Six H5N1 vaccine formulations showed immunogenicity and acceptable safety in 420 healthy children aged 6 months to 9 years.
Higher adjuvant content boosts immunity in children without added safety risks
This phase 2, observer-blind, multicenter study evaluated six formulations of MF59-adjuvanted H5N1 vaccine in 420 healthy infants and childr…
A Phase 2 trial in healthy children found that higher adjuvant content improved immune responses to an H5N1 vaccine without increasing side …
Valganciclovir dosing in congenital cytomegalovirus infection shows extensive drug accumulation in dried blood spots
New blood test tracks cCMV drug levels in infants
This randomized, placebo-controlled clinical trial (ValEAR) or open-label PK study evaluated infants with congenital cytomegalovirus infecti…
A new blood spot test helps doctors track cCMV medicine levels in babies to prevent dangerous side effects during treatment.
High-dose rifampicin pharmacokinetics differ across sites in tuberculosis infection randomized trial
High-dose rifampicin shows different drug levels in adults across three countries
This randomized controlled trial evaluated adults and adolescents aged ≥ 10 years with tuberculosis infection. Bioavailability was lower in …
Drug levels of high-dose rifampicin varied by country, with lower bioavailability seen in Canada and Vietnam compared to Indonesia in this t…
Vitamin A Supplementation at Birth Alters Vaccine Immune Responses Without Improving Antibody Levels in Infants
Vitamin A given at birth changes how babies respond to vaccines
This randomized, placebo-controlled trial enrolled 306 infants in Dhaka, Bangladesh receiving 50,000 IU Vitamin A within 48 hours of birth c…
A single vitamin A dose at birth may strengthen some vaccine responses in infants, but results vary by sex and vaccine type.
Meta-analysis shows clear aligners produce less skeletal expansion than conventional appliances in growing patients
Clear Aligners Produce Less Skeletal Expansion Than Conventional Appliances
This systematic review and meta-analysis evaluated clear aligners versus conventional expansion appliances for maxillary transverse deficien…
A review of 15 studies finds clear aligners create less skeletal expansion than traditional devices for growing patients with maxillary tran…
Narrative review discusses telemedicine potential and barriers for new immigrant children in the US
Telemedicine could help bridge healthcare gaps for immigrant children
This narrative review examines the acceptance, accessibility, and feasibility of telemedicine for new immigrant children in the US aged birt…
New immigrant families face massive hurdles in healthcare, but virtual doctor visits might help overcome language and travel barriers.
Containment surgery and radiographic outcomes in children with Waldenström stage III LCPD
Surgery shows potential benefits for advanced Legg-Calvé-Perthes disease
This retrospective cohort study of 58 children with Waldenström stage III LCPD observed an association between containment surgery and femor…
A study of children with advanced Legg-Calvé-Perthes disease found a trend toward better hip development after containment surgery.
Disease progression and death in a 10 year old male with lower esophageal squamous cell carcinoma
Rare case: child dies 7 months after esophageal cancer diagnosis
This case report and retrospective literature analysis describes a 10 year old male with lower esophageal squamous cell carcinoma. Following…
A 10-year-old with a rare esophageal cancer died 7 months after diagnosis, highlighting the urgent need for better treatments.
Azithromycin to doxycycline switching in children with Mycoplasma pneumoniae pneumonia resistance gene positivity
Testing for resistance genes may guide antibiotic choices
This retrospective cohort study of 150 children with Mycoplasma pneumoniae pneumonia evaluated resistance gene expression and antibiotic man…
New evidence suggests that checking for resistance genes in children with pneumonia could help doctors decide when to switch antibiotics.
Routine lab indicators help differentiate typical from incomplete Kawasaki disease and predict coronary lesions
Lab indicators may help identify Kawasaki disease risks
This retrospective study of 131 children with Kawasaki disease found that total protein was the only independent factor differentiating typi…
Routine blood markers could help doctors better identify Kawasaki disease types and predict potential heart complications in children.
Congenital urinary tract dilation resolves spontaneously in 96.2% of children over 3 to 44 months follow-up.
Most urinary tract dilation in babies goes away without surgery
This retrospective cohort study evaluated 341 children with congenital urinary tract dilation at Adiyaman University Pediatric Nephrology Cl…
New research shows most urinary tract dilation in babies resolves naturally without needing surgery or invasive procedures
MiniDock MTB Test Shows High Sensitivity and Specificity for Tuberculosis Detection
A new test finds TB in people who cough up nothing
This prospective cross-sectional study evaluated the MiniDock MTB test using sputum and tongue swabs in 1380 patients with presumptive pulmo…
A new test found tuberculosis in over 85% of patients who could not produce a cough sample, offering a faster way to diagnose the disease in…