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Propolis shows antimicrobial and anti-inflammatory potential for treating bacterial skin infections in companion animalsPropolis shows potential for treating skin infections in pets

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Key Takeaway
Note that propolis shows potential for antimicrobial activity in skin infections, but clinical trial data is currently lacking.

This narrative review explores the therapeutic potential of propolis for managing bacterial skin infections and pyoderma in companion animals. The authors synthesize evidence regarding the antimicrobial activity of propolis against several pathogens, including Staphylococcus spp., Pseudomonas aeruginosa, Malassezia pachydermatis, and various dermatophytes. Additionally, the review notes the potential for anti-inflammatory activity and support for wound healing.

Significant limitations exist in the current evidence base. The authors note that the evidence is primarily derived from in vitro studies, and there is a lack of clinical trials specifically investigating propolis for canine pyoderma. Furthermore, the chemically heterogeneous nature of propolis complicates its use as a standardized treatment.

Clinical application is currently limited by the lack of standardized protocols and large-scale clinical trials. While propolis shows potential as an alternative or adjunct to conventional antibiotics for skin infections in companion animals, its clinical efficacy remains unproven in vivo. Further research and standardization are required to establish its role in veterinary medicine.

How this fits prior evidence

This narrative review addresses a gap in veterinary medicine regarding alternative treatments for pyoderma. It expands upon prior evidence regarding propolis's role in human medicine, such as its use for oral mucositis in breast cancer patients and as a potential alternative for herpes lesions. While those findings established some clinical utility in humans, this review highlights that evidence for companion animal skin infections remains primarily in vitro and lacks specific clinical trials.

If your pet is struggling with a painful skin infection, finding the right treatment can be stressful. New research looks at propolis, a resin collected by bees, as a possible way to help manage these common skin issues in companion animals.

Researchers found that propolis has antimicrobial activity. This means it can fight off specific germs like Staphylococcus and Pseudomonas, as well as certain fungi and yeast. It also shows promise in reducing inflammation and helping wounds heal. These properties make it an interesting option for treating skin conditions like pyoderma.

While the results are promising, there are important things to keep in mind. Most of the evidence comes from lab tests rather than real-world clinical trials on dogs. Because propolis is chemically complex and lacks standardized testing in pets, it is not yet a proven replacement for standard medicine. Talk to your vet about how it might fit into your pet's care.

What this means for you:
Propolis shows potential to fight skin germs in pets, but more clinical trials are needed to confirm its use.

Common questions

What is propolis and can it help my pet's skin?

Propolis is a resin collected by bees. Research shows it has antimicrobial activity against common skin germs like Staphylococcus and Pseudomonas. It also shows anti-inflammatory activity and can help with wound healing, making it a potential option for treating skin infections in companion animals.

Is propolis a proven replacement for antibiotics?

Not yet. While propolis shows potential as an alternative or addition to conventional antibiotics, there are currently no clinical trials specifically investigating its use in treating canine pyoderma. More research and standardization are needed before it can be confirmed as a standard treatment.

Is the evidence for propolis in pets strong?

The current evidence is limited. Most findings are based on in vitro studies, which are tests done in a lab setting rather than on live animals. Because of this, the clinical data is currently very limited for use in companion animals.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
Bacterial skin infections are among the most prevalent health concerns in companion animals and represent a primary driver for antimicrobial prescriptions within veterinary practices. The widespread use of empirical broad-spectrum antibiotic prescribing has contributed to the emergence of antimicrobial-resistant pathogens, including Staphylococcus pseudintermedius and Pseudomonas aeruginosa in veterinary dermatology. This resistance complicates treatment outcomes and raises broader public health concerns under the One Health framework. Consequently, there is a growing need for alternative antimicrobial strategies that can reduce the reliance on conventional antibiotics. Propolis, a resinous substance produced by bees, has gained attention as a potential candidate due to its wide range of biological activities including antimicrobial, anti-inflammatory and wound healing. This structured narrative review evaluates the current evidence for propolis in the treatment of dermatologic infections in companion animals. The available evidence demonstrates that propolis exhibits antimicrobial activity against key veterinary dermatologic pathogens including Staphylococcus spp., Pseudomonas aeruginosa, Malassezia pachydermatis and dermatophytes. However, this evidence is primarily based on in vitro studies with very limited clinical data. While clinical studies have examined propolis in other veterinary dermatologic applications, no clinical trials to date have specifically investigated its use in the treatment of canine pyoderma, a common and frequently recurring skin infection in canine practice. Recommendations for future research include controlled clinical trials evaluating propolis for the treatment of companion animal skin infections as an adjunct to, or potential alternative for, conventional antibiotics, the development of standardization protocols due to the chemically heterogeneous nature of propolis and refinement of delivery systems. Overall, these findings support the promising potential of propolis as a treatment for skin infections in companion animals.
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