Nirmatrelvir-ritonavir reduced viral production by approximately 55% in SARS-CoV-2 BA.2-infected patients in Shanghai.
Your COVID Pill May Work Better—Or Worse—Than You Think
This cohort study of 48,243 SARS-CoV-2 BA.2-infected patients in Shanghai evaluated nirmatrelvir-ritonavir exposure. The analysis indicated …
How well your Paxlovid works depends heavily on your age and vaccination status.
AutoML model shows high accuracy for predicting carbapenem-resistant infections in hospitalized patients
A New AI Tool Spots Hospital's Hardest Infections Days Before They Strike
A retrospective cohort study of 958 hospitalized patients with CRO and CSO infections developed an automated machine learning model optimize…
A machine-learning tool could flag hospitalized patients at high risk for hard-to-treat drug-resistant infections — sometimes before the inf…
CRP dynamics after surgery may help detect surgical site infections in single-center analysis
A Common Blood Test Can Catch Hidden Surgical Infections Days Earlier
A single-center retrospective cohort analysis of 127 surgical patients found that CRP level >106 mg/L on postoperative day 3 was associated …
A common inflammation blood test, taken on the third day after surgery, predicted hidden surgical site infections better than waiting for sy…
Metagenomic sequencing reveals broader microbial detection than culture in biliary tract infections
A New DNA Test Reveals More of the Bugs Behind Bile-Duct Infections
This retrospective cohort study evaluated patients with biliary tract infections to compare metagenomic next-generation sequencing (mNGS) ag…
A new DNA test found bile infections usually contain a wide mix of bacteria, fungi, and viruses that standard lab cultures often miss.
Indoor residual spraying linked to over 70% reduction in malaria force of infection in Ghanaian children
A Clever Math Trick Just Measured Malaria Where Surveys Can't Reach
A cohort study in 1-5-year-old children in northern Ghana estimated malaria transmission using queuing theory approaches. Application to sur…
Borrowing math from call-center lines may help scientists prove whether malaria sprays actually work.
Global early-onset GBS mortality in neonates decreased nearly 50% from 1990 to 2021
A Major Cause of Newborn Death Has Halved Worldwide — but Not for Everyone
A systematic analysis of global burden data from 1990-2021 found that early-onset GBS mortality in neonates decreased by nearly 50% worldwid…
Deaths from a deadly newborn infection have nearly halved globally since 1990, but the world's poorest regions have seen almost no progress …
Reactive oral cholera vaccination reduced transmission by 53.5% to 62.1% in Blantyre, Malawi.
Oral Vaccine Cuts Cholera Spread by Over 60%
This observational case study from Blantyre, Malawi, assessed the impact of a reactive oral cholera vaccine (OCV) campaign on transmission d…
A new analysis of routine data from a Malawi cholera outbreak shows the oral vaccine cut disease spread by over 60% during the emergency.
R3clone strain accounts for 70% of rifampicin-resistant TB in Rwanda and transmits across borders.
How One Drug-Resistant TB Strain Quietly Crossed African Borders
This observational study analyzed 375 Mycobacterium tuberculosis isolates from Rwanda, Burundi, and public repositories. The R3clone was ide…
Genomic surveillance shows that a dominant drug-resistant TB strain causing most cases in Rwanda has been quietly spreading across borders i…
2024/25 KP.2 vaccination shows waning protection against COVID-19 hospitalization in adults over 60 in Quebec.
The COVID Booster Worked — Until Week 32, When Protection Nearly Vanished
This test-negative study evaluated the 2024/25 KP.2 vaccine in adults over 60 years old in Quebec, Canada. Among 49,949 participants, overal…
The latest COVID vaccine clearly helps older adults stay out of the hospital — but not for as long as many hoped.
Qualitative study identifies structural factors driving broad-spectrum antibiotic prescribing among healthcare staff in Singapore, Nepal, and Thailand.
Why hospitals keep reaching for antibiotics they don't need
This qualitative study interviewed 194 physicians, nurses, pharmacists, and management staff across ten institutions in Singapore, Nepal, an…
When hospitals lack good lab tests and clear rules, doctors lean on broad, heavy-duty antibiotics "just in case" — and that fuels resistance…
Meta-analysis finds doxycycline prophylaxis reduces STI risk in MSM and transgender women
A Common Pill Could Slash Your Risk of Common STIs
A systematic review and meta-analysis of 14 studies in men who have sex with men and transgender women found doxycycline prophylaxis reduced…
A major review of the latest science confirms that a simple antibiotic, taken strategically, offers powerful new protection against chlamydi…
Probiotic supplementation with phototherapy improved outcomes in jaundiced neonates compared to phototherapy alone.
A Simple Probiotic May Help Newborns Beat Jaundice Faster
This randomized controlled trial enrolled 79 jaundiced neonates receiving phototherapy with or without probiotic supplementation (M-16V, Bb-…
Adding a specific probiotic to standard jaundice treatment may help newborns get better faster and support their long-term development.