Review of multi-omics technologies supporting immune checkpoint inhibitor use in cancer patients.
New Data Helps Doctors Pick Better Cancer Treatments
This review examines the application of multi-omics technologies within cancer patients treated with immune checkpoint inhibitors. The autho…
Using many types of medical data helps doctors choose the right cancer drugs for each person.
Pharmacogenomic adherence low in paediatric cancer despite actionable recommendations
Doctors Often Ignore Genetic Test Results for Kids with Cancer
This cohort analysis within the MARVEL-PIC RCT assessed clinician adherence to pharmacogenomic recommendations for 216 children with cancer.…
Even when genetic tests tell doctors exactly how to adjust a child’s cancer medication, they often don’t listen—and that puts kids at risk.
Polygenic risk score enrichment reduces sample size needs for coronary artery disease and inflammatory bowel disease trials.
Smarter trial designs could cut study sizes by 60% for heart disease
This in silico observational cohort study used UK Biobank data to model trial designs enriched for polygenic risk. Enriching to the upper 25…
Using genetic risk scores to pick high-risk volunteers could shrink trial sizes by 60% for heart disease and 78% for IBD, speeding up resear…
Narrative review explores conceptual frameworks across RNA worlds
RNA Is Rewriting the Rules of Life—From Ancient Earth to Modern Medicine
This narrative review discusses conceptual frameworks across RNA worlds. It synthesizes qualitative arguments about RNA's roles in early lif…
This review reveals how the same molecule that may have started life on Earth is now being engineered to fight disease.
CDK1, B3GNT7, S100A9, and MMP9 Expression Associated with Thyroid Cancer Prognosis
Immune Genes Could Predict Thyroid Cancer Outcomes Better
This retrospective cohort study analyzed 180 thyroid cancer patients to evaluate gene expression and immune infiltration. Results showed hig…
A new tool uses immune markers to spot high-risk thyroid cancer cases earlier.
EBOV-specific gene signature identified in nonhuman primates and human cohorts with Ebola infection
New gene signature can spot Ebola infection in blood samples
This observational cohort study analyzed RNA-Seq data from nonhuman primates and human cohorts with Ebola virus infection and comparator inf…
Researchers found a 50-gene signature that reliably separates Ebola from other infections in blood tests, pointing to a future diagnostic to…
GSTM1 and GSTT1 null genotype frequencies in 300 healthy individuals from urban Venezuela.
Why Your Genes Vary by Region
This cross-sectional descriptive study assessed GSTM1 and GSTT1 null polymorphism frequencies in 300 healthy unrelated individuals in an urb…
Imagine you are at a party. Everyone is there to celebrate, but not everyone has the same background.
Demographic factors influence side preference and completeness in nonsyndromic orofacial clefts across multiethnic cohorts.
Left Side Clefts Are Often More Severe
This cohort study analyzed 3,561 individuals with nonsyndromic cleft lip with or without cleft palate from North and South America, Asia, an…
Knowing which side of a cleft is usually worse helps doctors plan better care for every child.
Rare CNV dosage associated with Alzheimer's disease risk in exome case-control study
Rare DNA Errors Found Linked to Higher Alzheimer's Risk
This case-control study analyzed exome data from individuals with Alzheimer's disease and controls. It found that 22q11.21 duplication carri…
Scientists found specific DNA changes that may make some people more likely to develop Alzheimer's.
RADAR pipeline identifies 20 high-confidence retired antigen candidates from 4,664 initial candidates.
Computers Find Safe Targets for New Cancer Vaccines
This Phase 1 computational pipeline development study utilized an in silico analysis of 4,664 initial candidates derived from GTEx. The RADA…
Imagine a protein that your body ignores when you are healthy but attacks when cells turn cancerous.
UK Biobank observational review links gene-diet interactions to gout risk
Your genes and diet may team up to trigger gout
This observational study from the UK Biobank synthesizes evidence on dietary exposures and gene-diet interactions for cardiometabolic outcom…
A huge UK Biobank study found 20 specific gene-diet interactions linked to health outcomes, including gout. Your genes might influence how f…
Observational transcriptomic analysis identifies genes associated with knee osteoarthritis severity in older adults.
Knee Pain Could Start in Your Thigh Muscles, Study Says
This observational study analyzed vastus lateralis muscle RNA from 523 older adults with knee radiographs. It found 27 and 41 genes differen…
Scientists found specific genes in thigh muscles linked to knee arthritis severity.