Hydroxyapatite composite sodium hyaluronate maintains alveolar ridge height and width during tooth extractionNew Implant Material Shows Promise for Preserving Jawbone After Extraction

Clinical oral investigations Published June 11, 2026 Study authors: Xue Yang, Liu Lin, Xue Chang'ao, Sun Ying, Wang Baoyan, Meng Jian, Zhou Hongzhi PubMed ↗ DOI ↗ Editorial oversight: Dr. Lars van Dijk, PhD · Surgical, Procedural & Diagnostic

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Key Takeaway

Note that HAp/HA implants show no significant difference from reference substitutes in preserving alveolar ridge dimensions.

This randomized controlled trial enrolled 200 patients requiring tooth extraction due to dental, periodontal, or periapical diseases with alveolar bone defects of depth greater than or equal to 3 mm. The study was conducted across five dental clinic centers in China to evaluate the efficacy of hydroxyapatite composite sodium hyaluronate (HAp/HA) implants compared to a reference bone substitute.

Primary outcomes included changes in alveolar ridge height and width at the implantation site over a 24-week follow-up period. Results showed an average change of -0.33 ± 1.74 mm for ridge height and -0.60 ± 1.95 mm for ridge width, with no significant variance compared to the control group. Secondary outcomes included local healing conditions, systemic safety profiles, and osseointegration scores.

Regarding secondary outcomes, the HAp/HA group achieved slightly higher average osseointegration scores than the control group, though this finding was not statistically significant. Safety assessments reported no post-operative infections or material rejections in either group. No serious adverse events were reported during the study period.

While the trial suggests that HAp/HA has clinical value for alveolar ridge preservation, the lack of statistical significance in osseointegration scores should be noted. The findings support the use of HAp/HA as a viable material for maintaining bone dimensions following extraction.

Researchers conducted a clinical trial involving 200 patients who needed tooth extractions because of dental, periodontal, or periapical diseases. The study looked at how different materials affected the alveolar ridge, which is the bone that holds your teeth in place. One group received a hydroxyapatite composite sodium hyaluronate (HAp/HA) implant, while the other group received a standard reference bone substitute.

After 24 weeks, the results showed that patients who received the HAp/HA material maintained their jawbone height and width similarly to those who received the standard material. While the HAp/HA group had slightly higher scores for how well the bone integrated with the implant, this difference was not statistically significant.

No infections or material rejections were reported in either group during the study. These findings suggest that the HAp/HA material is a safe and effective option for preserving jawbone structure after extractions. Patients should discuss these specific materials with their dentist to see if it is right for their treatment plan.

What this means for you:

The HAp/HA implant material showed no significant difference from standard bone substitutes in preserving jaw width.

Common questions

Is the new HAp/HA material safe for patients?

The study reported no post-operative infections or material rejections in either group. No serious adverse events were observed during the 24-week follow-up period, suggesting the material was well tolerated by the 200 patients involved in the trial.

How does this material compare to standard bone substitutes?

The study found no significant difference in alveolar ridge height or width between those using HAp/HA and those using a reference bone substitute. While HAp/HA had slightly higher average scores for osseointegration, the difference was not statistically significant.

Who would benefit from this type of implant?

This material is intended for patients who need tooth extractions due to dental, periodontal, or periapical diseases. It specifically targets those with alveolar bone defects of 3 mm or more to help preserve the jawbone structure.

Study Details

Study typeRct

Sample sizen = 200

EvidenceLevel 2

Follow-up5.5 mo

PublishedJun 2026

PMID42240710

View Original Abstract ↓

OBJECTIVES: Evaluate the efficacy and safety of the combination of sodium hyaluronate and hydroxyapatite for alveolar ridge preservation in fresh extraction sockets with bone defects. MATERIALS AND METHODS: A total of 200 patients, who required tooth extraction due to dental, periodontal, or periapical diseases, were enrolled in five dental clinic centers across China. Alveolar bone defects were identified, and bone grafting was indicated for defects with a depth of ≥ 3 mm on one or more sides of the affected tooth's bone wall, as measured by Cone Beam CT (CBCT). Participants were randomly and equally assigned to either the experimental group, which received hydroxyapatite composite sodium hyaluronate (HAp/HA) implants in the fresh tooth extraction socket, or the control group, which was given a reference bone substitute. Postoperative follow-up assessments were conducted for up to 24 weeks. Changes in alveolar ridge height and width at the implantation site were evaluated blindly using CBCT. Simultaneously, the local healing condition and systemic safety profiles were evaluated. RESULTS: HAp/HA exhibits superior adhesion, facilitating easier filling and shaping during dental procedures in comparison to control material. Postoperative CBCT images, performed right after the operation and at the 24-week follow-up, showed a minimal alteration in alveolar ridge height (-0.33 ± 1.74 mm) and width (-0.60 ± 1.95 mm) subsequent to HAp/HA implantation, indicating no significant variance when compared to the control material. At the 24-week follow-up, the osseointegration of the implanted material with the alveolar bone was scored using a 3-grade system, with the HAp/HA group showing slightly higher average scores than the control group, though not statistically significant. No post-operative infections or material rejections were observed in either group. CONCLUSIONS: HAp/HA can be an effective and safe material for alveolar ridge preservation in tooth extraction sockets with defects. CLINICAL RELEVANCE: Hydroxyapatite composite sodium hyaluronate possess clinical value for alveolar ridge preservation.

Hydroxyapatite composite sodium hyaluronate maintains alveolar ridge height and width during tooth extractionNew Implant Material Shows Promise for Preserving Jawbone After Extraction

Common questions

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