Pilot study assesses safety and feasibility of young donor plasma replacement in mild cognitive impairment
Twelve patients with early memory loss received young donor blood plasma safely.
This pilot study examined the safety and feasibility of replacing patient plasma with that from young donors in twelve individuals with mild…
Twelve patients with early memory loss received young donor blood plasma safely. The procedure was feasible and well tolerated.
Living alone not linked to incident dementia but associated with higher institutionalization risk in a cohort of 2,269 individuals.
Living Alone Does Not Raise Dementia Risk But Increases Care Needs
This French clinic-based cohort study followed 2,269 individuals with cognitive complaints or mild cognitive impairment for a median of 5 ye…
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Undifferentiated Pleomorphic Sarcoma Recurrence Observed two months Postoperatively in Case Report of Gastric Mass
Cancer returns quickly after surgery and chemo for a 71-year-old woman
This case report and literature review describes a 71-year-old female with undifferentiated pleomorphic sarcoma treated with R0 resection, s…
A 71-year-old woman with rare stomach tumors had surgery and chemo, but the cancer came back just two months later.
Early-Onset Colorectal Cancer Shows Superior Survival vs Late-Onset in Retrospective Cohort
Younger Colon Cancer Patients Live Longer After Surgery
A retrospective cohort study of 4,596 colorectal cancer patients found that early-onset disease (EOCRC) was associated with significantly be…
Even with tougher tumors, younger colon cancer patients are living longer after surgery than older patients, and doctors now have hard data …
Cross-sectional study observes differences in cardiovascular regulatory responses in mild cognitive impairment
Researchers find heart rhythm changes linked to mild cognitive impairment
This cross-sectional observational study investigated cardiovascular regulatory responses to acute cognitive stress in community-dwelling ol…
New observations suggest that how the heart responds to mental stress may differ in people with early signs of memory loss.
DISCO metric from proteomics predicts mortality and frailty in older adults
Brain entropy predicts death better than existing aging clocks in older adults
This cohort study in older adults found that a proteomic-based DISCO metric outperforms existing dysregulation measures and matches epigenet…
A new measure of brain entropy predicts death and disease in older adults as well as the best current aging clocks.
Prediabetes Associated With Higher Incidence of Frailty and Functional Deficits in Adults Aged 50 Years or Older
Prediabetes Linked to Higher Frailty Risk in Older Adults
This cohort study analyzed 18,571 adults aged 50 years or older across five longitudinal aging cohorts. Baseline prediabetes was associated …
In a large study of over 18,000 older adults, prediabetes was associated with higher rates of frailty and functional decline compared to nor…
Machine learning analysis identifies drivers of medication burden in older Nepalese patients
Older Adults in Nepal Face Hidden Pill Burden
This original article reports an observational study using machine learning to predict medication burden and adherence in older patients fro…
Seniors in Nepal are struggling with too many prescriptions, often needing help just to keep track — and it’s quietly harming their health.
Personalized swallowing rehab improves outcomes after oral cancer surgery
New Swallowing Therapy Helps Oral Cancer Patients Eat and Speak More Easily
This randomized controlled trial in 300 patients with oral squamous cell carcinoma found that a personalized swallowing rehabilitation progr…
Personalized swallowing therapy helps oral cancer patients recover faster, eat more naturally, and avoid dangerous complications like pneumo…
Infection status associated with hypoxemia and death rates varying by virus type in a large US cohort.
Triple Virus Infections Rarer Than Feared — Here’s the Real Risk
This cohort study of 835,987 triple-tested patients in the US Veterans Health Administration examined associations between infection status …
It’s winter. Your throat is scratchy. Your chest feels tight.
Narrative review on mpMRI and PSMA PET/CT for radiorecurrent prostate cancer restaging
Two imaging tests together spot prostate cancer return more accurately
This narrative review synthesizes evidence on mpMRI and PSMA-targeted PET/CT for restaging radiorecurrent prostate cancer. The authors repor…
For men with suspected prostate cancer return, combining two scans catches more tumors and avoids unnecessary biopsies.
AI-assisted Bayesian framework identifies Alzheimer's gene pathways in single-cell RNA data
AI finds hidden Alzheimer's genes in brain data
This observational study applied a generative AI-assisted Bayesian-frequentist hybrid framework to single-cell RNA sequencing data from the …
A new AI method uncovered Alzheimer's-related genes that standard analysis missed, pointing to fresh biological pathways.