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Retrospective CT study reports ACP pneumatization prevalence and morphological patterns in Thai adultsNew Map for Skull Base Surgery Risks

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Key Takeaway
Note that ACP pneumatization occurs in 30.8% of a Thai cohort, with isolated optic strut involvement being the most frequent subtype.

This retrospective computed tomography (CT)-based cohort study examined 400 instances of anterior clinoid process (ACP) pneumatization derived from 200 patients within a Thai population aged 10 years or older. The primary objective was to determine the prevalence and morphological patterns of ACP pneumatization. Secondary objectives included collecting ACP morphometric data and identifying associated bone variations. The analysis utilized existing CT imaging data to characterize these anatomical variations without prospective follow-up or intervention.

The study found that ACP pneumatization was present in 30.8% of the evaluated cases. Bilateral involvement was observed in 5% of cases. Among the identified subtypes, isolated optic strut pneumatization (subtype 1) was the most frequent, accounting for 16% of cases. Subtype 2a, characterized by limited ACP involvement via the optic strut, represented 6% of cases. Planum-based and combined subtypes were noted as uncommon findings within this cohort.

No adverse events, serious adverse events, discontinuations, or specific tolerability data were reported in the study, as the investigation was purely descriptive and observational. Consequently, no causal links between ACP pneumatization and clinical symptoms or surgical outcomes can be inferred from these data. The study design limits the ability to generalize findings beyond the specific Thai population sampled. Furthermore, the absence of a comparator group precludes assessment of the clinical significance of these anatomical variants compared to non-pneumatized ACPs.

These results offer descriptive anatomical data relevant to neurosurgical and otolaryngological planning but lack the evidence strength to guide clinical management decisions. The findings should be interpreted as baseline prevalence data rather than indicators of disease or risk. Further research is required to correlate these morphological patterns with clinical outcomes in broader populations.

Imagine a surgeon carefully removing a bone to reach a tumor. Suddenly, a hidden air pocket appears where solid bone should be. This can lead to dangerous leaks or nerve damage.

The anterior clinoid process is a small bone near your eye and brain. Surgeons need to remove it to treat certain tumors or blockages. But this bone changes shape in many people.

When air fills this bone, it creates a weak spot. This can cause spinal fluid to leak out. It can also push against the optic nerve. This nerve controls your vision.

Doctors have struggled with this for years. Old maps did not show all the different shapes. This left surgeons guessing during critical moments.

The surprising shift

For a long time, experts thought these air pockets were rare. They also believed they were easy to spot on scans. This study changes that view.

Researchers looked at 400 cases from 200 patients. They found air pockets in over 30% of skulls. That is much higher than previous estimates suggested.

What scientists didn't expect

The team found eight different ways air could fill the bone. Some air comes through the optic strut. Others come through the planum sphenoidale. Sometimes both routes are open.

Think of the bone like a wall with different windows. Air can enter through one window, the other, or both. The old maps only showed a few window types. This new map shows all of them.

Air enters the bone through natural openings. These openings connect the skull to air-filled spaces nearby. When the opening is wide, air rushes in. When it is narrow, air stays out.

The study measured how much of the bone was filled with air. If less than half was filled, it was one type. If more than half was filled, it was another. This detail helps surgeons know exactly what to expect.

The team used CT scans to look inside the skulls. They focused on people aged 10 and older. They checked 400 anterior clinoid processes in total.

They grouped the findings into eight clear categories. Each category described the path the air took and how far it traveled. This simple system replaces confusing old labels.

Air pockets appeared in 30.8% of the cases. This means roughly one in three people has this variation. In most cases, only one side of the skull was affected.

The most common type involved just the optic strut. This was seen in 16% of cases. Another type involved a small amount of bone. This was seen in 6% of cases.

Combined types were much rarer. Only a few cases showed air entering through both routes at once. This tells surgeons which risks are most common and which are rare.

This doesn't mean this treatment is available yet.

The study focuses on understanding the anatomy, not on a new drug or device. It gives doctors a better guidebook for what they will see.

Surgeons rely on accurate maps to stay safe. If a map is wrong, a surgeon might miss a hidden danger. This new classification makes the map more accurate for Thai patients.

It also helps doctors from other regions. Bone shapes can vary by population. Having a detailed map for this group is a big step forward.

If you need skull base surgery, talk to your doctor about your specific anatomy. Your scan will show your unique bone shape.

This research helps doctors plan better. It reduces the chance of surprises during surgery. You can feel more confident knowing the team has a clear plan.

This study looked only at patients in Thailand. Bone shapes might differ in other countries. Also, the data comes from past scans, not real-time surgery.

These limits mean the map needs more testing. It is a strong start, but more work is needed.

Next, doctors will test this map in real surgeries. They will see if it helps avoid leaks and nerve injuries.

More studies will check if this applies to other groups. The goal is a safe surgery for everyone. This research brings us closer to that goal.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
IntroductionThe anterior clinoid process (ACP) is a critical anatomical landmark during skull base surgery. However, ACP pneumatization poses several risks during anterior clinoidectomy, including cerebrospinal fluid (CSF) leakage and optic nerve injury. Existing classification systems inadequately address clinically significant variations such as those involving the optic strut or planum sphenoidale. Therefore, this study aimed to determine the prevalence and morphological patterns of ACP pneumatization in a Thai population and propose a refined radiological classification system based on the route and extent of pneumatization.MethodsA retrospective computed tomography (CT)-based study was conducted on 400 ACPs from 200 patients aged ≥10 years. Pneumatization patterns were categorized into eight subtypes based on the pneumatization route (optic strut, planum sphenoidale, or both) and the degree of ACP involvement (≤50% or >50%). ACP morphometric data and associated bone variations were also assessed.ResultsACP pneumatization was observed in 30.8% of ACPs, with bilateral involvement in 5% of cases. The most frequent subtype was isolated optic strut pneumatization (subtype 1, 16%), followed by limited ACP involvement via the optic strut (subtype 2a, 6%). Planum-based and combined subtypes (3a and 4b) were uncommon (
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