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PHOMS observed in both arteritic and nonarteritic anterior ischemic optic neuropathy in small cohortSmall study finds PHOMS in both A-AION and NA-AION eyes with no clear difference

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Key Takeaway
Note preliminary evidence of PHOMS in both A-AION and NA-AION from a small, exploratory cohort.

This exploratory retrospective cohort study analyzed 22 patients (22 eyes) with arteritic anterior ischemic optic neuropathy (A-AION) or nonarteritic anterior ischemic optic neuropathy (NA-AION), with 11 eyes in each subtype. The patients were enrolled from two prior prospective studies. The study compared the prevalence of peripapillary hyperreflective ovoid mass-like structures (PHOMS) and various structural retinal parameters between the two AION subtypes.

PHOMS was observed in both A-AION and NA-AION. The prevalence was 36.4% (4 of 11 eyes) in A-AION and 18.2% (2 of 11 eyes) in NA-AION, yielding an odds ratio of 2.57 (95% CI, 0.36–18.33; p = 0.635), which was not statistically significant. Bruch’s membrane opening diameter was similar between groups (A-AION: 1546.78 ± 134.14 µm; NA-AION: 1507.27 ± 133.95 µm). The mean peripapillary retinal nerve fiber layer thickness was reported as larger in A-AION than in NA-AION, though exact numbers were not provided. No differences were observed for macular ganglion cell layer volume, other retinal layer volumes, total retinal volume, or visual acuity.

Safety and tolerability data were not reported. Key limitations include the exploratory retrospective design, very small sample size, and the need for confirmation in larger, prospective studies. The authors suggest the presence of PHOMS in AION may reflect axoplasmic disturbance related to the ischemic insult itself rather than the underlying disease etiology. Given the preliminary nature of this evidence, these findings should not be used to guide clinical decision-making at this time.

This research looked at images from 22 patients who had either arteritic anterior ischemic optic neuropathy or nonarteritic anterior ischemic optic neuropathy. The team examined whether a bright spot known as PHOMS was present and measured other retinal structures like nerve fiber layers and cell volumes. They used data from two earlier studies that had already collected these scans.

The results showed that PHOMS was seen in 36.4% of eyes with arteritic disease and 18.2% of eyes with nonarteritic disease. However, the difference was not statistically significant, meaning the study could not prove a true link between the disease type and the presence of this spot. Other measurements of retinal thickness and cell volume did not show clear differences between the two groups.

The researchers suggest that seeing PHOMS in these patients may reflect damage from the lack of blood flow rather than the specific cause of the disease. Because the study was small and retrospective, the findings are uncertain. Readers should not assume this feature predicts one disease over the other or that it changes how doctors should treat these conditions right now.

What this means for you:
Small study shows PHOMS in both A-AION and NA-AION; larger research needed to confirm findings.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
IntroductionA peripapillary hyperreflective ovoid mass-like structure (PHOMS) is an optical coherence tomography (OCT) specific finding associated with axoplasmic stasis in various optic neuropathies. Its occurrence in arteritic anterior ischemic optic neuropathy (A-AION) has not previously been described, and its prevalence and structural implications across AION subtypes remain incompletely understood.Materials & methodsIn this exploratory retrospective, age-matched study, patients with A-AION and nonarteritic AION (NA-AION) enrolled in two prior prospective studies between March 2021 and August 2024 were included. All eyes had undergone high-resolution spectral-domain OCT imaging of the optic nerve head as well as visual acuity assessment on first visit of diagnosis. PHOMS was identified according to Optic Disc Drusen Studies (ODDS) Consortium criteria.ResultsTwenty-two patients (22 eyes) were included, with 11 eyes in each AION subtype. PHOMS was observed in both A-AION and NA-AION. PHOMS was identified in 4 of 11 eyes (36.4%) with A-AION compared with 2 of 11 eyes (18.2%) with NA-AION. The estimated odds ratio for PHOMS presence in A-AION compared with NA-AION was 2.57 (95% CI, 0.36–18.33; p = 0.635). Bruch’s membrane opening diameter was similar between groups (A-AION: 1546.78 ± 134.14 μm; NA-AION: 1507.27 ± 133.95 μm), while mean peripapillary retinal nerve fiber layer thickness was larger in A-AION than in NA-AION. No differences were observed in macular ganglion cell layer volume, other retinal layer volumes, total retinal volume, or visual acuity between subtypes.DiscussionThe observation of PHOMS across ischemic optic neuropathy subtypes suggests that PHOMS in AION may reflect axoplasmic disturbance related to the ischemic insult itself rather than the underlying disease etiology, although confirmation in larger, prospective studies is warranted.
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