PPAR Agonists Reduce Pruritus in PBC: Meta-Analysis of 660 Patients
New drugs ease itch for patients whose current treatment fails
This systematic review and meta-analysis of 660 patients with primary biliary cholangitis and inadequate response to UDCA found that PPAR ag…
A review of six hundred sixty patients found new medicines significantly reduced itch scores in people with primary biliary cholangitis who …
Single 6 mg erdafitinib dose shows similar pharmacokinetics in mild or moderate hepatic impairment versus healthy controls.
Single dose of erdafitinib showed no dose changes needed for mild or moderate liver issues
This Phase 1 open-label single-dose study evaluated pharmacokinetics of erdafitinib in 26 participants with hepatic impairment versus health…
A single dose of erdafitinib worked well in people with mild or moderate liver problems, showing no need for dose adjustments.
Narrative review of oxidative stress and antioxidant defense in periodontitis and peri-implantitis
Oxidative stress may drive gum disease and bone loss
This narrative review examines the role of oxidative stress and antioxidant defense systems in periodontitis and peri-implantitis. The autho…
New evidence suggests that an imbalance in your body's antioxidant defenses could play a major role in how gum disease progresses.
Narrative review discusses pharmacological and lifestyle interventions for type 2 diabetes and psychological health
New hope for diabetes patients struggling with anxiety and depression
This narrative review examines the relationship between type 2 diabetes and conditions such as anxiety, depression, and cognitive impairment…
Diabetes drugs that control blood sugar might also help improve mood and reduce anxiety for patients living with the condition.
Multi-omics profiling identifies molecular associations in recurrent pregnancy loss
Multi-omics profiling reveals new links to recurrent pregnancy loss
This review examines the role of multi-omics profiling, including genomics, proteomics, and transcriptomics, in understanding recurrent preg…
New research into complex biological layers shows how genetic and immune patterns may be linked to recurrent pregnancy loss.
Retrospective review suggests preoperative data predicts skeletal muscle loss in gastric cancer patients
Early scans predict muscle loss in gastric cancer patients after surgery
This retrospective cohort study review evaluates a model using routinely available preoperative and early postoperative clinical data to pre…
A new model using routine early data can predict dangerous muscle loss in gastric cancer patients, helping doctors plan better care sooner.
Meta-analysis shows reduced oral microbial Shannon diversity in Crohn's disease versus controls
Oral bacteria shifts could reveal Crohn's disease risk
This meta-analysis reviews data from multiple cohorts involving 1,136 IBD patients and 759 controls. The authors synthesize findings on oral…
A new study links distinct mouth bacteria changes to higher gut inflammation levels in Crohn's disease patients.
L-taurine shows no overall fatigue benefit in decompensated cirrhosis but may help non-anemic patients
Taurine for cirrhosis fatigue fails overall but helps one group
This randomized controlled trial in 220 adults with decompensated cirrhosis found no significant difference in fatigue scores with L-taurine…
Taurine did not reduce fatigue in most cirrhosis patients, but those without anemia saw meaningful improvement, suggesting a targeted approa…
Systematic review finds gut microbiota drugs reduce liver enzymes in MASLD patients compared to placebo.
New drugs targeting gut bacteria may finally treat fatty liver disease
This systematic review and network meta-analysis evaluated gut microbiota-regulating drugs, including probiotics, prebiotics, synbiotics, an…
New medicines that change gut bacteria lower liver enzymes in fatty liver patients, offering hope for those struggling with diet and exercis…
Ketotifen shows significant improvements in hepatic steatosis and fibrosis indices compared with vitamin E in a pilot study of NAFLD.
Ketotifen beats Vitamin E for fatty liver disease in new trial
This randomized pilot study enrolled 60 individuals with non-alcoholic fatty liver disease (NAFLD) and followed them for 6.0 months. Partici…
New research shows a common allergy medicine reduces liver fat and scarring more effectively than Vitamin E for people with fatty liver dise…
Cochrane review finds vitamin D may slightly reduce ARI healthcare visits in children
Vitamin D may slightly cut cold visits for kids, but safety is key.
This Cochrane systematic review of 31,521 participants found that vitamin D supplementation may slightly reduce the proportion of children w…
A large review of 31,521 people found vitamin D might slightly reduce cold visits for children, though it does not lower the average number …
Protocol for TEAS adjunct with PEG in elective colonoscopy bowel preparation
New Stimulation Method Could Help Clean Bowels for Colonoscopy
This study protocol describes a single-center, single-blind, randomized controlled trial involving 404 patients undergoing elective colonosc…
A new method combines electrical stimulation with standard prep to see if it cleans the bowel better for colonoscopy.