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Allergy & Immunology

782 published articles · Updated continuously

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
High ctDNA levels linked to poorer PFS and OS in hematologic malignancies on ICIs or CAR-T
Allergy & Immunology Meta-analysis
High ctDNA levels linked to poorer PFS and OS in hematologic malignancies on ICIs or CAR-T Blood cancer tests may help predict how well treatments work
This meta-analysis of 484 patients with hematologic malignancies receiving immune checkpoint inhibitors or CAR-T therapy found that high pre…
High levels of tumor DNA in the blood may signal a harder path for patients undergoing specific cancer therapies.
Tumor microenvironment factors drive fate hijacking of dendritic cells into immunosuppressive states
Allergy & Immunology Sys. Review
Tumor microenvironment factors drive fate hijacking of dendritic cells into immunosuppressive states Tumor Environment Hijacks Immune Cells to Help Cancer Grow
This systematic review of 129 publications examines how the tumor microenvironment (TME) influences dendritic cell (DC) fate. The authors co…
Cancer cells can trick immune cells into becoming helpers instead of defenders, creating a major hurdle for current cancer treatments.
Asthma, allergy, and low parental education linked to recurrent respiratory infections in preschoolers
Allergy & Immunology Meta-analysis
Asthma, allergy, and low parental education linked to recurrent respiratory infections in preschoolers Risk factors for frequent respiratory infections in preschool children
This meta-analysis of 15,271 preschool children estimates the prevalence of recurrent respiratory tract infections (RRTIs) at 24.14% and ide…
New data identifies how asthma, allergies, and environmental factors like smoking increase the risk of repeat respiratory infections in youn…
Neoadjuvant chemoimmunotherapy requires multidisciplinary interpretation of ctDNA and imaging to manage biomarker discordance
Allergy & Immunology Sys. Review
Neoadjuvant chemoimmunotherapy requires multidisciplinary interpretation of ctDNA and imaging to manage biomarker discordance New Findings Help Interpret Complex Lung Cancer Treatment Results
This narrative review examines the interpretation of biomarker discordance in patients with resectable non-small cell lung cancer undergoing…
Doctors are finding better ways to interpret complex data when patients with lung cancer undergo neoadjuvant chemoimmunotherapy.
TIM4 restoration enhances hepatocyte clearance and limits stellate cell activation in MASH models
Allergy & Immunology Sys. Review
TIM4 restoration enhances hepatocyte clearance and limits stellate cell activation in MASH models Specific liver cell signals may influence MASH disease progression
This mini review synthesizes preclinical data on TIM4, TREM2, and MerTK signaling in experimental MASH models. The review suggests TIM4 rest…
New research identifies how specific cell receptors influence liver inflammation and scarring in models of a common fatty liver disease.
Non-coding RNAs modulate macrophage polarization and immune microenvironment in breast cancer progression
Allergy & Immunology Sys. Review
Non-coding RNAs modulate macrophage polarization and immune microenvironment in breast cancer progression Non-coding RNAs May Help Reprogram Immune Cells in Breast Cancer
This systematic review of 63 studies examines how non-coding RNAs (ncRNAs) influence tumor-associated macrophages (TAMs) and immune suppress…
New research explores how specific non-coding RNAs can reprogram immune cells to potentially improve treatments for breast cancer patients.
PD-1/PD-L1 inhibitor-based regimens improve ORR and PFS compared to sunitinib in sarcomatoid renal cell carcinoma
Allergy & Immunology Meta-analysis
PD-1/PD-L1 inhibitor-based regimens improve ORR and PFS compared to sunitinib in sarcomatoid renal cell carcinoma PD-1 and PD-L1 Inhibitors Show Better Results for Certain Kidney Cancer
This meta-analysis of 618 randomized and 150 nonrandomized patients found that PD-1/PD-L1 inhibitor-based regimens significantly improved ob…
New analysis shows that PD-1 and PD-L1 inhibitor treatments may improve response rates and survival for patients with specific types of kidn…
Dupilumab treatment for CRSwNP results in a 7.9% pooled proportion of post-treatment hypereosinophilia
Allergy & Immunology Meta-analysis
Dupilumab treatment for CRSwNP results in a 7.9% pooled proportion of post-treatment hypereosinophilia Dupilumab treatment for nasal polyps can cause high eosinophil counts
This meta-analysis of 1,047 patients with CRSwNP found a pooled hypereosinophilia (HE) proportion of 7.9% following dupilumab treatment. Whi…
Patients with nasal polyps taking dupilumab may experience a rise in eosinophils, a type of white blood cell, during the first few months of…
JAK/IL-6 blockade may control TIF1γ-positive dermatomyositis with macrophage activation syndrome
Allergy & Immunology Sys. Review
JAK/IL-6 blockade may control TIF1γ-positive dermatomyositis with macrophage activation syndrome JAK and IL-6 inhibitors help manage severe dermatomyositis complications
This case-based review describes a single young man with TIF1γ-positive dermatomyositis who developed macrophage activation syndrome and ach…
A new case report shows how specific medications can control a dangerous immune response in a young man with a rare muscle disease.
Dupilumab 300 mg every 2 weeks sustains FEV improvements and low exacerbation rates
Allergy & Immunology Phase III
Dupilumab 300 mg every 2 weeks sustains FEV improvements and low exacerbation rates Trial Shows Dupilumab Maintains Asthma Control for Long Periods
This open-label extension study of 596 patients with moderate-to-severe asthma in Latin America found that dupilumab 300 mg every 2 weeks ma…
A long-term study shows that the medication dupilumab helps maintain lung function and lower flare-ups for people with moderate to severe as…
Thrombolytic therapy combined with RAAS inhibitors increases angioedema risk with an OR of 3.12
Allergy & Immunology Meta-analysis
Thrombolytic therapy combined with RAAS inhibitors increases angioedema risk with an OR of 3.12 Managing Risks of Swelling When Combining Blood Thinners and Blood Pressure Meds
This meta-analysis evaluates the risk of angioedema in patients receiving thrombolytic therapy with or without RAAS inhibitors. The analysis…
Doctors are looking at how certain blood pressure drugs can increase the risk of severe swelling when used with clot-busting treatments.
EMA-approved biologics and JAK inhibitors show meaningful short-term EASI-75 responses in moderate-to-severe atopic dermatitis
Allergy & Immunology Meta-analysis
EMA-approved biologics and JAK inhibitors show meaningful short-term EASI-75 responses in moderate-to-severe atopic dermatitis Newer Eczema Drugs Clear Skin for Many, But Comparisons Are Tricky
This systematic review narratively synthesized randomized trials of EMA-approved systemic therapies for moderate-to-severe atopic dermatitis…
Seven eczema drugs helped 18% to 73% of adults reach clearer skin in 12 to 16 weeks. But trials varied too much to say which works best.

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