This week's Diabetes & Endocrinology digest · 2026-W19
This Week in Diabetes & Endocrinology: Sleep Apnea, HIV Metabolic Risk, and New Agonists
Resveratrol supplementation significantly reduces LDL-C but lacks consistent impact on glycemic indices in type 2 diabetes
Resveratrol fails to improve blood sugar in type 2 diabetes
This umbrella review and meta-analysis of 10 meta-analyses evaluated resveratrol for managing type 2 diabetes. While a significant reduction…
Resveratrol supplements did not lower blood sugar or improve cholesterol in type 2 diabetes, except for a small drop in LDL cholesterol.
Pancreatic cancer involves multilayered mechanisms from environment to immune escape
Review reveals complex causes of pancreatic cancer
This narrative review synthesizes the multilayered mechanisms of pancreatic cancer, including environmental exposure, genetic susceptibility…
Pancreatic cancer arises from a mix of genetics, lifestyle, and inflammation, review finds.
High prevalence of microvascular and macrovascular complications among adult Ugandans with diabetes
High rates of diabetes complications found in adult Ugandans
This meta-analysis examined the prevalence of various diabetic complications, including neuropathy and retinopathy, in a large cohort of adu…
More than half of Ugandan adults with diabetes suffer from nerve damage, highlighting a critical need for earlier screening and better care.
Multi-marker models show higher diagnostic performance than single analytes for identifying recurrent implantation failure
Multi-marker models show promise for diagnosing recurrent implantation failure
This systematic review of 18 studies evaluates fluid-based biomarkers, including blood and uterine fluid, for diagnosing recurrent implantat…
Combining multiple biomarkers may offer a more accurate way to diagnose why some pregnancies fail to implant.
Tirzepatide at maximum tolerated dose achieved 21.9% bodyweight reduction over 112 weeks
Trial shows tirzepatide helps maintain weight loss over two years
This Phase 3b randomized controlled trial evaluated tirzepatide in 378 adults with obesity over a 112-week period. Patients receiving the ma…
A long-term study shows that tirzepatide can help people with obesity maintain significant weight loss for up to 112 weeks.
Transcriptomic analysis identifies 337 high-confidence genes associated with Type 2 Diabetes in human pancreatic islets
Meta-analysis reveals 337 genes linked to type 2 diabetes in islets
This meta-analysis of transcriptomic data from human pancreatic islets identified 337 high-confidence T2D-associated genes. The study also d…
A meta-analysis of human pancreatic islets identified 337 high-confidence genes tied to type 2 diabetes, and a 10-gene panel perfectly disti…
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
Understanding how high blood sugar damages the entire nervous system in diabetes
This narrative review synthesizes how chronic hyperglycemia impacts the entire neuroaxis in patients with diabetes. It details metabolic and…
High blood sugar can damage nerves throughout the whole body. This affects your senses, movement, and internal organs.
Meldonium lacks proven ergogenic benefit in healthy athletes, review finds
Evidence is lacking for Meldonium to improve athletic performance
This narrative review examines Meldonium's ergogenic potential and safety. It finds a profound lack of high-quality, randomized placebo-cont…
Athletes looking for a performance edge should know that high-quality evidence does not support the use of Meldonium.
Evolocumab reduces MACE by 29% in patients with BMI greater than or equal to 35 kg/m
Evolocumab shows greater heart protection for patients with higher BMI
This randomized controlled trial of 27,564 stable atherosclerotic cardiovascular disease patients found that evolocumab significantly reduce…
A large study finds that the heart medication evolocumab provides significantly more protection against heart attacks and strokes for patien…
Traditional Chinese Medicine reduces body weight by 5.86 kg and improves lipid profiles in obesity
Traditional Chinese Medicine may help manage weight and cholesterol
This meta-analysis of 3053 patients found that Traditional Chinese Medicine (TCM) significantly reduced body weight by 5.86 kg and BMI by 2.…
New data suggests Traditional Chinese Medicine can help people with obesity lower their body weight and improve heart health markers like ch…
Pancreatic tissue engineering faces vascularization hurdle in type 1 diabetes therapy
New tissue engineering methods aim to improve pancreatic transplants
This narrative review examines pancreatic tissue engineering for type 1 diabetes, highlighting insufficient vascularization as the dominant …
Current pancreas transplants are limited by a shortage of donors and the need for lifelong drugs. New engineering techniques may offer a dif…
Gut-joint axis and m6A epigenetic modifications provide a potential mechanism for gout pathophysiology
New theory links gut health to joint pain in gout
This narrative review explores the gut-joint axis and the role of bacterial outer membrane vesicles in gout. The authors propose a Two-Hit f…
A new theoretical model suggests that bacteria in the gut might play a hidden role in causing inflammation and crystal buildup in gouty join…
All Diabetes & Endocrinology Articles
- Resveratrol supplementation significantly reduces LDL-C but lacks consistent impact on glycemic indices in type 2 diabetes
- Pancreatic cancer involves multilayered mechanisms from environment to immune escape
- Multi-marker models show higher diagnostic performance than single analytes for identifying recurrent implantation failure
- High prevalence of microvascular and macrovascular complications among adult Ugandans with diabetes
- Tirzepatide at maximum tolerated dose achieved 21.9% bodyweight reduction over 112 weeks
- Transcriptomic analysis identifies 337 high-confidence genes associated with Type 2 Diabetes in human pancreatic islets
- Meldonium lacks proven ergogenic benefit in healthy athletes, review finds
- Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
- Pancreatic tissue engineering faces vascularization hurdle in type 1 diabetes therapy
- Gut-joint axis and m6A epigenetic modifications provide a potential mechanism for gout pathophysiology
- Myo-inositol and clomiphene with sildenafil are associated with improved pregnancy outcomes in women with infertility
- Evolocumab reduces MACE by 29% in patients with BMI greater than or equal to 35 kg/m
- Traditional Chinese Medicine reduces body weight by 5.86 kg and improves lipid profiles in obesity
- Metformin is associated with higher lactate concentrations during exercise in adults with prediabetes and type 2 diabetes
- Semaglutide reduces risk of kidney decline or death in type 2 diabetes and CKD
- MTARC1 inhibition may reduce cirrhosis and hepatocellular carcinoma risk in metabolic dysfunction-associated steatotic liver disease
- Stress-induced IL-6 upregulation impairs skeletal growth and bone health in children with inflammatory diseases
- Early genomic profiling optimizes treatment selection and expands precision therapy options across thyroid cancer subtypes
- FDA Approves Saxenda (liraglutide) for Weight Management in Adults and Adolescents
- FDA Approves Brenzavvy (bexagliflozin) for Type 2 Diabetes Glycemic Control
- FDA Approves Farxiga (dapagliflozin) for Chronic Kidney Disease and Heart Failure
- FDA Approves Steglujan (ertugliflozin/sitagliptin) for Type 2 Diabetes
- FDA Approves Steglatro (ertugliflozin) for Type 2 Diabetes Mellitus
- FDA Approves Invokana (canagliflozin) for Type 2 Diabetes and Related Conditions
- Oral white kidney bean extract reduces weight by 1.62 kg in adults with overweight or obesity compared to placebo
- IGFBPs show dual roles in metabolic dysfunction-associated steatotic liver disease progression
- Type 5 diabetes in low-income populations with early malnutrition is underdiagnosed and needs standardized care
- Review of ADSC-Exos for diabetic foot ulcers lacks reported efficacy data or safety outcomes in this narrative synthesis
- Meta-analysis finds no link between early-life antibiotics and type 1 diabetes risk
- Color Doppler ultrasound differentiates Graves' disease from silent thyroiditis in thyrotoxicosis patients
- Pancreaticoduodenectomy alters GLP-1 and GIP responses, exploratory meta-analysis finds
- Long-term voglibose use likely caused leukopenia in a 71-year-old man with type 2 diabetes
- Network meta-analysis ranks FGF21 analogs and SGLT2 inhibitors highest for MASH fibrosis
- Bile acid modifications and microbiota interventions show promise for metabolic and digestive diseases in preclinical models
- MDT management of insulinoma in pregnancy yields partial glycaemic control but fetal growth restriction occurred in this case
- Metabolic subtypes identify Japanese adults with prediabetes at highest or lowest T2D risk
- FDA Approves Afrezza (insulin human) Inhaled Insulin for Adult Diabetes
- Pantoprazole exposure linked to insulin autoimmune syndrome in case report
- Processing methods for ovarian tissue in healthy premenopausal patients were reviewed with no reported outcomes or safety data
- Network meta-analysis reveals optimal aerobic exercise frequency and intensity for improving bone mineral density in osteoporosis patients
- 37 loci linked to gestational diabetes, 7 novel, in large multi-ancestry meta-analysis
- Novel NBAS variants define severe immune dysregulation and poor prognosis in infantile liver failure syndrome type 2
- Anti-inflammatory reliever therapy outperforms SABA-only in asthma management
- GLP-1RAs show lower risk of serious liver events compared with DPP-4 inhibitors in adults with type 2 diabetes
- Ring-augmented gastric bypass shows similar weight loss and safety at one year
- Negative pressure wound therapy reduces hospital stay by 7.8 days in diabetic wounds
- Fertility preservation in female leukemia patients carries risks of leukemic cell contamination and disease reintroduction
- Antibiotic cement achieves 85.2% healing rate in diabetic foot osteomyelitis meta-analysis
- Real-time CGM improved HbA1c versus SMBG in adults with type 2 diabetes on basal insulin and modern therapies
- Thiazolidinediones show lower hepatocellular carcinoma risk than DPP-4 inhibitors, GLP-1RAs, insulin, and sulfonylureas in this network meta-analysis
- Adverse childhood experiences linked to higher gestational diabetes risk
- Tirzepatide improves waist-to-height ratio in adults with obesity or overweight
- SGLT2 inhibitor use associated with increased diabetic ketoacidosis risk, especially with elevated HbA1c
- Early-life antibiotic exposure linked to modest increased risk of childhood type 1 diabetes
- Paternal metformin use during spermatogenesis shows no increased risk for major congenital malformations in over 11 000 children across five countries
- Resistance training reduces hemoglobin A1c by 0.62% and systolic blood pressure by 3.91 mmHg in type 2 diabetes
- Multicomponent behavioral interventions show sustained HbA1c reduction in type 2 diabetes
- Exercise Improves Body Composition and Function in Sarcopenic Obesity
- GLP-1 receptor agonists reduce major adverse limb events with HR 0.59 in PAD
- Greater weight loss and supervised exercise reduce diabetes risk in adults with prediabetes
- Sarcopenia Significantly Increases Mortality Risk And Hospital Readmission Rates Among Patients With Diabetes In This Large Meta-Analysis
- Lifestyle programs show no significant diabetes incidence reduction in 14 studies of at-risk individuals
- Trans fatty acids from dairy foods show no increased cardiometabolic risk in systematic review and meta-analysis
- SGLT2 and dual SGLT1/2 inhibitors reduce cardiovascular death or heart failure hospitalization risk in type 2 diabetes patients
- Systematic review shows pre-pregnancy weight loss interventions do not significantly reduce gestational diabetes mellitus risk in women with overweight or obesity
- Roots, leaves, and fruits of Himachal Pradesh herbs are traditionally used for diabetes management
- Triple oral therapy with metformin, SGLT-2, and DPP-4 inhibitors lowers HbA1c better than dual regimens in adults with type 2 diabetes
- Natural polysaccharides enhance insulin sensitivity and protect pancreatic beta-cells in type 2 diabetes
- Probiotics, synbiotics, and berberine modestly lower fasting glucose and HbA1c in type 2 diabetes
- Women with Type 1 Diabetes have a 2.10 times higher risk of female sexual dysfunction compared to age-matched controls
- Cerivastatin best for total cholesterol, simvastatin for LDL-C in DKD with hyperlipidemia
- Antioxidant nanomedicine in sepsis: a narrative review with no reported outcomes or safety data
- Gut microbiota and metabolites may influence autoimmune thyroid disease, thyroid dysfunction, and thyroid cancer
- Review of laboratory rodent data with no reported clinical outcomes or safety signals
- Systematic review and meta-analysis of tirzepatide effects on HbA1c and weight in adults with type 2 diabetes
- Review of a case report on Type A insulin resistance syndrome in an adolescent
- Systematic review and meta-analysis on probiotics for glycemic control in pediatric type 1 diabetes
- Narrative review of fertility preservation techniques for women with malignant tumors in China
- Case report reviews possible autoimmune hypoparathyroidism after SARS-CoV-2 infection in a young adult
- Narrative review compares long-acting growth hormone to daily recombinant human GH in pediatric GH deficiency
- Complement activation in acute kidney injury a convergent mechanism
- Systematic review and meta-analysis of lifestyle interventions for Type 2 Diabetes in West Africa
- Network meta-analysis reveals placenta-derived products significantly improve diabetic foot ulcer healing rates versus standard care options
- Scoping review of micronutrient intake in midlife women across six Asian regions
- Meta-analysis finds higher intrapancreatic fat in type 2 diabetes
- Systematic review and meta-analysis links COVID-19 infection to 41% higher new-onset diabetes risk
- Systematic review explores metabolic-immune axis in glioma progression and resistance
- Systematic review and meta-analysis of prediction models for diabetic kidney disease progression to ESRD
- CGM may boost treatment satisfaction in type 2 diabetes, but other outcomes unclear
- Narrative review on BAT in older adults with obesity and exercise nutrition
- Narrative review suggests homocysteine combined with multi-index screening aids early warning for pregnancy complications
- Systematic review and meta-analysis on FGF23 levels in diabetic kidney disease
- Systematic review and meta-analysis of metformin for pediatric overweight and obesity shows modest BMI reduction
- Meta-analysis suggests high BMI causally increases vascular-related dementia risk via blood pressure mediation
- Meta-analysis: Resistance training improves vascular function in type 2 diabetes
- Systematic review finds no difference in hypoglycemia or ketoacidosis between insulin types
- CagriSema demonstrates superior weight loss efficacy compared to semaglutide monotherapy or placebo in obesity trials
- Scoping review synthesizes functional factors for enhancing physical strength and endurance
- Review of 32 cases of thyroid hemiagenesis with carcinoma highlights surgical and diagnostic patterns
- Review of PFAS exposure links to reproductive dysfunction in assisted reproductive technology
- Meta-analysis of blood pressure levels and outcomes in type 2 diabetes participants
- Systematic review and meta-analysis on VR for Type 2 Diabetes management
- Network meta-analysis compares bexagliflozin efficacy and safety with other SGLT2 inhibitors in type 2 diabetes
- Meta-analysis finds inconsistent diabetes mortality link in COPD exacerbations
- Meta-analysis shows SGLT2 inhibitors reduce all-cause mortality in heart failure patients
- Systematic review and meta-analysis of HIIT versus MICT for Type 2 Diabetes outcomes
- New APS criteria show higher specificity but lower sensitivity
- Meta-analysis shows intraovarian PRP improves ovarian markers but pregnancy rates remain unchanged in women with poor reserve
- Meta-analysis finds very uncertain evidence for CO therapy in wound healing
- Meta-analysis finds vitamin D supplementation does not significantly affect ovarian reserve markers in women
- Narrative review explores nesfatin-1 in infertility, pregnancy, and lactation
- Systematic review of 88 observational studies on missing data reporting in T2DM-MCI research
- Meta-analysis finds Type 2 diabetes linked to poorer survival in solid tumor patients on immune checkpoint inhibitors
- Scoping review on androgen pathways and therapy in adult sepsis and septic shock
- Case report suggests hemorrhagic fever with renal syndrome may trigger secondary hyperparathyroidism
- Bayesian network meta-analysis compares tirzepatide, liraglutide, and semaglutide for weight reduction in adults without diabetes
- Narrative review on managing hypertriglyceridemia in pregnancy, including olezarsen and volanesorsen
- Network meta-analysis compares osteoporosis drugs for bone density in men
- Review of environmental endocrine stressors and their effects on hormone systems
- Meta-analysis reports elevated IL-6 and IL-17 in thyroid eye disease patients
- Systematic Review and Meta-Analysis of Subcutaneous CGM in Elective Surgery
- Secondary analysis of HIV trial links hematologic factors to neurocognitive disorder risk in substance users
- Systematic review of saponins for type 2 diabetes and its complications
- FDA Approves Levothyroxine Sodium Tablets for Hypothyroidism and TSH Suppression
- Systematic review links psycho-emotional and environmental factors to eating behaviors in adults with overweight or obesity
- Narrative review examines voltage-dependent K+ channels in rodent and human studies
- Stand-alone digital lifestyle interventions show significant improvements in weight and dietary habits for adults with overweight or obesity compared to controls
- Pregabalin 300 or 600 mg/day significantly reduces pain in painful diabetic peripheral neuropathy versus placebo
- Network Meta-Analysis Finds Tirzepatide and Sleeve Gastrectomy Equally Effective for Weight Loss in Obesity
- Digital Health Interventions Show Mixed Results for Cardiovascular Risk Reduction in Type 2 Diabetes Patients Across Weight Categories
- Narrative review suggests gluten-free diet may help Hashimoto's in Celiac patients but evidence is insufficient for universal use
- Systematic review links gestational diabetes to higher maternal CKD risk in large cohort analysis
- INSTI switching linked to higher metabolic risk in people with HIV
- Guideline on severe pediatric obesity with MC4R variant and puberty management
- Propofol-first sequence reduces hypoxemia in obese patients undergoing gastroscopy
- Bayesian network meta-analysis of seven debridement approaches for diabetic foot ulcers shows low certainty evidence
- Induction of Labor Reduces Shoulder Dystocia in Suspected Large-for-Gestational-Age Fetuses: Meta-Analysis
- Acupuncture and moxibustion cake may reduce thyroid antibodies in Hashimoto thyroiditis
- Narrative review discusses Ganoderma lucidum polysaccharides for diabetes and related complications
- Narrative review of transposable element methylation in autoimmune diseases
- Meta-analysis shows associations between hypothyroidism and increased chronic kidney disease prevalence
- Systematic review and meta-analysis links Mediterranean diet to improved cardiometabolic markers
- Fasting plasma glucose shows higher diagnostic accuracy than HbA1c for undiagnosed diabetes in adults
- Review of NHANES data links metformin use to lower mortality and inflammatory markers in type 2 diabetes
- A 1-month nudge-based dietary intervention increased daily step counts by 1105 steps at 3 months in adults with type 2 diabetes
- Mobile app plus group sessions showed feasibility in Malaysian women with gestational diabetes
- Oral Sodium Butyrate Reduces Weight in Overweight Adults Without Diabetes
- Essential phospholipids reduced hepatic steatosis and improved HbA1c in patients with MASLD and type 2 diabetes over 6 months
- Naltrexone-Bupropion Aids Weight Loss in Overweight Adults With Depression
- Intensive lifestyle intervention improves health-related quality of life in patients with obesity
- Topical pyroligneous extract hydrogel may improve wound shrinkage in diabetic foot ulcers
- CPAP Most Effective for Apnea-Hypopnea Index, GLP-1 RAs Improve Weight in OSA
- Systematic review and meta-analysis finds no significant association between diabetic retinopathy and age-related macular degeneration
- Systematic review and meta-analysis finds elevated magnetic sphincter augmentation erosion after sleeve gastrectomy
- Meta-analysis: Postoperative oral antibiotics reduce cellulitis after cesarean in obese women
- Network meta-analysis suggests tirzepatide and surgery improve MASH resolution versus standard care in adults with obesity
- Systematic review identifies GDM risk factors in low- and middle-income countries
- Meta-analysis reports diabetes-related foot disease incidence from two large cohorts
- Reversion of Prediabetes to Normoglycemia Linked to 68% Lower Diabetes Risk
- Ecnoglutide Reduces HbA1c and Body Weight in Type 2 Diabetes: Meta-Analysis
- Emotional eating shows stronger link to elevated BMI in adults than youth in this meta-analysis
- Meta-analysis finds GLP-1RA plus SGLT2i reduces UACR in type 2 diabetes with kidney disease
- Systematic review and meta-analysis shows small BMI reduction in preschoolers with screen-time interventions
- Systematic review and meta-analysis shows antifungal resistance rates vary in diabetic foot ulcer patients
- Systematic review and meta-analysis of hypoglycaemia risk prediction models in type 2 diabetes
- SMS Text Messaging Lifestyle Programs Show No Significant Benefit for Prediabetes
- Narrative review advocates multi-omics models to clarify exercise associations
- Narrative review discusses pharmacological and lifestyle interventions for type 2 diabetes and psychological health
- Higher third trimester estradiol levels associated with maternal hypothyroxinemia and lower FT4
- Tai Chi and dietary adjustment for improving health lifestyle in women with PCOS
- Meta-analysis finds slight IQ difference in children with type 1 diabetes versus peers
- Diabetes and age increase surgical site infection risk in spinal surgery patients based on a multicenter cohort
- Machine learning radiomics on MRI sequences predicts osteoporosis and abnormal bone density in retrospective cohort
- Narrative review offers theoretical framework for precision interventions in periodontitis and peri-implantitis based on the neuro-osteo-immune axis
- Higher sdLDL-C Linked to Lower Kidney Stone Risk in Two Cohorts
- Baseline anti-GIP antibody levels associate with future diabetes-range glycemia in health checkup cohort
- Elevated free and bioavailable testosterone linked to non-alcoholic fatty liver disease risk in postmenopausal women
- Meta-analysis shows dietary nitrate supplementation lowers systolic blood pressure and cholesterol in adults with obesity
- Systematic review and meta-analysis of recurrent laryngeal nerve injury rates across thyroidectomy approaches
- Narrative review examines coronary risk and vascular effects of bisphosphonates, denosumab, and romosozumab in osteoporosis
- Review of miRNA associations with high-risk diabetes profiles in midlife women
- Inflammatory indicators associated with increased lung cancer incidence in Kailuan cohort
- Endometrial preparation protocols in patients with prior intrauterine adhesion separation surgery
- C-reactive protein-to-albumin ratio predicts 6-month major adverse limb events in hospitalized diabetic foot ulcer patients
- Educational films for gestational diabetes do not reduce adverse perinatal outcomes in Uganda and India trial
- Narrative review compares brown and white adipose tissue anatomy and metabolism in adults
- Observational study links PADI4 haplotypes to wound healing and infection risk in diabetes
- Systematic review and meta-analysis compares non-invasive and interstitial continuous glucose monitoring accuracy
- Semaglutide high dose for weight reduction in people with Type 2 Diabetes
- Central lymph node ratio threshold predicts lateral lymph node metastasis in pediatric differentiated thyroid carcinoma
- Barriers and promoters to CGM and AID use in youth with T1D and public insurance
- Ultrasound markers of adenomyosis linked to lower live birth and higher pregnancy loss in IVF
- Machine learning model predicts central lymph node metastasis in papillary thyroid carcinoma
- Higher estimated pulse wave velocity linked to incident impaired fasting glucose in Chinese adults
- Intravenous tocilizumab improves clinical activity in moderate-to-severe thyroid eye disease patients
- Machine learning model improves early detection of occult diabetic kidney disease in hospitalized patients
- Cumulative LDL-C exposure strongly influences cardiovascular risk more than later-life levels
- In adult classic CAH, males show higher obesity rates and BMI than females in Italian cohort
- CHG index outperforms TyG index for gestational dysglycemia risk prediction in NHANES cohorts
- High LDL-C to HDL-C ratio linked to cardiovascular events in type 2 diabetes with retinopathy