Multilayer facial fat grafting with processed adipose products shows aesthetic improvement in retrospective cohort

A retrospective cohort study evaluated 105 patients undergoing facial rejuvenation for age-related contour deformities using multilayer fat grafting with differentially processed adipose products. The approach involved strategic application of high-density fat (HDF) and adipose matrix complex (AMC) for structural support in deeper facial regions, and stromal vascular fraction gel (SVF-gel) for periorbital rejuvenation and skin quality enhancement. No control group was included in this observational design.

All 105 patients (105/105) achieved significant aesthetic improvement according to clinical evaluation. Patient-reported satisfaction scores increased from preoperative 5.26 ± 1.84 to postoperative 8.01 ± 1.09 on a Visual Analog Scale. Observer assessments using the Global Aesthetic Improvement Scale showed a postoperative score of 1.88 ± 0.65, though the scale range and interpretation were not reported. Sixteen patients required secondary procedures due to partial volume absorption.

Safety data indicated early side effects resolved spontaneously within 3 weeks, with no major complications reported. Key limitations include the retrospective design, absence of a control group, and lack of reported follow-up duration. The study did not report primary outcomes, effect sizes, or statistical comparisons. Funding and conflicts of interest were not disclosed.

For clinical practice, these findings suggest that targeted application of processed adipose products based on biological properties may enable effective multilayer facial restoration. However, the low certainty evidence from this uncontrolled retrospective cohort prevents definitive conclusions about efficacy compared to standard approaches. Clinicians should interpret these results cautiously while awaiting prospective comparative studies with longer follow-up.