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Rectal endometriosis as a potential diagnosis for women with rectal submucosal lesionsRectal endometriosis can mimic other gastrointestinal tumors in women

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Key Takeaway
Consider rectal endometriosis as a possible diagnosis for women presenting with rectal submucosal lesions.

The authors presented a case report and a review of literature regarding rectal endometriosis. The primary focus was on the histopathological confirmation of ectopic endometrial glands and stroma in a patient presenting with a rectal submucosal lesion. The study also explored the overlap between intestinal endometriosis and gastrointestinal tumors in terms of diagnostic presentation.

Findings indicated that the case patient showed positive estrogen and progesterone receptors along with specific stromal markers. The literature review of additional cases highlighted that these conditions can present with overlapping features, making clinical differentiation important. The authors noted that symptoms may not always be periodic in patients with these lesions.

Limitations include the small sample size consisting of one case report and a limited number of reviewed cases. Because this is not a large-scale trial, the evidence is primarily descriptive. Clinicians should consider rectal endometriosis as a possible diagnosis for women with rectal submucosal lesions, even in the absence of periodic symptoms, to ensure accurate management.

When a woman presents with a growth in the rectum, doctors often look for common gastrointestinal tumors. However, a new look at these cases suggests that rectal endometriosis—where tissue similar to the lining of the uterus grows in the rectum—can look almost identical to other tumors. This makes it a tricky diagnosis to catch early.

One specific case and a review of 12 other cases showed that these conditions share overlapping features. In the primary case, doctors confirmed the presence of endometrial glands and stroma, which are the building blocks of the uterine lining. This finding highlights that even if a patient does not experience symptoms tied to her menstrual cycle, the condition could still be present.

Because these conditions look so similar under a microscope, doctors should consider rectal endometriosis as a possibility for any woman with a rectal submucosal lesion. While the evidence comes from a small number of cases rather than a large trial, it serves as a reminder to look closely at all possibilities when treating these complex issues.

What this means for you:
Rectal endometriosis can mimic other tumors, so it should be considered for any woman with rectal lesions.

Common questions

What is rectal endometriosis?

Rectal endometriosis happens when tissue similar to the lining of the uterus grows in the rectum. In this study, doctors confirmed the presence of endometrial glands and stroma in a patient's tissue. This means the tissue behaved like uterine tissue even though it was located in the digestive tract.

Can rectal endometriosis look like other conditions?

Yes. The study found that intestinal endometriosis and gastrointestinal tumors have overlapping diagnoses. This means they can look very similar during medical exams. Because they look so much alike, it is important for doctors to consider both possibilities when they find a lesion in the rectum.

Does a patient need period symptoms to have rectal endometriosis?

Not necessarily. The findings suggest that doctors should consider rectal endometriosis for women with rectal submucosal lesions even if they do not have periodic symptoms. Because the condition can mimic other tumors, it is important to check for it regardless of whether the patient's symptoms follow a cycle.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedNov 2026
View Original Abstract ↓
Rectal endometriosis may be similar to gastrointestinal stromal tumors (GIST), especially in women without typical gynecological or cyclical gastrointestinal symptoms. A 45-year-old female patient had an eight-year history of rectal defecation difficulty and increased defecation frequency, but no dysmenorrhea or increased menstrual flow. Colonoscopy revealed a smooth protruding lesion on the rectal surface, and endoscopic ultrasound showed a heterogeneous lesion within the muscular layer, with intact surface mucosa, suggesting the possibility of GIST. A laparoscopic anterior resection was performed. Postoperative histopathology showed ectopic endometrial glands and stroma, combined with positive estrogen and progesterone receptors and expression of CD10 in the stroma, confirming rectal endometriosis. The patient’s symptoms improved significantly and recovered well. Subsequently, this study reviewed 12 reported cases, and the results showed that intestinal endometriosis and gastrointestinal tumors have overlapping diagnoses in terms of diagnosis. Even without periodic symptoms, the possibility of rectal endometriosis should be considered for women with rectal submucosal lesions. A comprehensive assessment of clinical history, pelvic anatomical relationship, imaging examinations, and histological evaluation should be conducted to establish the diagnosis and guide treatment.
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