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FDA approved Trelstar (triptorelin) for Advanced Prostate CancerFDA approved Trelstar for advanced prostate cancer treatment.

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Key Takeaway
Consider Trelstar as a GnRH agonist option for advanced prostate cancer with dosing every 4, 12, or 24 weeks.

The FDA has approved Trelstar (triptorelin) for the treatment of advanced prostate cancer. Trelstar is a gonadotropin releasing hormone (GnRH) agonist that suppresses testosterone production. The approval provides clinicians with a flexible dosing option: 3.75 mg every 4 weeks, 11.25 mg every 12 weeks, or 22.5 mg every 24 weeks, administered as a single intramuscular injection in either buttock. The dosage strengths are not additive and must be selected based on the desired dosing schedule. The drug is supplied as a lyophilized powder that must be reconstituted with sterile water and injected within 2 minutes. This approval offers an additional hormonal therapy option for patients with advanced prostate cancer.

Clinical Details (Mechanism · Dosing · Trial Data · Warnings)
Mechanism of Action

Trelstar is a gonadotropin releasing hormone (GnRH) agonist. It suppresses testosterone production in patients with advanced prostate cancer.

Indication & Patient Population

Trelstar is indicated for the treatment of advanced prostate cancer.

Dosing & Administration

Trelstar is administered as a single intramuscular injection in either buttock. The dosage strengths are not additive and must be selected based on the desired dosing schedule: 3.75 mg every 4 weeks, 11.25 mg every 12 weeks, or 22.5 mg every 24 weeks. The lyophilized microgranules are to be reconstituted in sterile water only. The suspension should be administered within 2 minutes after reconstitution. The injection site should be alternated periodically.

Key Clinical Trial Data

Trial data not available in label.

Warnings & Contraindications

Not reported in label.

Place in Therapy

Trelstar is a GnRH agonist indicated for the treatment of advanced prostate cancer, providing a hormonal therapy option with flexible dosing schedules.

The FDA has approved a new drug called Trelstar (triptorelin) for the treatment of advanced prostate cancer. Trelstar works by lowering testosterone levels in the body, which can help slow the growth of prostate cancer cells. It is a type of hormone therapy known as a GnRH agonist.

This drug is given as a shot into a muscle, usually in the buttock. It comes in three different doses: a shot every 4 weeks, every 12 weeks, or every 24 weeks. Your doctor will choose the schedule that is right for you. The drug is a powder that must be mixed with sterile water and injected within 2 minutes.

This approval gives patients and doctors more flexibility in choosing a treatment plan. It is an additional option for managing advanced prostate cancer. However, it is important to remember that Trelstar is not a cure. It is a treatment that helps control the disease.

If you or a loved one has advanced prostate cancer, talk to your doctor about whether Trelstar might be a good option. Your doctor can help you understand the benefits and risks based on your specific health situation.

What this means for you:
Trelstar is a new hormone therapy option for advanced prostate cancer, but it is not a cure.

Study Details

Study typeFda approval
PublishedMar 2010
View Original Abstract ↓
1 INDICATIONS AND USAGE TRELSTAR is indicated for the treatment of advanced prostate cancer [ see Clinical Studies (14) ]. TRELSTAR is a gonadotropin releasing hormone (GnRH) agonist indicated for the treatment of advanced prostate cancer. ( 1 )
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