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Segment 4b/5 resection versus wedge resection showed no impact on long-term oncological outcomes in gallbladder cancer patientsSurgical removal of specific liver parts did not improve survival or safety for gallbladder cancer patients

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Key Takeaway
Consider that segment 4b/5 resection versus wedge resection showed no impact on long-term oncological outcomes in gallbladder cancer.

This single-center phase 3 randomized controlled trial evaluated segment 4b/5 resection versus wedge resection in 163 patients undergoing surgery for gallbladder cancer after ruling out metastatic or unresectable disease. The study assessed duration of surgery, blood loss, morbidity, mortality, R0 resection rates, disease-free survival, and overall survival. The median follow-up was 27 months.

Segment 4b/5 resection was associated with a longer duration of surgery (318 min vs 287 min; P = 0.009) and higher blood loss (265 mL vs 223 mL; P = 0.05). There was no difference in morbidity or mortality between the groups. R0 resection rates were also not different between segment 4b/5 resection and wedge resection.

Disease-free survival was 41.8 months versus 44.7 months (HR: 0.8; 95% CI: 0.47-1.4, P = 0.50). Overall survival was 45.3 months versus 50.7 months (HR: 0.6; 95% CI: 0.36-1.14, P = 0.12). Safety data regarding adverse events, serious adverse events, discontinuations, and tolerability were not reported. The study was limited by its single-center design. Funding or conflicts of interest were not reported. The practice relevance indicates that the type of liver resection in radical cholecystectomy did not have any impact on long-term oncological outcomes.

This study looked at patients who needed surgery for gallbladder cancer. The team compared a standard larger cut, called segment 4b or 5 resection, with a smaller cut known as wedge resection. The goal was to see if the bigger cut helped remove the cancer better or kept people alive longer.

During the operation, the larger cut took about thirty minutes longer and caused patients to lose more blood. However, the risk of getting sick or dying during recovery was the same for both groups. The surgeons were just as successful at removing all the cancer with either method.

After an average of two years and three months, patients who had the larger cut lived for about three and a half years. Those with the smaller cut lived for about three and a quarter years. The study found no real difference in how long people lived or how well the cancer was controlled.

In conclusion, doing a bigger cut during surgery for gallbladder cancer does not make patients live longer or get better results. The extra time in the operating room and more blood loss are not worth it. Doctors can choose the smaller cut without worrying about worse long-term health.

What this means for you:
A larger liver cut for gallbladder cancer surgery does not improve survival or safety compared to a smaller cut.

Study Details

Study typeRct
Sample sizen = 163
EvidenceLevel 2
Follow-up27.0 mo
PublishedMay 2026
View Original Abstract ↓
BACKGROUND AND OBJECTIVES: The 2 techniques for liver resection during radical cholecystectomy for gallbladder cancer (GBC) are: nonanatomical wedge resection (wedge) and anatomic segment 4b+5 resection (4b/5). There is a lack of prospective studies and randomized controlled trials (RCT) comparing these 2 techniques. So we conducted this RCT to compare these 2 techniques with respect to surgical and oncological outcomes. PATIENTS AND METHODS: It was a single-center, phase 3, balanced allocation (1:1), and open-label RCT. Patients undergoing surgery for GBC were randomized intraoperatively to wedge or segment 4b/5 resection after ruling out metastatic or unresectable disease. RESULTS: A total of 163 patients were included in final analysis (4b/5=83, wedge=80). Both the groups were similar in baseline characteristics. Segment 4b/5 group had significantly longer duration of surgery (318 vs. 287 min, P =0.009) and higher blood loss (265 mL vs. 223 mL, P =0.05). But there was no difference in morbidity, mortality, and R0 resection rates. At a median follow-up of 27 months mean DFS for segment 4b/5 and wedge group was 41.8 months and 44.7 months, respectively (HR: 0.8, 95% CI: 0.47-1.4, P =0.50). Mean OS for segment 4b/5 and wedge group was 45.3 months and 50.7 months, respectively (HR:0.6, 95% CI: 0.36-1.14, P =0.12). CONCLUSIONS: Anatomic segment 4b/5 resection and wedge resection had similar morbidity, mortality, DFS, and OS. So type of liver resection in radical cholecystectomy did not have any impact on long-term oncological outcomes.
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