Systematic review assesses liquid biopsy technologies for early detection of drug resistance and therapeutic response monitoring in people.
A Simple Blood Test May Catch When Your Cancer Treatment Stops Working
This systematic review evaluated liquid biopsy technologies, including ctDNA, CTCs, and EVs, for monitoring tumor genomics and customizing t…
A simple blood test can detect when cancer evolves to resist treatment weeks before standard scans show any change.
Strategies to screen and reduce adverse events in patients with asthma using systemic corticosteroids
Asthma Patients Are Still Getting Too Many Steroids — Here Is Why That Matters
This systematic review examined real-world practice strategies aimed at identifying and screening patients at risk of adverse events associa…
Asthma patients face serious, preventable harm from overused systemic steroids, yet safer biologics aren't reaching enough people who need t…
Mini-review examines natural product compounds in rodent depression models.
Nature's Keys Unlock Depression's Fire
This mini-review evaluated compounds from natural products in rodent models of depression. The publication discusses therapeutic potential a…
Natural compounds may fight depression by targeting brain inflammation through the P2X7 receptor, offering new hope for treatments beyond tr…
Systematic review examines miRNA-mediated neutrophil regulation for acute lung injury, asthma, fibrosis, and lung cancer.
Tiny Molecules in Your Blood May Control Lung Inflammation
This systematic review evaluated miRNA-mediated regulation of neutrophil dynamics as a potential therapeutic strategy for acute lung injury,…
Tiny molecules in your blood act as a switch that controls the immune cells causing lung damage in asthma, fibrosis, and cancer.
Systematic review links gut dysbiosis and AhR/TLR4 pathway alterations to non-IgE-mediated cow's milk allergy in infants.
Does gut imbalance drive cow's milk allergy in babies?
This systematic review with integrated multi-omics corroboration analyzed 39 studies involving infants aged 0 to 3 years with physician-conf…
Babies with non-IgE cow's milk allergy show gut imbalances with fewer helpful bacteria and fewer signals that help regulate the immune syste…
Pyroptosis endotypes and malnutrition linked to mortality in older adults with community-acquired pneumonia
High inflammation markers linked to higher death risk in older pneumonia patients
This retrospective cohort study evaluated 282 hospitalized older adults (aged ≥75 years) with community-acquired pneumonia. Researchers asse…
Older pneumonia patients with high inflammation markers faced a 57.5% death risk, while those with low levels had only 1.2% mortality within…
In lung cancer patients, immune-checkpoint inhibitors were associated with a 16.4% incidence of thyroid irAEs.
Thyroid Trouble Might Mean Better Lung Cancer Response
This retrospective analysis of 420 lung cancer patients treated with immune-checkpoint inhibitors at a single Italian center found that 16.4…
Having a mild thyroid reaction while on cancer drugs could actually mean the medicine is working well inside your body.
NIID patients with kidney injury show higher immune markers compared to those without kidney injury
Kidney Pain in NIID Linked to Immune Fire
This retrospective cohort study analyzed 150 genetically confirmed Neuronal intranuclear inclusion disease (NIID) patients across nine terti…
Doctors can now spot kidney trouble in Neuronal Intranuclear Inclusion Disease (NIID) by looking for a specific type of immune fire rather t…
High-dose pegylated liposomal doxorubicin shows comparable survival to conventional doxorubicin in DLBCL with reduced toxicity
A Gentler Chemo Version Holds Its Own in Lymphoma
A retrospective cohort of 512 DLBCL patients found comparable 2-year PFS (74.3% vs. 69.6%) and OS (81.4% vs. 83.8%) between overall PLD and …
A gentler chemo drug wrapped in fat bubbles matched standard treatment for lymphoma survival while sharply cutting serious side effects like…
Machine learning models predict macrophage activation syndrome risk in 737 patients with Still's disease.
New Tool Predicts Dangerous Fever Flare
This multicenter, prospective observational study analyzed 737 patients with Still's disease to identify risk factors for macrophage activat…
A new tool predicts dangerous fever flares in Still's disease by spotting high-risk signs like age, ferritin levels, and inflammation marker…
Timing of surgery after neoadjuvant chemoimmunotherapy impacts survival in operable esophageal squamous cell carcinoma
Shrink Faster, Live Longer: Timing Saves Lives in Esophageal Cancer
This multicenter retrospective cohort study evaluated 163 patients with operable esophageal squamous cell carcinoma receiving neoadjuvant ch…
Faster tumor shrinkage and surgery within six weeks of treatment predict longer survival for esophageal cancer patients receiving new therap…
NR2F2 expression in CAFs linked to poor prognosis and enhanced tumor progression in lung adenocarcinoma models.
A Hidden Cell Type in Lung Cancer May Hold a New Target
This preclinical and computational study analyzed public databases and performed in vitro experiments to evaluate cancer-associated fibrobla…
A hidden protein in support cells around lung tumors may drive cancer growth, pointing to a new treatment target for lung adenocarcinoma.