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FDA approved Trelstar (triptorelin pamoate) for Advanced Prostate CancerFDA approved Trelstar for advanced prostate cancer treatment.

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Key Takeaway
Consider Trelstar as a GnRH agonist option for advanced prostate cancer with dosing every 4, 12, or 24 weeks.

The FDA has approved Trelstar (triptorelin pamoate) for the treatment of advanced prostate cancer. Trelstar is a gonadotropin releasing hormone (GnRH) agonist that works by suppressing testosterone production. The approval provides clinicians with a flexible dosing option: 3.75 mg every 4 weeks, 11.25 mg every 12 weeks, or 22.5 mg every 24 weeks, administered as a single intramuscular injection in either buttock. The different strengths are not additive and must be selected based on the desired dosing schedule. The drug is supplied as a lyophilized powder that must be reconstituted with sterile water and injected within 2 minutes. This approval offers an additional hormonal therapy option for patients with advanced prostate cancer.

Clinical Details (Mechanism · Dosing · Trial Data · Warnings)
Mechanism of Action

Trelstar is a gonadotropin releasing hormone (GnRH) agonist. It suppresses testosterone production in patients with advanced prostate cancer.

Indication & Patient Population

Trelstar is indicated for the treatment of advanced prostate cancer.

Dosing & Administration

Trelstar is administered as a single intramuscular injection in either buttock. The dosage strengths are 3.75 mg every 4 weeks, 11.25 mg every 12 weeks, and 22.5 mg every 24 weeks. The strengths are not additive and must be selected based on the desired dosing schedule. The lyophilized microgranules are reconstituted in sterile water only, and the suspension should be administered within 2 minutes after reconstitution. The injection site should be alternated periodically.

Key Clinical Trial Data

Trial data not available in label.

Warnings & Contraindications

Not reported in label.

Place in Therapy

Trelstar is a GnRH agonist indicated for the treatment of advanced prostate cancer, providing a hormonal therapy option with flexible dosing schedules.

The FDA has approved a new drug called Trelstar (triptorelin pamoate) for the treatment of advanced prostate cancer. Trelstar is a type of hormone therapy known as a GnRH agonist. It works by reducing the amount of testosterone in the body, which can help slow the growth of prostate cancer cells.

Trelstar is given as a shot into a muscle in the buttock. It comes in three different strengths that allow for flexible dosing schedules: a shot every 4 weeks, every 12 weeks, or every 24 weeks. Your doctor will choose the strength and schedule that is best for you. The different strengths are not meant to be combined.

The drug is a powder that must be mixed with sterile water before injection. It should be used within 2 minutes after mixing. This approval gives patients and doctors another option for treating advanced prostate cancer with hormone therapy.

As with any new treatment, it is important to talk to your doctor about whether Trelstar is a good choice for you. Your doctor can explain the potential benefits and risks based on your specific health situation.

What this means for you:
Trelstar is a new hormone therapy option for advanced prostate cancer with flexible dosing schedules.

Study Details

Study typeFda approval
PublishedJun 2000
View Original Abstract ↓
1 INDICATIONS AND USAGE TRELSTAR is indicated for the treatment of advanced prostate cancer [ see Clinical Studies (14) ]. TRELSTAR is a gonadotropin releasing hormone (GnRH) agonist indicated for the treatment of advanced prostate cancer. ( 1 )
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