Preoperative HALP, SII, and LMR scores predict disease-free survival in stage III colon cancer patients.
This retrospective cohort study analyzed preoperative HALP, SII, and LMR scores in a population comprising 210 patients with stage III colon cancer who underwent curative resection and 220 patients with benign colonic lesions. The primary outcome was disease-free survival (DFS), with secondary outcomes assessing diagnostic performance for malignancy. The study design was retrospective, and follow-up duration was not reported.
For diagnostic performance, HALP showed an AUC of 0.773, SII showed an AUC of 0.758, and LMR showed an AUC of 0.739. All three markers demonstrated moderate discrimination for malignancy. Absolute numbers for these performance metrics were not reported, and p-values or confidence intervals were not reported for the diagnostic outcomes.
Regarding DFS, HALP was an independent predictor with a hazard ratio of 0.384 (95% CI: 0.225–0.655). LMR was also an independent predictor with a hazard ratio of 0.483 (95% CI: 0.286–0.815). Tumor stage was a risk factor with a hazard ratio of 2.435 (95% CI: 1.432–4.140). Chemotherapy cycles were protective with a hazard ratio of 0.380 (95% CI: 0.223–0.647). A nomogram built on these variables showed good discrimination with a C-index of 0.759 in the training set and 0.743 in the validation set.
Safety data, including adverse events and tolerability, were not reported. The study limitations include its retrospective design, which prevents distinguishing association from causation. Additionally, surrogate versus clinical outcomes were not distinguished. These scores may enable individualized recurrence risk estimation and inform postoperative risk-adapted management.
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