Extracellular vesicles in RA: biomarkers and therapeutic vehicles, but clinical utility remains unproven
Extracellular Vesicles May Offer New Paths for Rheumatoid Arthritis
This mini-review examines extracellular vesicles (EVs) in rheumatoid arthritis, highlighting their cargo of citrullinated proteins, miRNAs, …
Small particles called extracellular vesicles may help doctors track and treat rheumatoid arthritis by signaling immune responses and carryi…
IV-PEG asparaginase compared to IM-EC in children with acute lymphoblastic leukemia
PEG-asparaginase shows lower toxicity in childhood leukemia trial
This Phase 3 randomized controlled trial evaluated intravenous PEG-asparaginase (IV-PEG) versus intramuscular native E. coli L-asparaginase …
A new trial finds that PEG-asparaginase may cause fewer side effects than standard treatment for children with leukemia.
Four specific miRNAs in extracellular vesicles satisfy high-tier causality for metabolic and inflammatory regulation
Extracellular Vesicles Show Potential for Managing Metabolic Health Conditions
This systematic review evaluates the role of extracellular vesicles (EVs) in managing obesity, type 2 diabetes, MASLD, and atherosclerosis. …
New research identifies specific molecules within extracellular vesicles that may play a role in managing obesity, diabetes, and liver disea…
FDA Approves Inrebic (fedratinib) for Intermediate-2 or High-Risk Myelofibrosis
FDA approves new pill Inrebic for rare bone marrow cancer.
The FDA approved Inrebic (fedratinib) for adult patients with intermediate-2 or high-risk primary or secondary myelofibrosis. The recommende…
The FDA approved Inrebic (fedratinib) for adults with a type of bone marrow cancer called myelofibrosis. It is a daily pill for patients wit…
FDA Approves Jakafi (ruxolitinib) for Steroid-Refractory Acute Graft-Versus-Host Disease
FDA approves Jakafi for acute graft-versus-host disease in patients 12 and older.
The FDA approved Jakafi (ruxolitinib) for treatment of steroid-refractory acute graft-versus-host disease in adult and pediatric patients 12…
The FDA approved Jakafi (ruxolitinib) to treat acute graft-versus-host disease (aGVHD) in people aged 12 and older who do not respond to ste…
FDA Approves Vonjo (pacritinib) for Myelofibrosis with Low Platelet Counts
FDA approves new drug Vonjo for rare bone marrow cancer with low platelets.
The FDA approved Vonjo (pacritinib) for adults with intermediate or high-risk primary or secondary myelofibrosis with platelet counts below …
The FDA approved Vonjo (pacritinib) for adults with myelofibrosis who have very low platelet counts. It helps reduce spleen size. This offer…
ctDNA and immune profiling offer a pathway toward individualized treatment for recurrent colorectal cancer
New tools help identify high risk of colorectal cancer relapse
This mini review explores ctDNA-guided surveillance, immune checkpoint blockade, and engineered cell therapies for patients with colorectal …
Doctors are using blood tests and immune profiling to better predict when colorectal cancer might return after treatment.
Susceptibility-guided combination therapy improves neurological status and reduces abscess size in a patient with nocardiosis
Case report: Brain infection in autoimmune hepatitis patient
This case report describes the management of disseminated nocardiosis in a 55-year-old man with autoimmune hepatitis. The patient showed gra…
A man with autoimmune hepatitis developed a rare brain infection after immunosuppression. Doctors treated it successfully with targeted anti…
Piezoelectric osteotomy reduces edema, ecchymosis, and pain in patients undergoing rhinoplasty
Piezoelectric tools reduce swelling and bruising after nose surgery
This meta-analysis of 905 patients found that piezoelectric osteotomy significantly reduces postoperative edema, ecchymosis, and pain compar…
New research shows that using piezoelectric tools during nose surgery can significantly lower pain, bruising, and swelling for patients.
Acupuncture Modalities Show Distinct Benefits for Trigeminal Neuralgia
New analysis shows acupuncture and bloodletting help trigeminal neuralgia
A network meta-analysis of 58 RCTs finds bloodletting therapy improves total effective rate and pain scores, while acupuncture combined with…
New research highlights how specific acupuncture techniques and bloodletting can reduce pain and attack frequency for those with trigeminal …
FDA Approves Sarclisa Escena (isatuximab-irfc) Subcutaneous for Multiple Myeloma
FDA approves new multiple myeloma drug Sarclisa Escena for injection under the skin.
The FDA approved Sarclisa Escena (isatuximab-irfc) subcutaneous injection for multiple myeloma in three combination regimens. It is indicate…
The FDA approved Sarclisa Escena (isatuximab-irfc) for subcutaneous injection to treat multiple myeloma. It can be used in three different d…
Immune microenvironment characterization provides a framework for precision immunotherapy in various thyroid cancer types
New Model Identifies Immune Pathways in Thyroid Cancer Treatment
This systematic review synthesizes the immune evolution of thyroid cancer from autoimmune-driven inflammation to exhausted states in advance…
A new framework maps how immune cells change in thyroid cancer, helping researchers identify better ways to target tumors and overcome treat…
All Hematology Articles
- Extracellular vesicles in RA: biomarkers and therapeutic vehicles, but clinical utility remains unproven
- IV-PEG asparaginase compared to IM-EC in children with acute lymphoblastic leukemia
- Four specific miRNAs in extracellular vesicles satisfy high-tier causality for metabolic and inflammatory regulation
- FDA Approves Inrebic (fedratinib) for Intermediate-2 or High-Risk Myelofibrosis
- FDA Approves Jakafi (ruxolitinib) for Steroid-Refractory Acute Graft-Versus-Host Disease
- FDA Approves Vonjo (pacritinib) for Myelofibrosis with Low Platelet Counts
- ctDNA and immune profiling offer a pathway toward individualized treatment for recurrent colorectal cancer
- Susceptibility-guided combination therapy improves neurological status and reduces abscess size in a patient with nocardiosis
- Piezoelectric osteotomy reduces edema, ecchymosis, and pain in patients undergoing rhinoplasty
- Acupuncture Modalities Show Distinct Benefits for Trigeminal Neuralgia
- FDA Approves Sarclisa Escena (isatuximab-irfc) Subcutaneous for Multiple Myeloma
- Vivaray Hb pro shows 1.5 g/dL mean absolute error in hemoglobin measurement
- Immune microenvironment characterization provides a framework for precision immunotherapy in various thyroid cancer types
- Efgartigimod PH20 SC showed no significant difference versus placebo in primary ITP
- Avatrombopag shows 80.0% response rate and 2.82% thromboembolic event rate in adult immune thrombocytopenia
- Venetoclax plus intensive chemo yields 63.79% ORR in relapsed/refractory AML meta-analysis
- FDA Approves Besremi (interferon alfa-2b) for Polycythemia Vera
- AI-augmented screening improves hereditary hemolytic anemia detection with 92.8% pooled sensitivity
- Low-dose ATG plus PTCy shows no significant difference in acute GVHD compared to standard regimens
- Functional appliances induce significant three-dimensional condylar changes and forward positioning in Class II malocclusion
- Acute cellular senescence facilitates tissue repair while chronic accumulation drives intestinal fibrosis in Crohn's disease
- FDA Approves Argatroban in Sodium Chloride for Thrombosis in HIT and PCI
- FDA Approves Hympavzi (marstacimab) for Routine Prophylaxis in Hemophilia A and B Without Inhibitors
- OTUD7B acts as a context-dependent regulator in various cancers and inflammatory conditions
- Anatomical and immunological factors drive pathogenesis in plasma cell mastitis cases
- Precision diagnostics and novel biomarkers improve the management of graft-versus-host disease clinical spectrum
- 7-day venetoclax with intensive chemotherapy achieves 90.3% composite complete remission in AML
- Proximal gastrectomy offers shorter operative time but similar survival vs total gastrectomy in advanced gastric cancer
- Ianalumab plus eltrombopag extends time to treatment failure in primary ITP adults
- FDA Approves Ultomiris (ravulizumab-cwvz) for Generalized Myasthenia Gravis
- Platelet-derived DKK1 enhances leukocyte-platelet aggregation and recruits immune cells in Leishmaniasis models
- Zanubrutinib Delivers High Response Rates And Survival Benefits Across Diffuse Large B-Cell Lymphoma Patient Groups In This Meta-Analysis
- Recombinant ADAMTS13 shows no significant difference in acute TTP events versus standard therapy or placebo in phase 2 and 3 trials
- HMA-venetoclax yields 50% overall response rate in relapsed/refractory AML meta-analysis
- Systematic review reveals high prevalence of sickle cell disease across infants and youth in sub-Saharan Africa
- Non-pharmacological interventions in adult ICU patients did not improve health-related quality of life in this network meta-analysis
- NINJ1 targeting shows potential for multiple sclerosis and other neurological conditions but faces significant knowledge gaps
- Xatmep receives FDA approval for pediatric acute lymphoblastic leukemia and polyarticular juvenile idiopathic arthritis
- Reduced-intensity ATRA plus arsenic with GO or low-dose anthracycline improves event-free survival in high-risk APL
- Clinical and laboratory abnormalities linked to higher mortality in malaria patients with acute kidney injury
- Narrative review suggests idiotype-directed CAAR-T therapy remains hypothetical for B-cell malignancies
- FDA Approves Venclexta (venetoclax) for CLL/SLL and AML
- FDA Approves Argatroban for Thrombosis in Heparin-Induced Thrombocytopenia
- TEG-ROTEM guided transfusion may lower death and bleeding in cardiac surgery
- FDA Approves Inqovi (decitabine/cedazuridine) for Myelodysplastic Syndromes
- Scoping review examines imatinib gonadotoxicity in males with chronic myeloid leukemia or gastrointestinal stromal tumors
- Network meta-analysis of 107 RCTs on blood-invigorating Chinese herbal medicines for endometriosis
- Delphi guideline on Para athletics talent identification and development strategies
- Meta-analysis links HLA alleles and ADAMTS13 variants to thrombotic thrombocytopenic purpura risk
- Narrative Review Explores Immune Checkpoint Inhibition in Pediatric Medulloblastoma
- Meta-analysis finds no clear benefit of adding nutrition to BFR training for strength or hypertrophy in healthy adults
- Genetic variants in ABCB1 and ABCG2 raise imatinib trough levels in CML patients
- Systematic review and meta-analysis of interim FDG PET in large B-cell lymphoma patients
- FDA Approves Epysqli (eculizumab-sbja) for PNH, aHUS, and gMG
- Machine learning predicts recreational therapy engagement in veterans
- Systematic review and meta-analysis finds high prevalence of ocular manifestations in leukemia patients
- Fixed-duration subcutaneous mosunetuzumab shows favorable efficacy and safety versus IV in relapsed follicular lymphoma
- Meta-analysis links perinatal factors to childhood acute leukemia risk
- Meta-analysis links maternal infection in pregnancy to childhood ALL risk
- Longitudinal TCR profiling predicts EBV, CMV, and GVHD in 108 allo-HSCT recipients
- Systematic Review Links Lysosomal Pathways to Autoimmune Kidney Disease Progression
- Eight-gene signature associated with survival in patients with Diffuse Large B-cell lymphoma
- Meta-analysis associates emerging lesions after lutetium-177 therapy with worse overall survival in mCRPC
- Systematic review suggests partial glossectomy with speech therapy improves speech retention and reduces costs for oral cancer patients
- Eltrombopag monotherapy assessed in moderate aplastic anemia and unilineage bone marrow failure disorders
- Three Biomarkers Show High Diagnostic Accuracy for Ulcerative Colitis in Cohort Study
- Scoping review of wastewater-based surveillance for AMR and SARS-CoV-2 in GCC countries
- Narrative review discusses sarcopenia and intramuscular vaccination immune landscape gaps
- Network meta-analysis of vital pulp therapy success in mature permanent teeth with carious exposure
- Review summarizes fenofibrate, metformin, and MSC modulation in Primary Sjögren disease management
- Case report and literature review of ENKTL presenting with ocular symptoms and treated with GemOx
- Review of solitary plasmacytoma radiotherapy outcomes in Indian tertiary care
- Observational study identifies PF4-dependent antibodies in ELISA-negative HIT patients via functional testing
- FDA Approves Rytelo (telomerase inhibitor oligonucleotide) for transfusion-dependent anemia in low- to intermediate-1 risk MDS
- AMH Levels in Pediatric Cancer Patients Before and After Treatment
- Phase 2 trial tests single-dose IV iron isomaltoside in severe aortic stenosis with iron deficiency
- BR regimen shows survival outcomes in newly diagnosed Waldenstroms Macroglobulinemia patients
- Meta-analysis of HSCT with treosulfan in Ataxia Telangiectasia patients shows mixed survival outcomes and significant toxicities
- Meta-analysis finds non-clotting factor therapies reduce bleeding in congenital hemophilia
- Biomarkers and clinical factors show statistical associations with sepsis-induced coagulopathy in 37,459 patients
- Systematic review validates iPSC-derived organoids as models for ALS pathology compared to traditional 2D or animal models
- Hyperbaric oxygen pretreatment in autologous HSCT patients shows trends toward improved survival and reduced organ damage
- Recurrent low back pain accounts for disproportionate healthcare costs in Polish working-age adults
- Knowledge graph system for Jin San Zhen acupuncture therapy evaluation
- Hetrombopag increases platelet counts in children with immune thrombocytopenia in phase 3 trial
- Renizgamglogene autotemcel infusion showed engraftment and hemoglobin increases in severe sickle cell disease patients
- Phase 2 trial compares Inotuzumab Ozogamicin plus R-CVP for DLBCL patients unfit for anthracycline
- Phase 2 trial finds mezagitamab increases platelet counts in adults with persistent or chronic ITP
- In children with Ph+ ALL, TKI-based therapy reduced HSCT use while maintaining comparable outcomes versus Ph+ALL04
- Meta-analysis compares CAR T-cell constructs in 1540 relapsed/refractory B-ALL patients
- Direct pressure for 5 minutes reduces ecchymosis after venipuncture in older anticoagulated patients
- Systematic review explores necroptosis as a therapeutic target in multiple myeloma
- Point-of-care hemoglobin meters show high sensitivity but lower specificity versus analyzer in Ghanaian study
- Phase II trial shows high remission and survival with frontline ATRA-ATO for newly diagnosed APL
- Systematic review shows increased fat mass and decreased fat-free mass in children with acute lymphoblastic leukemia during treatment
- Observational study explores daratumumab resistance mechanisms in primary light-chain amyloidosis
- Gene therapy reduces bleeding rates and factor use in adults with severe hemophilia A
- CellSearch CMMC assay shows analytical sensitivity for non-invasive MRD monitoring in multiple myeloma
- Phase 1b trial finds tafasitamab combinations manageable in Japanese B-cell NHL patients
- Meta-analysis reports 53% 2-year overall survival after haploidentical HSCT in older adults
- Case report describes likely first autochthonous Chagas disease case in Missouri blood donor
- CDC updates blood lead reference value policy for US population
- Observational study finds race, ethnicity, and socioeconomic factors affect hemodialysis-associated S. aureus bloodstream infections
- Report examines use of recommended health care measures for sickle cell anemia complications in youth
- Case report links traditional eye cosmetic surma to lead poisoning in NYC family
- Case report associates elevated blood lead levels with kansa and pital metalware use in a pregnant woman
- Single case report describes durable response to nivolumab in relapsed ALK+ large B-cell lymphoma
- Damoctocog alfa pegol shows safety and maintained bleed protection in children with severe haemophilia A
- Phase 3 trial of damoctocog alfa pegol in previously treated children with severe haemophilia A
- R-CVP after radiotherapy improves progression-free survival in early-stage follicular lymphoma
- L-arginine shows no significant benefit for pain or hospital outcomes in sickle cell disease meta-analysis
- Case report: CMML initially diagnosed as ITP in one patient, stabilized with decitabine
- Imatinib reduces TNF-α levels in CML patients; persistent levels correlate with poor response
- Case report: obinutuzumab and venetoclax associated with nephrotic syndrome resolution in two CLL patients
- Siltuximab shows partial response in two iMCD-IPL cases with xanthelasma; skin lesions unchanged
- Spectral flow cytometry panel identifies hematopoietic lineages in mouse bone marrow models
- Perspective highlights diagnostic overlap between idiopathic multicentric Castleman disease and systemic lupus erythematosus
- Retrospective US claims analysis examines complications in non-transfusion-dependent thalassemia
- Case report describes management of Burkitt's lymphoma with concurrent HIV, CMV encephalitis, and salmonella bacteremia
- Phase I/II trial tests IMRT with chemotherapy before transplant for relapsed/refractory ALL/AML
- Phase 2 trial explores idelalisib plus ofatumumab in untreated CLL/SLL requiring treatment
- Phase III trial compares tisagenlecleucel to standard transplant in relapsed aggressive B-cell NHL
- Phase II trial compares quizartinib vs placebo with chemotherapy in FLT3 wild-type AML
- Daratumumab + Len/Dex shows ORR in relapsed/refractory multiple myeloma phase 1/2 trial
- Phase 2 Study of BGB-16673 in B-Cell Malignancies: Safety and Dose Findings
- Phase II Trial: HST-NEETs Shows Promise in HIV-Associated Lymphoma Post-ASCT
- Huaiqihuang Granule Improves Bleeding in Childhood CITP: 71.74% Effectiveness vs 45.65% Placebo
- Concizumab Reduces Bleeding in Hemophilia with Inhibitors: Median ABR 0.8 at 56 Weeks