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Endoscopic ultrasound-guided gastrojejunostomy shows no significant difference from surgical gastrojejunostomy in malignant gastric outlet obstructionEndoscopic procedure may shorten hospital stay for stomach blockage

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Key Takeaway
Note that EUS-GJ and SGJ show no significant differences in technical success or clinical success for MGOO.

This meta-analysis evaluated the comparative efficacy and safety of endoscopic ultrasound-guided gastrojejunostomy (EUS-GJ) versus surgical gastrojejunostomy (SGJ) in 760 patients with malignant gastric outlet obstruction (MGOO). The analysis focused on technical success, clinical success, obstruction recurrence, re-intervention rates, and length of hospital stay.

The meta-analysis found no significant difference between EUS-GJ and SGJ regarding technical success (RR = 0.98, P = 0.08) or clinical success (RR = 1.08, P = 0.07). Regarding obstruction recurrence, the results showed no significant difference (RR = 0.48, P = 0.05). Re-intervention rates also showed no significant difference between the two groups (RR = 1.48, P = 0.61).

While the mean difference for length of hospital stay was -3.57 days in favor of the EUS-GJ group, no p-value was reported for this specific outcome. No data regarding adverse events, tolerability, or specific study limitations were provided in the source. Clinical implications for choosing one procedure over the other based on these specific outcomes remain uncertain due to the lack of statistically significant differences in primary and secondary outcomes.

When a tumor blocks the exit of the stomach, it is a serious condition that requires medical intervention. Doctors have traditionally used a surgical procedure called gastrojejunostomy to clear the path. However, a newer method using endoscopic ultrasound-guided gastrojejunostomy is being compared to see if it offers a different experience for patients.

Researchers looked at data from 760 patients to compare these two methods. They found that both the surgical approach and the endoscopic procedure were equally successful in terms of technical success and clinical success. While the risk of the blockage coming back was similar in both groups, the endoscopic procedure did show a trend toward shorter hospital stays, with patients staying about 3.57 days less in the hospital.

It is important to note that while the results for recurrence were close to the threshold of being statistically significant, the overall data shows both methods are comparable in effectiveness. Because the study did not report specific safety data or side effects, patients should talk to their doctors to decide which path is best for their specific needs.

What this means for you:
Endoscopic procedures and surgery show similar success rates for stomach blockages, but the endoscopic route may shorten hospital stays.

Common questions

How does the endoscopic procedure compare to surgery for stomach blockages?

The study of 760 patients found no significant difference between the endoscopic ultrasound-guided gastrojejunostomy and surgical gastrojejunostomy in terms of technical success or clinical success. Both methods were equally effective at treating the blockage.

Can the endoscopic procedure help patients get home sooner?

Yes, the data showed that patients who underwent the endoscopic procedure stayed in the hospital for about 3.57 days less than those who had the surgical procedure. This suggests a potentially faster recovery period in the hospital.

Is the risk of the blockage coming back different between the two treatments?

The study found no significant difference in the rate of obstruction recurrence between the endoscopic and surgical methods. While the result was close to the threshold of statistical significance, both methods performed similarly in preventing the blockage from returning.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
ObjectiveTo systematically compare the key outcomes of endoscopic ultrasound-guided gastrojejunostomy (EUS-GJ) versus surgical gastrojejunostomy (SGJ) for the palliative treatment of malignant gastric outlet obstruction (MGOO).MethodsA systematic review and meta-analysis was conducted in accordance with the PRISMA statement. Databases including PubMed, Embase, Web of Science and Cochrane Library were comprehensively searched from inception to December 2025 for comparative studies of EUS-GJ and SGJ in treating MGOO. Meta-analysis was performed using a random-effects model, with subgroup and sensitivity analyses.ResultsEight studies involving 760 patients were included. Pooled analysis showed no significant differences between EUS-GJ and SGJ in technical success (RR = 0.98, P = 0.08), clinical success (RR = 1.08, P = 0.07), obstruction recurrence (RR = 0.48, P = 0.05), or re-intervention rates (RR = 1.48, P = 0.61). However, the EUS-GJ group demonstrated significant advantages, including a shorter length of hospital stay (MD= -3.57 days, P
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