Case report describes complete remission in PDTC with combined radiotherapy and chemotherapy

This systematic review includes a case report of a 55-year-old male with advanced poorly differentiated thyroid carcinoma (PDTC) and a literature review of the general PDTC population. For the case patient, the treatment plan combined local radiotherapy and intravenous chemotherapy. The literature review described PDTC's histological features (island-like, solid-like, or trabecular-like structures) and immunohistochemical profile, with most tumors positive for thyroid globulin and TTF-1, and some positive for p53.

The case report patient achieved complete remission, with a PET/CT scan showing no increased metabolic activity throughout the body. Overall survival for this patient is currently around one year. The literature review did not report specific treatment outcomes or comparative efficacy data for the various treatments examined.

Safety and tolerability data for the combined radiotherapy and chemotherapy regimen were not reported. Key limitations include the rarity of PDTC, with very few case reports available, and the fact that treatment methods remain controversial, requiring more clinical experience. The practice relevance is restrained; while this single case may offer insights, findings from one patient cannot be generalized, and treatment decisions should be based on broader evidence when available.