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Retrospective study describes injury patterns and tetanus vaccination practices in Hangzhou trauma patients

Retrospective study describes injury patterns and tetanus vaccination practices in Hangzhou trauma p…
Photo by Tom Jur / Unsplash
Key Takeaway
Note descriptive patterns of injury and low tetanus immunoglobulin use in a Hangzhou cohort.

A retrospective cross-sectional study analyzed 2,825 trauma and animal-injury patients who received tetanus vaccination in Sandun Town, Hangzhou. The study described injury characteristics and vaccination practices without a formal comparator group. The most common injury types were animal-induced injuries (1,029 cases, 36.4%) and traffic accident injuries (943 cases, 33.4%), followed by cutting injuries (374 cases, 13.2%), blunt force injuries (242 cases, 8.6%), and other causes (237 cases, 8.4%). The upper limb was the most common injury site across all categories (56.7–74.1%), and employees/workers were the predominant occupational group (56.4–76.4%). Notably, high-risk wounds were observed in 88.2–98.9% of patients, yet the use of passive immunizing agents (tetanus immunoglobulin) was generally low, ranging from 2.1% to 10.4%, with the highest rate in animal-induced injuries. Females were the majority in animal-induced injuries (53.3%), while males predominated in other trauma categories. No safety or adverse event data were reported. Key limitations include the observational, descriptive nature of the study, which cannot establish causality, and the authors' note that gaps persist compared with developed countries, mainly reflected in the underutilization of passive immunizing agents for high-risk wounds and inconsistent application of guidelines. The practice relevance is restrained to informing local public health strategies; the authors suggest targeted education for students, migrant workers, and pet owners—particularly during warmer months—and continued training for healthcare personnel in this specific setting.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
To describe tetanus vaccination practices and injury characteristics in Sandun Town, Hangzhou during February 2024 to January 2025. A retrospective cross-sectional study was conducted using data from trauma and animal-injury patients who received tetanus vaccination in Sandun Town, Hangzhou from February 2024 to January 2025. Demographic characteristics, injury profiles, vaccination status, and relationships with season/temperature were analyzed. Total of 3,174 patients were initially identified, and 2,825 were included in the final analysis after applying exclusion criteria. Among them, animal-induced injuries accounted for 1,029 cases (36.4%), traffic accident injuries for 943 cases (33.4%), cutting injuries for 374 cases (13.2%), blunt force injuries for 242 cases (8.6%), and other causes for 237 cases (8.4%). Males predominated in all trauma categories except animal-induced injuries, where females were the majority (53.3%). Employees/workers were the predominant occupational group across all categories (56.4–76.4%). The upper limb was the most common injury site across all categories (56.7–74.1%). High-risk wounds were observed in 88.2–98.9% of patients. The use of passive immunizing agents was generally low (2.1–10.4%), with the highest rate in animal-induced injuries. Following the implementation of China’s 2024 non-neonatal tetanus guideline, the treatment of external injuries is becoming more standardized. However, gaps persist compared with developed countries, mainly reflected in the underutilization of passive immunizing agents for high-risk wounds and inconsistent application of guidelines. Targeted education for students, migrant workers, and pet owners-particularly during warmer months-and continued training for healthcare personnel are needed.
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