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Multimodal treatment and surgical resection manage ameloblastic carcinoma with no recurrence at 6 monthsTreatment Approach for a Rare Case of Ameloblastic Carcinoma

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Key Takeaway
Note the importance of multimodal imaging to detect occult lymph node metastasis in ameloblastic carcinoma.

This case report and review of the literature describes the management of a 17-year-old male patient diagnosed with maxillary ameloblastic carcinoma. The patient underwent extensive surgical intervention, including extended tumorectomy, segmental maxillectomy, and various lymphadenectomies, followed by radiotherapy and chemotherapy. At the 6-month follow-up, no evidence of tumor recurrence or distant metastatic lesions was reported.

The authors emphasize the clinical importance of identifying occult buccofacial lymph node metastasis in patients where ameloblastic carcinoma invades buccal soft tissues. They suggest that multimodal imaging is necessary for accurate preoperative staging in these cases.

Due to the small sample size of a single case report, these findings are not generalizable to a broader population. The evidence is limited by the lack of a larger cohort to confirm the long-term efficacy of the specific multimodal treatment regimen. Clinicians should remain alert for lymph node involvement in patients with local tissue invasion.

This report describes the treatment of a 17-year-old male diagnosed with ameloblastic carcinoma, a rare type of cancer involving the upper jaw. The patient underwent a complex series of procedures, including an extended tumorectomy, a segmental maxillectomy, and a reconstruction using a submental island flap. The treatment also included radiation and chemotherapy.

After six months of follow-up, the patient showed no signs of tumor recurrence or distant metastatic lesions. The case highlights the importance of identifying hidden lymph node involvement in the face and jaw area. Doctors recommend using multimodal imaging before surgery to ensure all areas are properly staged.

Because this is a single case report, the findings cannot be applied to all patients with this condition. The results are specific to this one individual. Patients with similar concerns should discuss their specific diagnosis and treatment options with their oncology team.

What this means for you:
This single case shows a successful treatment plan for a rare jaw cancer, highlighting the need for thorough imaging.

Common questions

What was the treatment for this case of ameloblastic carcinoma?

The patient received a combination of surgeries, including an extended tumorectomy and a segmental maxillectomy. They also underwent a submental island flap reconstruction, an extended resection of the buccal mass, and lymph node dissections. Additionally, the treatment plan included both radiotherapy and chemotherapy.

What were the results of the treatment after six months?

After a six-month follow-up period, there was no evidence of tumor recurrence or distant metastatic lesions. This indicates that the multi-step treatment approach was effective for this specific patient's condition.

Why is imaging important for this type of cancer?

The case highlights the need for clinicians to be alert for hidden lymph node involvement in the face and jaw. The report recommends using multimodal imaging before surgery to properly stage the cancer and ensure all areas are addressed.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
ObjectivesTo report a rare case of maxillary ameloblastic carcinoma (AC) with buccofacial lymph node metastasis in a 17-year-old male patient, describe its clinical, radiological, and pathological progression, and provide clinical references for routine patient management.Case descriptionThe patient presented to our hospital with suspected recurrent peripheral ameloblastoma (PA). Cone-beam computed tomography (CBCT) revealed an osteolytic lesion in the right maxilla. Intraoperative frozen section pathology confirmed the diagnosis of ameloblastoma, extended tumorectomy, segmental maxillectomy, and submental island flap reconstruction were conducted. Histopathological examination confirmed the diagnosis of AC. Eight months after segmental maxillectomy, a soft tissue mass overlying the right mandibular buccal region rapidly enlarged. Contrast-enhanced CT revealed heterogeneous enhancement of the lesion with internal necrotic components. Intraoperative pathological examination suggested a malignant tumor. The patient subsequently underwent reoperation: extended resection of the right buccal mass, right suprahyoid lymphadenectomy, and right cervical lymph node dissection. Postoperative pathological examination confirmed AC with supramandibular lymph node metastasis. Following lymph node dissection, the patient received radiotherapy and chemotherapy for two months. At the 6-month follow-up, imaging and clinical examinations revealed no evidence of tumor recurrence or distant metastatic lesions. The patient is currently under regular long-term surveillance to monitor disease progression.ConclusionThis study reports a case of maxillary AC with isolated supramandibular lymph node metastasis. To our knowledge, this represents the first documented case. Clinicians should be alert to occult buccofacial lymph node metastasis in patients with AC invading the buccal soft tissues, and multimodal imaging is recommended for complete preoperative tumor staging. Individualized combined buccofacial and cervical lymph node dissection may improve locoregional control in patients complicated with buccofacial lymph node metastasis. This study can provide a reference for the identification of rare metastatic patterns and individualized diagnosis and treatment of AC.
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