therapy and mitochondrial protection emerge as targets
• Bidirectional virus-metabolism interaction in chronic hepatitis B and metabolic dysfunction-associated fatty liver disease
• Host-targeting antivirals offer a potential transformative treatment strategy for rhinovirus infection
• Pembrolizumab plus chemotherapy improves ORR and OS in HER2-negative advanced gastric or gastroesophageal junction cancer
• Talquetamab monotherapy linked to 51% any-grade infection rate in relapsed/refractory myeloma
• Vonoprazan therapy associated with anaphylaxis in a patient with pollen-food allergy syndrome
• Community governance models for nutrition-oriented care aim to reduce survival disparities across multiple cancers
• Endoplasmic reticulum stress and unfolded protein response drive thyrocyte apoptosis and immune cell dysfunction
• Alpha-gal syndrome review: delayed reactions, 15,000 new US cases yearly
• Nanotechnology may overcome immune checkpoint blockade resistance in esophageal cancer by reprogramming the tumor microenvironment
• Surfactant protein D serves as a prognostic marker and potential therapeutic agent in various cancers
• Cell surface glycoRNAs engage immune receptors, influencing neutrophil trafficking and immune activation
• HLA alleles and haplotypes influence the magnitude of CMV and EBV specific T-cell responses
• Immune checkpoint inhibitors show limited activity in unselected pancreatic ductal adenocarcinoma without specific biomarkers
• HLA-B*13:01 screening shows strong association with Dapsone Hypersensitivity Syndrome in leprosy patients
• B7-H3-targeted ADCs achieve 54% objective response rate in previously treated small cell lung cancer
• Ixekizumab Q2W shows highest P-score among IL-17 inhibitors for active psoriatic arthritis
• Hematopoietic stem cell transplantation for Krabbe disease is associated with 84% overall survival
• Anti-CD6 monoclonal antibodies increase lymphocyte cytotoxicity against various human cancer cells in experimental systems
• Neoadjuvant immune checkpoint inhibitors plus chemotherapy increase pathological complete response in early-stage triple-negative breast cancer
• FDA Approves Xolair (omalizumab) for IgE-Mediated Food Allergy
• Antenatal factors in the fetal exposome may program neonatal immune development via epigenetic mechanisms
• Framework Maps Skin-Nose Link in Pediatric Allergy
• IL-10 Levels Predict Mortality in Severe Fever with Thrombocytopenia
• Intrinsic and extrinsic factors shape the unique aromatic profile of Qingke products during processing
• Three-dose HPV vaccine regimens provide highest seroconversion rates and protection against persistent infection
• Aberrant IgG glycosylation correlates with cancer progression and serves as a novel aging-associated factor
• PD-(L)1 plus VEGF monoclonal antibody shows most favorable overall survival in advanced hepatocellular carcinoma
• Postoperative food allergen exposure may impede wound healing through inflammatory responses and delayed angiogenesis
• Pharmacokinetic and clinical data inform therapeutic selection for difficult to treat Pseudomonas aeruginosa CNS infections
• Ivonescimab-containing chemoimmunotherapy can trigger rare ADAMTS13 inhibitor-positive immune thrombotic thrombocytopenic purpura
• FDA Approves Cellcept (mycophenolate mofetil) for Organ Rejection Prophylaxis
• FDA Approves Cellcept (mycophenolate mofetil) for Organ Rejection Prophylaxis
• Cloud-based intelligent management system improves medication adherence 89.2% vs 58.0% in pediatric asthma
• Depemokimab maintains trough concentrations 90% above EC level with predicted half-life of 47 days
• Nanomedicine platforms reshape osteosarcoma tumor microenvironment, showing strong preclinical potential
• Asthma and COPD are associated with significantly increased risk of pertussis infection
• High-dose omega-3 PUFA and EPA significantly reduce risk of asthma and wheezing in children
• FDA Approves Cellcept (mycophenolate mofetil) for Organ Rejection Prophylaxis
• FDA Approves Cellcept (mycophenolate mofetil) for Organ Rejection Prophylaxis
• FDA Approves Myhibbin (mycophenolate mofetil) for Organ Rejection Prophylaxis
• Triple consolidation with CAR T cells yields sustained remission in relapsed BPDCN
• Chemo combinations with ivonescimab, sacituzumab tirumotecan, and amivantamab show significant progression-free survival benefits
• Bortezomib, cyclophosphamide, and dexamethasone achieved remission in a patient with AL amyloidosis and POEMS syndrome
• Combination Immunotherapy Improves Outcomes for BCG Unresponsive Non Muscle Invasive Bladder Cancer
• Financial toxicity and food insecurity create a health-economic pathway impacting nutrition in women with cancer
• Lower baseline soluble PD-L1 levels correlate with improved progression-free and overall survival in NSCLC
• TKI plus chemotherapy achieves deep molecular remission in Ph+ leukemia case with diagnostic framework
• Immunonutrition may improve management of radiation-induced oral mucositis in head and neck cancer patients
• Calcium homeostasis dysregulation serves as an integrative regulatory node in allergic rhinitis inflammation
• Sintilimab may trigger autoimmune GFAP astrocytopathy in esophageal squamous cell carcinoma patients
• Diverse therapeutic approaches including immunotherapy are utilized for patients with occult squamous cell carcinoma
• Metabolic checkpoints like lactate and adenosine drive immune escape and resistance to checkpoint blockade
• Lower serum vitamin D levels correlate with increased severity in chronic rhinosinusitis
• Pneumococcal conjugate vaccines reduce antimicrobial resistance through direct suppression and reduced antibiotic exposure
• Immunosuppression with corticosteroids and cyclophosphamide leads to clinical improvement in AAV patients with hepatic granulomas
• OTUD1 serves as a potential biomarker for tumor prognosis and cardiovascular disease progression
• Chemoradiotherapy combined with immunotherapy improves progression-free and overall survival in limited-stage small-cell lung cancer
• Neural-immune-cardiovascular axis emerges as therapeutic target in atherosclerosis, hypertension, heart failure
• Mesenchymal stem cell transplantation shows no significant improvement in EDSS scores for progressive multiple sclerosis
• Regulatory and financing barriers primarily hinder optimal care delivery for hereditary angioedema in Balkan countries
• Obinutuzumab achieves 86% overall clinical remission rate in refractory membranous nephropathy
• Advanced diagnostic techniques including molecular profiling and AI offer evolving strategies for allergic rhinitis management
• Omics technologies identify inflammatory, fibrotic, and metabolic programs in secondary lymphedema for target identification
• FTO-targeted strategies currently lack clinical evaluation and rely on preclinical evidence for cancer treatment
• Existing food security scales lack the ability to capture unique cultural dimensions for immigrant populations
• Upstream alarmins IL-33 and TSLP emerge as key targets in T2 asthma pathogenesis
• Integrated biomarker panels provide more complete insights into mechanism-specific therapeutic responses in rheumatoid arthritis
• Proposed CTS protocol aims to convert cold tumors to hot and improve immunotherapy response
• Succinate accumulation drives inflammatory and immune dysregulation in rheumatoid arthritis through three distinct pathways
• Zolbetuximab combined with chemotherapy improves progression-free survival and overall survival in CLDN18.2-expressing gastric cancers
• Immune ecotypes may offer more refined patient stratification for ccRCC than current biomarkers
• Calcium signaling dysregulation drives keratinocyte defects and immune activation in psoriasis
• Higher systemic immune-inflammation index values are associated with patients diagnosed with rheumatic diseases
• m6A modification regulates renal tubular epithelial cell fate and inflammatory responses in acute kidney injury
• Scavenger receptor-guided and cathepsin B-triggered nanodelivery systems enable targeted macrophage remodeling for atherosclerosis and cancer
• FDA Approves Children's Zyrtec Hives (cetirizine) for Hives Relief
• HMGB1 and LPS interactions provide potential therapeutic targets for inflammation and coagulation in sepsis
• FDA Approves Tuxarin Er (codeine/chlorpheniramine) for Cough and Upper Respiratory Symptoms
• Primary and acquired resistance to immune checkpoint inhibitors in NSCLC involves antigen presentation and TME remodeling
• Immune checkpoint inhibitor regimens for colorectal cancer increase risk of endocrine adverse events
• LncRNA signatures predict ICI response and survival across cancers in systematic review
• Immune checkpoint inhibitors are associated with acute kidney injury and multi-organ immune-related adverse events
• Macrophage phenotypic plasticity and metabolism influenced by tissue niches contribute to obesity and metabolic disease
• FDA Approves Ryaltris (olopatadine/mometasone) for Seasonal Allergic Rhinitis
• KRAS G12C inhibitors improve progression-free survival with HR 0.62 in KRASG12C-mutated solid tumors
• Neoadjuvant chemoimmunotherapy improves pathological response and surgical rates in resectable esophageal squamous cell carcinoma
• B cell and humoral immunity pathways provide potential targets for modulating inflammation in Inflammatory Bowel Disease
• Metabolic reprogramming in the tumor microenvironment drives immune evasion and immunotherapy resistance in gastric cancer
• Radiomics and spatial omics offer theoretical framework for precision bladder cancer care
• FDA Approves Zyrtec-d 12 Hour (cetirizine/pseudoephedrine) for Allergy Symptoms
• FDA Approves Zyrtec Allergy (cetirizine) for Hay Fever and Upper Respiratory Allergy Symptoms
• Dysregulated m6A methylation contributes to hepatic fibrosis and inflammation in radiation-induced liver injury
• Single-cell and spatial omics provide detailed mapping of tumor-immune ecosystems in non-small cell lung cancer
• Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
• Lipid metabolism disorders drive podocyte injury and extracellular matrix deposition in diabetic kidney disease
• Genistein shows potential to attenuate inflammation and reduce disease severity in autoimmune conditions
• Adalimumab and its biosimilar IBI303 show distinct response clusters in ankylosing spondylitis
• Genetic variant identification improves polygenic risk prediction for patients with asthma
• Dysregulation of tRNA expression, modification, and tsRNAs is linked to tumor proliferation and therapy resistance
• Dendritic cell-based therapies face significant clinical translation barriers due to tumor microenvironment suppression
• Tumor-infiltrating pDCs lose interferon production despite nucleic acid exposure
• Therapeutic advances in IgE-mediated food allergy lack validated risk-stratification tools for individualized care
• Cytokine and endothelial markers show strong associations with severe dengue cases across 47,612 patients
• PEFR-guided therapy shows no difference in symptom control compared to symptom-guided therapy in acute asthma
• BiPAP improves oxygenation over HFNC in pediatric asthma exacerbation, but evidence is limited
• Over one-third of workers with occupational asthma experience adverse occupational outcomes
• GSTO1 inhibition induces apoptosis in AML cells while LMRS model stratifies patient risk
• Topical clobetasol resolves recalcitrant Pagetoid reticulosis in a single case report
• Purified phytochemicals and multicomponent botanical formulas may modulate the pulmonary fibrosis immune microenvironment in IPF
• Cell-mediated immunity and mucosal responses characterize early infection in ruminants with Johne's disease
• Bidirectional associations exist between obstructive lung diseases and inflammatory bowel disease across 30 observational studies
• Next-generation engineered constructs aim to overcome immunosuppressive tumor microenvironments in refractory malignancies
• Targeting metabolic checkpoints and mechanotransduction may address structural deterioration in axial spondyloarthritis
• Refractory mastoiditis may signal granulomatosis with polyangiitis: case highlights need for early ANCA testing
• Routine serum lipid profiles may serve as markers for systemic metabolism in allergic diseases
• Vitamin D supplementation alleviates symptoms of allergic rhinitis, atopic dermatitis, and urticaria
• FDA Approves Adrenalin (epinephrine) for Anaphylaxis and Septic Shock Hypotension
• Systemic Immune-Inflammation Index Shows Diagnostic and Prognostic Value in Thyroid Cancer
• Small PNH clones in SLE linked to thrombotic events and hemolysis in case series
• Nanomedicine delivery systems may enhance immunotherapy efficacy in colorectal cancer
• Point-of-care smell testing serves as an effective screening tool for various neurodegenerative and respiratory conditions
• Residual (meth)acrylate monomers trigger type IV hypersensitivity in dental settings
• Phenotype-weighted and organ-prioritized frameworks should guide treatment for autoinflammatory diseases despite molecular diagnosis limitations
• Metabolic reprogramming of lipid-associated macrophages creates an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
• Ferroptosis contributes to endothelial dysfunction, macrophage foam cell death, and necrotic core expansion in atherosclerosis
• The osteoimmune-brain axis links systemic inflammation and bone hormones to neurodegenerative pathology
• NLRP3 inflammasome modulates immune evasion and chemotherapy sensitivity in gynecological cancers
• Allergic conjunctivitis pathogenesis and endotypes point toward precision therapy
• Training programs to teach behavioral mealtime interventions for children with food refusal and selectivity
• Immune-mediated loss of HCRT neurons drives sleep-wake circuit instability and brain network reconfiguration in narcolepsy