Optimal Pathological Response in LACC After Neoadjuvant Chemoimmunotherapy Shows Promising Short-Term Survival
Good news for advanced cervical cancer patients
A retrospective real-world analysis of 89 patients with locally advanced cervical cancer treated with neoadjuvant chemoimmunotherapy and rad…
Women with advanced cervical cancer who respond well to initial treatment show over 90% survival and may avoid harsh follow-up drugs.
Mepolizumab plus FESS improved lung function and symptoms versus mepolizumab alone in severe CRSwNP.
When Your Nose and Lungs Are Fighting the Same War
This single randomized controlled trial enrolled 58 patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) with or without a…
A biologic drug improves both sinus and lung symptoms in people with severe nasal polyps, and adding surgery helps the nose more but doesn't…
Early daratumumab or immunomodulatory agents in high-risk smoldering multiple myeloma show uncertain benefits versus observation.
Early Drug May Delay Multiple Myeloma
This systematic review evaluated early intervention with monoclonal antibodies, immunomodulatory agents, or alkylating agents versus observa…
Imagine waking up with a headache. You take a pill, and the pain goes away.
Respiratory virus prevalence is higher in acute asthma than stable asthma across children and adults.
Your Asthma Flare-Up Might Not Be What You Think
This systematic review and meta-analysis pooled data from 111 studies involving children and adults with asthma. The analysis found that res…
A major new analysis reveals viruses are found in more than half of all asthma attacks, forcing a rethink of what a positive test really mea…
Biomarkers and functional assays evaluated for shrimp allergy in African American populations in the United States.
Why a Shrimp Allergy Test Might Be Wrong—And What to Do Next
This systematic review examined molecular and environmental biomarkers, extract-based IgE testing, component-resolved diagnostics, and funct…
A common shrimp allergy test often gives false positives, especially in certain communities, meaning many people may be avoiding a food they…
Breg-related gene signature predicts survival and immune landscape in head and neck squamous cell carcinoma.
Your Immune System Holds a Hidden Clue to Head and Neck Cancer Survival
This cohort study analyzed patients with head and neck squamous cell carcinoma (HNSCC) using bioinformatics data from TCGA and GEO databases…
A new eight-gene test predicts head and neck cancer survival better than standard measures, helping doctors identify which patients might be…
Case report and review of primary cervical melanoma shows inconsistent response to PD-1/PD-L1 inhibitors
Rare cervical melanoma cases show mixed results with immunotherapy and surgery
A case report of two patients with primary malignant melanoma of the cervix and a review of nine reported cases treated with PD-1/PD-L1 inhi…
Surgery alone fails for rare cervical melanoma, as 80% of patients progress on immunotherapy without chemotherapy or radiation.
Mepolizumab fails to improve refractory chronic cough in small eosinophilic airways disease trial
Mepolizumab reduced inflammation but did not improve cough in a small study.
A single-centre randomised controlled trial of 30 patients with refractory chronic cough and eosinophilic airways disease found subcutaneous…
Mepolizumab lowered inflammation markers in patients with chronic cough but failed to reduce their coughing or improve their quality of life…
Asthma associated with increased odds of venous thromboembolism, pulmonary embolism, and deep vein thrombosis in observational studies.
Asthma Linked to Higher Risk of Blood Clots in Observational Data
This meta-analysis of observational studies involving patients with asthma found a statistically significant association between asthma and …
People with asthma face a 1.61 times higher risk of blood clots, with the danger of pulmonary embolism rising 2.41 times and deep vein throm…
House dust mite immunotherapy reduces IgE and symptoms in Indonesian children with allergic rhinitis and asthma
Could weekly dust mite shots help Indonesian children breathe easier with less medicine?
A small RCT of 41 Indonesian children with allergic rhinitis and asthma found 14 weeks of weekly subcutaneous HDM immunotherapy significantl…
Weekly dust mite shots helped Indonesian children with allergies and asthma breathe easier, needing fewer pills and feeling less discomfort …
Fermentation enhances finger millet and soybean nutritional value and functional properties in functional foods.
Review finds fermentation improves nutritional value of finger millet and soybean
This systematic review analyzed 59 peer-reviewed studies on the fermentation of finger millet and soybean globally. The evidence suggests th…
Fermenting finger millet and soybean boosts nutrient absorption, reduces compounds that block vitamins, and improves taste and shelf life fo…
Engineering antibody-armed oncolytic viruses may enhance tumor-specific delivery and immune effects
Can viruses carry antibodies right to tumors to fight cancer better?
A systematic review examines strategies for engineering oncolytic viruses to express therapeutic antibodies within tumors. The approach aims…
Engineered viruses could carry cancer-fighting antibodies directly to tumors, boosting drug levels where needed while sparing healthy organs…