Interferon-alpha gel reduces recurrence in nasal inverted papilloma patients compared to surgery alone

To investigate the expression of HPV 6/11 in NIP tissues and evaluate the adjuvant therapeutic effect of interferon-α gel on HPV-positive NIP patients. Forty-two newly diagnosed Nasal Inverted Papilloma（NIP） patients were included, and the expression of HPV6/11 in tissues was detected using fluorescence in situ hybridization with specific probes. Twenty-two HPV-positive patients were randomly divided into an interferon treatment group（=11） and a control group（=11）. Both groups underwent endoscopic tumor resection, with the treatment group receiving local application of interferon-α gel during and after surgery. Postoperative recovery was assessed using the DIP endoscopic scoring system at 3, 6, and 12 months. The positive expression rate of HPV6/11 in NIP tissues was 52.38%（22/42）, which was significantly higher than that in the nasal polyp control group（8.33%, 1/12）（<0.05）. Among HPV-positive NIP patients, there were no statistically significant differences were observed in DIP scores between the interferon treatment group and the control group at 3, 6, and 12 months postoperatively（>0.05）. HPV6/11 shows high expression in NIP tissues, but the use of interferon-α gel did not improve postoperative recovery in HPV-positive patients.