Prenatal MRI detects imaging characteristics in fetuses with complete agenesis of the corpus callosum and associated malformations
Photo by Scott Goodwill / Unsplash
Key Takeaway
Note that prenatal MRI accurately detects associated unilateral hemispheric cortical malformations missed by ultrasound in fetal cACC.
This retrospective cohort study included 101 cases of fetuses diagnosed with complete agenesis of the corpus callosum via prenatal MRI. Sixteen of these cases also had associated unilateral hemispheric cortical malformation. The study setting was not reported, and the follow-up duration was not reported. Safety data regarding adverse events, serious adverse events, discontinuations, and tolerability were not reported.
The fetal gender distribution consisted of 13 male and 3 female cases. Gestational age at diagnosis ranged from 23 weeks to 27 weeks and 2 days. Regarding hemispheric location, the left hemisphere was involved in 7 cases and the right hemisphere in 9 cases. Malformation types included Type I (C1 type) in 11 cases, Type II (C4 type) in 1 case, and Type III (C5 type) in 4 cases. The rake sign and garland sign were observed in all 11 Type I cases. Lobar involvement showed the frontal lobe in 16 cases, the parietal lobe in 10 cases, the occipital lobe in 8 cases, and no temporal lobe involvement.
The primary outcome assessed imaging characteristics and associations with fetal gender and gestational age. No secondary outcomes were reported. The study limitations were not explicitly detailed in the provided data. Funding or conflicts of interest were not reported. The evidence is observational, so causal language is avoided. The practice relevance notes that prenatal MRI is essential for optimizing perinatal management and parental genetic counseling.
View Original Abstract ↓
IntroductionTo explore the prenatal MRI features of fetal complete agenesis of the corpus callosum (cACC) associated with unilateral hemispheric cortical malformation.MethodsA retrospective analysis was conducted on 101 cases diagnosed with cACC via prenatal MRI. Among them, 16 cases were found to be associated with unilateral hemispheric cortical malformation. The imaging characteristics of this specific malformation were analyzed, and its associations with fetal gender and gestational age were investigated.ResultsIn this group of 16 cases of cACC with unilateral cortical malformation, 13 fetuses were male and 3 were female. The gestational age at diagnosis ranged from 23 weeks to 27 weeks and 2 days. The malformation was located in the left hemisphere in 7 cases and in the right hemisphere in 9 cases. Type I (C1 type: extensive cortical twisting/folding) was observed in 11 cases, all of which exhibited the “rake sign” and “garland sign”. The “rake sign” manifests as abnormally folded dysplastic cortex resembling a rake on axial or coronal views, while the “garland sign” appears as abnormally folded dysplastic cortex resembling a garland on sagittal views. Type II (C4 type: transcortical cleft formation) was observed in 1 case, and Type III (C5 type: focal cortical indentation or serrated changes) was observed in 4 cases. The unilateral cortical malformation involved the frontal lobe in 16 cases, the parietal lobe in 10 cases, and the occipital lobe in 8 cases, with no involvement of the temporal lobe.DiscussionFetal agenesis of the corpus callosum has a relatively high probability of being associated with unilateral cortical malformation. This malformation occurs more frequently in males, is mostly detected during the mid-trimester, and most commonly involves the frontal lobe. The “rake sign” and “garland sign” are its characteristic imaging features. Prenatal definitive diagnosis aids in the perinatal management of this malformation. Prenatal MRI is a crucial supplementary examination for fetal cACC diagnosed by prenatal ultrasound, as it can accurately detect associated unilateral hemispheric cortical malformations that are easily missed by ultrasound, and thus is essential for optimizing perinatal management and parental genetic counseling.
Muscle ultrasonography shows high diagnostic accuracy for fasciculation detection in ALS
A Simple Scan Could Speed Up an ALS Diagnosis
Related in Radiology & Imaging
Two-bottle bleaching gels show similar efficacy but differ in pulp chamber hydrogen peroxide diffusion and enamel surface effects.
One whitening gel lets teeth brighten with less nerve pain
This in vitro study evaluated two-bottle in-office bleaching gels applied in 30-minute sessions to sixty sound human premolars and thirty mo…
A common teeth whitening treatment may be safer for sensitive teeth thanks to a gel that blocks more pain-causing chemicals from reaching th…
Meta-analysis links perihematomal edema growth to poor outcomes in intracerebral hemorrhage patients
Brain swelling linked to worse outcomes in hemorrhage patients
This meta-analysis examines the association between perihematomal edema volume changes and outcomes in 1523 participants with intracerebral …
Early swelling in the brain after a bleed may predict higher risk of death or disability within three months.
Risk factor modeling showed modest performance for predicting visual function progression in acute NAION eyes.
Risk Factors for Vision Loss in NAION Identified in Trial Analysis
This secondary analysis of a multicenter, double-masked, sham-controlled, randomized clinical trial evaluated 589 study eyes with acute NAIO…
Analysis of trial data links sleep apnea and high diastolic pressure to early vision decline in NAION patients.
Ultrasound-guided microconvex in-plane subclavian puncture reduces composite risk and improves success rates compared to landmark technique.
Ultrasound-guided puncture lowers risks for subclavian vein catheterization
This randomized controlled trial enrolled 101 patients scheduled for elective surgery. The ultrasound-guided microconvex in-plane subclavian…
A trial of 101 patients found ultrasound-guided microconvex in-plane subclavian puncture reduced complications and improved success rates co…
From Other Specialties
Digital single session reappraisal intervention affects social media interpretation bias in college students
Digital session helps change how social media is interpreted
In this randomized controlled trial of 162 college students, the PRISM digital intervention led to greater reductions in negative interpreta…
A single digital session may help college students reduce negative ways they interpret social media posts and increase positive ones.
Meta-analysis finds 24% incidence of cognitive dysfunction after pediatric liver transplant
Nearly 1 in 4 kids face thinking problems after liver transplant
This meta-analysis of 7494 children after liver transplantation reports a pooled incidence of cognitive dysfunction of 24% (95% CI: 19.0%-30…
One in four children develops thinking problems after a liver transplant, with infants facing the highest risk.
Systematic review and meta-analysis of disitamab vedotin efficacy in urothelial carcinoma
Researchers Find Disitamab Vedotin Shows Activity In Bladder Cancer
This systematic review and meta-analysis evaluates disitamab vedotin-based therapy in HER2-negative and HER2-low locally advanced or metasta…
A new review suggests the drug disitamab vedotin might work for some bladder cancer patients with low or negative HER2 levels.
Intravenous dexmedetomidine improves sleep quality scores in women after elective cesarean section
A single dose of dexmedetomidine improved sleep for women after elective cesarean section.
This randomized controlled trial enrolled 68 women undergoing elective cesarean section. Participants receiving intravenous dexmedetomidine …
Women who received a specific medicine infusion slept better in the first few days after having an elective cesarean section.