Antithyroid drug-induced agranulocytosis patients show distinct T-cell receptor repertoires compared to Graves' disease patients.
Why Your Thyroid Meds Might Trigger Rare Infections
This observational study compared immune receptor repertoires in patients with antithyroid drug-induced agranulocytosis (TiA) versus those w…
A rare but deadly reaction to thyroid drugs is linked to specific immune cell changes, offering clues to predict who's at risk before infect…
Somatic ELF4 truncation mutation linked to autoinflammatory disease in pediatric patient
Somatic Mutation Causes Rare Fever Disease
This case report describes a pediatric patient with recurrent mucocutaneous inflammation and periodic fever. Analysis of somatic truncating …
A single gene change in just some cells can cause recurring fevers and skin inflammation, expanding how doctors understand rare immune disea…
Systematic review examines lipid-immune crosstalk and dyslipidemia in rheumatoid arthritis patients.
The Hidden Link Between Arthritis Pain and Your Heart Health
This systematic review evaluated epidemiological evidence, clinical management strategies, and pathophysiological mechanisms regarding lipid…
Abnormal cholesterol is a direct driver of rheumatoid arthritis, explaining why people with RA face such a high risk of heart attack and str…
High TRIM25 expression associates with shorter survival in hepatocellular carcinoma patients.
Why a Hidden Liver-Cancer Switch Helps Tumor Cells Resist Their Own Death
This cohort study analyzed TRIM25 expression levels in patients with hepatocellular carcinoma (HCC) using TCGA, ICGC, and paired tissue samp…
A single protein helps liver cancer cells block their body's natural self-destruct mode, and removing it could open new treatment doors.
Tumor regression patterns predict ypN positivity in advanced gastric cancer patients
A Tumor's Shrinkage Pattern Could Change Stomach Cancer Surgery
This cohort study of 195 patients with advanced gastric cancer assessed how tumor regression patterns influence ypN positivity. Centripetal …
For patients facing stomach cancer surgery, the way a tumor responds to chemo may be a powerful clue to personalize their treatment and pote…
Machine learning model predicts omalizumab efficacy duration in moderate-to-severe perennial allergic rhinitis patients.
A smart model that predicts how long your allergy shot will last
This retrospective cohort study evaluated predictors of omalizumab efficacy duration in 561 patients with moderate-to-severe perennial aller…
A new computer model can estimate how long a popular allergy shot will keep working for each person, making treatment more personal.
CXCL13 quantification in PBMCs and plasma distinguishes Sézary syndrome from other cutaneous T-cell lymphomas and dermatoses.
A simple blood test could spot a rare skin cancer faster
This cohort study analyzed CXCL13 expression in peripheral blood mononuclear cells (PBMCs) and plasma concentrations in patients with suspec…
A simple blood test for a protein called CXCL13 may help doctors catch a rare, aggressive skin cancer that often looks like eczema for years…
Multiomics analysis reveals sustained immune dysregulation in pediatric MIS-C patients compared to healthy controls.
Why Some Children Stay Inflamed Months After a Rare COVID Complication
This multiomics study examined plasma and peripheral immune cells from 13 acute and 18 recovered pediatric MIS-C patients alongside 15 healt…
Some children recovering from rare COVID complications carry invisible inflammation for up to three months because their immune systems stay…
Virome and mycobiome roles in female reproductive tract health are increasingly recognized as potential ecosystem modulators.
Viruses and Fungi Hold the Key to Vaginal Health
This systematic scoping review examined the impact of the virome and mycobiome on female reproductive tract health compared to a bacteriocen…
Doctors need to look at the whole microbial team, not just the bacteria, to fix vaginal infections.
Network meta-analysis compares endoscopic techniques for sarcoidosis diagnosis
A Better Way to Diagnose Sarcoidosis Could Save Patients Months of Uncertainty
A network meta-analysis of 35 studies in patients with suspected sarcoidosis compared endoscopic tissue sampling techniques. EBUS-IFB and EB…
Getting the right diagnosis for a complex lung condition just got clearer, potentially saving patients from repeated, less effective tests.
Systematic review evaluates Treg depletion and reprogramming strategies for glioblastoma in adults.
A New Tactic to Outsmart the Brain’s Most Aggressive Cancer
This systematic review examined interventions targeting regulatory T cells in adults with glioblastoma. Specific main results and numerical …
Researchers are designing new weapons that could help a patient’s own immune system finally attack a deadly brain tumor.
Proton radiotherapy linked to lower severe lymphopenia incidence than photon therapy in lung cancer
Proton Therapy May Slash a Dangerous Side Effect in Half for Lung Cancer
A retrospective cohort study of 131 lung cancer patients receiving curative-intent radiotherapy found severe radiation-induced lymphopenia (…
For lung cancer patients, the type of radiation you get—protons versus standard photons—could dramatically change your risk of a serious tre…