Can a US registry report confirm Zika-associated birth defects in pregnancies with infection?
The U.S. Zika Pregnancy and Infant Registry tracks pregnancies with confirmed or possible Zika virus infection to identify resulting birth defects. Data from this registry shows that Zika infection is linked to serious defects of the brain and eyes. Approximately 4.6% of all live-born infants from these pregnancies had any Zika-associated birth defect, while the rate rose to 6.1% among infants with a positive lab test for the virus.
What the research says
The registry specifically monitors for defects such as microcephaly, intracranial calcifications, and cerebral atrophy. Studies using this data found that one-third of infants with any Zika-associated defect had more than one type of defect reported 4.
Researchers also looked at how accurately head circumference measurements identified microcephaly. They found that some infants initially thought to have microcephaly based on small head size actually had measurement inaccuracies or normal growth later on. This means the registry carefully reviews data to ensure defects are real and not just measurement errors 6.
Beyond physical defects, the registry also tracks neurodevelopmental abnormalities. Among children who received follow-up care, about 9% showed at least one neurodevelopmental abnormality possibly linked to the infection 5.
What to ask your doctor
- What specific brain or eye defects should I watch for if my partner had Zika during pregnancy?
- How often does the registry update its data on Zika-associated birth defects?
- What screening tests are recommended for my baby if Zika was suspected?
- Can early intervention help with neurodevelopmental issues found in the registry studies?
This question is drawn from common patient questions about OB/GYN & Women's Health and answered using cited medical research. We do not provide individualized advice.