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How can screening nulliparous women prevent fetal growth restriction and preeclampsia?

high confidence  ·  Last reviewed May 20, 2026

Doctors typically screen nulliparous women to detect those at risk for fetal growth restriction and preeclampsia. Standard care includes measuring blood pressure, checking urine for protein, and assessing uterine artery blood flow with ultrasound. Identifying high-risk women early allows for interventions like low-dose aspirin, which can reduce the chance of these complications.

What the research says

Current guidelines recommend measuring maternal blood pressure, urinalysis, and symphyseal fundal height to detect women at increased risk. These basic checks help identify placental dysfunction early in pregnancy 2.

Adding uterine artery Doppler ultrasonography improves the ability to detect preeclampsia and fetal growth restriction. This test looks at blood flow in the arteries supplying the placenta. Women identified as high risk by this test may benefit from starting low-dose aspirin before 16 weeks of gestation 7.

Research also suggests that combining homocysteine levels with other indicators can aid early warning for pregnancy complications. Elevated homocysteine is linked to adverse outcomes, and adding it to screening helps differentiate risks 1.

What to ask your doctor

  • Do I need a uterine artery Doppler ultrasound to check my blood flow to the placenta?
  • Is low-dose aspirin recommended for me based on my screening results?
  • How often should I have my blood pressure and urine checked during my pregnancy?
  • Are there other biomarkers, like homocysteine, that might be useful for my specific risk profile?

This question is drawn from common patient questions about OB/GYN & Women's Health and answered using cited medical research. We do not provide individualized advice.