Systematic Review Links Lysosomal Pathways to Autoimmune Kidney Disease Progression
Lysosomal pathways may control autoimmune kidney disease progression
This systematic review synthesizes evidence that lysosomal functions act as checkpoints in autoimmune kidney diseases like lupus nephritis a…
New evidence suggests that targeting lysosomal functions could offer a new way to manage serious autoimmune kidney diseases.
Longitudinal TCR profiling predicts EBV, CMV, and GVHD in 108 allo-HSCT recipients
TCR Monitoring Predicts Dangerous Complications Before They Start
This longitudinal cohort study evaluated TCR beta repertoire profiling in 108 allogeneic hematopoietic stem cell transplantation recipients …
A new scan of immune cells can predict dangerous post-transplant complications weeks before symptoms appear.
Eight-gene signature associated with survival in patients with Diffuse Large B-cell lymphoma
Doctors find a new way to predict who needs stronger cancer care sooner
In this cohort study, a predictive signature based on the reactivation of eight normally silent tissue-dependent genes was identified in pat…
A new blood test can spot dangerous lymphoma risks early so doctors can change treatment plans before patients get sicker.
Meta-analysis associates emerging lesions after lutetium-177 therapy with worse overall survival in mCRPC
Emerging lesions on scans linked to lower survival in prostate cancer patients
This systematic review and meta-analysis evaluated interim post-treatment SPECT/CT findings in 648 patients with metastatic castration-resis…
New spots appearing on scans after treatment for advanced prostate cancer are linked to significantly lower survival rates.
Eltrombopag monotherapy assessed in moderate aplastic anemia and unilineage bone marrow failure disorders.
Oral Drug May Reduce Need for Frequent Blood Transfusions
This Phase 2 trial evaluated eltrombopag by mouth once a day in 34 people at least 2 years of age with moderate aplastic anemia or unilineag…
A new oral medication offers hope for patients who rely on regular blood transfusions.
Systematic review suggests partial glossectomy with speech therapy improves speech retention and reduces costs for oral cancer patients.
Partial glossectomy with speech therapy offers better speech recovery for oral cancer patients.
This systematic review synthesizes evidence regarding interventions for oral cancer patients, focusing on speech retention, mental health, a…
For oral cancer patients, early-stage partial surgery combined with speech therapy may improve speech recovery and lower costs compared to l…
Three Biomarkers Show High Diagnostic Accuracy for Ulcerative Colitis in Cohort Study
Three biomarkers show promise for diagnosing ulcerative colitis
This cohort study evaluated ARHGEF3, S100A8, and RHOU as diagnostic biomarkers for ulcerative colitis. A nomogram achieved AUCs of 0.991 in …
A new study identifies three biomarkers that may help diagnose ulcerative colitis and distinguish it from Crohn's disease.
Narrative review discusses sarcopenia and intramuscular vaccination immune landscape gaps
Understanding muscle immunity helps improve vaccines for people with sarcopenia.
This narrative review examines the intersection of sarcopenia and intramuscular vaccination. The authors highlight significant gaps in under…
We still do not fully understand how muscle immunity changes in health and disease, which makes it hard to predict vaccine responses in peop…
Scoping review of wastewater-based surveillance for AMR and SARS-CoV-2 in GCC countries
Wastewater Tests Could Save Lives Across the Gulf
This scoping review and questionnaire survey examined 26 studies on wastewater-based surveillance (WBS) for microbial pathogens in GCC count…
Imagine walking down a busy street. You can hear the noise of cars and people.
Network meta-analysis of vital pulp therapy success in mature permanent teeth with carious exposure
New Study Reveals Which Fillings Actually Save Your Tooth
This network meta-analysis of 2906 teeth from 35 RCTs synthesized evidence on vital pulp therapy for carious pulp exposure in mature permane…
This major analysis shows that for saving a damaged tooth nerve, newer materials are more reliable than the old standard, giving patients a …
Case report and literature review of ENKTL presenting with ocular symptoms and treated with GemOx
A Rare Eye Symptom Led Doctors Down the Wrong Path for Months
This case report and literature review describes a single patient with extranodal natural killer/T cell lymphoma presenting with ocular symp…
Double vision and sinus scans that looked clean hid a rare lymphoma that stole a man's sight after months of wrong treatments.
Review summarizes fenofibrate, metformin, and MSC modulation in Primary Sjögren disease management.
The Dry Mouth Disease Has an Immune Fix Researchers Didn't Expect
This review examines the potential of fenofibrate, metformin, and mesenchymal stem cells in Primary Sjögren disease management. Authors sugg…
Three existing drugs may restore the immune balance broken in Sjögren's disease, a chronic condition that destroys saliva and tear glands.