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Surgical resection of submandibular schwannoma can preserve hypoglossal nerve function and tongue movementRare Nerve Tumor Found in Woman's Jaw, Surgery Saves Tongue Function

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Key Takeaway
Note that surgical resection of submandibular schwannoma can preserve hypoglossal nerve function and tongue movement.

This case report describes the surgical management of a submandibular mass in a 44-year-old woman. The report focuses on the histopathological and immunohistochemical confirmation of a schwannoma and the subsequent preservation of neurological function following surgical resection.

Key findings include the successful identification of the tumor as a schwannoma through histopathological and immunohistochemical examinations. Following the surgical procedure, the patient demonstrated normal tongue movement at a one-year follow-up, and no recurrence was noted. The anatomical continuity of the hypoglossal nerve was preserved during the intervention.

The authors note limitations including a small sample size of a single case and the fact that an MRI was not performed due to financial considerations and patient reluctance. Because this is a single case report, the findings are not generalizable to the broader population. Clinical relevance lies in the potential for preoperative recognition of the hypoglossal nerve origin to facilitate surgical planning and the preservation of both the functional nerve and the uninvolved submandibular gland.

How this fits prior evidence

This case report addresses a gap in surgical management of submandibular schwannomas by demonstrating successful nerve preservation. It differs from the previously reported mediastinal schwannoma, which was noted for mimicking malignancy on PET, and the pediatric tongue root schwannoma, which was managed via endoscopic plasma resection.

A new case report describes a 44-year-old woman who had a mass under her left jaw. Doctors removed it with surgery. Tests later confirmed it was a schwannoma, a rare, usually noncancerous tumor that grows from nerve tissue. This one came from the hypoglossal nerve, which controls tongue movement.

The report is very early evidence: it is a single case, so the results cannot be applied to everyone. The woman did not have an MRI before surgery because of cost and her own reluctance, so doctors could not see the tumor's exact location beforehand. Still, during surgery they were able to keep the nerve intact. One year later, her tongue moved normally and the tumor had not come back. No complications were reported.

The main reason to be careful is that one case cannot show what will happen for other patients. But the report suggests that when doctors suspect a tumor comes from the hypoglossal nerve, planning surgery with that in mind may help preserve both the nerve and the nearby salivary gland. People with a jaw mass should talk with their doctor about the right tests and treatment for their situation.

What this means for you:
A single case shows a rare nerve tumor can be removed while preserving tongue function, but more research is needed.

Common questions

What is a schwannoma?

A schwannoma is a tumor that grows from Schwann cells, which wrap around nerves. In this case, it grew from the hypoglossal nerve, which controls tongue movement. The report says it was confirmed by histopathological and immunohistochemical tests. Most schwannomas are noncancerous, but only a doctor can diagnose and advise on treatment.

How was the tumor treated?

The woman had surgery to remove the mass. During the operation, doctors were able to keep the hypoglossal nerve intact. One year later, her tongue moved normally and there was no sign of the tumor returning. No adverse events were reported. Treatment decisions should always be made with a doctor.

Why didn't she have an MRI before surgery?

The report says an MRI was not done because of financial considerations and the patient's reluctance. Without an MRI, doctors had less information about the tumor's exact location before surgery. This is one of the limitations of the case. If you are considering imaging, discuss the benefits and costs with your doctor.

Does this mean surgery is safe for everyone with this tumor?

No. This is a single case report, so the results cannot be generalized to all patients. The outcome was good for this woman, but more research is needed to understand how other people might respond. Always talk with your doctor about the risks and benefits of any procedure.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
Schwannomas are benign, encapsulated tumors arising from Schwann cells. Extracranial hypoglossal nerve schwannomas located in the submandibular region are exceptionally rare and may clinically and radiologically mimic primary submandibular gland tumors. A 44-year-old woman presented with a painless left submandibular mass of three months' duration. Ultrasonography and contrast-enhanced computed tomography demonstrated a well-circumscribed heterogeneous lesion closely associated with the left submandibular gland, and a pleomorphic adenoma was suspected preoperatively. Preoperative needle biopsy was not performed because of concern regarding sampling error and a potentially nondiagnostic result. Magnetic resonance imaging was not performed because of financial considerations and the patient's reluctance to undergo further examination. During surgery, the encapsulated tumor was found to arise from the hypoglossal nerve and was carefully dissected from the nerve sheath while preserving the anatomical continuity of the main nerve trunk. Histopathological and immunohistochemical examinations confirmed schwannoma. At the one-year follow-up, the patient showed normal tongue movement without recurrence or neurological deficit. A review of published reports indicates that extracranial hypoglossal nerve schwannomas have been reported to present as painless submandibular masses and may be misdiagnosed before surgery. This case emphasizes that preoperative recognition of hypoglossal nerve origin may facilitate appropriate surgical planning and may allow preservation of both the functional nerve and the uninvolved submandibular gland.
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