Mode
Text Size
Log in / Sign up

Osteoporotic fracture prevalence in Latin America is 10.2% among 1,182,219 participantsMeta-analysis reveals commonality of osteoporotic fractures in Latin America

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Note that osteoporotic fractures have a 10.2% prevalence in Latin America, with vertebral fractures being the most frequent.

This meta-analysis synthesized data from a large population of 1,182,219 adults in Latin America to evaluate the prevalence of osteoporotic fractures (OF) and fragility fractures. The study aimed to provide a comprehensive epidemiological overview of fracture prevalence across diverse regions within Latin America, focusing on both clinical and population-based samples.

The primary outcome measured was the pooled prevalence of osteoporotic fractures. The analysis reported a pooled prevalence of 10.2%, representing 47,954 osteoporotic fractures out of 1,182,219 participants. The 95% confidence interval for this estimate was 5.0-16.9%. Due to the high level of heterogeneity in the included data, these prevalence estimates are characterized as indicative rather than precise.

Secondary outcomes included the analysis of prevalence by population type, fracture type, and sex. Regarding population type, the analysis found significantly higher estimates in clinical samples compared to population-based studies (p < 0.001). Analysis of fracture types revealed that vertebral fractures were the most frequent, with a prevalence of 19.1% (p = 0.002). When examining sex differences, the data showed no overall sex differences in prevalence. However, after stratification, women demonstrated a higher prevalence of both vertebral and non-vertebral fractures.

Safety and tolerability data were not reported, as the study was an epidemiological meta-analysis rather than a clinical trial. The study identified substantial heterogeneity (I = 100%) across the included data, which impacts the precision of the pooled estimates. This heterogeneity suggests significant variability in reporting, study design, or population characteristics across the Latin American region.

These results provide a baseline for understanding the scale of the osteoporotic fracture burden in Latin America. While the study does not provide direct clinical intervention data, it highlights the prevalence of specific fracture types, such as vertebral fractures, which are the most frequent. The finding of higher prevalence in clinical samples compared to population-based studies suggests a potential selection bias or a higher concentration of symptomatic patients in clinical settings.

Clinically, these results indicate that osteoporotic fractures represent a substantial health burden in the region. The high prevalence of vertebral fractures suggests a need for targeted screening and early diagnosis in these patients. The findings underscore the necessity for improved epidemiological surveillance to better understand the distribution of fractures. The high heterogeneity noted in the study suggests that local variations in healthcare access and reporting may influence the observed prevalence rates.

Several questions remain regarding the specific drivers of the higher prevalence in clinical samples and the specific factors contributing to the 100% heterogeneity. Further research is needed to determine if these trends are consistent across all sub-regions of Latin America and to identify specific risk factors that contribute to the higher prevalence of vertebral fractures in women.

How this fits prior evidence

How this fits prior evidence This meta-analysis addresses a gap in regional epidemiological data for Latin America. While previous coverage noted a lack of robust clinical evidence and safety data for angiogenesis-targeting strategies in osteoporosis, this study provides a large-scale quantification of the actual burden of osteoporotic fractures in the region, specifically identifying a 10.2% prevalence and the high frequency of vertebral fractures.

Osteoporotic fractures occur when bones become weak and brittle, often due to a condition called osteoporosis. These fractures are a significant concern for many adults, as they can lead to chronic pain and a loss of independence. For people living in Latin America, understanding how common these fractures are is a vital first step toward improving healthcare, early diagnosis, and prevention strategies for the aging population.

To understand the scope of this issue, researchers conducted a meta-analysis involving a very large group of participants. The study included data from 1,182,219 individuals across Latin America. By looking at such a large number of people, the researchers aimed to find a clear picture of how often osteoporotic fractures, also known as fragility fractures, occur in this specific region.

The results showed that the overall prevalence of osteoporotic fractures was about 10.2%. This means that out of the large group studied, nearly 48,000 people experienced these types of fractures. When looking closer at the types of fractures, the researchers found that vertebral fractures, which occur in the bones of the spine, were the most common type, occurring in about 19.1% of cases. When looking at gender, the study found no overall difference in fracture rates between men and women. However, when the data was broken down into specific categories, women did show a higher prevalence of both vertebral and non-vertebral fractures.

It is important to note that this study has some limitations that should be considered when looking at the results. The data showed a high level of variation, which means the results are intended to give a general idea of the situation rather than a precise, exact number for every specific area. Because the data came from many different sources, the findings are meant to be indicative of the general trend rather than a perfect calculation.

For patients and healthcare providers, these findings highlight that osteoporotic fractures are a significant health burden in the region. While this study does not provide a new treatment or a specific medical recommendation, it highlights the need for better monitoring and earlier detection of bone weakness. Currently, these results serve as a call to action for better public health awareness and more consistent screening for those at risk of bone fractures.

What this means for you:
About 10% of the population in Latin America experiences osteoporotic fractures, with spine fractures being common.

Study Details

Study typeMeta analysis
Sample sizen = 1,182,219
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
BACKGROUND: Osteoporotic fractures (OF), or fragility fractures, are a major cause of morbidity, mortality, and healthcare utilization worldwide. While their burden is well described in high-income countries, data in Latin America remain fragmented and poorly synthesized. OBJECTIVE: To systematically review and synthesize available evidence on the prevalence of OF among adults in Latin America. METHODS: We conducted a systematic review and meta-analysis of observational studies, following JBI methodology and PRISMA 2020 guidelines. MEDLINE, Scopus, Virtual Health Library, and Google Scholar were searched up to January 8, 2025. Random-effects meta-analysis with restricted maximum likelihood estimation and Hartung-Knapp adjustment was used. Subgroup and sensitivity analyses were conducted according to population type, fracture ascertainment method, age group, sex, country, setting, and fracture type. Univariable meta-regression was used to explore sources of heterogeneity. Risk of bias was assessed using the JBI checklist. RESULTS: Twenty-two studies were included in the systematic review, and 16 contributed to the meta-analysis, comprising 1,182,219 participants and 47,954 osteoporotic fractures. The pooled prevalence of OF was 10.2% (95% CI 5.0-16.9%), with substantial heterogeneity (I = 100%). Prevalence varied significantly according to population type (p < 0.001), with higher estimates in clinical samples than in population-based studies, and by fracture type (p = 0.002), with vertebral fractures being the most frequent (19.1%). No overall sex differences were identified, although women had higher prevalence of vertebral and non-vertebral fractures after stratification. Meta-regression identified country and fracture type as significant contributors to heterogeneity. CONCLUSIONS: OF represent a substantial but highly heterogeneous health burden, and pooled prevalence estimates should be interpreted as indicative rather than precise estimates. Strengthening epidemiological surveillance and implementing early diagnosis and prevention strategies should be prioritized to address the growing impact of OF in the region.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.