Text reminders and letters increased FIT completion in overdue colorectal cancer screening patients
Text reminders and letters boost colorectal cancer screening completion in primary care
This randomized trial evaluated screening completion in primary care patients aged 50 to 74 years who were overdue for colorectal cancer scr…
Text messages and reminder letters significantly increased colorectal cancer screening completion, while a branded box did not improve rates…
TaTME shows lower conversion rates with similar short-term safety compared to LapTME for low rectal cancer.
New surgical approach for rectal cancer cuts conversion rate
This randomized trial compared transanal total mesorectal excision with laparoscopic total mesorectal excision for patients with low rectal …
A new surgical technique for rectal cancer reduces the need to switch to open surgery, with similar complication rates.
Meta-analysis of placebo responses in metabolic dysfunction-associated steatohepatitis trials reveals modest natural resolution rates and low progression risk.
New meta-analysis shows how many patients improve on placebo for MASH
This systematic review and meta-analysis examined placebo outcomes in patients with metabolic dysfunction-associated steatohepatitis. The au…
This analysis of 6,880 patients reveals natural improvement rates in metabolic dysfunction-associated steatohepatitis when no active drug is…
Avelumab plus cetuximab versus cetuximab alone in metastatic colorectal cancer patients
Adding avelumab to cetuximab helps only a specific subgroup of colorectal cancer patients
This randomized phase II trial evaluated adding avelumab to cetuximab in RAS/BRAF wild-type metastatic colorectal cancer patients. The combi…
A new trial shows adding avelumab to cetuximab improves survival only for patients without certain genetic changes, not for everyone.
Systematic review and meta-analysis assesses SWDS diagnostic accuracy for MASLD liver inflammation grading
Shear-wave dispersion slope helps doctors grade liver inflammation in metabolic disease
This systematic review and diagnostic test accuracy meta-analysis evaluates the Shear-wave dispersion slope (SWDS) for detecting and grading…
A new analysis shows a noninvasive test can accurately detect and grade liver inflammation in patients with metabolic dysfunction-associated…
Educational programs improve self-care values in ostomized colorectal cancer patients
Educational programs boost self-care values in ostomized colorectal cancer patients
This systematic review analyzed educational intervention programs for ostomized colorectal cancer patients. Results showed significant diffe…
A meta-analysis of 1,011 patients found educational programs significantly improve self-care values compared to no intervention.
Zibotentan plus dapagliflozin shows no HVPG reduction in compensated cirrhosis
Early trial shows zibotentan plus dapagliflozin trended toward lowering blood pressure in cirrhosis patients
This Phase II randomized placebo-controlled exploratory study in 28 patients with compensated cirrhosis found that zibotentan 2.5 mg plus da…
An early study found that a combination drug lowered blood pressure in patients with compensated cirrhosis, though it did not conclusively i…
Meta-analysis finds R1 vascular margin acceptable for HCC but not CLM in minimally invasive liver surgery
Tumor margin choice matters differently for liver cancer types
This meta-analysis of 839 patients undergoing minimally invasive liver surgery found that R1 vascular margin (R1v) hepatectomy yields local …
For liver cancer, leaving a narrow margin is safe. For colorectal metastases, it raises recurrence risk.
Systematic review and meta-analysis of biopsy-guided versus clinically guided withdrawal in autoimmune hepatitis
Biopsy-guided withdrawal shows no benefit over clinical guidance for autoimmune hepatitis
This systematic review and meta-analysis evaluated relapse rates after treatment withdrawal in patients with autoimmune hepatitis. The poole…
A meta-analysis of 518 patients found that biopsy-guided withdrawal did not lower relapse rates compared to clinically guided withdrawal in …
Chiglitazar reduces liver fat in MASLD patients with hypertriglyceridemia and insulin resistance
Two doses of chiglitazar cut liver fat far more than a placebo in 18 weeks
In a phase II randomized, double-blind, placebo-controlled trial, 104 patients with MASLD, hypertriglyceridemia, and insulin resistance rece…
Patients with fatty liver disease and high triglycerides saw liver fat drop significantly with chiglitazar compared to placebo after 18 week…
AI-Assisted Colonoscopy Improves Right-Sided Adenoma Detection in Gastroenterology Fellows
AI helps trainee doctors find more polyps in colonoscopies
This pragmatic randomized controlled trial assigned 16 gastroenterology fellows to AI-enhanced or conventional colonoscopy for 1045 procedur…
AI-assisted colonoscopy helped gastroenterology fellows detect more polyps on the right side of the colon, a hard-to-see area.
Preoperative symbiotic supplementation alters gut microbiota in colorectal cancer patients
Small trial shows symbiotic changes gut bacteria in colorectal cancer patients
This randomized clinical trial in 46 adults undergoing colorectal cancer surgery found that preoperative symbiotic supplementation increased…
A small Brazilian trial found that taking a symbiotic before surgery changed gut bacteria and fatty acid levels in colorectal cancer patient…