Gut microbiome interventions show conceptual promise for allergic rhinitis but clinical application remains constrained
Can fixing your gut help with seasonal allergies? The science isn't ready yet.
A narrative mini-review examining gut microbiome-based interventions for allergic rhinitis found these therapies represent a promising conce…
Gut microbiome therapies for seasonal allergies show promise, but doctors lack standard tests to measure results or confirm long-term safety…
Review explores mitochondrial transfer mechanisms in immune microenvironment remodeling across diseases
Review explores how cells share mitochondria to influence immune responses in disease
A systematic review summarizes emerging evidence on intercellular mitochondrial transfer mechanisms in inflammation, cancer, and autoimmune …
Cells swap energy factories to reshape immune responses in cancer, inflammation, and autoimmune diseases, offering new ways to target these …
Review suggests T cell epitope vaccines may help control dengue infection and modulate ADE risk
Could targeting T cells lead to a safer dengue vaccine?
A systematic review examines research on dengue virus T cell epitope-mediated immunity and antibody-dependent enhancement (ADE). The analysi…
A new dengue vaccine strategy targeting T cells could help control the virus and reduce the risk of severe disease from antibody-dependent e…
Elevated neutrophil-to-lymphocyte ratio correlates with higher mortality in rheumatoid arthritis
Higher blood cell ratio linked to increased mortality risk in rheumatoid arthritis patients
A meta-analysis of seven observational studies in patients with rheumatoid arthritis found elevated neutrophil-to-lymphocyte ratio (NLR) was…
A high blood cell ratio linked to severe inflammation raises the risk of death by 70% for people with rheumatoid arthritis.
Phase 3 trial compares switch to doravirine/islatravir versus continuing bictegravir/FTC/TAF in HIV-1
Phase 3 trial compares two HIV drug regimens for people already virologically suppressed.
A phase 3 randomized controlled trial enrolled 643 virologically suppressed adults with HIV-1 to compare switching to doravirine/islatravir …
People with HIV already on effective treatment can safely switch to a new two-drug pill without losing virus control, according to a complet…
Systematic review finds neoantigen vaccines show recurrence-free survival benefit in adjuvant melanoma
Can a custom vaccine help stop melanoma from coming back?
A systematic review of clinical trial data found that customised neoantigen vaccines, specifically mRNA-4157 from the KEYNOTE-942 trial, dem…
A custom mRNA vaccine linked to longer recurrence-free survival for melanoma patients after surgery, though it works best against 'hot' tumo…
Meta-analysis finds 2.31% EoE incidence with food allergen immunotherapy, none with aeroallergen SLIT
Study finds link between food allergy treatment and rare swallowing condition
A systematic review and meta-analysis of 17 studies in patients receiving allergen immunotherapy found the incidence of confirmed eosinophil…
Food allergy treatment linked to rare swallowing condition in 2.3% of patients receiving food desensitization, while airborne treatments sho…
Remote digital asthma management shows modest quality of life and lung function improvements in adults
Can asthma apps and websites help adults breathe easier?
A meta-analysis of 10 trials in adults with asthma found interactive remote digital management improved quality of life, symptom control, an…
Digital asthma tools show small lung function gains, but quality of life improvements were modest and didn't reach the threshold for patient…
Review explores ferroptosis in ocular microenvironment and potential therapeutic interventions
Could a new type of cell death be harming your eyes?
A systematic review evaluates the role of ferroptosis in ocular neuroinflammation and tissue degeneration. It highlights natural compounds a…
Scientists are focusing on a destructive process called ferroptosis, where cells die from iron overload, as a potential driver of eye inflam…
Digital technologies in food supply chains show promise for safety and loss reduction, but nutrition evidence is limited
Digital tools show promise for food safety and waste reduction in supply chains
A scoping review of 46 studies found digital technologies like blockchain, IoT, and AI are applied primarily in storage and transportation. …
Digital tools in food supply chains boost safety and cut waste, but only 6.5% of studies prove they improve the nutrition people actually ea…
Neuroimmune mechanisms may sustain urticaria pruritus and contribute to treatment resistance
Why do some hives keep itching? New research points to a brain-immune connection.
A systematic review synthesizes evidence on neuro-immune interactions in urticaria, suggesting these mechanisms amplify pruritic signaling a…
Chronic hives may persist due to a brain-immune feedback loop that amplifies itching and inflammation, making some treatments less effective…
Systematic review describes polysaccharide mechanisms and structure-activity relationships for anti-cancer effects
Review explores how natural polysaccharides may work against cancer in lab studies
A systematic review summarizes preclinical research on natural polysaccharides, describing multi-target anti-cancer mechanisms including imm…
Natural plant sugars might fight cancer by boosting immune cells, triggering tumor death, and stopping blood vessel growth in lab tests.