This week's Diabetes & Endocrinology digest · 2026-W24
This Week in Diabetes & Endocrinology: Liver Risks, Limb Events, Kidney Decline
Efficacy and Safety Profile of Subcutaneous Semaglutide for Weight Management in Adults
Semaglutide helps people with obesity lose significant body weight
Semaglutide demonstrates significant weight reduction in patients with obesity, though clinicians must manage increased gastrointestinal sid…
A new review shows semaglutide leads to significant weight loss for adults with obesity, though it can cause common stomach issues.
Diabetic retinopathy is associated with a significantly higher risk of all-cause dementia
Diabetic retinopathy is linked to a higher risk of dementia
This meta-analysis of observational studies involving 2,887,409 patients found that diabetic retinopathy is associated with an increased ris…
A large analysis shows people with diabetic retinopathy may face an increased risk of developing dementia, highlighting the need for closer …
High-intensity interval training associated with -0.73% HbA1c reduction in adults with type 2 diabetes
Exercise Helps Lower Blood Sugar in Type 2 Diabetes
This meta-analysis of 5022 adults with type 2 diabetes and overweight or obesity found that high-intensity interval training (HIIT) and comb…
A review of 5,022 adults with type 2 diabetes found that exercise, especially high-intensity interval training, helps lower blood sugar leve…
External oblique intercostal block provides greatest opioid-sparing effect for laparoscopic sleeve gastrectomy patients
Specific nerve blocks may reduce opioid use after weight loss surgery
This network meta-analysis of 2,005 adults undergoing laparoscopic sleeve gastrectomy found that the external oblique intercostal (EOI) bloc…
New research suggests specific regional nerve blocks can significantly lower morphine needs and nausea for patients undergoing stomach sleev…
Evaluating Enoxaparin Dosing Strategies for Venous Thromboembolism Prophylaxis in Bariatric Surgery Patients
Higher enoxaparin doses do not change outcomes for bariatric surgery
A meta-analysis of 1,276 patients indicates that while 60 mg enoxaparin achieves higher anti-factor Xa levels, clinical outcomes remain simi…
A review of 1,276 patients shows that higher doses of the blood thinner enoxaparin do not improve safety or results for those undergoing wei…
High Intensity Interval Training Improves Cardiometabolic Risk Factors in Pediatric Overweight Populations
High intensity interval training improves heart health in children
Meta-analysis reveals high-intensity interval training significantly improves BMI, blood pressure, and lipid profiles in children with obesi…
High intensity interval training can improve weight, blood pressure, and cholesterol levels for children and teens with overweight or obesit…
Orlistat and semaglutide may improve ovulation and pregnancy rates in women with overweight or obesity
Weight loss medications may help women with obesity achieve pregnancy
This meta-analysis of 7 clinical trials involving 575 women found that orlistat increased ovulation and pregnancy rates compared to lifestyl…
New data suggests that certain weight-lowering drugs like orlistat and semaglutide could improve ovulation and pregnancy rates for women wit…
GLP-1 RA exposure in early pregnancy not significantly tied to hypertensive disorders
GLP-1 Medications Show No Link to Pregnancy Hypertension Risk
This meta-analysis of observational cohort studies assessed the risk of hypertensive disorders of pregnancy (HDP) after periconceptional or …
A large review of over 10,000 pregnancies suggests that GLP-1 medications may not increase the risk of high blood pressure during pregnancy.
Postpartum dietary interventions improve BMI, waist circumference, weight, HOMA-IR, and HbA1c in women with GDM
Postpartum diets improve heart health for women with gestational diabetes
This meta-analysis of 19 randomized controlled trials found that postpartum dietary interventions significantly improved several cardiometab…
New research shows that specific dietary changes after pregnancy can improve weight and blood sugar levels for women who had gestational dia…
Culturally tailored self-management interventions significantly decrease HbA1c levels in people with type 2 diabetes
Culturally tailored programs help people with type 2 diabetes
This systematic review and meta-analysis of 7 studies found that culturally tailored self-management interventions lead to a significant red…
Tailoring diabetes management to a person's specific culture can lower blood sugar levels and improve daily habits like diet and exercise.
Face-to-face DSME produces approximately 1.3% HbA1c reduction at 30 weeks in type 2 diabetes
Face-to-face education helps manage blood sugar in type 2 diabetes
This dose-response meta-analysis of 103 studies evaluated face-to-face Diabetes Self-Management Education (DSME) for adults with type 2 diab…
In person education can quickly lower blood sugar for people with type 2 diabetes, though these gains may fade after several months.
Mitochondrial metabolic reprogramming and epigenetic modifications drive bidirectional regulation in renal tubular epithelial cells
Mitochondrial Changes and Epigenetics Linked to Diabetic Kidney Disease
This narrative review examines the interplay between mitochondrial metabolism and epigenetic modifications in renal tubular epithelial cells…
New research highlights a two-way link between cell energy production and gene regulation in patients with diabetic kidney disease.
All Diabetes & Endocrinology Articles
- Postpartum dietary interventions improve BMI, waist circumference, weight, HOMA-IR, and HbA1c in women with GDM
- Diabetic retinopathy is associated with a significantly higher risk of all-cause dementia
- Face-to-face DSME produces approximately 1.3% HbA1c reduction at 30 weeks in type 2 diabetes
- Orlistat and semaglutide may improve ovulation and pregnancy rates in women with overweight or obesity
- High-intensity interval training associated with -0.73% HbA1c reduction in adults with type 2 diabetes
- Culturally tailored self-management interventions significantly decrease HbA1c levels in people with type 2 diabetes
- High Intensity Interval Training Improves Cardiometabolic Risk Factors in Pediatric Overweight Populations
- Efficacy and Safety Profile of Subcutaneous Semaglutide for Weight Management in Adults
- GLP-1 RA exposure in early pregnancy not significantly tied to hypertensive disorders
- External oblique intercostal block provides greatest opioid-sparing effect for laparoscopic sleeve gastrectomy patients
- Evaluating Enoxaparin Dosing Strategies for Venous Thromboembolism Prophylaxis in Bariatric Surgery Patients
- Mitochondrial metabolic reprogramming and epigenetic modifications drive bidirectional regulation in renal tubular epithelial cells
- Current molecular and cellular phenotypes do not yet support clinical subtype identification for recurrent pregnancy loss
- TNF inhibitors may be effective for juvenile idiopathic arthritis in patients with DiGeorge syndrome
- mHealth apps reduce HbA1c by 0.39% in type 2 diabetes across 19 RCTs
- Oral-health promotion improves outcomes for adults with type 2 diabetes when guidance is provided
- Prediabetes linked to 2.78-fold higher odds of obstructive sleep apnea in meta-analysis
- OSAS not significantly tied to diabetic retinopathy overall, but risk doubles in Asian subgroups
- Radiomics and deep learning provide promising tools for precise assessment of adrenal masses
- Proposed pathway for systematic MASLD/MASH assessment in type 2 diabetes
- Metabolic surgery review outlines framework for T2DM and obesity management
- Protein acetylation serves as a critical regulatory hub for inflammation and metabolism in atherosclerosis
- SGLT2 inhibitors and GLP-1 receptor agonists show similar MACE reduction in type 2 diabetes
- SGLT2 inhibitors reduce body fat without significant impacts on skeletal muscle mass in type 2 diabetes
- Overweight and obesity prevalence in individuals with Down syndrome reaches 22% across mixed-age cohorts
- Gut microbiota dysbiosis and metabolic pathway abnormalities are associated with pediatric Type 1 Diabetes
- Insulin resistance and hyperinsulinemia drive bidirectional links between biological aging and age-related chronic diseases
- Vitamin D deficiency is prevalent among African patients with Type 2 Diabetes and higher HbA1c
- GLP-1 receptor agonists and tirzepatide provide cardiovascular benefits across multiple clinical scenarios
- Laryngeal obstruction as initial sign of MEN2B in two pediatric cases with RET mutations
- T cell signaling and metabolic rewiring are critical for T cell engager efficacy in solid tumors
- Exercise ameliorates both type 1 and type 2 diabetes through multiple mechanisms
- Exercise snacks significantly reduce postprandial glucose iAUC by 5.69 mmol·h/L in sedentary adults
- SSRIs show significant reduction in depressive symptoms only when used for 6 months or longer
- Oral antioxidants improve clinical pregnancy and live birth rates in IVF patients
- Obesity is associated with lower PASI90, PASI75, and PASI100 responses in patients with psoriasis
- AI-OCT reports reduced false-positive DME referral rates from 69.1% to 24.1%
- Diverse transmission dynamics and national control strategies characterize African swine fever and PRRS in Asia
- Dapagliflozin plus pioglitazone reduces HbA1c by 0.49% and improves liver fat content in T2DM
- Coastal regions show higher thyroid cancer prevalence while inland areas have more goiter and hypothyroidism
- Risk factors for intracranial lesions in males with central precocious puberty include neurological symptoms
- Meta-analysis examining the association between diabetes mellitus and low back pain
- Microbial dysbiosis impairs healing of diabetic foot ulcers through reduced diversity and biofilm formation
- GQD plus metformin significantly reduces FPG and 2hPG in adults with Type 2 Diabetes
- A novel PTHLH nonsense variant is associated with brachydactyly type E and short stature
- Women with Polycystic Ovary Syndrome have 24% prevalence of Gestational Diabetes Mellitus
- Balanced nutrition and specific macronutrient guidelines support performance for table tennis athletes
- Age, male sex, low BMI, and comorbidities like diabetes are significant risk factors for sepsis incidence
- High-intensity interval training reduces body weight and fat mass more than moderate-intensity continuous training
- Maternal type 1 diabetes exposure associated with lower offspring risk of developing the condition
- Automated insulin delivery increases time-in-range by 9.88% in young children with type 1 diabetes
- GnRHa treatment for central precocious puberty is associated with 2.7 cm greater adult height gain
- Deep learning models show high sensitivity for identifying various stages of diabetic retinopathy
- Donor KIR B/X genotype is associated with significantly superior overall survival in allogeneic hematopoietic stem cell transplantation
- Shorter cryopreservation duration associated with higher live birth and clinical pregnancy rates in FET
- TCM formulations significantly reduce TCM syndrome scores and improve response rates in Graves' disease
- Orforglipron Demonstrates Superior Glycaemic Control Over Dapagliflozin in Type 2 Diabetes
- Tirzepatide Efficacy and Safety for Managing Type 2 Diabetes in Chinese Patients
- AI models demonstrate high accuracy in predicting progression from Gestational Diabetes to Type 2 Diabetes
- Adrenergic receptor signaling modulates pulmonary innate immunity and barrier integrity in acute lung injury
- Prediction models demonstrate high accuracy for identifying progression from prediabetes to Type 2 Diabetes Mellitus
- Cagrilintide-semaglutide reduces HbA1c by up to 2.33% in adults with type 2 diabetes
- PCSK9 monoclonal antibodies show promise for renal benefit in diabetic kidney disease
- Ubiquitination modifications by E3 ligases and DUBs form tissue-specific regulatory networks in Type 2 Diabetes
- TSH suppression therapy promotes tumor progression via G-protein signaling pathways in differentiated thyroid cancer
- Oral small-molecule GLP-1RAs reduce body weight by 3.93 and HbA1c by 0.94
- Streptozotocin and high-fat diets are common methods for establishing diabetic neurogenic bladder animal models
- Enteral nutrition is associated with 30% to 80% incidence of hyperglycemia in critically ill patients
- Contrast-enhanced ultrasound shows 81.6% diagnostic accuracy for differentiating benign from malignant thyroid nodules
- Early subcutaneous basal insulin plus IV insulin reduces time to DKA resolution by 4.06 hours
- Smartphone app intervention resulted in a -0.13 reduction in HbA1c for patients with diabetes after CABG
- Stem cell therapy associated with marginal HbA1c reduction of -0.57% at 6 months in Type 1 Diabetes
- Two-year exercise training improves bone mineral density and trabecular bone score in type 2 diabetes
- Metabolic Dysfunction-Associated Steatotic Liver Disease prevalence reaches 56.9% among diabetic adults in India
- Pre-transplant parathyroidectomy may reduce graft loss while maintaining comparable long-term renal function
- Obesogenic exposures and endocrine disruptors may impair testicular descent and gonadal maturation in males
- GLP-1 receptor agonists combined with metformin most effectively reduce weight and BMI in PCOS
- Intermittent fasting plus early time-restricted eating results in greater weight loss than standard care
- Male sex, age, multifocality, and BRAFV600E mutation increase risk of metastasis in papillary thyroid microcarcinoma
- Lymphatic dysfunction may drive inflammation and insulin resistance in older adults with sarcopenic obesity
- Bariatric surgery is associated with a significantly lower incidence of gallbladder cancer in people living with obesity
- Chronic stress exposure may flatten circadian patterns and suppress reproductive axes in functional hypercortisolism
- Pharmacologic treatments for gestational diabetes mellitus show varying impacts on glucose and neonatal outcomes
- Mobile-ecological momentary assessment shows 70% compliance rate among adolescents and young adults with diabetes
- T cell-targeted immunotherapy preserves C-peptide AUC and reduces insulin requirements in newly diagnosed Type 1 Diabetes
- Automated insulin delivery systems increase time-in-range by 9.29% in children with Type 1 Diabetes
- Combined FGF-21 and GDF-15 show high diagnostic accuracy for insulin resistance in type 2 diabetes
- Pooled prevalence of diabetic kidney disease among Brazilian adults is 27.06% across 46 studies
- GLP-1 receptor agonists are associated with a 3.587 risk ratio for hair loss in obese patients
- Initial dual oral therapy improves HbA1c target achievement in early stage type 2 diabetes
- Diet and physical activity reduce weight, waist circumference, and systolic blood pressure in GDM patients
- Environmental pollutants including air pollution and heavy metals are associated with increased Gestational Diabetes Mellitus risk
- Diabetes doubles the odds of moderate-to-severe hearing loss compared to healthy controls
- Semaglutide significantly reduces BMI and improves hypertension control in patients with obesity and CKD
- Total testosterone and BMI predict clomiphene citrate resistance in 6.8% of women with PCOS
- Quantitative pancreatic MRI shows promise as non-invasive biomarker in diabetes
- Combined exercise interventions significantly reduce glycated hemoglobin and fasting blood glucose in type 2 diabetes
- Surgery remains the only curative treatment for primary hyperparathyroidism, review confirms
- General medical management improves medication adherence and lifestyle outcomes in older adults with type 2 diabetes
- Apoptotic regulation and multi-hit factors drive germ cell loss in non-obstructive azoospermia
- IL-6 blockade causes early lipid increases but maintains cardiovascular neutrality in rheumatoid arthritis
- Preoperative androgen therapy reduces odds of urethrocutaneous fistula in pediatric hypospadias repair
- Hyperuricemia affects 22% of type 2 diabetes patients in global meta-analysis
- TTM-based interventions significantly reduce BMI and waist circumference in individuals with overweight or obesity
- Post-translational modifications represent a critical target for precise molecular intervention in diabetic kidney disease
- Selpercatinib tops cabozantinib and vandetanib for PFS in advanced medullary thyroid cancer
- Elecoglipron results in 40.4% to 88.8% of patients reaching at least 5% weight loss
- Over half of Arab adults with chronic diseases possess high digital health literacy scores
- Hormonal transformations during pregnancy and placental contributions influence maternal bone remodeling and metabolism
- Performance-enhancing peptides modulating the GH-IGF1 axis present significant risks of endocrine and metabolic disturbances
- Aerobic exercise and high-intensity interval training reduce fat mass in women with overweight or obesity
- Retatrutide Demonstrates Dose Dependent Glycemic Control and Weight Loss in Type 2 Diabetes
- Untreated glucose intolerance in pregnancy linked to postpartum metabolic dysfunction similar to treated GDM
- Nutritional Supplementation Combined With Exercise Improves BMI And Lipid Profiles In Obesity
- High glucose variability is associated with 2.10 increased risk of all-cause mortality in COVID-19
- Non-obese women with PCOS show no significant differences in serum vitamin D levels
- Once-weekly basal insulin improves HbA1c by 0.09% and time in range over daily regimens
- A 6 dimension and 42 item system provides early risk assessment for high-risk diabetic feet
- Resveratrol supplementation significantly reduces LDL-C but lacks consistent impact on glycemic indices in type 2 diabetes
- Pancreatic cancer involves multilayered mechanisms from environment to immune escape
- Multi-marker models show higher diagnostic performance than single analytes for identifying recurrent implantation failure
- High prevalence of microvascular and macrovascular complications among adult Ugandans with diabetes
- Tirzepatide at maximum tolerated dose achieved 21.9% bodyweight reduction over 112 weeks
- Transcriptomic analysis identifies 337 high-confidence genes associated with Type 2 Diabetes in human pancreatic islets
- Meldonium lacks proven ergogenic benefit in healthy athletes, review finds
- Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
- Pancreatic tissue engineering faces vascularization hurdle in type 1 diabetes therapy
- Gut-joint axis and m6A epigenetic modifications provide a potential mechanism for gout pathophysiology
- Myo-inositol and clomiphene with sildenafil are associated with improved pregnancy outcomes in women with infertility
- Evolocumab reduces MACE by 29% in patients with BMI greater than or equal to 35 kg/m
- Traditional Chinese Medicine reduces body weight by 5.86 kg and improves lipid profiles in obesity
- Metformin is associated with higher lactate concentrations during exercise in adults with prediabetes and type 2 diabetes
- Semaglutide reduces risk of kidney decline or death in type 2 diabetes and CKD
- MTARC1 inhibition may reduce cirrhosis and hepatocellular carcinoma risk in metabolic dysfunction-associated steatotic liver disease
- Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases
- Early genomic profiling optimizes treatment selection and expands precision therapy options across thyroid cancer subtypes
- FDA Approves Saxenda (liraglutide) for Weight Management in Adults and Adolescents
- FDA Approves Brenzavvy (bexagliflozin) for Type 2 Diabetes Glycemic Control
- FDA Approves Farxiga (dapagliflozin) for Chronic Kidney Disease and Heart Failure
- FDA Approves Steglujan (ertugliflozin/sitagliptin) for Type 2 Diabetes
- FDA Approves Steglatro (ertugliflozin) for Type 2 Diabetes Mellitus
- FDA Approves Invokana (canagliflozin) for Type 2 Diabetes and Related Conditions
- Oral white kidney bean extract reduces weight by 1.62 kg in adults with overweight or obesity compared to placebo
- IGFBPs show dual roles in metabolic dysfunction-associated steatotic liver disease progression
- Type 5 diabetes in low-income populations with early malnutrition is underdiagnosed and needs standardized care
- Review of ADSC-Exos for diabetic foot ulcers lacks reported efficacy data or safety outcomes in this narrative synthesis
- Meta-analysis finds no link between early-life antibiotics and type 1 diabetes risk
- Color Doppler ultrasound differentiates Graves' disease from silent thyroiditis in thyrotoxicosis patients
- Pancreaticoduodenectomy alters GLP-1 and GIP responses, exploratory meta-analysis finds
- Long-term voglibose use likely caused leukopenia in a 71-year-old man with type 2 diabetes
- Network meta-analysis ranks FGF21 analogs and SGLT2 inhibitors highest for MASH fibrosis
- Bile acid modifications and microbiota interventions show promise for metabolic and digestive diseases in preclinical models
- MDT management of insulinoma in pregnancy yields partial glycaemic control but fetal growth restriction occurred in this case
- Metabolic subtypes identify Japanese adults with prediabetes at highest or lowest T2D risk
- FDA Approves Afrezza (insulin human) Inhaled Insulin for Adult Diabetes
- Pantoprazole exposure linked to insulin autoimmune syndrome in case report
- Processing methods for ovarian tissue in healthy premenopausal patients were reviewed with no reported outcomes or safety data
- Network meta-analysis reveals optimal aerobic exercise frequency and intensity for improving bone mineral density in osteoporosis patients
- 37 loci linked to gestational diabetes, 7 novel, in large multi-ancestry meta-analysis
- Novel NBAS variants define severe immune dysregulation and poor prognosis in infantile liver failure syndrome type 2
- Anti-inflammatory reliever therapy outperforms SABA-only in asthma management
- GLP-1RAs show lower risk of serious liver events compared with DPP-4 inhibitors in adults with type 2 diabetes
- Ring-augmented gastric bypass shows similar weight loss and safety at one year
- Negative pressure wound therapy reduces hospital stay by 7.8 days in diabetic wounds
- Fertility preservation in female leukemia patients carries risks of leukemic cell contamination and disease reintroduction
- Antibiotic cement achieves 85.2% healing rate in diabetic foot osteomyelitis meta-analysis
- Real-time CGM improved HbA1c versus SMBG in adults with type 2 diabetes on basal insulin and modern therapies
- Thiazolidinediones show lower hepatocellular carcinoma risk than DPP-4 inhibitors, GLP-1RAs, insulin, and sulfonylureas in this network meta-analysis
- Adverse childhood experiences linked to higher gestational diabetes risk
- Tirzepatide improves waist-to-height ratio in adults with obesity or overweight
- SGLT2 inhibitor use associated with increased diabetic ketoacidosis risk, especially with elevated HbA1c
- Early-life antibiotic exposure linked to modest increased risk of childhood type 1 diabetes
- Paternal metformin use during spermatogenesis shows no increased risk for major congenital malformations in over 11 000 children across five countries
- Resistance training reduces hemoglobin A1c by 0.62% and systolic blood pressure by 3.91 mmHg in type 2 diabetes
- Multicomponent behavioral interventions show sustained HbA1c reduction in type 2 diabetes
- Exercise Improves Body Composition and Function in Sarcopenic Obesity
- GLP-1 receptor agonists reduce major adverse limb events with HR 0.59 in PAD
- Greater weight loss and supervised exercise reduce diabetes risk in adults with prediabetes
- Sarcopenia Significantly Increases Mortality Risk And Hospital Readmission Rates Among Patients With Diabetes In This Large Meta-Analysis
- Lifestyle programs show no significant diabetes incidence reduction in 14 studies of at-risk individuals
- Trans fatty acids from dairy foods show no increased cardiometabolic risk in systematic review and meta-analysis
- SGLT2 and dual SGLT1/2 inhibitors reduce cardiovascular death or heart failure hospitalization risk in type 2 diabetes patients
- Systematic review shows pre-pregnancy weight loss interventions do not significantly reduce gestational diabetes mellitus risk in women with overweight or obesity
- Roots, leaves, and fruits of Himachal Pradesh herbs are traditionally used for diabetes management
- Triple oral therapy with metformin, SGLT-2, and DPP-4 inhibitors lowers HbA1c better than dual regimens in adults with type 2 diabetes
- Natural polysaccharides enhance insulin sensitivity and protect pancreatic beta-cells in type 2 diabetes
- Probiotics, synbiotics, and berberine modestly lower fasting glucose and HbA1c in type 2 diabetes
- Women with Type 1 Diabetes have a 2.10 times higher risk of female sexual dysfunction compared to age-matched controls
- Cerivastatin best for total cholesterol, simvastatin for LDL-C in DKD with hyperlipidemia
- Antioxidant nanomedicine in sepsis: a narrative review with no reported outcomes or safety data
- Gut microbiota and metabolites may influence autoimmune thyroid disease, thyroid dysfunction, and thyroid cancer
- Review of laboratory rodent data with no reported clinical outcomes or safety signals
- Systematic review and meta-analysis of tirzepatide effects on HbA1c and weight in adults with type 2 diabetes
- Review of a case report on Type A insulin resistance syndrome in an adolescent
- Systematic review and meta-analysis on probiotics for glycemic control in pediatric type 1 diabetes
- Narrative review of fertility preservation techniques for women with malignant tumors in China
- Case report reviews possible autoimmune hypoparathyroidism after SARS-CoV-2 infection in a young adult
- Narrative review compares long-acting growth hormone to daily recombinant human GH in pediatric GH deficiency
- Complement activation in acute kidney injury a convergent mechanism
- Systematic review and meta-analysis of lifestyle interventions for Type 2 Diabetes in West Africa