Gastroenterology

All Gastroenterology Articles

• Gut microbiota and nutrition proposed as integrated targets in colorectal cancer cardio-oncology
• Targeted and biological therapies offer potential to reduce disease activity and organ damage in SLE
• MASLD in people living with HIV may represent a distinct immunometabolic condition with rising prevalence
• Global HBsAg prevalence 3.2% in nurses, with 5.6% in Africa and 3.6% in LMICs
• Transcriptomic analysis identifies 846 genes and key pathways associated with MASLD fibrosis progression
• Mycobacterium avium subsp. paratuberculosis may contribute to Crohn's disease through complex pathogenic mechanisms
• Elevated preoperative SIRI correlates with worse survival and progression in patients with bladder cancer
• Mesenchymal stem cells alleviate liver injury and inflammation in preclinical alcoholic hepatitis models
• Robotic liver resection reduces intraoperative blood loss and conversion rates compared to laparoscopic resection
• Natural products like Aloe vera and guar gum show significant improvements in diarrhea management
• Bioactive components of medicinal-food homology substances show marked efficacy in treating functional constipation
• Microbiota-directed interventions reduce hospital stay and infection risk in acute pancreatitis patients
• Seaweed sulfated polysaccharides modulate gut microbiota and mucosal barrier in inflammatory bowel disease
• TZ84-based hepatitis A vaccine shows higher seroconversion rates and GMCs than HM175-based vaccine
• Gut microbiota influence innate immune signaling and promote colibactin-associated mutational signatures in colorectal cancer
• Microbial exopolysaccharides improve intestinal health and gut microbiome modulation in 28 in vivo studies
• Epigenetic mechanisms provide a molecular interface between genetic susceptibility and immune dysregulation in asthma
• Dietary macronutrients influence intestinal barrier integrity and immune responses in inflammatory bowel disease
• Extracellular vesicle-based therapies show potential for tissue repair and barrier restoration in inflammatory bowel disease
• Impact of RAS and BRAF Mutation Status on Immune Checkpoint Inhibitor Efficacy
• Cocaine use is associated with higher mortality and surgical rates in ischemic colitis cases
• Aerosolized liposomal amphotericin B provides strongest evidence for invasive pulmonary aspergillosis prophylaxis in high-risk patients
• Antenatal or intrapartum N-acetylcysteine may reduce severe neonatal morbidity and bronchopulmonary dysplasia rates
• Impact of Mechanical Bowel Preparation and Oral Antibiotics on Rectal Surgery Outcomes
• Evaluating High-Dose Vitamin D3 Supplementation in Metastatic Colorectal Cancer Treatment Regimens
• Huangqi Guizhi Wuwu Decoction reduces grade 2 or higher OIPN from 38.6% to 21.3%
• Phase 2 Trial Evaluating Zalfermin and Semaglutide Combinations for Metabolic Dysfunction Associated Steatohepatitis
• Doublet-LC TNT improves 3-year DFS to 74.8% compared to 66.0% in high-risk rectal cancer
• rs2896019 G allele associated with 51% increased risk of MASLD susceptibility
• Clinical trials for MASLD show limited racial and ethnic diversity despite increasing Hispanic enrollment
• EUS-guided cyanoacrylate injection reduces rebleering rates compared to direct endoscopic cyanoacrylate for gastric varices
• Multidrug-resistant pathogens are prevalent in cirrhosis with higher rates in lower-middle-income countries
• Impact of Visceral Obesity on Surgical Outcomes in Colorectal Cancer Resection
• Multimodal preoperative prehabilitation improves 6-minute walk distance in patients with colorectal cancer
• Major HCV genotypes G1, G2, and G3 account for 98.02% of infections in FSU regions
• Efficacy of High-Intensity Interval Training and Moderate-Intensity Continuous Training in MASLD
• Local therapies for liver, lung, and locoregional recurrence improve survival in pancreatic ductal adenocarcinoma
• 19 G needles provide superior tissue adequacy and histological diagnosis compared to 22 G needles
• PET/CT Matches MRI Sensitivity but Boosts Specificity in Rectal Cancer
• HBsAg prevalence 9.98% in Cameroon, higher-risk groups 12.70%
• Telmisartan leads to modest fasting blood sugar reduction in patients with MASLD
• Prevotella exhibits dual pro-tumorigenic and anti-tumorigenic roles in gastrointestinal cancer progression
• Immune markers correlate with clinical outcomes following nucleos(t)ide analogue withdrawal in chronic hepatitis B
• Precision glucocorticoid dosing remains investigational; genetic markers not yet clinically actionable
• Skin lesions typically precede spinal arthritis in patients with follicular occlusion triad and spondyloarthritis
• Gut-brain axis dysregulation links Crohn's disease activity with heterogeneous mood improvements from emerging therapies
• Infliximab treatment in pediatric IBD is associated with specific microbial shifts rather than uniform diversity recovery
• Pediatric GERD and proton pump inhibitor exposure are associated with reduced microbial diversity
• Traditional Chinese Medicine potentially influences gastrointestinal motility and gut microbiota in Irritable Bowel Syndrome
• Immune checkpoint inhibitors in rectal cancer: balancing anti-tumor effects against ICI-associated colorectal injury
• Gut microbiota alpha diversity increases during the first year of life in infants and toddlers
• FABP2 serves as a sensitive biomarker of intestinal mucosal injury in inflammatory bowel disease
• FDA Approves Iqirvo (elafibranor) for Primary Biliary Cholangitis
• ALPPS yields fastest liver growth but worse 1-year DFS than PVE in meta-analysis
• Dietary quality and precision nutrition may mitigate the vegetarian hepatoprotection paradox in MASLD patients
• MRI-based radiomics models predict tumor budding grade in rectal cancer with 0.88 AUC
• Durvalumab plus tremelimumab median PFS was 5.4 months in HIMALAYA eligible patients
• PCE with indigo carmine increases adenoma detection rate to 51.5% compared to 34.5% for WLE
• CADe improves adenoma detection rate from 44% to 63% in standard-detector endoscopists
• Thromboembolic events cost 2.5-fold more per event than bleeding after high-risk endoscopy
• Itopride 150 mg once daily matches 50 mg thrice daily in functional dyspepsia
• Higher tolerance of ambiguity correlates with higher perceived benefit in colorectal cancer screening
• FIT positivity and neoplasia detection rates peak in the first round of screening programs
• Terminal ileal intubation provides a 0.28% diagnostic yield for clinically significant pathology in asymptomatic patients
• Pelvic peritoneum closure reduces risk of severe postoperative complications in rectal cancer patients
• Carvedilol and endoscopic variceal ligation show similar efficacy for preventing variceal bleeding in cirrhosis
• Steatotic liver disease prevalence reaches 57.75% in patients with primary hypobetalipoproteinemia
• Semaglutide improves MASH resolution (OR 3.48) and liver fat reduction in MASLD patients
• Statin therapy reduces hepatocellular carcinoma risk and hepatic decompensation by 46% in chronic liver disease
• Multidisciplinary team management reduces mortality risk in patients with hepatobiliary and pancreatic malignancies
• Transanal transection and single-stapled anastomosis reduces anastomotic leakage risk in rectal cancer surgery
• Elevated IGF-I levels correlate with increased risk of colorectal adenoma and colorectal cancer
• Intermittent fasting reduces liver fat content and CAP scores in patients with MASLD
• Multidrug-resistant bacterial infections are prevalent among hospitalized patients with cirrhosis
• Viscoelastic Testing Cuts Transfusions in Cirrhosis Procedures
• Heterozygous SERPINA1 genotypes are associated with increased liver disease risks in Alpha-1 Antitrypsin Deficiency
• Organ transplantation impacts oral microbiome composition and bacteria associated with periodontal inflammation
• Bismuth quadruple and concomitant regimens achieve >85% H. pylori eradication amid rising clarithromycin resistance
• FDA Approves Rezdiffra (resmetirom) for Noncirrhotic NASH with Moderate to Advanced Fibrosis
• Acidic microenvironments reprogram immune cells via pH sensors, driving tissue injury
• Subcutaneous semaglutide more than doubles the likelihood of NASH resolution without fibrosis progression
• New guideline tool curates 51 instruments for theory-driven implementation science assessment
• Intensive CV management reduces cIMT progression in RA patients without hepatic steatosis
• Robotic hepatectomy is safe and offers lower blood loss and shorter hospital stays than open surgery
• Probiotics modestly reduce pain intensity and weekly episodes in children with abdominal pain disorders
• Tissue-resident memory T cells drive disease relapse after biologic and JAK inhibitor discontinuation in atopic dermatitis
• CD4+ T cells and Tim-3 regulate immune responses and cytokine-mediated injury in severe pediatric pneumonia
• MAGIC algorithm and multi-omics approaches facilitate precision management of gastrointestinal acute graft-versus-host disease
• Tryptophan metabolism pathways like IDO and TDO2 influence immune cell function in end-stage liver disease
• Training programs improve healthcare professional confidence and competence in video and text based consultations
• Trained immunity drives mucosal inflammation and recurrence in patients with chronic rhinosinusitis
• Physical exercise may attenuate inflammation and alveolar bone loss in patients with periodontitis
• Google NotebookLM achieves 99.77% critical accuracy and 89.3% workflow time reduction in systematic review data extraction
• Linaclotide combined with polyethylene glycol significantly improves bowel preparation quality in patients with constipation
• Robustly generalizable gut microbiome signatures are identified in patients with colorectal cancer regardless of age
• Antibiotic exposure is associated with an 18.7% higher risk of gastrointestinal cancers
• Gut microbiome biomarkers show AUROC of 0.89 for differentiating colorectal cancer from controls
• Prevention interventions may reduce e-cigarette ever use while cessation-focused efforts likely reduce current adolescent usage
• Microbiota-immune-enteric nervous system interactions provide a framework for understanding functional and slow-transit constipation
• Upadacitinib 15 mg daily improves pruritus and skin sclerosis in a case of refractory lichen sclerosus
• Splenic stiffness measurement shows high sensitivity for varices in children with non-cirrhotic portal hypertension
• Twenty-two factors across five ecological levels are significantly associated with fear of cancer recurrence
• MELD and MELD-Na demonstrate higher specificity than Maddrey discriminant function for alcoholic hepatitis mortality
• Persistent descending mesocolon increases operative time and conversion rates in colorectal cancer surgery
• Endoscopic investigation for iron deficiency anemia reveals 52.0% prevalence of normal upper gastrointestinal findings
• Metabolic and bariatric surgery achieves 70% steatohepatitis remission in patients with MAFLD
• Hepatic vein occlusion with portal vein embolization yields 24.5% greater future liver remnant increase
• JAK inhibitors are associated with higher hepatitis B virus reactivation rates than IL-12/23 or IL-17 inhibitors
• Immune crosstalk between innate and adaptive compartments drives inflammatory mechanisms in MASLD and MASH progression
• Schroth combined with sensory integration training shows greatest Cobb angle reduction in adolescent idiopathic scoliosis
• Plant-derived exosome-like nanoparticles mitigate weight loss and improve colon length in ulcerative colitis models
• The bile acid-gut microbiota-vitamin D axis may influence pathogenesis of biliary atresia
• Axial psoriatic arthritis is associated with significantly lower HLA-B27 positivity than axial spondyloarthritis
• Oral diseases stem from disrupted host-microbiome-immune balance, narrative review argues
• Anthraquinone laxatives may produce active metabolites via gut microbiota conversion leading to melanosis coli
• Long COVID causes consistent long-term deterioration in physical functioning, vitality, fatigue, and respiratory distress
• Astragalus membranaceus derivatives restore immune tolerance and homeostasis in digestive system diseases
• Laparoscopic partial hepatectomy provides definitive diagnosis and treatment for large atypical hepatic lesions in adolescents
• Lower liver-expressed TRIB1AL levels are associated with reduced liver fat and cardiovascular risk
• Infliximab may offer clinical improvement and wound reduction in non-Crohn's disease related fistulas
• Acupuncture modulates the microbiota-gut-brain axis to remodel microbial structure in patients with irritable bowel syndrome
• Reduced Shannon index indicates lower alpha-diversity in the gut microbiota of patients with primary biliary cholangitis
• Probiotic supplementation may improve salivary buffering and reduce cariogenic bacteria
• Balloon-assisted ESD shows comparable outcomes to conventional ESD for colorectal polyps
• Sympathovagal imbalance correlates with IBS symptom severity and shows subtype specificity
• Narrative review offers a theoretical framework for personalized management of acute upper gastrointestinal bleeding in patients
• Adding linaclotide to PEG did not improve bowel prep quality in high-risk colonoscopy patients undergoing screening procedures
• CYP7A1 and SLC39A9 variants linked to bile acid levels and cholestasis in Chinese women
• Gut-liver axis models evolve from static co-cultures to microfluidic systems, review finds
• Macrophage targeting offers new theoretical approaches for treating gastrointestinal motility disorders and constipation
• Dynamic LSM changes predict liver events in advanced chronic liver disease
• Gut microbiota alterations linked to anxiety and depression in inflammatory bowel disease patients
• Large meta-analysis identifies 30 new genetic loci for ankylosing spondylitis risk
• Oxaliplatin addition to rectal cancer chemoradiation improves tumor regression
• PFIC null genotype linked to 2.79-fold higher odds of liver transplantation
• Hepatologist-led palliative care matches specialist care for cirrhosis and cancer patients
• Fecal DNA testing improved colorectal cancer screening rates compared to immunochemical testing in primary care
• 1 in 6 dromedary camels in Africa carries Rift Valley Fever antibodies
• General obesity, central obesity, and high triglycerides increase risk of precancerous polyps in colorectal cancer surveillance
• Combining Pentraxin-3 and AFP increases sensitivity to 0.92 for hepatocellular carcinoma diagnosis in chronic liver disease
• Endovascular interventions reduce rebleeding risk versus endoscopic cyanoacrylate injection in gastric variceal hemorrhage
• Antimicrobial resistance reaches 33.3% in cirrhosis patients with bacterial infections across global settings
• Prophylactic clipping after colorectal ESD reduces delayed bleeding risk by 74%
• FIPS AUC 0.821 outperforms MELD scores for 90-day mortality prediction in TIPS for ascites
• Blood-based ctDNA tests show low sensitivity for advanced colorectal neoplasia in asymptomatic adults
• Chemoimmunotherapy improves survival in solid tumors regardless of liver metastasis status
• Persistent ymrEMVI and ymrTD on post-neoadjuvant MRI predict inferior disease-free and overall survival in rectal cancer patients
• Higher TyG Index Linked to 4.36-Fold Increased Odds of NAFLD in Large Meta-Analysis
• Microbiome and metabolite markers may enhance colorectal cancer detection and therapeutic guidance strategies
• GLP-1 receptor agonists show potential benefits for metabolic dysfunction-associated steatotic liver disease with acceptable safety
• IL-1β inhibition may alleviate aortic aneurysm immunopathology, review suggests
• Narrative review links gut microbial metabolites to colorectal cancer mechanisms
• FDA Approves Linzess (linaclotide) for IBS-C, CIC, and Pediatric Functional Constipation
• Narrative review links hidradenitis suppurativa to metabolic dysfunction and systemic inflammation
• Bayesian network meta-analysis of drugs for pediatric NAFLD steatosis improvement
• FDA Approves Cholbam (cholic acid) for Bile Acid Synthesis Disorders and Peroxisomal Disorders
• Narrative review explores microbiome-targeting therapies for inflammatory bowel disease patients
• Ursodeoxycholic acid reduces ALT and fibrosis in chronic liver disease patients
• Review of chemopreventive strategies for familial adenomatous polyposis including NSAIDs and other agents
• Review of dietary patterns and probiotics in swine production provides theoretical basis for microbiome interventions
• Pediatric Gut Microbiome Links to Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes
• Systematic review shows high fatigue and pruritus prevalence in primary biliary cholangitis patients
• Meta-analysis shows curcumin reduces weight but lacks impact on BMI or waist circumference in metabolic fatty liver disease patients
• Systematic Review Explores Ubiquitination in Bacterial Infection and Immune Response
• Review of sphincter-preserving techniques for ultra-low rectal cancer
• Network meta-analysis of phase 2-3 therapies for non-cirrhotic metabolic dysfunction-associated steatohepatitis
• Narrative review explores plant-derived extracellular vesicles for rheumatoid arthritis
• Chinese Version of IBS-SSS Validated for Outcome Assessment in IBS Patients
• Critical review links ADMA levels to endothelial impairment in pregnant women with HIV and preeclampsia in sub-Saharan Africa
• Integrative review links chronic heavy metal exposure to intestinal infection susceptibility in Yunnan
• Meta-analysis of perioperative probiotics shows non-significant reduction in postoperative infections for GI surgery patients
• Systematic review and meta-analysis shows worse liver transplant survival for Black patients compared to White patients
• Review of gut microbiota and colorectal cancer highlights unresolved causality and clinical translation challenges
• Systematic review links gut microbial metabolites to colitis-associated colorectal cancer risk
• High CALLY index predicts improved survival outcomes in colorectal cancer patients compared to low scores
• Metabolic dysfunction-associated steatotic liver disease patients with advanced fibrosis face high hepatocellular carcinoma risk over ten years
• Endoscopic submucosal dissection outperforms precut mucosal resection for colorectal polyp removal
• Surgical resection shows superior survival outcomes compared to radiofrequency ablation for small hepatocellular carcinoma cases
• Bismuth quadruple therapy shows higher H. pylori eradication in pediatric patients with clarithromycin resistance
• Early magnesium sulphate catharsis reduces severe acute pancreatitis and mortality in high-risk patients
• Sequential SBRT, pembrolizumab, and resection in oligometastatic colorectal cancer shows 60% 1-year RFS
• Narrative review discusses NF-kB inhibition for inflammatory bowel diseases and related conditions
• Narrative review explores ferroptosis-immune crosstalk in CNS diseases as therapeutic target
• Single 6 mg erdafitinib dose shows similar pharmacokinetics in mild or moderate hepatic impairment versus healthy controls
• Five ACLF diagnostic models and prognostic scores identified markedly different proportions of patients at risk of 28-day mortality in a cohort study
• SABR shows worse survival in ultracentral pulmonary oligometastases compared to nonultracentral tumors
• SABR in oligometastatic cancer showed median overall survival of 64.6 months in a single-arm phase 2 study
• Tislelizumab plus chemotherapy and radiotherapy yields 89.1% 3-year disease-free survival in pMMR/MSS locally advanced rectal cancer
• Patient Buddy App reduced avoidable readmissions in cirrhosis inpatients compared to standard of care
• Chiglitazar reduces liver fat in MASLD patients with hypertriglyceridemia and insulin resistance
• Text reminders and letters increased FIT completion in overdue colorectal cancer screening patients
• AI-Assisted Colonoscopy Improves Right-Sided Adenoma Detection in Gastroenterology Fellows
• Zibotentan plus dapagliflozin shows no HVPG reduction in compensated cirrhosis
• Avelumab plus cetuximab versus cetuximab alone in metastatic colorectal cancer patients
• Preoperative symbiotic supplementation alters gut microbiota in colorectal cancer patients
• HEV 239 vaccine induces durable humoral and cellular immunity in Bangladeshi women
• TaTME shows lower conversion rates with similar short-term safety compared to LapTME for low rectal cancer
• Systematic review and meta-analysis evaluates ML and DL models for diagnosing MASH and fibrosis
• Meta-analysis of placebo responses in metabolic dysfunction-associated steatohepatitis trials reveals modest natural resolution rates and low progression risk
• Meta-analysis finds Virtual Scale Endoscopy improves colorectal polyp measurement accuracy