Daily polyphenol-rich extra virgin olive oil increased occipital connectivity in nine healthy adults.

This randomized crossover pilot neuroimaging substudy enrolled nine healthy adults. The study setting was not reported. Participants were assigned to consume daily polyphenol-rich extra virgin olive oil or regular olive oil as the comparator. Follow-up duration was not reported.

The primary outcome measured was resting-state occipital functional connectivity. Results showed increased connectivity with the polyphenol-rich intervention. The effect size was not reported. No absolute numbers or p-values were provided for this outcome.

A secondary outcome assessed urinary hydroxytyrosol-glucuronide excretion. This measure increased significantly with the intervention. The specific effect size was not reported. A significant interaction between intervention and metabolite levels was observed on occipital connectivity.

Safety data were not reported regarding adverse events, serious adverse events, discontinuations, or tolerability. Funding or conflicts of interest were not reported. The study is a pilot with preliminary findings. Limitations include the small sample size and lack of replication. Replication in larger, adequately powered studies is required. Practice relevance was not reported.