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VTE risk models in multiple myeloma show low predictive accuracy, pooled AUC below 0.7Current risk tools for blood clots in multiple myeloma patients do not work well enough for doctors to trust

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Key Takeaway
Interpret existing VTE risk models in multiple myeloma cautiously due to low AUC and high bias risk.

This systematic review and meta-analysis of 14 studies assessed VTE risk prediction models in patients with multiple myeloma. The pooled VTE incidence across studies was 7.9% (95% CI 6.2-10.1%). However, the predictive performance of existing models was low, with combined area under the curve (AUCs) ranging from 0.57 to 0.68, indicating poor discrimination.

All included studies were at high risk of bias, particularly in the outcome and analysis domains. Only two studies used the Hosmer-Lemeshow test for model calibration, and all models were presented in formula form, which may limit their practical use in clinical settings.

The authors note that existing VTE risk models for multiple myeloma patients show low predictive performance (pooled AUC < 0.7) and limited clinical utility. Clinicians should interpret these models cautiously, as their ability to accurately stratify VTE risk is suboptimal. Further research with robust methodology and external validation is needed before these models can be recommended for routine practice.

Doctors need reliable ways to spot patients at risk for dangerous blood clots, known as VTE. This review looked at fourteen different studies to see how well current prediction models work for people with multiple myeloma. The goal was to check if these tools could help prevent serious health problems.

The results showed that the models are not very good. When doctors used these tools, they found that about 7.9% of patients actually got blood clots. However, the models were not accurate enough to catch all the risks. The accuracy scores, called AUC, were low, ranging from 0.57 to 0.68. A score below 0.7 is generally considered poor for medical predictions.

Several problems were found with the research. Most of the studies had a high risk of errors in how they measured results. Only two studies checked if the models fit the real data well. Also, all the studies shared the same mathematical formulas, which might limit how well they work in different hospitals. Because of these issues, the review says these tools have limited use in real life.

What this means for you:
Current blood clot risk models for multiple myeloma patients are not accurate enough for safe medical decisions.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJan 2026
View Original Abstract ↓
BACKGROUND: Risk prediction models help identify multiple myeloma (MM) patients at high risk of venous thromboembolism (VTE) and guide clinical decisions. However, their applicability and accuracy remain unclear. This study aims to systematically review existing VTE risk models in MM patients. METHODS: We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for studies on VTE risk prediction models in patients with MM, up to March 31, 2026. Two investigators independently screened the literature, extracted data, and assessed the risk of bias and applicability of the included studies using the PROBAST tool. Data analysis was performed using the "meta" and "metafor" packages in R software. RESULTS: A total of 14 studies on VTE risk prediction models in MM patients were included, involving the development and/or validation of seven risk assessment tools. Meta-analysis showed that the overall VTE incidence in MM patients was 7.9% (95% CI [6.2-10.1%]). The combined area under the curve (AUCs) of the seven tools ranged from 0.57 to 0.68, with the IMPEDE VTE and IMPEDED VTE scores showing the best performance. Only two studies used the Hosmer-Lemeshow test for model calibration, and all studies presented the models in formula form. All included studies were at high risk of bias, mainly in the outcome and analysis domains. CONCLUSION: Existing VTE risk models for MM patients show low predictive performance (pooled AUC < 0.7) and limited clinical use. Future research should focus on model updating and external validation to improve accuracy and applicability. PROSPERO Registration number ID: CRD420251024346.
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