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Surgical exploration resolved recurrent hemarthrosis in a patient with total knee arthroplastyKnee Bleeding Solved Without Major Angio

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Key Takeaway
Note that surgical exploration may resolve recurrent hemarthrosis after TKA when angiography is negative or embolization is not feasible.

This case report details the management of a 69-year-old woman presenting with recurrent hemarthrosis after total knee arthroplasty. The patient underwent surgical exploration which included ligation, synovectomy, and spacer exchange. Angiography was negative, and embolization was not performed, leading to the decision for surgical intervention to identify occult bleeding sources or mechanical instability.

At two-year follow-up, the patient achieved complete symptom resolution and restored joint function. No adverse events, serious adverse events, discontinuations, or specific tolerability issues were reported in this single case. The study design is a case report with a literature review, involving a sample size of one patient.

Key limitations include the lack of a control group, the absence of statistical analysis, and the inherent constraints of a single-patient report. Statistical significance and confidence intervals were not reported. The certainty of the evidence is low due to the study phase and design.

In the setting of negative angiography or inability to perform embolization, surgical exploration may play a critical role in identifying occult bleeding sources, mechanical instability, and soft-tissue pathology in patients with recurrent hemarthrosis after total knee arthroplasty. However, this practice relevance is based on a single case and should be interpreted with caution.

The Sticky Situation

Imagine waking up with a fresh bruise on your knee every morning. It feels like a fresh cut that never heals. For many people, this is just a bad bruise. But for others, it is a serious medical problem called hemarthrosis. This means blood is filling the space inside the knee joint.

This happens after total knee arthroplasty, or a full knee replacement. Most patients do fine. But some face a frustrating cycle of swelling and pain. They get scans. The doctors say the blood vessels look fine. Yet, the bleeding continues.

Current standard practice relies heavily on angiography. This is a special X-ray test that looks at blood vessels. Doctors use it to find leaks. If they see a leak, they can plug it with a tiny catheter. This is called embolization. It is less invasive than open surgery.

But here is the problem. Sometimes the X-ray looks normal. The test says there is no active bleeding. Yet, the patient still bleeds. This leaves doctors guessing. They might miss the real cause. The patient suffers in the meantime.

The Surprising Shift

Old thinking said if the X-ray was clean, the vessel was fine. This new case changes that view. It shows the bleeding can come from other places. It can come from a torn soft tissue or a mechanical issue.

But here is the twist. Sometimes the blood vessel is not the only problem. The tissue around it might be weak. Or the knee might be unstable. When the X-ray misses these details, surgery becomes the necessary next step.

What Scientists Didn't Expect

To understand this, we need a simple picture. Think of a garden hose. If water sprays out, you see the leak. But what if the water is coming from a crack in the pipe wall? You might not see the spray from the outside.

In the knee, the "pipe" is the artery. The "wall" is the soft tissue. Sometimes the tissue gets thick and overgrown. This is called synovial hyperplasia. It can press on a small artery. This pressure causes a tiny leak. Standard X-rays often miss this pressure. They only see the main pipe, not the wall around it.

Doctors treated a 69-year-old woman. She had both knees replaced. Eleven months later, her left knee started bleeding again. It was not from an injury. She had no falls or accidents.

The team performed a detailed angiogram. This is the gold standard for finding vessel leaks. The scan showed a strange spot. It looked like a possible aneurysm. But there was no active spray of contrast dye. This meant no active leak was seen on the scan.

Because the scan was negative, they did not do the catheter procedure. Instead, they went straight to surgery. They opened the knee to look directly at the problem.

The surgery revealed the truth. The X-ray had missed the real issue. The team found three main problems. First, the lining of the knee was too thick. Second, the knee was unstable when bent. Third, a small artery was pulsing blood out.

They fixed the artery by tying it off. They removed the thick lining. They also changed the spacer inside the knee. This addressed the instability.

The result was complete healing. Two years later, the patient had no pain. Her knee function returned to normal. She could walk and move without the daily cycle of swelling.

This doesn't mean this treatment is available yet. This specific case highlights a pattern that might happen in other patients. It suggests that negative scans do not always mean the job is done.

The Bigger Picture

Experts agree that knee bleeding is often complex. It is rarely just one thing. It can be a mix of vessel issues and soft tissue problems. Relying only on scans can lead to missed diagnoses.

Direct surgical exploration allows doctors to see everything. They can feel the instability. They can see the thick tissue. They can find the small leak that a camera missed. This comprehensive view leads to better long-term results.

If you have had a knee replacement and bleeding returns, talk to your doctor. Ask if a scan was done. If the scan was normal but bleeding continues, ask about surgical options.

Do not assume the problem is gone just because an X-ray says so. Persistent bleeding needs a full investigation. Sometimes, looking directly is the only way to find the answer.

The Limitations

This report is a single case. It involves one woman. We cannot say this will happen to everyone. Other patients might have different causes for their bleeding. Some might still be fixed with a catheter.

Also, the study includes a literature review. This means it looks at many past cases. Some of those cases are older. Medical tools change over time. The findings must be applied carefully to modern patients.

More research is needed to understand these hidden causes. Doctors need to know how often this happens. They need to decide when to scan and when to operate.

Until then, the message is clear. Do not ignore persistent bleeding. If scans fail, surgery is a valid and important option. It helps patients get back to their lives.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
BackgroundRecurrent hemarthrosis following total knee arthroplasty (TKA) is an uncommon but challenging complication. While angiographic intervention is typically effective, some cases require surgical intervention.Case presentationWe report a 69-year-old woman who developed recurrent, non-traumatic hemarthrosis of the left knee 11 months after bilateral total knee arthroplasty. Diagnostic digital subtraction angiography (DSA) demonstrated an abnormal angiographic blush in the suspected branch of the lateral inferior genicular artery, raising suspicion of a possible pseudoaneurysm but without definitive diagnostic features. No active contrast extravasation was observed during angiography, and therefore transcatheter arterial embolization was not performed at that time. Surgical exploration revealed synovial hyperplasia, flexion instability, and pulsatile bleeding from a small artery at the posterolateral superior aspect of the knee joint. Ligation, synovectomy, and spacer exchange were performed.OutcomeThe patient experienced complete symptom resolution and restored joint function during a two-year follow-up.ConclusionThis case underscores that recurrent hemarthrosis after total knee arthroplasty may be multifactorial. In the setting of negative angiography or inability to perform embolization, surgical exploration plays a critical role in identifying occult bleeding sources, mechanical instability, and soft-tissue pathology.
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