Forty-two patients with newly diagnosed nasal inverted papilloma underwent endoscopic tumor resection. Some received local application of interferon-alpha gel during and after the surgery, while others received surgery alone without the gel. The study tracked recovery using a specific endoscopic scoring system at three, six, and twelve months. The researchers also checked for high-risk HPV types in the tissue samples.
The results showed that the interferon gel did not lead to better recovery scores compared to the control group. There were no statistically significant differences between the two groups at any of the follow-up points. Additionally, the rate of high-risk HPV expression was higher in the tumor tissues than in a separate group of nasal polyp controls.
No adverse events or safety concerns were reported for the patients receiving the gel. Because the study involved a small number of participants and showed no clear benefit, this treatment does not currently change standard surgical care. Readers should understand that this early evidence does not prove the gel is ineffective, but it does not support its use for improving recovery in this specific condition.