Deep hyperthermia with tislelizumab and chemotherapy in advanced squamous NSCLC
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Key Takeaway
Note the association between adding deep hyperthermia to tislelizumab and chemotherapy and increased ORR in squamous NSCLC.
This single-center retrospective cohort study included 100 patients with advanced squamous non-small cell lung cancer (NSCLC) undergoing initial treatment. The study compared a group receiving deep hypertherma combined with tislelizumab and chemotherapy to a control group receiving only tislelizumab plus chemotherapy.
The primary outcome was the objective response rate (ORR). In the experimental group, the ORR was 66.0% (33/50), whereas the control group ORR was 46.0% (23/50), representing a statistically significant difference (P = 0.044). The disease control rate (DCR) was 86.0% (43/50) in the experimental group and 84.0% (42/50) in the control group, though a p-value was not reported for this metric.
Regarding survival, there was no statistically significant difference in median progression-free survival (PFS) (P = 0.647) or median overall survival (OS) (P = 0.370) between the two groups. Follow-up duration was not reported.
Safety assessments showed no statistically significant difference in the incidence of treatment-related adverse events (TRAEs) between the experimental and control groups. Data regarding serious adverse events, discontinuations, and specific tolerability metrics were not reported.
As a single-center retrospective study, these results are limited by potential biases. While the addition of deep hyperthermia was associated with higher ORR, larger-scale testing is necessary to confirm these findings.
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View Original Abstract ↓
PurposeTo investigate the efficacy and safety of deep hyperthermia combined with tislelizumab and chemotherapy in patients with advanced squamous non-small cell lung cancer (NSCLC).MethodsA total of 100 patients with advanced squamous NSCLC undergoing initial treatment at our hospital between January 2021 and early January 2023 were enrolled. Patients were categorized into an experimental group (n=50) and a control group (n=50). The control group received tislelizumab plus chemotherapy, while the experimental group received deep hyperthermia combined with tislelizumab and chemotherapy. The main objective was objective response rate (ORR). Secondary endpoints encompassed overall survival (OS), progression-free survival (PFS), disease control rate (DCR), and safety.ResultsORR in the experimental group was 66.0% (33/50), with a DCR of 86.0% (43/50). The ORR and DCR in the control group were 46.0% (23/50) and 84.0% (42/50), respectively. ORR in the experimental group was higher than that in the control group(P = 0.044). There was no statistically difference in the incidence of treatment-related adverse events (TRAEs) between the two groups (P>0.05). The median PFS and median OS in the experimental group showed no statistically difference compared to the control group (P = 0.647; P = 0.370).ConclusionThe combination of deep hyperthermia, tislelizumab, and chemotherapy as an initial therapy for advanced squamous non-small-cell lung cancer (NSCLC) is safe and effective and should be tested on a larger scale in the future.
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