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Music therapy cuts delirium risk by half in ICU patients, meta-analysis findsMusic Therapy May Reduce Delirium Risk for ICU Patients

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Key Takeaway
Consider music therapy as a safe, low-cost intervention to reduce delirium incidence in adult ICU patients.

This meta-analysis of randomized controlled trials pooled data from 1,552 adult ICU patients to evaluate the effect of music therapy on delirium and related outcomes. The primary finding was a significant reduction in delirium incidence (RR=0.49, 95% CI 0.40-0.60). Secondary outcomes included restored sleep architecture, alleviated anxiety and depression, and accelerated weaning from mechanical ventilation, though effect sizes were not reported for these endpoints.

The authors note that music therapy was described as safe, but the analysis was limited by heterogeneity across studies and lower certainty in some secondary outcomes based on GRADE assessment. No adverse events were reported.

While these results suggest music therapy is a low-cost, non-pharmacological intervention that may reduce delirium in the ICU, the authors emphasize that larger multicenter trials are needed before routine integration into standard protocols. Clinicians should interpret the secondary findings cautiously given the lack of reported effect sizes and lower certainty.

How this fits prior evidence

This meta-analysis extends prior evidence linking delirium to adverse outcomes by showing that music therapy may reduce delirium incidence in ICU patients. It contrasts with mixed long-term cognitive outcomes reported for other delirium-directed interventions in ICU survivors. The finding also complements the high delirium prevalence noted in advanced cancer patients, suggesting a potential preventive role for music therapy across settings.

A review of several studies looked at how music therapy affects adult patients in intensive care units (ICU). The researchers analyzed data from 1,552 patients to see if listening to music could help with common complications like delirium and poor sleep quality.

The findings showed that music therapy significantly reduced the occurrence of delirium. It also appeared to alleviate feelings of anxiety and depression while helping to restore sleep patterns for those in the ICU. Additionally, some data suggested it may help patients move off mechanical ventilation more quickly.

While these results are promising, the evidence for some secondary benefits is less certain because the studies varied in how they were conducted. Music therapy is considered a safe and low-cost way to support patients. However, experts suggest that larger trials are needed before it becomes a standard part of every hospital routine.

What this means for you:
Music therapy may reduce delirium and anxiety in ICU patients, but more large-scale studies are needed.

Common questions

Can music therapy help with delirium in the ICU?

Yes, this meta-analysis of 1,552 patients found that music therapy significantly reduced the incidence of delirium. The results showed a reduction in risk (RR=0.49) for those in intensive care settings. Because it is non-pharmacological, it is considered a safe option for patients.

Does music therapy help with anxiety or sleep in ICU patients?

The study found that music therapy helped alleviate symptoms of anxiety and depression in adult ICU patients. It also showed an improvement in sleep architecture. However, researchers noted there is lower certainty regarding these specific secondary outcomes.

Is music therapy safe for patients on ventilators?

Music therapy is described as a safe intervention for ICU patients. While the study showed it may accelerate weaning from mechanical ventilation, larger trials are still needed before it is officially added to standard hospital protocols.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
Delirium and psychological stress are major clinical challenges for adult ICU patients, contributing to increased mortality and resource consumption. This study evaluated the efficacy of music therapy (MT) on delirium incidence, resource utilization, and psychological and sleep outcomes. Seven electronic databases (Medline, Embase, Cochrane Library, CNKI, Wanfang, VIP, and CBM) were searched from inception to December 20, 2025. Following PRISMA guidelines, 15 randomized controlled trials (RCTs) involving 1,552 patients were included. Two researchers independently performed screening and data extraction. Risk of bias was assessed using RoB 2.0, and evidence certainty was graded using the GRADE system. Primary outcomes focused on delirium assessments; secondary outcomes included mortality and resource utilization; exploratory outcomes encompassed anxiety, depression, pain, and sleep. A total of 863 records were identified, and 15 RCTs involving 1,552 patients were finally included. Meta-analysis indicated that music therapy significantly reduced the incidence of delirium (RR = 0.49; 95% CI: 0.40–0.60; p  Music therapy is a safe, low-cost non-pharmacological intervention that significantly reduces delirium risk, restores sleep architecture, alleviates anxiety and depression, and accelerates weaning from mechanical ventilation in adult ICU patients. However, due to heterogeneity and lower certainty in some secondary outcomes, larger multicenter trials are needed before routinely integrating music therapy into standard ICU and ERAS protocols. https://www.crd.york.ac.uk/PROSPERO/view/CRD420261329297.
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