This report describes a 47-year-old woman with a rare duodenal malignant glomus tumor. The medical team performed a Whipple resection to remove the tumor. Histopathology and immunohistochemistry confirmed the diagnosis of this specific cancer type.
Molecular testing revealed two genetic variants of uncertain significance. These included a change in the FOXP1 gene and another in the KDM5A gene. The tumor also showed low tumor mutation burden and microsatellite stability.
Because these genetic changes have not been seen before in this tumor type, their exact role is unclear. The co-occurrence of these mutations suggests they might affect how the tumor develops. This case highlights the importance of integrating molecular profiling into the diagnosis and management of rare tumors. While surgical resection remains the cornerstone of therapy, understanding these genetic markers may help guide future care for patients with similar conditions.