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UFT combined with radiotherapy achieves a 38% pooled objective response rate in advanced pancreatic cancerUFT Combined with Radiotherapy Shows Promise for Pancreatic Cancer

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Key Takeaway
Note that UFT combined with radiotherapy shows a 38% pooled ORR in advanced pancreatic cancer based on observational data.

This meta-analysis synthesizes data from observational studies to evaluate the efficacy of UFT combined with radiotherapy in patients with advanced pancreatic cancer. The analysis focuses on the objective response rate (ORR) as the primary outcome and monitors adverse drug reactions (ADR) as a secondary outcome.

The meta-analysis reports a pooled ORR of 38% for the combination of UFT and radiotherapy, with a 95% CI of 13% to 67%. These findings are derived from a total sample size of 237 patients. The study also notes the occurrence of adverse drug reactions, though specific rates and tolerability metrics were not reported.

Because the underlying data consists of observational studies rather than randomized controlled trials, the results indicate an association rather than a confirmed causal effect. The evidence is limited by the observational nature of the source data and the lack of reported follow-up durations or specific safety metrics. Clinical application should be tempered by the inherent uncertainty of observational data.

How this fits prior evidence

This meta-analysis addresses a gap in the current evidence regarding the efficacy of UFT combined with radiotherapy for advanced pancreatic cancer. While other covered evidence focuses on risk factors such as fatty pancreas prevalence of 30.5% or prognostic markers like NLRP-3 expression and Surfactant protein D, this finding specifically addresses treatment response in advanced disease.

Researchers analyzed data from 237 patients with advanced pancreatic cancer to look at treatment outcomes. They specifically looked at the combination of UFT, which contains the drugs Tegafur and uracil, when used alongside radiotherapy. This type of analysis is based on observational studies rather than a controlled clinical trial.

The analysis found a pooled objective response rate of 38 percent for patients receiving both UFT and radiotherapy. While this shows a measurable response in some patients, the results come from a wide range of data points. The study also tracked adverse drug reactions to monitor how well patients tolerated the treatment.

Because these results come from observational studies, they show a link between the treatment and patient response rather than a direct cause. The findings are currently not enough to change standard medical practices. Patients should talk to their doctors to understand how these specific treatments might fit into an individual care plan.

What this means for you:
UFT combined with radiotherapy showed a 38% response rate in patients with advanced pancreatic cancer.

Common questions

What is the response rate for UFT and radiotherapy?

The analysis found a pooled objective response rate of 38 percent for patients receiving UFT combined with radiotherapy. This means that about 38 percent of the patients in the observed groups showed a measurable response to the treatment.

Who is this treatment for?

The study specifically looked at patients diagnosed with advanced pancreatic cancer. The data focused on how these patients responded when UFT, which includes the drugs Tegafur and uracil, was used together with radiotherapy.

Is this treatment proven to work?

The results come from a meta-analysis of observational studies, not a randomized controlled trial. This means the data shows a link between the treatment and the response, but it is not enough to prove a direct cause or change standard medical practices.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedAug 2026
View Original Abstract ↓
BackgroundTegafur–uracil (UFT) combined with radiotherapy is a treatment option for advanced pancreatic cancer. The purpose of this study was to evaluate the overall efficacy and safety of this combination therapy and explore potential factors associated with treatment outcomes.MethodThe meta-analysis was in line with the PRISMA 2020 and MOOSE guidelines. Web of Science, PubMed, Scopus and Embase databases were searched for eligible studies. The outcomes variables were objective response rate (ORR) and adverse drug reaction (ADR). Pooled proportions were synthesized using meta-analysis method with a random-effect model. Influential publication was determined by performing a sensitivity analysis. In addition, the potential sources of heterogeneity were examined using subgroup analyses. Publication bias was assessed using a funnel plot, Begg’s and Egger’s tests.ResultsThe 7 observational studies, included for the SRMA, were conducted between 2004 and 2016, involving secondary data of 237 patients who underwent UFT combined with radiotherapy. We found that the pooled ORR of UFT combined with radiotherapy was 38% (95% CI: 13% to 67%, P 
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