MCH1 Receptor Antagonist RGH-706 Shows Weight Loss in Preclinical and Early Clinical Study
New Drug Targets Hunger Brain Signals to Help Shed Pounds
A preclinical and phase I/II study evaluated the MCH1 receptor antagonist RGH-706 for obesity and Prader-Willi Syndrome. In diet-induced obe…
Scientists found a new medicine that may help people lose weight by turning off hunger signals.
Longitudinal ABCD Study links central fat dynamics to cognitive deficits in adolescents
How Fat Gain in Teens Changes the Brain’s Wiring
This longitudinal observational study from the Adolescent Brain Cognitive Development (ABCD) Study analyzed central fat dynamics in 8,519 ad…
Your teen’s brain is still building itself.
FDA Approves Tzield (teplizumab) to Delay Onset of Stage 3 Type 1 Diabetes
FDA approves Tzield to delay type 1 diabetes in high-risk patients
The FDA approved Tzield (teplizumab) to delay the onset of Stage 3 type 1 diabetes in patients aged 1 year and older with Stage 2 disease. T…
The FDA approved Tzield (teplizumab) to delay the onset of stage 3 type 1 diabetes in people aged 1 and older with stage 2 disease. This is …
Meta-analysis of sex differences in insulin therapy outcomes for adults with Type 1 and Type 2 diabetes
Women and Men Respond Differently to Insulin Therapy
This systematic review and meta-analysis evaluated sex differences in insulin therapy outcomes across 24 studies involving adults with Type …
Maria takes insulin every day for type 2 diabetes.
GZR18 showed weight loss in Chinese adults with overweight or obesity in a phase 1b/2a trial.
New Drug Cuts Weight by Nearly 20% in Just 35 Weeks
In this randomized, placebo-controlled phase 1b/2a trial, 60 Chinese adults with overweight or obesity received GZR18 or placebo. Over 26 to…
This new treatment shows huge promise for helping people reach their weight goals without daily pills.
Systematic review of endocrine-disrupting chemicals and neurotoxic effects in zebrafish
Common Chemicals May Quietly Rewire Your Brain and Nerves
This systematic review synthesizes evidence from 12 studies on endocrine-disrupting chemicals (EDCs) in zebrafish. The authors identify sign…
Everyday chemicals found in plastics and pesticides may harm brain development and nerve function in ways that can last for generations.
Meta-analysis links genetic variants to gestational diabetes mellitus risk in British, Finnish, and Chinese populations.
New genes linked to gestational diabetes risk identified
This meta-analysis synthesizes GWAS data regarding genetic variants associated with gestational diabetes mellitus and Type 2 Diabetes. It id…
Two newly discovered genes, ELL2 and ATRAID, may increase risk for gestational diabetes, offering clues for future treatments.
Narrative review on dyslipidemia and erectile dysfunction pathophysiology
High Cholesterol May Damage Sexual Function Directly
This narrative review synthesizes evidence on dyslipidemia and erectile dysfunction. It concludes dyslipidemia contributes to ED through vas…
High blood fats may directly harm sexual function beyond just heart risks.
Narrative review discusses mitochondria and immune crosstalk in breast cancer patients.
Mitochondria and immune cells interact in complex ways for breast cancer patients.
This narrative review explores the role of mitochondrial biology and immune crosstalk in breast cancer. The authors note that metabolic hete…
Mitochondrial biology and immune system interactions represent a complex, context-dependent factor in breast cancer that requires careful co…
ZJU index predicts diabetes progression and normoglycemia reversion in 11,243 individuals with impaired fasting glucose.
Your Blood Sugar Future May Be Predictable Sooner Than You Think
This retrospective multicenter cohort study of 11,243 individuals with impaired fasting glucose evaluated the ZJU index. Each one-unit incre…
You’re 45, feel fine, and your last checkup showed slightly high blood sugar.
High-dose dexamethasone during chemotherapy shows no significant cortisol changes in breast cancer.
Chemotherapy Steroids May Not Shut Down Your Body’s Stress System
This prospective pilot study included 47 women with breast cancer receiving paclitaxel and dexamethasone. Morning serum cortisol and adrenoc…
This small study suggests that the body’s natural ability to make stress hormones might stay intact during certain chemotherapy regimens, ea…
Inflammatory indices associated with increased chronic kidney disease risk in coronary artery disease cohort.
A Simple Blood Test Could Predict Kidney Disease Risk in Heart Patients
This cohort study of 5181 patients with coronary artery disease examined inflammatory markers. All four indices showed significant associati…
A common blood test could warn heart patients about their kidney risk years before damage starts.