Depemokimab maintains trough concentrations 90% above EC level with predicted half-life of 47 days
New data supports twice yearly dosing for asthma and sinus disease
This observational analysis of pharmacokinetic and pharmacodynamic data from Phase I and Phase III trials evaluated depemokimab in patients …
A new analysis of trial data shows a specific treatment for asthma and nasal polyps may only need to be given twice a year.
High-dose omega-3 PUFA and EPA significantly reduce risk of asthma and wheezing in children
High dose omega-3 fatty acids may lower asthma risk in children
This meta-analysis of 4156 children evaluated the impact of omega-3 polyunsaturated fatty acids on asthma. Findings indicate that high-dose …
New data suggests that specific high doses of omega-3 fatty acids and EPA could significantly reduce the risk of asthma and wheezing in chil…
Cloud-based intelligent management system improves medication adherence 89.2% vs 58.0% in pediatric asthma
Smart monitoring helps children with asthma manage their symptoms better
This randomized controlled trial of 208 children aged 6 to 12 years found that a cloud-based integrated intelligent management system signif…
A cloud-based management system significantly improved medication habits and lung function for children living with bronchial asthma.
Nanomedicine platforms reshape osteosarcoma tumor microenvironment, showing strong preclinical potential
New delivery methods show promise for treating bone cancer
This mini-review examines nanomedicine delivery systems, including biomimetic, stimuli-responsive, and bone-targeted platforms, for osteosar…
Nanomedicine platforms may help overcome physical and cellular barriers to reshape the environment around osteosarcoma tumors.
Asthma and COPD are associated with significantly increased risk of pertussis infection
Asthma and COPD Patients Face Higher Risk of Pertussis Infection
This meta-analysis of 10 studies involving over 18.6 million participants indicates that patients with asthma or COPD face a higher risk of …
People with asthma or COPD may face a significantly higher risk of contracting pertussis, according to an analysis of over 18 million partic…
FDA Approves Cellcept (mycophenolate mofetil) for Organ Rejection Prophylaxis
FDA approves Cellcept to prevent organ rejection in transplant patients.
The FDA approved Cellcept (mycophenolate mofetil) for prophylaxis of organ rejection in adult and pediatric recipients 3 months and older of…
The FDA has approved Cellcept (mycophenolate mofetil) to help prevent organ rejection in patients who have received a kidney, heart, or live…
FDA Approves Cellcept (mycophenolate mofetil) for Organ Rejection Prophylaxis
FDA approves Cellcept to prevent organ rejection in transplant patients.
The FDA approved Cellcept (mycophenolate mofetil) for prophylaxis of organ rejection in adult and pediatric patients 3 months and older rece…
The FDA has approved Cellcept (mycophenolate mofetil) to help prevent organ rejection in adults and children aged 3 months and older who hav…
FDA Approves Myhibbin (mycophenolate mofetil) for Organ Rejection Prophylaxis
FDA approves new liquid and capsule form of transplant rejection drug
The FDA approved Myhibbin (mycophenolate mofetil) for prophylaxis of organ rejection in adult and pediatric recipients 3 months and older of…
The FDA approved Myhibbin, a new form of mycophenolate mofetil, to prevent organ rejection in kidney, heart, and liver transplant patients a…
Chemo combinations with ivonescimab, sacituzumab tirumotecan, and amivantamab show significant progression-free survival benefits
New Treatment Combinations Show Promise for Advanced Lung Cancer
This systematic review and meta-analysis of 3,606 patients evaluated 8 treatment strategies for advanced EGFR-mutant NSCLC. The analysis fou…
Specific drug combinations, including ivonescimab and amivantamab, show potential benefits for patients with advanced EGFR-mutant lung cance…
Triple consolidation with CAR T cells yields sustained remission in relapsed BPDCN
New treatment strategy shows promise for rare blood cancer
This case report and literature review describes a 55-year-old man with relapsed/refractory BPDCN and CNS involvement who achieved sustained…
A new three-part treatment plan helped a man with a rare, aggressive blood cancer achieve long-term remission when no donor was available.
Bortezomib, cyclophosphamide, and dexamethasone achieved remission in a patient with AL amyloidosis and POEMS syndrome
Treatment shows success for heart failure and rare blood diseases
This case report and literature review describes the treatment of an elderly male with concurrent AL amyloidosis and POEMS syndrome. The pat…
A new look at a complex case reveals how a specific drug combination helped an elderly man with multiple rare conditions.
Combination Immunotherapy Improves Outcomes for BCG Unresponsive Non Muscle Invasive Bladder Cancer
Combination immunotherapy shows promise for bladder cancer patients
Multi-agent immunotherapy regimens show superior response rates and progression-free survival compared to monotherapy in patients with NMIBC…
A new combination of immunotherapies may improve response rates and survival for patients with specific types of bladder cancer.
All Allergy & Immunology Articles
- Cloud-based intelligent management system improves medication adherence 89.2% vs 58.0% in pediatric asthma
- Depemokimab maintains trough concentrations 90% above EC level with predicted half-life of 47 days
- Nanomedicine platforms reshape osteosarcoma tumor microenvironment, showing strong preclinical potential
- Asthma and COPD are associated with significantly increased risk of pertussis infection
- High-dose omega-3 PUFA and EPA significantly reduce risk of asthma and wheezing in children
- FDA Approves Cellcept (mycophenolate mofetil) for Organ Rejection Prophylaxis
- FDA Approves Cellcept (mycophenolate mofetil) for Organ Rejection Prophylaxis
- FDA Approves Myhibbin (mycophenolate mofetil) for Organ Rejection Prophylaxis
- Triple consolidation with CAR T cells yields sustained remission in relapsed BPDCN
- Chemo combinations with ivonescimab, sacituzumab tirumotecan, and amivantamab show significant progression-free survival benefits
- Bortezomib, cyclophosphamide, and dexamethasone achieved remission in a patient with AL amyloidosis and POEMS syndrome
- Combination Immunotherapy Improves Outcomes for BCG Unresponsive Non Muscle Invasive Bladder Cancer
- Financial toxicity and food insecurity create a health-economic pathway impacting nutrition in women with cancer
- Lower baseline soluble PD-L1 levels correlate with improved progression-free and overall survival in NSCLC
- TKI plus chemotherapy achieves deep molecular remission in Ph+ leukemia case with diagnostic framework
- Immunonutrition may improve management of radiation-induced oral mucositis in head and neck cancer patients
- Calcium homeostasis dysregulation serves as an integrative regulatory node in allergic rhinitis inflammation
- Sintilimab may trigger autoimmune GFAP astrocytopathy in esophageal squamous cell carcinoma patients
- Diverse therapeutic approaches including immunotherapy are utilized for patients with occult squamous cell carcinoma
- Metabolic checkpoints like lactate and adenosine drive immune escape and resistance to checkpoint blockade
- Lower serum vitamin D levels correlate with increased severity in chronic rhinosinusitis
- Pneumococcal conjugate vaccines reduce antimicrobial resistance through direct suppression and reduced antibiotic exposure
- Immunosuppression with corticosteroids and cyclophosphamide leads to clinical improvement in AAV patients with hepatic granulomas
- OTUD1 serves as a potential biomarker for tumor prognosis and cardiovascular disease progression
- Chemoradiotherapy combined with immunotherapy improves progression-free and overall survival in limited-stage small-cell lung cancer
- Neural-immune-cardiovascular axis emerges as therapeutic target in atherosclerosis, hypertension, heart failure
- Mesenchymal stem cell transplantation shows no significant improvement in EDSS scores for progressive multiple sclerosis
- Regulatory and financing barriers primarily hinder optimal care delivery for hereditary angioedema in Balkan countries
- Obinutuzumab achieves 86% overall clinical remission rate in refractory membranous nephropathy
- Advanced diagnostic techniques including molecular profiling and AI offer evolving strategies for allergic rhinitis management
- Omics technologies identify inflammatory, fibrotic, and metabolic programs in secondary lymphedema for target identification
- FTO-targeted strategies currently lack clinical evaluation and rely on preclinical evidence for cancer treatment
- Existing food security scales lack the ability to capture unique cultural dimensions for immigrant populations
- Upstream alarmins IL-33 and TSLP emerge as key targets in T2 asthma pathogenesis
- Integrated biomarker panels provide more complete insights into mechanism-specific therapeutic responses in rheumatoid arthritis
- Proposed CTS protocol aims to convert cold tumors to hot and improve immunotherapy response
- Succinate accumulation drives inflammatory and immune dysregulation in rheumatoid arthritis through three distinct pathways
- Zolbetuximab combined with chemotherapy improves progression-free survival and overall survival in CLDN18.2-expressing gastric cancers
- Immune ecotypes may offer more refined patient stratification for ccRCC than current biomarkers
- Calcium signaling dysregulation drives keratinocyte defects and immune activation in psoriasis
- Higher systemic immune-inflammation index values are associated with patients diagnosed with rheumatic diseases
- m6A modification regulates renal tubular epithelial cell fate and inflammatory responses in acute kidney injury
- Scavenger receptor-guided and cathepsin B-triggered nanodelivery systems enable targeted macrophage remodeling for atherosclerosis and cancer
- FDA Approves Children's Zyrtec Hives (cetirizine) for Hives Relief
- HMGB1 and LPS interactions provide potential therapeutic targets for inflammation and coagulation in sepsis
- FDA Approves Tuxarin Er (codeine/chlorpheniramine) for Cough and Upper Respiratory Symptoms
- Primary and acquired resistance to immune checkpoint inhibitors in NSCLC involves antigen presentation and TME remodeling
- Immune checkpoint inhibitor regimens for colorectal cancer increase risk of endocrine adverse events
- LncRNA signatures predict ICI response and survival across cancers in systematic review
- Immune checkpoint inhibitors are associated with acute kidney injury and multi-organ immune-related adverse events
- Macrophage phenotypic plasticity and metabolism influenced by tissue niches contribute to obesity and metabolic disease
- FDA Approves Ryaltris (olopatadine/mometasone) for Seasonal Allergic Rhinitis
- KRAS G12C inhibitors improve progression-free survival with HR 0.62 in KRASG12C-mutated solid tumors
- Neoadjuvant chemoimmunotherapy improves pathological response and surgical rates in resectable esophageal squamous cell carcinoma
- B cell and humoral immunity pathways provide potential targets for modulating inflammation in Inflammatory Bowel Disease
- Metabolic reprogramming in the tumor microenvironment drives immune evasion and immunotherapy resistance in gastric cancer
- Radiomics and spatial omics offer theoretical framework for precision bladder cancer care
- FDA Approves Zyrtec-d 12 Hour (cetirizine/pseudoephedrine) for Allergy Symptoms
- FDA Approves Zyrtec Allergy (cetirizine) for Hay Fever and Upper Respiratory Allergy Symptoms
- Dysregulated m6A methylation contributes to hepatic fibrosis and inflammation in radiation-induced liver injury
- Single-cell and spatial omics provide detailed mapping of tumor-immune ecosystems in non-small cell lung cancer
- Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
- Lipid metabolism disorders drive podocyte injury and extracellular matrix deposition in diabetic kidney disease
- Genistein shows potential to attenuate inflammation and reduce disease severity in autoimmune conditions
- Adalimumab and its biosimilar IBI303 show distinct response clusters in ankylosing spondylitis
- Genetic variant identification improves polygenic risk prediction for patients with asthma
- Dysregulation of tRNA expression, modification, and tsRNAs is linked to tumor proliferation and therapy resistance
- Dendritic cell-based therapies face significant clinical translation barriers due to tumor microenvironment suppression
- Tumor-infiltrating pDCs lose interferon production despite nucleic acid exposure
- Therapeutic advances in IgE-mediated food allergy lack validated risk-stratification tools for individualized care
- Cytokine and endothelial markers show strong associations with severe dengue cases across 47,612 patients
- PEFR-guided therapy shows no difference in symptom control compared to symptom-guided therapy in acute asthma
- BiPAP improves oxygenation over HFNC in pediatric asthma exacerbation, but evidence is limited
- Over one-third of workers with occupational asthma experience adverse occupational outcomes
- GSTO1 inhibition induces apoptosis in AML cells while LMRS model stratifies patient risk
- Topical clobetasol resolves recalcitrant Pagetoid reticulosis in a single case report
- Purified phytochemicals and multicomponent botanical formulas may modulate the pulmonary fibrosis immune microenvironment in IPF
- Cell-mediated immunity and mucosal responses characterize early infection in ruminants with Johne's disease
- Bidirectional associations exist between obstructive lung diseases and inflammatory bowel disease across 30 observational studies
- Next-generation engineered constructs aim to overcome immunosuppressive tumor microenvironments in refractory malignancies
- Targeting metabolic checkpoints and mechanotransduction may address structural deterioration in axial spondyloarthritis
- Refractory mastoiditis may signal granulomatosis with polyangiitis: case highlights need for early ANCA testing
- Routine serum lipid profiles may serve as markers for systemic metabolism in allergic diseases
- Vitamin D supplementation alleviates symptoms of allergic rhinitis, atopic dermatitis, and urticaria
- FDA Approves Adrenalin (epinephrine) for Anaphylaxis and Septic Shock Hypotension
- Systemic Immune-Inflammation Index Shows Diagnostic and Prognostic Value in Thyroid Cancer
- Small PNH clones in SLE linked to thrombotic events and hemolysis in case series
- Nanomedicine delivery systems may enhance immunotherapy efficacy in colorectal cancer
- Point-of-care smell testing serves as an effective screening tool for various neurodegenerative and respiratory conditions
- Residual (meth)acrylate monomers trigger type IV hypersensitivity in dental settings
- Phenotype-weighted and organ-prioritized frameworks should guide treatment for autoinflammatory diseases despite molecular diagnosis limitations
- Metabolic reprogramming of lipid-associated macrophages creates an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
- Ferroptosis contributes to endothelial dysfunction, macrophage foam cell death, and necrotic core expansion in atherosclerosis
- The osteoimmune-brain axis links systemic inflammation and bone hormones to neurodegenerative pathology
- NLRP3 inflammasome modulates immune evasion and chemotherapy sensitivity in gynecological cancers
- Allergic conjunctivitis pathogenesis and endotypes point toward precision therapy
- Training programs to teach behavioral mealtime interventions for children with food refusal and selectivity
- Immune-mediated loss of HCRT neurons drives sleep-wake circuit instability and brain network reconfiguration in narcolepsy
- Necroptosis emerges as pathogenic hub in asthma, linking type 2 inflammation and steroid resistance
- Pola-R-CHP reduces progression risk 35% in double-expressor DLBCL, but OS unchanged
- Biologic-assisted immunotherapy including omalizumab and dupilumab may support oral and sublingual immunotherapy for pediatric food allergies
- Extracellular vesicles show consistent presence and biological activity across diverse neonatal conditions
- Solid organ transplant recipients face higher cancer-related mortality with SMR 2.21 across multiple organs
- Panax ginseng flower phytochemicals demonstrate antioxidant, anti-inflammatory, and cardiovascular protective effects for food ingredients
- Protein lactylation promotes tumor cell malignancy and drives immune evasion in the tumor microenvironment
- Programmed cell death pathways form a spatiotemporally regulated network driving tubular damage in renal IRI
- 101-PGC-005 achieves HR 2.31 for faster WHO scale improvement over dexamethasone in COVID-19
- Anti-PD-1 based chemo-immunotherapy for nasopharyngeal carcinoma yields objective response rates of 20 to 91 percent
- Natural anti-inflammatory products modulate the FOXP3-C5aR1-LIF axis to potentially manage chronic rhinosinusitis
- LDHA promotes malignant progression and drug resistance while modulating tumor-infiltrating immune cell differentiation
- scTCR/BCR-seq enables identification of pathogenic clones and informs treatment response in autoimmune diseases
- Circular RNAs may regulate ferroptosis and anti-tumor immunity in cancer via multiple mechanisms
- Meningeal Immune System Offers New Target for Glioblastoma Immunotherapy
- FDA Approves Exdensur for Add-On Maintenance Treatment of Severe Eosinophilic Asthma
- CD8+ T cells and associated signaling pathways influence osteoclast formation and osteoblast differentiation in osteoporosis
- E3 ubiquitin ligases modulate SARS-CoV-2 replication and immune evasion through targeted protein degradation mechanisms
- Rare overlap of myasthenia gravis and Kennedy's disease identified in case report
- Mechanism-based strategies including CAR-T and bispecific engagers offer options for rituximab-resistant primary membranous nephropathy
- Multitarget designs and microenvironment remodeling may overcome resistance to CAR T-cell therapy in B-cell malignancies
- System-level strategies and task-shifted care improve equity in global allergic disease management
- Dysregulation of the TOX/TCF-1 axis and IDH-mutation driven silencing drive cytotoxic failure in glioblastoma
- Innovative diagnostic techniques improve risk stratification and specificity in food allergy diagnosis
- Mucus-barrier regulatory programs in Crohn's disease and ulcerative colitis involve ER stress and microbial sensing
- Staphylococcal infections may mimic paradoxical psoriasis in patients receiving TNF-alpha inhibitors for systemic conditions
- Casirivimab plus imdevimab reduced risk of hospitalization or death in patients with and without asthma
- Gut eosinophils emerge as central regulators of intestinal homeostasis and immunity
- Maternal free vitamin D linked to offspring asthma risk
- Global allergy research grows 7.59% annually but risk-factor studies dominate, burden data scarce
- NF-κB signaling integrates mechanical stress and immunity in osteoarthritis joint degeneration
- Artificial intelligence as a mechanistic microscope and digital twin in colorectal cancer faces generalizability and regulatory validation limitations
- Endothelial ferroptosis blockade targets ischemic stroke and neurodegenerative conditions in brain microvascular endothelial cells
- CAR technology for autoimmune disorders, infectious diseases, fibrotic lesions, inflammatory bowel disease, and type 1 diabetes is reviewed
- Higher pan-immune-inflammation value linked to worse outcomes after PCI for ACS
- 1 514 781 patients shows methylisothiazolinone allergy prevalence is 5.48% in dermatitis cases
- Tumor occurrence was 25% in patients with anti-mGluR5 autoimmune encephalitis, higher in Western than Chinese patients
- Modulation of neutrophil function and death in critically ill patients with sepsis is discussed in this narrative review
- Immunotherapy and metabolic-targeted drug combination shows promise for osteosarcoma treatment
- Narrative review discusses cerebral small vessel disease without reporting specific interventions or outcomes
- Erratum published for vaccine recommendations report
- Biologic and targeted synthetic DMARDs show reassuring malignancy safety in inflammatory arthritides, but non-melanoma skin cancer risk rises with TNF inhibitors
- Ultrasound-driven mechanical immunomodulation shows promise for tumor therapy but faces key hurdles
- Combination therapy with 3M-052 and anti-TNFR2 antibody suppressed colon cancer growth in mouse models while enhancing immune response
- HLA-DPA1 and HLA-DPB1 expression is downregulated in pediatric asthma with high diagnostic value
- Chemo-immunotherapy yields 12-month disease-free status in rare triple-negative neuroendocrine breast cancer
- scFv-based biologics show potential for immunomodulation in type 1 and type 2 diabetes
- Periodontitis and chronic liver disease linked through proposed oral-gut-liver axis
- Combining immunoglobulins and cytokine levels could predict allergen-specific immunotherapy effectiveness
- Glycolysis-centered understanding of ovarian cancer may support biomarker-guided combination strategies and improve translational therapeutic design
- Multispecies animal models often fail to reflect human nasal sinus anatomy and physiology in chronic rhinosinusitis research
- Extracellular vesicle signalling may participate in postoperative neurocognitive disorder progression in older surgical patients
- Epstein–Barr virus infection shows higher seropositivity and viral loads in systemic lupus erythematosus patients compared to healthy controls
- Follicular T cell subsets and tertiary lymphoid structures may guide immunotherapy in ovarian cancer
- Tertiary lymphoid structures represent a promising but context-dependent biomarker and potential therapeutic intermediate in breast cancer
- Prenatal beta-2-adrenergic agonist exposure linked to increased ASD risk with aOR 1.34 preconception
- PD-1/PD-L1 inhibitors plus chemotherapy improve survival in advanced endometrial cancer
- Botulinum toxin type A improves nasal symptoms in refractory allergic rhinitis with SMD -2.07 at 4 weeks
- Transitioning from static TNM staging to a multidimensional, adaptive treatment model integrating genomics and immunology for HPV-associated OPSCC
- Immune checkpoint inhibitors appear safe in cancer patients with pre-existing sarcoidosis
- New HAE subtypes involving endothelial dysfunction support biomarker discovery and therapeutic strategies to stabilize the vascular barrier
- Antibody-based therapies offer potential efficacy and durability options for relapsed refractory acute myeloid leukemia patients
- Chronic HCV infection drives T cell dysfunction, regulatory T cell accumulation, and metabolic defects that persist after viral clearance
- Kounis syndrome shows male predominance 75 percent and 4 percent mortality in systematic review
- Telemedicine strategies improve asthma control and quality of life in adults
- Tumor Treating Fields may disrupt tumor communication and induce conditional BRCAness in malignant pleural mesothelioma
- Lactate-driven lactylation and acidification reshape tumor immunity in the TME
- High tumor extracellular matrix stiffness in solid tumors drives immune suppression and therapy resistance via YAP1
- Probiotics reduce nasal and eye symptom scores in children with allergic rhinitis
- Boron neutron capture therapy combined with immunotherapy may enhance anti-tumor response and transform the tumor microenvironment
- AI technologies for immunotherapy optimization face data quality and safety concerns hindering routine clinical adoption
- TLS manipulation and immunotherapy in pancreatic cancer face significant mechanistic and regulatory uncertainties
- Immunotherapies beyond rituximab show high response rates in diffuse large B-cell lymphoma
- CD38+ NK cells may link disrupted immune tolerance in rheumatoid arthritis and colorectal cancer
- Stimulus-responsive sonodynamic immunotherapy shows promise in preclinical cancer models
- Prior Exorchis infection blocks S. japonicum in snails: a narrative review
- Narrative review explores HNRNPA2B1 as a possible regulator of RNA fate in cancer
- Narrative review on KMT2C alterations in gastrointestinal cancers and therapeutic implications
- Narrative review on machine learning for immunogenicity risk assessment in preclinical research
- Review of T cell engagers highlights potential for treating solid tumors and small cell lung cancer cases
- Systematic review links viral infections to persistent and chronic urticaria in children and adults
- Narrative review discusses inflammaging and immunosenescence in older adults with colorectal cancer
- Systematic review finds vitamin D supplementation offers no lung function benefit for children with asthma
- Systematic Review of Macrophage Polarization in Osteosarcoma Immunotherapy
- Case report and review on autoimmune nodopathy with Sjogren's disease and nephrotic syndrome
- Observational study links ADAM9 expression to survival in lung adenocarcinoma patients
- Narrative review of extracellular vesicles for atopic dermatitis notes significant methodological gaps and safety data limitations
- Review: Targeting mRNA Processing Enhances Immune Checkpoint Blockade in Cancer
- Narrative review proposes time window framework for post-infarction ventricular remodeling intervention
- Meta-analysis finds ADHD linked to asthma but no causal effect in children
- Speleotherapy improves asthma control and breathing patterns in patients with respiratory conditions
- Meta-analysis of micronutrient supplementation for immune function in older adults
- FDA Approves Children's Claritin (loratadine) for Allergic Rhinitis Symptoms
- FDA Approves Xyzal Allergy 24hr (levocetirizine) for Hay Fever and Respiratory Allergy Symptoms
- Review of platelet extravasation without reported outcomes or safety data
- Review of lifestyle factors linked to Type 2 Diabetes risk in Qatar
- COPD guideline proposes cellular phenotype classification for targeted therapy
- Review of alpha-gal syndrome highlights tick bite link and knowledge gaps
- Narrative review discusses colorectal cancer metastasis patterns with immune checkpoint inhibitors and targeted therapies
- Narrative review examines metabolic syndrome and novel agents in kidney transplant recipients
- Molecular review explores Siglec signaling pathways in cancer and inflammatory disorders
- Systematic review and meta-analysis of resveratrol for spinal cord injury in animal models