Meta-analysis finds 30.7% molecular prevalence of yellow fever virus in non-human primates
Yellow fever virus found in many monkeys in the Americas, study shows
A meta-analysis of 39 studies involving 7,183 non-human primates found pooled molecular prevalence of yellow fever virus infection was 30.7%…
Yellow fever virus was found in 31% of monkey samples and 43% of tissue tests, with infected animals in detailed cases all dying from severe…
Review: New syphilis tests bridge diagnostic window but face standardization hurdles
New syphilis tests show promise for earlier detection but face standardization hurdles
A systematic review synthesizes evidence on technological innovations for syphilis diagnosis.
New syphilis tests could detect infections earlier than traditional methods, but global standardization hurdles remain before they can be wi…
Engineered bacteriophage systems show potential framework for treating multidrug-resistant bacterial infections
Can engineered viruses help fight superbugs? A new review maps a path forward
A systematic review discusses advances in engineered bacteriophage therapeutic systems for multidrug-resistant pathogens.
Engineered viruses paired with advanced imaging offer a new way to fight dangerous superbugs that no longer respond to standard antibiotics.
Systematic review examines PI3K/Akt-mTOR pathway role in host defense and pathogen evasion
How do germs outsmart our immune system? A key cellular pathway holds clues
A systematic review synthesizes research on the PI3K/Akt-mTOR signaling pathway in infectious diseases.
Our immune system fights infection by activating a key cellular switch, but clever germs hijack the same control panel to hide and survive i…
Systematic review details metabolic adaptations of intracellular bacterial pathogens within host cells
How do bacteria hide inside our cells to survive and cause disease?
A systematic review synthesized evidence on how intracellular bacterial pathogens, including Listeria and Chlamydia species, employ sophisti…
Bacteria like Listeria and Chlamydia act as metabolic thieves, stealing nutrients from our cells to hide from our immune system and survive.
Meta-analysis finds endothelial swelling and plasma cell infiltration common in secondary syphilis histology
What do syphilis skin lesions look like under the microscope? A new review finds patterns
A systematic review and meta-analysis of eight studies involving 384 patients with secondary syphilis found endothelial swelling (85% preval…
When blood tests or rashes aren't clear, doctors use skin biopsies to spot swelling in tiny blood vessels and dense white blood cell cluster…
MT-2301 Hib vaccine candidate shows efficacy in phase 2 study of 154 infants
How well does a new Hib vaccine protect infants when given with other routine shots?
A phase 2 study evaluated the efficacy and safety of MT-2301 (Haemophilus b conjugate vaccine) co-administered with DPT-IPV in healthy infan…
A new Hib vaccine given with routine shots reached the same antibody protection levels as the current approved vaccine in healthy infants.
Potential drug interactions did not affect rifampin TB prevention completion or adverse events
Do drug interactions make tuberculosis prevention harder to finish?
A secondary analysis of 1368 participants in a rifampin TPT trial found no difference in treatment completion or adverse events between thos…
Tuberculosis prevention treatment works safely with other drugs, but patients taking them face more unscheduled doctor visits during the cou…
Phase 1/2/3 trial of BNT162b2, BNT162b1, and BNT162b2SA COVID-19 vaccines in 46,969 healthy individuals
How did the original COVID-19 vaccine hold up? A massive study tested its safety and effectiveness in nearly 47,000 people
This Phase 1/2/3, randomized, placebo-controlled, observer-blind study evaluated the safety, tolerability, immunogenicity, and efficacy of t…
A massive study tested the safety and effectiveness of the original COVID-19 vaccine in nearly 47,000 healthy people across different ages.
Bictegravir-lenacapavir single-tablet regimen non-inferior to complex regimens for HIV-1 suppression at 48 weeks
Can a single daily pill control HIV as well as complex multi-pill regimens?
In this phase 3 randomized trial of 557 virologically suppressed adults with HIV-1 on complex regimens, switching to once-daily oral…
A new single daily pill kept HIV suppressed just as well as complex multi-pill regimens in a trial of 557 adults who had been on treatment f…
Livelihood Intervention Reduces Food Insecurity and Depression in HIV-Affected Kenyan Adolescents
Can improving livelihoods help HIV-affected teens feel better and safer?
A Kenyan RCT found that an agricultural livelihood intervention reduced food insecurity (OR: 0.45; p=0.04) and depressive symptoms (OR: 0.53…
An agricultural program in Kenya helped HIV-affected teens feel safer by reducing food insecurity, depression, anxiety, and intimate partner…
Antibiotics for Appendicitis: 37.8% Recurrence, 44.3% Appendectomy at 10 Years
Is Antibiotic Treatment for Appendicitis a Safe Long-Term Option?
In a 10-year follow-up of the APPAC trial, 37.8% of patients treated with antibiotics for uncomplicated appendicitis experienced recurrence,…
Nearly half of patients treated with antibiotics for appendicitis avoided surgery entirely over 10 years, though about 38% experienced a rec…