Oral quadruple therapy reduces HbA more than metformin uptitration in type 2 diabetes on triple therapy
When three diabetes pills aren't enough, does adding a fourth help more than increasing metformin?
A 24-week, multicenter RCT in 193 adults with type 2 diabetes (HbA 7.0-9.0%) on triple oral therapy compared adding a fourth oral agent vers…
When three diabetes pills fail to control blood sugar, adding a fourth medication lowered HbA1c better than simply increasing the metformin …
Calorie restriction plus exercise reduced IL-6 and knee pain more than diet alone in knee OA
Small study finds adding exercise to calorie restriction may reduce knee pain and inflammation
A 4-week RCT in 23 overweight/obese adults with knee osteoarthritis compared calorie restriction alone to restriction plus aerobic exercise.…
Adding exercise to a calorie-reduced diet lowered knee pain and a specific inflammation marker in overweight people with knee osteoarthritis…
App-supported resistance training linked to lean mass and bone gains in youth with type 1 diabetes
App-guided resistance training linked to muscle and bone gains in youth with type 1 diabetes
A 24-week RCT in 62 children and adolescents with type 1 diabetes found a progressive resistance training program delivered via the Diactive…
A smartphone app guiding resistance training helped youth with type 1 diabetes gain more lean muscle and bone mass than usual care over six …
Subgroup analysis finds tirzepatide superior to dulaglutide for HbA1c and weight in type 2 diabetes
For people struggling with diabetes on dulaglutide, could switching drugs help?
This subgroup analysis of a phase IV RCT examined adults with type 2 diabetes inadequately controlled on dulaglutide. Switching to tirzepati…
Switching from dulaglutide to tirzepatide led to greater drops in blood sugar and body weight for adults with type 2 diabetes after 40 weeks…
Tadalafil reduces some plasma neurodegeneration biomarkers in type 2 diabetes patients
Small study finds tadalafil may lower some Alzheimer's biomarkers in diabetes patients
A post-hoc analysis of a 6-week RCT in 15 individuals with type 2 diabetes found tadalafil reduced plasma amyloid-β 40, amyloid-β 42, and gl…
A small study suggests tadalafil lowers certain Alzheimer's-related blood markers in people with type 2 diabetes, though it did not change o…
Liraglutide reduces OSA severity in patients with COPD and obesity in exploratory analysis
Could a weight loss drug help people with COPD breathe easier at night?
A secondary exploratory analysis of a 40-week RCT in 40 patients with COPD and overweight/obesity found liraglutide (3.0 mg) significantly r…
A weight loss drug reduced breathing pauses and oxygen drops for people with COPD and sleep apnea, improving general health while day-time s…
GAHT in transgender men shows no significant BMD changes but increases muscle strength and body composition
Does hormone therapy affect bone health and strength for transgender men?
A systematic review with meta-analysis of transgender men found gender affirming hormone treatment was not associated with significant longi…
After four years of gender-affirming hormone therapy, transgender men show no bone loss at key sites while gaining muscle strength and lean …
Phase II RCT: Amiloride reduces arterial stiffness and blood pressure in adults with obesity and metabolic syndrome
Low-dose amiloride reduced arterial stiffness and blood pressure in adults with obesity
A phase II, single-center RCT of 137 adults with overweight/obesity and metabolic syndrome features found 24 weeks of low-dose amiloride (5 …
Low-dose amiloride reduced arterial stiffness and blood pressure in adults with obesity, offering a potential new tool to improve heart heal…
Capnography shows high diagnostic accuracy for diabetic ketoacidosis in meta-analysis
Capnography shows promise for detecting diabetic ketoacidosis in early research
A meta-analysis of 7 observational studies including 1,123 diabetic patients found capnography had 91% sensitivity and 90% specificity for d…
A simple breath test that measures carbon dioxide levels could help doctors spot dangerous diabetic ketoacidosis earlier by correctly identi…
Triple therapy for CHH shows lower hCG dose but similar spermatogenesis rates in small RCT
Can a triple-hormone approach help men with a rare fertility condition?
A randomized trial in 45 adult males with congenital hypogonadotropic hypogonadism compared triple therapy (hCG, FSH, testosterone) to combi…
Men with a rare fertility condition using three hormones together needed lower weekly doses of one drug and reported better quality of life …
Network meta-analysis finds GnRHa trigger reduces OHSS risk versus hCG in predicted high responders undergoing IVF
Study compares four IVF trigger methods for women at high risk of over-response
A network meta-analysis of 7 RCTs involving 632 predicted high responders undergoing IVF with GnRH antagonist protocols compared four final …
For women at high risk of painful IVF complications, a specific hormone trigger shot significantly lowers that risk without reducing egg cou…
Patient-led insulin titration in GDM linked to faster glycemic control and lower macrosomia risk in small RCT
Could letting pregnant women adjust their own insulin lead to healthier babies?
A single-center, nonblinded RCT of 56 individuals with GDM requiring insulin found patient-led titration achieved target fasting glucose fas…
Pregnant women who adjusted their own insulin doses reached target blood sugar faster and had babies far less likely to be born very large t…